2013 Analysis of the UK Molecular Diagnostics Market: Emerging Opportunities, Supplier Shares, Country Forecasts, Innovative Technologies, and Competitive Landscape

April 2013 | 855 pages | ID: 242B14983D8EN
Venture Planning Group

Abstracts

This report presents a comprehensive analysis of the UK molecular diagnostics market, including:

• Major issues pertaining to the UK molecular diagnostics laboratory practice, as well as key economic, regulatory, demographic, social and technological trends with significant market impact during the next ten years.
• An extensive review of DNA probe and biochip technologies, test formats, detection methodologies, trends in testing automation and amplification methods.
• Ten-year test volume and reagent sales forecasts for the following categories:
  • Infectious Diseases
  • Genetic Diseases
  • Cancer
  • Paternity Testing/HLA Typing
  • Forensic Testing
• Review of testing methodologies an instrumentation technologies.
• Feature comparison of automated and semiautomated analyzers.
• Sales and market shares of leading suppliers.
• Over 60 specific opportunities for molecular diagnostic instruments, test systems, IT and auxiliary products.
• Profiles of major suppliers, and emerging market entrants, including their sales, product portfolios, marketing tactics, technological know-how, new products in R&D, collaborative arrangements and business strategies.
• Alternative market penetration strategies.
• Potential market entry barriers and risks.
• Business planning issues and concerns.

Contains 855 pages and 35 tables

Contents

INTRODUCTION

WORLDWIDE MARKET AND TECHNOLOGY OVERVIEW

A. DNA Sequencing
  1. Introduction
  2. Sequencing Methods
  3. Autoradiography
  4. The Human Genome Project
  5. Sequencing Automation
  6. Image Scanners
  7. Fluorescent Detection
  8. Gene Profiling
  9. Gene Expression
  10. Polymorphism Screening
  11. Protein Interaction Networks
B. DNA And RNA Probe Technology
  1. Basic Principles
  2. Probe Preparation
  3. The DNA Probe Test
    a. Sample Preparation
    b. Hybridization
    c. Separation
    d. Detection/Measurement
  4. Test Formats
    a. Filter Hybridization
    b. Southern Blot
    c. Northern Blot
    d. In Situ Hybridization
    e. Others
  5. Labeling Techniques
  6. Amplification Methods
    Polymerase Chain Reaction
      Temperature Cyclers
      PCR Variations
    Immuno-PCR
    QC-PCR
    DAP-PCR
      Strand Displacement Activation
      TMA
      Ligase Chain Reaction
      Branched DNA
        Hybridization Protection Assay
      Nucleic-Acid Sequence-Based Amplification
      Self-Sustained Sequence Replicase
      Others
        Ampliprobe
        CAR
        CAS
        CPT
        Dendritic Polymer Technology
        ISO-CR
        LAT
        Probe Networks
        RAMP
        Repair Chain Reaction
        Rolling Circles
        Sequence Independent Gene Amplification
        Sequence Initiation Reaction
        SISPA
        Solid Phase Amplification
C. Detection Technologies
  1. Radioactive Methods
    a. Overview
    b. Major Isotopes
      P-32
      S-35
      H-3
      I-125
  2. Non-Isotopic Methods
    a. Enzymatic Labels
    b. Chemical Labeling
      Indirect Chemical Labeling
      Direct Chemical Labeling
    c. Fluorescence
    d. Chemiluminescence
    e. Electrical Conductivity
D. Instrumentation Review
  1. Abbott LCx
  2. Beckman Coulter/Biomek FK
  3. Becton Dickinson SDA
  4. Bio-Rad GeneScope
  5. Gen-Probe Tigris
  6. Roche Cobas Amplicor
  7. Tecan LS Series
E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip
  Liquid Transportation and Mixing
  Separation
  Reaction
  Detection
F. Pharmacogenomics
G. Major Applications
  1. Microbiology/Infectious Diseases
    a. Overview
    b. Major Infectious Diseases
    AIDS
      Structure and Composition
      Classification
      AIDS Origins
      Animal Lentivirus Systems
      Virus Receptors
      HIV Infections in Humans
        Pathogenesis and Pathology
      CD4T Lymphocytes and Memory Cells
      Monocytes and Macrophages
      Lymphoid Organs
      Neural Cells
      Viral Coinfections
        Clinical Findings
      Plasma Viral Load
      Pediatric AIDS
        Neurologic Disease
        Opportunistic Infections
        Cancer
      Immunity
        Virus Isolation
        Serology
        Viral Nucleic Acid/Antigen Detection
      Epidemiology
        Worldwide Spread of AIDS
        United States
        Routes of Transmission
      DNA Probes
        Overview
        Quantitative PCR
        In Situ PCR
        Needed Improvements
      Viral Load/Drug Resistance Testing
      Genotype and Phenotype Testing
      Blood Banking Considerations
    Adenovirus
      Background
      Diagnostic Tests
      Vaccines and Drugs
      Adeno-Associated Viruses (AAV)
    Anthrax/Bacillus Anthracis
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Babesiosis
      Background
    BEA and Other Bartonella Diseases
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Chagas Disease
      Background
    Campylobacter
      Background
      Diagnostic Tests
        Culture Identification
      Vaccines and Drugs
    Chlamydia
      Background
        Chlamydia psittaci
        Chlmaydia pneumoniae
        Chlamydia trachomatis
      Diagnostic Tests
      Vaccines and Drugs
    Creutzfeldt-Jakob’s Disease
      Background
      Blood Transmission
      Diagnostic Tests
      Major Commercial and Academic Players
        Bayer
        Disease Sciences/Bio Tec Global
        Imperial College School of Medicine
        Ortho-Clinical Diagnostics
        Pall
        ProMetic Life Sciences
        Proteome Sciences/Idexx
        Q-One Biotech
        Serono
        U.S. Agricultural Research Service
      Drugs
      Vaccines
    Cytomegalovirus
      Background
        Chorioretinitis
        Gastrointestinal
        Central Nervous System Disease
      Diagnostic Tests
      Vaccines and Drugs
    Ebola Virus
      Background
        Epidemiology
        Clinical Syndromes
      Diagnostic Tests
      Vaccines and Drugs
    EchoVirus
      Background
        Acute Aseptic Meningitisis
        Encephalitis
        Exanthems
        Respiratory Disease
        Myopericarditis
        Neonatal Infections
      Diagnostic Tests
      Vaccines and Drugs
    Encephalitis
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Enteroviruses
      Background
      Diagnostic Tests
        Viral Isolation and Identification
        Antibody Tests
      Vaccines and Drugs
    Epstein-Barr Virus
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Gonorrhea
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Hepatitis
      Hepatitis A
      Hepatitis B
        Structure and Composition
        Replication
      Hepatitis C
      Hepatitis D (Delta)
      Hepatitis E
      Hepatitis G
      Hepatitis Infections Pathology
      Clinical Findings
      Laboratory Tests
        Hepatitis A
        Hepatitis B
        Hepatitis C
        Hepatitis D
        Hepatitis E
      Virus-Host Immune Reactions
      Epidemiology
        Hepatitis A
        Hepatitis B
        Hepatitis C
        Hepatitis D (Delta)
      Vaccines and Drugs
    Herpes Simplex Virus
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Legionella
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Lyme Disease
      Background
        Clinical Description
        Clinical Case Definition
        Laboratory Criteria for Diagnosis
        Case Classification
      Diagnostic Tests
      Vaccines and Drugs
    Malaria
    Mycoplasma
      Background
        Ureaplasma Urealyticum & Mycoplasma
Hominis
      Diagnostic Tests
      Vaccines and Drugs
    Papillomaviruses/HPV
      Background
        HPV in Cancer
        Cervical Neoplasm
      Diagnostic Tests
      Vaccines and Drugs
        Prevention
    Parvovirus B19
      Background
        Microbiology
        Epidemiology
        Clinical Syndromes
        Erythema Infectiosum (Slapped Cheek)
        Adult Polyarthropathy
        Transient Aplastic Crisis
        Transient Pancytopenia
        Red Cell Aplasia in Immunocompromised
        Perinatal Infections
      Diagnostic Test
      Vaccines and Drugs
    Pneumonia
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Polyomaviruses
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Salmonellosis
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Shigellosis
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Streptococci
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Group A Streptococci
        Group B Streptococci
    Toxoplasmosis
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Tuberculosis
      Background
      Diagnostic Tests
        Microscopic Characteristics
        Cultural Characteristics
        Skin Tests
        MDRTB
      Vaccines and Drugs
    West Nile Virus
      Background
        Clinical Syndromes
      Diagnostic Tests
      Vaccines and Drugs
    Yersinia
      Background
      Diagnostic Tests
      Vaccines and Drugs
    c. Antibiotic Susceptibility
  2. Cancer Testing
    a. Overview
    b. Major Cancer Types
    Prostate
    Lung
    Colon and Rectum
    Breast
    Skin
    Uterine
    Leukemia
    Oral
    c. Oncogenes
      Abl/abl-bcr
      AIB1
      BCL-2
      BRCA1
      CD44
      C-fos
      C-myb
      C-myc
      CYP17
      Erb-B
      HPC1
      N-myc
      P40
      P51
      P53
      PIK3CA
      PTI-1
      Ras
      Reg
      Sis
      Src
  3. Genetic Diseases
    a. Overview
    b. Nucleic Acid Amplification
    c. Chromosome Imaging
    d. Genomics Technologies
    e. Proteomics Technologies
    f. Current Pharmacogenomic Tests
    g. Future Pharmacogenomic Testing
    h. Major Diseases
      Achondroplasia
      Autosomal Dominant Polycystic Kidney Disease
      Cancer
      Cosmetogenomics
      Cystic Fibrosis
      Down's Syndrome
      Duchenne and Becker Muscular Dystrophy
      Factor V (Leiden)
      Factor IX Deficiency
      Fragile X Syndrome
      Heart Disease
      Hemochomatosis
      Hemophilia
      Huntington's Disease
      Maternal-Fetal Incompatibility
      Multiple Endocrine Neoplasia
      Phenylketonuria (PKU)
      Polycystic Kidney Disease (PKD)
      Prenatal Screening
      Retinitis Pigmentosa
      Retinoblastoma
      Sickle Cell Anemia
      Spinal Muscular Atrophy
      Vitamin B12 Metabolism
    i. Social Issues and Concerns
  4. Forensic Testing
    a. Overview
    b. Multilocus and Single Locus Probes
      Multilocus Probes
      Single Locus Probes
      PCR and RFLP
    c. The FBI
    d. DNA Profile Data Banks
      U.S.A.
      U.K.
    e. Judicial Implementation
    f. Major Crime Categories
    g. Factors Contributing to the DNA Probe Market Expansion
      Technology Availability
      Use of Hair as Evidence
    h. Wildlife Forensics
  5. Paternity Testing/HLA Typing
  6. Other Applications
    a. Disease Susceptibility Testing
    b. Cardiovascular Diseases
    c. Diabetes
    d. Alzheimer's Disease
    e. Periodontal Disease
    f. Plasma Purification
    g. Organ Transplantation
    h. Water Contamination
    i. Other
H. Competing/complementing Technologies
  1. Monoclonal Antibodies/Immunoassays
  2. RNA Probes
  3. Two-Dimensional Electrophoresis
  4. Flow Cytometry

U.K.

A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares

MAJOR PRODUCT DEVELOPMENT OPPORTUNITIES

A. Instrumentation
B. Reagent Kits and Test Systems/panels
C. Computers, Software and Automation
D. Auxiliary Products

DESIGN CRITERIA FOR DECENTRALIZED TESTING PRODUCTS

ALTERNATIVE MARKET PENETRATION STRATEGIES

A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies For Decentralized Testing Markets
  1. Marketing Approaches
  2. Product Complexity
  3. Customer Preference
  4. Established Suppliers
  5. Emerging Suppliers
  6. Major Types Of Distributors
  7. Market Segmentation

POTENTIAL MARKET ENTRY BARRIERS AND RISKS

A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge And Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges

COMPETITIVE PROFILES

Abbott
Affymetrix
Agilent
Applied Gene Technologies
Arca
Beckman Coulter/Danaher
Becton Dickinson
Biokit
BioMerieux
Bio-Rad
Biotest
Caliper
Cepheid
Decode
Diadexus
Eiken
Enzo
Exact Sciences
Fujirebio
Gen-Probe
Hologic
Illumina
Innogenetics/Solvay
Kreatech
Li-Cor Biosciences
Life Technologies
Monogram Biosciences
Myriad Genetics
Nanogen/Elitech
Novartis
Orchid CellMark
Ortho-Clinical Diagnostics
Proteome Sciences
Qiagen
Roche
Scienion
Sequenom
Shimadzu
Siemens
Sierra Molecular
Takara Bio
Tecan Group

APPENDIXES

Appendix I: Major Universities and Research Centers Developing Molecular Diagnostic Technology
Appendix II: Glossary of Terms
Appendix III: Currency Exchange Rates

List Of Tables

LIST OF TABLES

Major Companies Developing or Marketing AIDS Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Adenovirus Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Campylobacter Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Chlamydia Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing CMV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing EBV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Gonorrhea Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Hepatitis Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Herpes Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Legionella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Lyme Disease Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Mycoplasma Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Papilloma Virus Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Pneumonia Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Salmonella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Shigella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Streptococci Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Toxoplasmosis Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Tuberculosis Molecular Diagnostic And Other Direct Identification Tests
Oncogenes Potential Application in Cancer Diagnosis Major Companies Developing or Marketing Cancer Molecular Diagnostic Tests
Major Companies Developing or Marketing Molecular Diagnostic Test For Genetic Diseases
Summary Table U.K., Molecular Diagnostics Test Volume And Sales Forecast by Major Application
U.K., Laboratories Performing Dna Sequencing by Market Segment
U.K., Molecular Diagnostics Market Potential Laboratory Universe by Market Segment
U.K., Molecular Diagnostics Test Volume Forecast By Major Application
U.K., Major Infectious Disease Molecular Diagnostics Test Volume Forecast
U.K., Infectious Disease Screening NAT Volume Forecast
U.K., Molecular Diagnostics Market Forecast By Major Application
U.K., Infectious Disease Screening NAT Reagent Market Forecast by Test
U.K., Molecular Diagnostics Market by Major Supplier