TPGS-VE (CAS 9002-96-4) is Efficient Source of Natural Vitamin E
24 May 2012 • by Natalie Aster
TPGS-VE (tocophersolan, tocofersolan, vitamin E TPGS) is a water-soluble form of natural-source vitamin E, with the molecular formula C35H58O6. It is prepared by esterifying the acid group of crystalline d-?-tocopheryl acid succinate with polyethylene glycol 1000. Vitamin E TPGS is very stable and does not hydrolyze under normal conditions. It is practically tasteless.
Possessing unparalleled properties and a solid history of safety and efficacy, this non-toxic multi role excipient is used in a variety of industries and applications.
Vitamin E TPGS enhances the absorption and bioavailability of lipid and poorly soluble compounds especially in conditions of malabsorption by three major mechanisms: emulsification of lipid compounds and solubilization of poorly soluble compounds; formation of micelle-like particles which facilitate absorption; and modulation of efflux pump activity by inhibition of the P-glycoprotein (P-gp) which is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs.
The properties of vitamin E TPGS as an amphiphile, emulsifier and its ability to form micelle particles and various liquid crystalline phases enable TPGS to serve in drug delivery and controlled release systems. Vitamin E TPGS is used to affect physical form, solubility and other properties of drug delivery and controlled release systems.
A host of pharmaceutical companies have been incorporating vitamin E TPGS mainly in oral dosage forms for years but new delivery applications are being investigated such as parental delivery, nasal delivery, ophthalmic delivery, etc.
TPGS-VE market is covered in the study TPGS-VE (CAS 9002-96-4) Market Research Report 2012. The report encompasses proper description of the product, unveils application areas, and briefly summarizes patents in the sphere. It overlooks TPGS-VE market situation, names manufacturers, suppliers as well as users. The report also provides current TPGS-VE prices in the market.
More information on the TPGS-VE market can be found in the report “TPGS-VE (CAS 9002-96-4) Market Research Report 2012”.