Pemphigus Vulgaris (PV) – Pipeline Insight, 2020
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DelveInsight’s, “Pemphigus Vulgaris (PV) – Pipeline Insight, 2020,” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Pemphigus Vulgaris pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Pemphigus Vulgaris (PV): Overview
Pemphigus vulgaris is an autoimmune disorder that involves blistering and erosion of the skin and mucous membranes. It occurs almost exclusively in middle-aged or older people. The primary lesion of pemphigus vulgaris is a soft blister filled with clear fluid that appears on healthy or irritated skin. Many cases begin with blisters in the mouth, followed by skin blisters that may come and go. The blisters inside the mouth can make it hard for the person to eat. The rupture of blisters on the skin may be painful and limit the person's daily activities. Complications due to infections can be serious and the damaging nature of the blisters can cause loss of body fluids and protein. The exact cause of pemphigus vulgaris is unknown, but the blisters in pemphigus vulgaris are associated with the binding of antibodies to the skin cells.
Symptoms
The major symptom of pemphigus vulgaris is the development of clear, soft, and painful (sometimes tender) blisters of various sizes. In addition, the top layer of skin may detach from the lower layers in response to slight pinching or rubbing, causing it to peel off in sheets and to leave painful areas of open skin (erosions). Blisters can form on the skin and rupture, leaving raw, painful, crusted wounds. The person feels generally ill.
Diagnosis
Doctors usually recognize pemphigus vulgaris by its characteristic blisters, but the disorder is diagnosed with certainty by examining a sample of skin under a microscope (skin biopsy). Sometimes doctors use special chemical stains that allow antibody deposits to be seen under the microscope (called an immunofluorescence assay).
Treatment
Pemphigus Vulgaris Emerging Drugs Chapters
This segment of the Pemphigus Vulgaris report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Pemphigus Vulgaris Emerging Drugs
Efgartigimod is being evaluated for the treatment of patients with Pemphigus Vulgaris in an open-label, non-controlled, phase II study. The proposed study is an open-label, non-controlled, adaptive-design Phase II study to evaluate the safety, pharmacodynamics, pharmacokinetics, efficacy, and conditions of use (dosage, frequency of administration at maintenance) of ARGX-113 in patients with mild to moderate Pemphigus (Vulgaris or Foliaceus), either newly diagnosed or relapsing.
Further product details are provided in the report……..
Pemphigus Vulgaris: Therapeutic Assessment
This segment of the report provides insights about the different Pemphigus Vulgaris drugs segregated based on following parameters that define the scope of the report, such as:
Phases
DelveInsight’s report covers around 5+ products under different phases of clinical development like
Pemphigus Vulgaris: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Pemphigus Vulgaris therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Pemphigus Vulgaris drugs.
Report Highlights
Current Treatment Scenario and Emerging Therapies:
DelveInsight’s, “Pemphigus Vulgaris (PV) – Pipeline Insight, 2020,” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Pemphigus Vulgaris pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
Pemphigus Vulgaris (PV): Overview
Pemphigus vulgaris is an autoimmune disorder that involves blistering and erosion of the skin and mucous membranes. It occurs almost exclusively in middle-aged or older people. The primary lesion of pemphigus vulgaris is a soft blister filled with clear fluid that appears on healthy or irritated skin. Many cases begin with blisters in the mouth, followed by skin blisters that may come and go. The blisters inside the mouth can make it hard for the person to eat. The rupture of blisters on the skin may be painful and limit the person's daily activities. Complications due to infections can be serious and the damaging nature of the blisters can cause loss of body fluids and protein. The exact cause of pemphigus vulgaris is unknown, but the blisters in pemphigus vulgaris are associated with the binding of antibodies to the skin cells.
Symptoms
The major symptom of pemphigus vulgaris is the development of clear, soft, and painful (sometimes tender) blisters of various sizes. In addition, the top layer of skin may detach from the lower layers in response to slight pinching or rubbing, causing it to peel off in sheets and to leave painful areas of open skin (erosions). Blisters can form on the skin and rupture, leaving raw, painful, crusted wounds. The person feels generally ill.
Diagnosis
Doctors usually recognize pemphigus vulgaris by its characteristic blisters, but the disorder is diagnosed with certainty by examining a sample of skin under a microscope (skin biopsy). Sometimes doctors use special chemical stains that allow antibody deposits to be seen under the microscope (called an immunofluorescence assay).
Treatment
- Corticosteroids (oral or intravenous)
- Antibiotics and protective dressings for ruptured blisters
- Often immunosuppressants or immune globulin to reduce corticosteroid use
Pemphigus Vulgaris Emerging Drugs Chapters
This segment of the Pemphigus Vulgaris report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Pemphigus Vulgaris Emerging Drugs
- Efgartigimod: argenx
Efgartigimod is being evaluated for the treatment of patients with Pemphigus Vulgaris in an open-label, non-controlled, phase II study. The proposed study is an open-label, non-controlled, adaptive-design Phase II study to evaluate the safety, pharmacodynamics, pharmacokinetics, efficacy, and conditions of use (dosage, frequency of administration at maintenance) of ARGX-113 in patients with mild to moderate Pemphigus (Vulgaris or Foliaceus), either newly diagnosed or relapsing.
Further product details are provided in the report……..
Pemphigus Vulgaris: Therapeutic Assessment
This segment of the report provides insights about the different Pemphigus Vulgaris drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Pemphigus Vulgaris
Phases
DelveInsight’s report covers around 5+ products under different phases of clinical development like
- Mid-stage products (Phase II and Phase I/II)
- Early-stage products (Phase I/II and Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Intravenous
- Intramuscular
- Molecule Type
- Monoclonal antibodies
- T lymphocyte cell therapies
- Gene therapies
- Product Type
Pemphigus Vulgaris: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Pemphigus Vulgaris therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Pemphigus Vulgaris drugs.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Pemphigus Vulgaris R&D. The therapies under development are focused on novel approaches to treat/improve Pemphigus Vulgaris.
- May 2020: Argenx reported interim data from first cohort of Phase 2 proof-of-concept clinical trial of efgartigimod for the treatment of pemphigus vulgaris.
- Pemphigus Vulgaris Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Pemphigus Vulgaris drugs?
- How many Pemphigus Vulgaris drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Pemphigus Vulgaris?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Pemphigus Vulgaris therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Pemphigus Vulgaris and their status?
- What are the key designations that have been granted to the emerging drugs?
- argenx BVBA
- Cabaletta Bio
- Efgartigimod
- DSG3 CAART
Introduction
Executive Summary
Pemphigus Vulgaris: Overview
Causes
Mechanism of Action
Signs and Symptoms
Diagnosis
Disease Management
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Pemphigus Vulgaris – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Pemphigus Vulgaris companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Pemphigus Vulgaris Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Mid Stage Products (Phase II)
Comparative Analysis
Efgartigimod: argenx
Product Description
Research and Development
Product Development Activities
Early Stage Products (Phase I)
DSG3-CAART: Cabaletta Bio
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Pemphigus Vulgaris Key Companies
Pemphigus Vulgaris Key Products
Pemphigus Vulgaris- Unmet Needs
Pemphigus Vulgaris- Market Drivers and Barriers
Pemphigus Vulgaris- Future Perspectives and Conclusion
Pemphigus Vulgaris Analyst Views
Pemphigus Vulgaris Key Companies
Appendix
Executive Summary
Pemphigus Vulgaris: Overview
Causes
Mechanism of Action
Signs and Symptoms
Diagnosis
Disease Management
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Pemphigus Vulgaris – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Pemphigus Vulgaris companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Pemphigus Vulgaris Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Mid Stage Products (Phase II)
Comparative Analysis
Efgartigimod: argenx
Product Description
Research and Development
Product Development Activities
Early Stage Products (Phase I)
DSG3-CAART: Cabaletta Bio
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Pemphigus Vulgaris Key Companies
Pemphigus Vulgaris Key Products
Pemphigus Vulgaris- Unmet Needs
Pemphigus Vulgaris- Market Drivers and Barriers
Pemphigus Vulgaris- Future Perspectives and Conclusion
Pemphigus Vulgaris Analyst Views
Pemphigus Vulgaris Key Companies
Appendix
LIST OF TABLES
Table 1 Total Products for Pemphigus Vulgaris
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products
Table 1 Total Products for Pemphigus Vulgaris
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products
LIST OF FIGURES
Figure 1 Total Products for Pemphigus Vulgaris
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products
Figure 1 Total Products for Pemphigus Vulgaris
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products