Hospital-Acquired Infections: Diagnostic Markets and Testing Developments, Treatments, Key Competitors and Trends

Date: July 22, 2011
Pages: 150
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Publisher: Kalorama Information
Report type: Strategic Report
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Hospital-Acquired Infections: Diagnostic Markets and Testing Developments, Treatments, Key Competitors and Trends
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A hospital-acquired infection (HAI) is a new infection that develops in a patient during hospitalization. It is usually defined as an infection that is identified at least forty-eight to seventy-two hours following admission, so infections incubating, but not clinically apparent, at admission are excluded. This type of infection is also known as a nosocomial infection (or more generically healthcare-associated infections).

The following market data is provided in this report:

  • Market for HAI Diagnostics
  • Forecast for HAI Diagnostics to 2015
  • HAI Tests on the Market
  • Market for Diagnostics by Infection Type (C. Diff., MRSA, Pneumonia, Other)
  • Molecular HAI Market vs. Conventional HAI Market, Present and in 2015
  • Geographic Breakdown of Testing (U.S., Europe, Asia, ROW)
  • New Hospital Infection Product Testing Products in the Market
  • Company Profiles
  • Treatment Products on the Market, HAI Antibiotic market Size and Forecast

Both diagnostics and treatment segments have unique circumstances for growth which are discussed in detail in the report. Worldwide, both segments combined are worth more than $9 billion for 2010 with 2015 sales expected to reach $10.3 billion. The market has shown an increase of 3% annually with sales increasing from $7.9 billion in 2005. Although the treatment segment will continue to struggle to maintain growth, the testing segment will offset declines beginning in 2012.

This report primarily focuses on bacterial nosocomial infections with some mention of viral infections. The major consideration is given to bacterial nosocomial infections because a) they are the most frequent type of infections spread in the hospital setting, and b) the practical aspects of diagnosis and therapy are more meaningful based both on medical considerations and on market considerations.

Some of the issues discussed in this report include:
  • Development of Potential Life-Saving Products
  • Development of Fast Testing Systems
  • Growing Drug Resistance
  • Development of Better Pharmacodiagnostics
  • Market Opportunity and Growth Rates Expected in Diagnostics versus Treatment
  • Hospital Procedures for Use of Testing and Antibiotics
  • Attention to Special Population Issues
  • Demographics and Epidemiology
  • New Government Guidelines and Requirements for Preventing Infection
  • Focus on Alliances and Partnerships

Market analysis in this report considers primarily the epidemiological considerations and the size of patient groups both in the United States and globally, where available. We have accumulated the most recent data available, understanding that virtually no organization does extensive studies on these applications on a regular basis. Many studies are highly localized and may only apply to a community, state or country (more often countries that are not a part of the major markets for nosocomial diagnostic and therapeutic products). In many instances, we have had to draw from broader epidemiologic data, that is, on data that reach outside of the hospital environment in order to try and construct a picture of the nosocomial testing and treatment needs.
CHAPTER ONE: EXECUTIVE SUMMARY

Overview
Infection Control Summary
Scope and Methodology
Total Size and Growth of the Market
Issues and Trends Affecting Market
  Molecular Testing vs. Conventional Testing
Leading Competitors

CHAPTER TWO: INTRODUCTION AND INDUSTRY TRENDS

Overview
Introduction to Pathogens
Classification of Antibacterial Organisms
Common Hospital (nosocomial) Infections
  Description of Infections
  Acinetobacter Baumannii
  Clostridium Difficile
  Gastroenteritis
  Hospital-Acquired Pneumonia (HAP)
  Pseudomonas Aeruginosa
  Staphylococcus Aureus/Methicillin-Resistant Staphylococcus Aureus
  Stenotrophomonas Maltophilia
  Tuberculosis
  Urinary Tract Infections
  Vancomycin-Resistant Enterococcus
Hospital Units and Infection Risks
  Burn Units
  Intensive Care Units
  Emergency Departments
Principles of Anti-bacterial Therapy
Infecting Organism
Antibiotic Sensitivity Testing
Site of Infection
Host Defenses and Organ Function
Antibiotic Pharmacokinetics
Monitoring Therapy
General Infection Statistics
Nosocomial Infection Statistics
Populations at Risk for Infection
Demographics of the World
Infections and Drug Resistance
Causes of Drug Resistance
Antibiotic Abuse
Antibiotic Use in Agriculture
Drug Resistance in Select Populations
Children
The Elderly
Compromised Individuals
Measures for Reducing Resistance
Antibiotic Cycling
Antibiotic Education
Screening Hospitalized patients
The American Recovery and Reinvestment Act of 2009
Financial Impact of Hospital Infections
State Level Case Study of HAI Admissions and Readmissions
Manufacturer and Marketer Trends
Trends in Partnerships and Alliances
Developers Trends

CHAPTER THREE: HOSPITAL INFECTION DIAGNOSTICS

Overview
Methods of Transmission
  Airborne
  Contact
  Direct-Contact Transmission
  Indirect-Contact Transmission
  Droplet
  Vehicle
  Prevention Measures
Testing
  Drug-Resistance/Susceptibility Testing
  Genotypic Methods
  DNA Sequencing
  Solid-phase Hybridization Techniques
  Microarrays
  Real-time Polymerase Chain Reaction Techniques
  Phenotypic Methods
  Phage-based Assays
  Colorimetric Methods
  The Nitrate Reductase Assay
Nosocomial Disease Testing
  Acinetobacter Baumannii
  Clostridium Difficile
  Hospital-Acquired Pneumonia
  Ventilator-Associated Pneumonia
  Pseudomonas Aeruginosa
  Staphylococcus Aureus
  Tuberculosis
  Urinary Tract Infections
New Developments
Market Overview
Total Market Size and Forecast
HAI Testing by Infection Type
Hospital Infection Testing Market by Geographical Region
Molecular Testing vs. Conventional Testing.
Market and Forecast for Molecular HAI
Competitors in HAI Testing

CHAPTER FOUR: TREATING HOSPITAL INFECTIONS

Overview
Treatment Guidelines
Clostridium Difficile
Gastroenteritis
Hospital-Acquired Pneumonia
Ventilator-associated Pneumonia
Pseudomonas Aeruginosa
Staphylococcus Aureus
Stenotrophomonas maltophilia
Tuberculosis
Urinary Tract Infections
Recent Drug Approvals
Market Overview

CHAPTER FIVE: MARKET SUMMARY

Market Considerations
Market Overview
Regional Breakdown of Market
Competitive Summary

CHAPTER SIX: COMPANY PROFILES

Introduction
Abbott Laboratories
AdvanDx, Inc.
Alere
AstraZeneca
Bayer Healthcare Pharmaceuticals (Bayer Schering Pharma) v Becton, Dickinson
Cepheid
Cubist Pharmaceuticals
Daiichi Sankyo
Diatherix Laboratories Inc.
Gen-Probe Inc.
GlaxoSmithKline
Johnson & Johnson
Merck & Co.
Meridian Bioscience, Inc.
Pfizer
Roche
Seegene, Inc.

APPENDIX: LIST OF MAJOR PROVIDERS

LIST OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

Table 1-2: The Global Market for Hospital Infections by Product Segment (Diagnostics, Treatment), 2005-2015
Figure 1-1: The Global Market for Hospital Infections 2005-2015
Figure 1-2: Growth Rate - HAI Diagnostic Market vs. HAI Treatment Market
Table 1-3: MRSA Risk and Testing Priority

CHAPTER TWO: INTRODUCTION AND INDUSTRY TRENDS

Table 2-1: Antibiotics with Difficult Penetration
Table 2-2: Common Nosocomial Infections
Table 2-3: Risk Factors for M. tuberculosis
Table 2-4: Common ICU Infections
Table 2-5: Estimated World and U.S. Incidence of Bacterial Infections
Figure 2-1: Estimated World and U.S. Incidence of Bacterial Infections
Figure 2-2: U.S. Hospital Admissions, Percent Acquiring HAIs
Table 2-6: World Population at Risk for Serious Bacterial Infections, Secondary to Chronic Diseases by Selected Geographical Region (World, U.S., Europe), 2010
Figure 2-3: World Population at Risk for Serious Bacterial Infections, Secondary to Chronic Diseases by Selected Geographical Region, 2010
Table 2-4: Estimated World Population by Age and Geographical Region, 2010
Figure 2-4: Estimated World Population by Age and Geographical Region, 2010
Table 2-5: Pennsylvania State Analysis of HAI Readmissions and Related Costs, 2009
Table 2-6: Pennsylvania State Analysis of HAIs, 2009

CHAPTER THREE: HOSPITAL INFECTION DIAGNOSTICS

Table 3-1: CDC Healthcare Setting Guidelines
Table 3-2: MRSA Risk and Testing Priority
Table 3-3: Recent Approvals for Hospital Infection Testing (Product, Company, Description of Test, Approved Regions)
Table 3-4: New Developments, Hospital Infection Testing (Developer, Description, Status, Indication)
Table 3-5: The World Market for Hospital Infection Testing/Diagnostics 2005-2015 (Revenues, Percent Change)
Figure 3-1: The World Market for Hospital Infection Testing/Diagnostics 2005-2015
Figure 3-2: Distribution of Revenues for HAI Testing by Infection Type, 2010 Estimates (MRSA, Cdiff, Other HAIs)
Table 3-6: The World Market for Hospital Infection Testing/Diagnostics Estimated Products Sales by Geographic Region (US, Europe, ROW) 2005-2015
Figure 3-3: The World Market for Hospital Infection Testing/Diagnostics Estimated Product Sales by Geographic Region (US, Europe, ROW) 2005-2015
Table 3-7: Detection Time for MRSA by Screening Method (Test Type, Turnaround Time, Average Cost)
Figure 3-4: Molecular vs. Conventional Diagnostic Market for HAIs in 2010 and Projected to 2015
Table 3-8: The World Market for Hospital Infection Diagnostics (Top 9 Leading Suppliers vs. Others) 2010

CHAPTER FOUR: TREATING HOSPITAL INFECTIONS

Table 4-1: Treatment Options for Bacterial Infections (Type, Brand, and Manufacturer)
Table 4-3: Recent Approvals for Hospital Infection Treatments
Table 4-5: The World Market for Hospital Infection Treatment 2005-2015
Figure 4-3: The World Market for Hospital Infection Treatment Estimated Market Share by Region, 2010

CHAPTER FIVE: MARKET SUMMARY

Table 5-1: The Global Market for Hospital Infections by Product Segment, 2005-2015
Figure 5-1: The Global Market for Hospital Infection Products 2005-2015
Figure 5-2: The Global Market for Hospital Infection Products by Product Segment, 2010 (Diagnostics, Treatment)
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