Enhancer of zeste homolog 2 protein inhibitors - Pipeline Insight, 2022
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DelveInsight’s, “Enhancer of zeste homolog 2 protein inhibitors - Pipeline Insight, 2022” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Enhancer of zeste homolog 2 protein inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Enhancer of zeste homolog 2 protein inhibitors: Overview
Enhancer of zeste homolog 2 is a component of the Polycomb repressive complex 2 that mediates chromatin-based gene silencing through trimethylation of lysine 27 on histone H3. This complex plays vital roles in the regulation of development-specific gene expression.
Function – Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme encoded by EZH2 gene, that participates in histone methylation and, ultimately, transcriptional repression. EZH2 catalyzes the addition of methyl groups to histone H3 at lysine 27, by using the cofactor S-adenosyl-L-methionine. Mutation or over-expression of EZH2 has been linked to many forms of cancer. EZH2 inhibits genes responsible for suppressing tumor development, and blocking EZH2 activity may slow tumor growth. EZH2 has been targeted for inhibition because it is up regulated in multiple cancers.
Enhancer of zeste homolog 2 protein inhibitors – EZH2 is upregulated in various cancers with high levels associated with metastatic cancer and poor prognosis. Dysregulation of the histone methyltransferase EZH2 plays a critical role in the development of a variety of malignancies including B-cell lymphomas.
Enhancer of zeste homolog 2 protein inhibitors Emerging Drugs Chapters
This segment of the Enhancer of zeste homolog 2 protein inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Enhancer of zeste homolog 2 protein inhibitors Emerging Drugs
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Further product details are provided in the report……..
Enhancer of zeste homolog 2 protein inhibitors: Therapeutic Assessment
This segment of the report provides insights about the different Enhancer of zeste homolog 2 protein inhibitors drugs segregated based on following parameters that define the scope of the report, such as:
Enhancer of zeste homolog 2 protein inhibitors: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Enhancer of zeste homolog 2 protein inhibitors therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Enhancer of zeste homolog 2 protein inhibitors drugs.
Report Highlights
Current Scenario and Emerging Therapies:
DelveInsight’s, “Enhancer of zeste homolog 2 protein inhibitors - Pipeline Insight, 2022” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Enhancer of zeste homolog 2 protein inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
Enhancer of zeste homolog 2 protein inhibitors: Overview
Enhancer of zeste homolog 2 is a component of the Polycomb repressive complex 2 that mediates chromatin-based gene silencing through trimethylation of lysine 27 on histone H3. This complex plays vital roles in the regulation of development-specific gene expression.
Function – Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme encoded by EZH2 gene, that participates in histone methylation and, ultimately, transcriptional repression. EZH2 catalyzes the addition of methyl groups to histone H3 at lysine 27, by using the cofactor S-adenosyl-L-methionine. Mutation or over-expression of EZH2 has been linked to many forms of cancer. EZH2 inhibits genes responsible for suppressing tumor development, and blocking EZH2 activity may slow tumor growth. EZH2 has been targeted for inhibition because it is up regulated in multiple cancers.
Enhancer of zeste homolog 2 protein inhibitors – EZH2 is upregulated in various cancers with high levels associated with metastatic cancer and poor prognosis. Dysregulation of the histone methyltransferase EZH2 plays a critical role in the development of a variety of malignancies including B-cell lymphomas.
Enhancer of zeste homolog 2 protein inhibitors Emerging Drugs Chapters
This segment of the Enhancer of zeste homolog 2 protein inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Enhancer of zeste homolog 2 protein inhibitors Emerging Drugs
- Tazemetostat: Epizyme, Inc.
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- CPI-1205: Constellation Pharmaceuticals
Further product details are provided in the report……..
Enhancer of zeste homolog 2 protein inhibitors: Therapeutic Assessment
This segment of the report provides insights about the different Enhancer of zeste homolog 2 protein inhibitors drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players working on Enhancer of zeste homolog 2 protein inhibitors
- Phases
- Late-stage products (Phase III and
- Mid-stage products (Phase II and
- Early-stage products (Phase I/II and Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Infusion
- Intradermal
- Intramuscular
- Oral
- Parenteral
- Subcutaneous
- Topical.
- Molecule Type
- Vaccines
- Monoclonal Antibody
- Peptides
- Polymer
- Small molecule
- Product Type
Enhancer of zeste homolog 2 protein inhibitors: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Enhancer of zeste homolog 2 protein inhibitors therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Enhancer of zeste homolog 2 protein inhibitors drugs.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Enhancer of zeste homolog 2 protein inhibitors R&D. The therapies under development are focused on novel approaches for Enhancer of zeste homolog 2 protein inhibitors.
- Enhancer of zeste homolog 2 protein inhibitors Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Scenario and Emerging Therapies:
- How many companies are developing Enhancer of zeste homolog 2 protein inhibitors drugs?
- How many Enhancer of zeste homolog 2 protein inhibitors drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for Enhancer of zeste homolog 2 protein inhibitors?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Enhancer of zeste homolog 2 protein inhibitors therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Enhancer of zeste homolog 2 protein inhibitors and their status?
- What are the key designations that have been granted to the emerging drugs?
Introduction
Executive Summary
Enhancer of zeste homolog 2 protein inhibitors: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Enhancer of zeste homolog 2 protein inhibitors – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Enhancer of zeste homolog 2 protein inhibitors companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Enhancer of zeste homolog 2 protein inhibitors Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
Comparative Analysis
Tazemetostat: Epizyme, Inc.
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
CPI-1205: Constellation Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
PF 06821497: Pfizer
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
OR S1: Daiichi Sankyo
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Enhancer of zeste homolog 2 protein inhibitors Key Companies
Enhancer of zeste homolog 2 protein inhibitors Key Products
Enhancer of zeste homolog 2 protein inhibitors- Unmet Needs
Enhancer of zeste homolog 2 protein inhibitors- Market Drivers and Barriers
Enhancer of zeste homolog 2 protein inhibitors- Future Perspectives and Conclusion
Enhancer of zeste homolog 2 protein inhibitors Analyst Views
Enhancer of zeste homolog 2 protein inhibitors Key Companies
Appendix
Executive Summary
Enhancer of zeste homolog 2 protein inhibitors: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Enhancer of zeste homolog 2 protein inhibitors – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Enhancer of zeste homolog 2 protein inhibitors companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Enhancer of zeste homolog 2 protein inhibitors Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
Comparative Analysis
Tazemetostat: Epizyme, Inc.
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
CPI-1205: Constellation Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
PF 06821497: Pfizer
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
OR S1: Daiichi Sankyo
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Enhancer of zeste homolog 2 protein inhibitors Key Companies
Enhancer of zeste homolog 2 protein inhibitors Key Products
Enhancer of zeste homolog 2 protein inhibitors- Unmet Needs
Enhancer of zeste homolog 2 protein inhibitors- Market Drivers and Barriers
Enhancer of zeste homolog 2 protein inhibitors- Future Perspectives and Conclusion
Enhancer of zeste homolog 2 protein inhibitors Analyst Views
Enhancer of zeste homolog 2 protein inhibitors Key Companies
Appendix
LIST OF TABLES
Table 1 Total Products for Enhancer of zeste homolog 2 protein inhibitors
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products
Table 1 Total Products for Enhancer of zeste homolog 2 protein inhibitors
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products
LIST OF FIGURES
Figure 1 Total Products for Enhancer of zeste homolog 2 protein inhibitors
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products
Figure 1 Total Products for Enhancer of zeste homolog 2 protein inhibitors
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products
