Non-alcoholic Steatohepatitis Treatment Global Market Insights 2025, Analysis and Forecast to 2030, by Market Participants, Regions, Technology, Application, Product Type

May 2025 | 80 pages | ID: N1811709D953EN
Prof Research

Abstracts

Non-alcoholic Steatohepatitis Treatment Market Summary

Introduction and Market Overview

Non-alcoholic steatohepatitis (NASH) treatments, including vitamin E, obeticholic acid, and resmetirom, address a progressive liver disease driven by obesity (650 million adults globally), type 2 diabetes (537 million cases), and metabolic syndrome. NASH, projected to affect 27 million U.S. patients by 2030, is a leading cause of liver transplants and increases cardiovascular risk by 50%. The market is propelled by rising prevalence, non-invasive diagnostics improving accuracy by 40%, and accelerated regulatory approvals, such as Rezdiffra in 2024. Government funding, including USD 2.31 billion from NIDDK, and 60% OECD reimbursement coverage further drive growth. The global NASH treatment market is estimated at USD 5.0-9.0 billion in 2025, with a CAGR of 22%-30% through 2030.

Regional Market Trends

• North America: The U.S. leads with high obesity rates and Rezdiffra adoption, while Canada emphasizes metabolic health programs.
• Europe: Germany, France, and the UK drive growth with advanced liver disease management and biomarker adoption.
• Asia Pacific: China and India see rising NASH cases due to lifestyle changes, with Japan focusing on novel therapies.
• Rest of the World: Brazil expands diagnostic infrastructure, while the Middle East addresses diabetes-related NASH.

Distribution Channel Analysis

• Hospital Pharmacies: Expected growth of 22.5%-30.5%, driven by novel therapies like resmetirom. Trends focus on specialized liver care.
• Retail and Specialty Pharmacies: Projected growth of 22.0%-30.0%, linked to outpatient management. Advances emphasize patient access.
• Other Pharmacies: Anticipated growth of 21.5%-29.5%, covering online platforms. Trends highlight digital prescriptions.

Type Analysis

• Vitamin E and Pioglitazone: Expected growth of 20.0%-28.0%, used for early-stage NASH. Trends focus on cost-effective options for mild cases.
• Obeticholic Acid (OCA): Projected growth of 22.5%-30.5%, effective for fibrosis. Advances emphasize regulatory progress and combination therapies.
• Lanifibranor: Anticipated growth of 23.0%-31.0%, valued for multi-pathway action. Trends highlight metabolic and anti-fibrotic benefits.
• Semaglutide: Expected growth of 22.8%-30.8%, leveraging weight loss and diabetes synergy. Developments prioritize dual indications.
• Resmetirom: Expected growth of 24.0%-32.0%, a first-in-class therapy reducing liver fat. Trends focus on transformative outcomes.
• Aramchol: Expected growth of 21.5%-29.5%, targeting steatosis. Trends highlight potential in combination regimens.
• Cenicriviroc: Expected growth of 21.0%-29.0%, addressing inflammation. Developments prioritize anti-fibrotic effects.
• Other Drugs: Expected growth of 20.5%-28.5%, covering pipeline candidates. Trends focus on diverse mechanisms.

Key Market Players

• Madrigal Pharmaceuticals: Pioneers resmetirom for NASH treatment.
• Intercept Pharmaceuticals: Develops obeticholic acid for fibrosis.
• Inventiva: Focuses on lanifibranor for metabolic benefits.
• Novo Nordisk: Offers semaglutide, leveraging diabetes expertise.
• Pfizer: Innovates combination therapies for NASH.

Porter’s Five Forces Analysis

• Threat of New Entrants: Moderate, as high R&D costs and regulatory hurdles exist, but unmet medical needs attract new players.
• Threat of Substitutes: Moderate, with lifestyle interventions competing, but advanced NASH requires pharmacological solutions.
• Bargaining Power of Buyers: Moderate, as insurers negotiate prices, but limited approved therapies strengthen providers.
• Bargaining Power of Suppliers: Low, with multiple suppliers of active pharmaceutical ingredients.
• Competitive Rivalry: High, with companies competing on efficacy, safety, and speed to market.

Market Opportunities and Challenges

Opportunities:

• Addressing NASH, projected to affect 27 million U.S. patients by 2030.
• Leveraging obesity and diabetes, impacting 650 million and 537 million people, respectively.
• Utilizing non-invasive diagnostics, improving accuracy by 40%.
• Benefiting from USD 2.31 billion NIDDK funding for research.
• Expanding 60% OECD reimbursement coverage for NASH therapies.
• Developing combination therapies for comprehensive management.

Challenges:

• High costs of novel therapies limiting patient access.
• Regulatory delays for pipeline drugs.
• Limited NASH awareness and diagnostics in developing regions.
• Competition from lifestyle-based interventions.
• Complexity in managing advanced NASH and comorbidities.

Contents

CHAPTER 1 EXECUTIVE SUMMARY

CHAPTER 2 ABBREVIATION AND ACRONYMS

CHAPTER 3 PREFACE

3.1 Research Scope
3.2 Research Sources
  3.2.1 Data Sources
  3.2.2 Assumptions
3.3 Research Method
Chapter Four Market Landscape
4.1 Market Overview
4.2 Classification/Types
4.3 Application/End Users

CHAPTER 5 MARKET TREND ANALYSIS

5.1 Introduction
5.2 Drivers
5.3 Restraints
5.4 Opportunities
5.5 Threats

CHAPTER 6 INDUSTRY CHAIN ANALYSIS

6.1 Upstream/Suppliers Analysis
6.2 Non-Alcoholic Steatohepatitis Treatment Analysis
  6.2.1 Technology Analysis
  6.2.2 Cost Analysis
  6.2.3 Market Channel Analysis
6.3 Downstream Buyers/End Users

CHAPTER 7 LATEST MARKET DYNAMICS

7.1 Latest News
7.2 Merger and Acquisition
7.3 Planned/Future Project
7.4 Policy Dynamics

CHAPTER 8 HISTORICAL AND FORECAST NON-ALCOHOLIC STEATOHEPATITIS TREATMENT MARKET IN NORTH AMERICA (2020-2030)

8.1 Non-Alcoholic Steatohepatitis Treatment Market Size
8.2 Non-Alcoholic Steatohepatitis Treatment Market by End Use
8.3 Competition by Players/Suppliers
8.4 Non-Alcoholic Steatohepatitis Treatment Market Size by Type
8.5 Key Countries Analysis
  8.5.1 United States
  8.5.2 Canada
  8.5.3 Mexico

CHAPTER 9 HISTORICAL AND FORECAST NON-ALCOHOLIC STEATOHEPATITIS TREATMENT MARKET IN SOUTH AMERICA (2020-2030)

9.1 Non-Alcoholic Steatohepatitis Treatment Market Size
9.2 Non-Alcoholic Steatohepatitis Treatment Market by End Use
9.3 Competition by Players/Suppliers
9.4 Non-Alcoholic Steatohepatitis Treatment Market Size by Type
9.5 Key Countries Analysis
  9.5.1 Brazil
  9.5.2 Argentina
  9.5.3 Chile
  9.5.4 Peru

CHAPTER 10 HISTORICAL AND FORECAST NON-ALCOHOLIC STEATOHEPATITIS TREATMENT MARKET IN ASIA & PACIFIC (2020-2030)

10.1 Non-Alcoholic Steatohepatitis Treatment Market Size
10.2 Non-Alcoholic Steatohepatitis Treatment Market by End Use
10.3 Competition by Players/Suppliers
10.4 Non-Alcoholic Steatohepatitis Treatment Market Size by Type
10.5 Key Countries Analysis
  10.5.1 China
  10.5.2 India
  10.5.3 Japan
  10.5.4 South Korea
  10.5.5 Southest Asia
  10.5.6 Australia

CHAPTER 11 HISTORICAL AND FORECAST NON-ALCOHOLIC STEATOHEPATITIS TREATMENT MARKET IN EUROPE (2020-2030)

11.1 Non-Alcoholic Steatohepatitis Treatment Market Size
11.2 Non-Alcoholic Steatohepatitis Treatment Market by End Use
11.3 Competition by Players/Suppliers
11.4 Non-Alcoholic Steatohepatitis Treatment Market Size by Type
11.5 Key Countries Analysis
  11.5.1 Germany
  11.5.2 France
  11.5.3 United Kingdom
  11.5.4 Italy
  11.5.5 Spain
  11.5.6 Belgium
  11.5.7 Netherlands
  11.5.8 Austria
  11.5.9 Poland
  11.5.10 Russia

CHAPTER 12 HISTORICAL AND FORECAST NON-ALCOHOLIC STEATOHEPATITIS TREATMENT MARKET IN MEA (2020-2030)

12.1 Non-Alcoholic Steatohepatitis Treatment Market Size
12.2 Non-Alcoholic Steatohepatitis Treatment Market by End Use
12.3 Competition by Players/Suppliers
12.4 Non-Alcoholic Steatohepatitis Treatment Market Size by Type
12.5 Key Countries Analysis
  12.5.1 Egypt
  12.5.2 Israel
  12.5.3 South Africa
  12.5.4 Gulf Cooperation Council Countries
  12.5.5 Turkey

CHAPTER 13 SUMMARY FOR GLOBAL NON-ALCOHOLIC STEATOHEPATITIS TREATMENT MARKET (2020-2025)

13.1 Non-Alcoholic Steatohepatitis Treatment Market Size
13.2 Non-Alcoholic Steatohepatitis Treatment Market by End Use
13.3 Competition by Players/Suppliers
13.4 Non-Alcoholic Steatohepatitis Treatment Market Size by Type

CHAPTER 14 GLOBAL NON-ALCOHOLIC STEATOHEPATITIS TREATMENT MARKET FORECAST (2025-2030)

14.1 Non-Alcoholic Steatohepatitis Treatment Market Size Forecast
14.2 Non-Alcoholic Steatohepatitis Treatment Application Forecast
14.3 Competition by Players/Suppliers
14.4 Non-Alcoholic Steatohepatitis Treatment Type Forecast

CHAPTER 15 ANALYSIS OF GLOBAL KEY VENDORS

15.1 Madrigal Pharmaceuticals
  15.1.1 Company Profile
  15.1.2 Main Business and Non-alcoholic Steatohepatitis Treatment Information
  15.1.3 SWOT Analysis of Madrigal Pharmaceuticals
  15.1.4 Madrigal Pharmaceuticals Non-alcoholic Steatohepatitis Treatment Revenue, Gross Margin and Market Share (2020-2025)
15.2 Intercept Pharmaceuticals
  15.2.1 Company Profile
  15.2.2 Main Business and Non-alcoholic Steatohepatitis Treatment Information
  15.2.3 SWOT Analysis of Intercept Pharmaceuticals
  15.2.4 Intercept Pharmaceuticals Non-alcoholic Steatohepatitis Treatment Revenue, Gross Margin and Market Share (2020-2025)
15.3 Inventiva
  15.3.1 Company Profile
  15.3.2 Main Business and Non-alcoholic Steatohepatitis Treatment Information
  15.3.3 SWOT Analysis of Inventiva
  15.3.4 Inventiva Non-alcoholic Steatohepatitis Treatment Revenue, Gross Margin and Market Share (2020-2025)
15.4 Nordisk
  15.4.1 Company Profile
  15.4.2 Main Business and Non-alcoholic Steatohepatitis Treatment Information
  15.4.3 SWOT Analysis of Nordisk
  15.4.4 Nordisk Non-alcoholic Steatohepatitis Treatment Revenue, Gross Margin and Market Share (2020-2025)
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Tables and Figures
Table Abbreviation and Acronyms
Table Research Scope of Non-Alcoholic Steatohepatitis Treatment Report
Table Data Sources of Non-Alcoholic Steatohepatitis Treatment Report
Table Major Assumptions of Non-Alcoholic Steatohepatitis Treatment Report
Figure Market Size Estimated Method
Figure Major Forecasting Factors
Figure Non-Alcoholic Steatohepatitis Treatment Picture
Table Non-Alcoholic Steatohepatitis Treatment Classification
Table Non-Alcoholic Steatohepatitis Treatment Applications
Table Drivers of Non-Alcoholic Steatohepatitis Treatment Market
Table Restraints of Non-Alcoholic Steatohepatitis Treatment Market
Table Opportunities of Non-Alcoholic Steatohepatitis Treatment Market
Table Threats of Non-Alcoholic Steatohepatitis Treatment Market
Table Covid-19 Impact For Non-Alcoholic Steatohepatitis Treatment Market
Table Raw Materials Suppliers
Table Different Production Methods of Non-Alcoholic Steatohepatitis Treatment
Table Cost Structure Analysis of Non-Alcoholic Steatohepatitis Treatment
Table Key End Users
Table Latest News of Non-Alcoholic Steatohepatitis Treatment Market
Table Merger and Acquisition
Table Planned/Future Project of Non-Alcoholic Steatohepatitis Treatment Market
Table Policy of Non-Alcoholic Steatohepatitis Treatment Market
Table 2020-2030 North America Non-Alcoholic Steatohepatitis Treatment Market Size
Figure 2020-2030 North America Non-Alcoholic Steatohepatitis Treatment Market Size and CAGR
Table 2020-2030 North America Non-Alcoholic Steatohepatitis Treatment Market Size by Application
Table 2020-2025 North America Non-Alcoholic Steatohepatitis Treatment Key Players Revenue
Table 2020-2025 North America Non-Alcoholic Steatohepatitis Treatment Key Players Market Share
Table 2020-2030 North America Non-Alcoholic Steatohepatitis Treatment Market Size by Type
Table 2020-2030 United States Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Canada Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Mexico Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 South America Non-Alcoholic Steatohepatitis Treatment Market Size
Figure 2020-2030 South America Non-Alcoholic Steatohepatitis Treatment Market Size and CAGR
Table 2020-2030 South America Non-Alcoholic Steatohepatitis Treatment Market Size by Application
Table 2020-2025 South America Non-Alcoholic Steatohepatitis Treatment Key Players Revenue
Table 2020-2025 South America Non-Alcoholic Steatohepatitis Treatment Key Players Market Share
Table 2020-2030 South America Non-Alcoholic Steatohepatitis Treatment Market Size by Type
Table 2020-2030 Brazil Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Argentina Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Chile Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Peru Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Asia & Pacific Non-Alcoholic Steatohepatitis Treatment Market Size
Figure 2020-2030 Asia & Pacific Non-Alcoholic Steatohepatitis Treatment Market Size and CAGR
Table 2020-2030 Asia & Pacific Non-Alcoholic Steatohepatitis Treatment Market Size by Application
Table 2020-2025 Asia & Pacific Non-Alcoholic Steatohepatitis Treatment Key Players Revenue
Table 2020-2025 Asia & Pacific Non-Alcoholic Steatohepatitis Treatment Key Players Market Share
Table 2020-2030 Asia & Pacific Non-Alcoholic Steatohepatitis Treatment Market Size by Type
Table 2020-2030 China Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 India Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Japan Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 South Korea Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Southeast Asia Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Australia Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Europe Non-Alcoholic Steatohepatitis Treatment Market Size
Figure 2020-2030 Europe Non-Alcoholic Steatohepatitis Treatment Market Size and CAGR
Table 2020-2030 Europe Non-Alcoholic Steatohepatitis Treatment Market Size by Application
Table 2020-2025 Europe Non-Alcoholic Steatohepatitis Treatment Key Players Revenue
Table 2020-2025 Europe Non-Alcoholic Steatohepatitis Treatment Key Players Market Share
Table 2020-2030 Europe Non-Alcoholic Steatohepatitis Treatment Market Size by Type
Table 2020-2030 Germany Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 France Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 United Kingdom Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Italy Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Spain Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Belgium Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Netherlands Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Austria Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Poland Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Russia Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 MEA Non-Alcoholic Steatohepatitis Treatment Market Size
Figure 2020-2030 MEA Non-Alcoholic Steatohepatitis Treatment Market Size and CAGR
Table 2020-2030 MEA Non-Alcoholic Steatohepatitis Treatment Market Size by Application
Table 2020-2025 MEA Non-Alcoholic Steatohepatitis Treatment Key Players Revenue
Table 2020-2025 MEA Non-Alcoholic Steatohepatitis Treatment Key Players Market Share
Table 2020-2030 MEA Non-Alcoholic Steatohepatitis Treatment Market Size by Type
Table 2020-2030 Egypt Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Israel Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 South Africa Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Gulf Cooperation Council Countries Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2030 Turkey Non-Alcoholic Steatohepatitis Treatment Market Size
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Treatment Market Size by Region
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Treatment Market Size Share by Region
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Treatment Market Size by Application
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Treatment Market Share by Application
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Treatment Key Vendors Revenue
Figure 2020-2025 Global Non-Alcoholic Steatohepatitis Treatment Market Size and Growth Rate
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Treatment Key Vendors Market Share
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Treatment Market Size by Type
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Treatment Market Share by Type
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Treatment Market Size by Region
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Treatment Market Size Share by Region
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Treatment Market Size by Application
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Treatment Market Share by Application
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Treatment Key Vendors Revenue
Figure 2025-2030 Global Non-Alcoholic Steatohepatitis Treatment Market Size and Growth Rate
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Treatment Key Vendors Market Share
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Treatment Market Size by Type
Table 2025-2030 Non-Alcoholic Steatohepatitis Treatment Global Market Share by Type