2013 Analysis of the German Molecular Diagnostics Market: Emerging Opportunities, Supplier Shares, Country Forecasts, Innovative Technologies, and Competitive Landscape

April 2013 | 850 pages | ID: 2025943C74BEN
Venture Planning Group

Abstracts

This report presents a comprehensive analysis of the German molecular diagnostics market, including:

• Major issues pertaining to the German molecular diagnostics laboratory practice, as well as key economic, regulatory, demographic, social and technological trends with significant market impact during the next ten years.
• An extensive review of DNA probe and biochip technologies, test formats, detection methodologies, trends in testing automation and amplification methods.
• Ten-year test volume and reagent sales forecasts for the following categories:
  • Infectious Diseases
  • Genetic Diseases
  • Cancer
  • Paternity Testing/HLA Typing
  • Forensic Testing
• Review of testing methodologies an instrumentation technologies.
• Feature comparison of automated and semiautomated analyzers.
• Sales and market shares of leading suppliers.
• Over 60 specific opportunities for molecular diagnostic instruments, test systems, IT and auxiliary products.
• Profiles of major suppliers, and emerging market entrants, including their sales, product portfolios, marketing tactics, technological know-how, new products in R&D, collaborative arrangements and business strategies.
• Alternative market penetration strategies.
• Potential market entry barriers and risks.
• Business planning issues and concerns.

Contains 850 pages and 36 tables

Contents

INTRODUCTION

WORLDWIDE MARKET AND TECHNOLOGY OVERVIEW

A. DNA Sequencing
  1. Introduction
  2. Sequencing Methods
  3. Autoradiography
  4. The Human Genome Project
  5. Sequencing Automation
  6. Image Scanners
  7. Fluorescent Detection
  8. Gene Profiling
  9. Gene Expression
  10. Polymorphism Screening
  11. Protein Interaction Networks
B. DNA And RNA Probe Technology
  1. Basic Principles
  2. Probe Preparation
  3. The DNA Probe Test
    a. Sample Preparation
    b. Hybridization
    c. Separation
    d. Detection/Measurement
  4. Test Formats
    a. Filter Hybridization
    b. Southern Blot
    c. Northern Blot
    d. In Situ Hybridization
    e. Others
  5. Labeling Techniques
  6. Amplification Methods
    Polymerase Chain Reaction
      Temperature Cyclers
      PCR Variations
    Immuno-PCR
    QC-PCR
    DAP-PCR
      Strand Displacement Activation
      TMA
      Ligase Chain Reaction
      Branched DNA
        Hybridization Protection Assay
      Nucleic-Acid Sequence-Based Amplification
      Self-Sustained Sequence Replicase
      Others
        Ampliprobe
        CAR
        CAS
        CPT
        Dendritic Polymer Technology
        ISO-CR
        LAT
        Probe Networks
        RAMP
        Repair Chain Reaction
        Rolling Circles
        Sequence Independent Gene Amplification
        Sequence Initiation Reaction
        SISPA
        Solid Phase Amplification
C. Detection Technologies
  1. Radioactive Methods
    a. Overview
    b. Major Isotopes
      P-32
      S-35
      H-3
      I-125
  2. Non-Isotopic Methods
    a. Enzymatic Labels
    b. Chemical Labeling
      Indirect Chemical Labeling
      Direct Chemical Labeling
    c. Fluorescence
    d. Chemiluminescence
    e. Electrical Conductivity
D. Instrumentation Review
  1. Abbott LCx
  2. Beckman Coulter/Biomek FK
  3. Becton Dickinson SDA
  4. Bio-Rad GeneScope
  5. Gen-Probe Tigris
  6. Roche Cobas Amplicor
  7. Tecan LS Series
E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip
  Liquid Transportation and Mixing
  Separation
  Reaction
  Detection
F. Pharmacogenomics
G. Major Applications
  1. Microbiology/Infectious Diseases
    a. Overview
    b. Major Infectious Diseases
      AIDS
        Structure and Composition
        Classification
        AIDS Origins
        Animal Lentivirus Systems
        Virus Receptors
        HIV Infections in Humans
          Pathogenesis and Pathology
        CD4T Lymphocytes and Memory Cells
        Monocytes and Macrophages
        Lymphoid Organs
        Neural Cells
        Viral Coinfections
          Clinical Findings
      Plasma Viral Load
      Pediatric AIDS
        Neurologic Disease
        Opportunistic Infections
        Cancer
      Immunity
        Virus Isolation
        Serology
        Viral Nucleic Acid/Antigen Detection
      Epidemiology
        Worldwide Spread of AIDS
        United States
        Routes of Transmission
      DNA Probes
        Overview
        Quantitative PCR
        In Situ PCR
        Needed Improvements
      Viral Load/Drug Resistance Testing
      Genotype and Phenotype Testing
        Blood Banking Considerations
      Adenovirus
      Background
      Diagnostic Tests
      Vaccines and Drugs
      Adeno-Associated Viruses (AAV)
    Anthrax/Bacillus Anthracis
      Background
      Diagnostic Tests
      Vaccines and Drugs
    Babesiosis
      Background
      BEA and Other Bartonella Diseases
      Background
      Diagnostic Tests
      Vaccines and Drugs
      Chagas Disease
      Background
      Campylobacter
        Background
        Diagnostic Tests
          Culture Identification
        Vaccines and Drugs
      Chlamydia
      Background
        Chlamydia psittaci
        Chlmaydia pneumoniae
        Chlamydia trachomatis
        Diagnostic Tests
        Vaccines and Drugs
      Creutzfeldt-Jakob’s Disease
        Background
        Blood Transmission
        Diagnostic Tests
        Major Commercial and Academic Players
          Bayer
          Disease Sciences/Bio Tec Global
          Imperial College School of Medicine
          Ortho-Clinical Diagnostics
          Pall
          ProMetic Life Sciences
          Proteome Sciences/Idexx
          Q-One Biotech
          Serono
          U.S. Agricultural Research Service
        Drugs
        Vaccines
      Cytomegalovirus
        Background
          Chorioretinitis
          Gastrointestinal
          Central Nervous System Disease
        Diagnostic Tests
        Vaccines and Drugs
      Ebola Virus
        Background
          Epidemiology
          Clinical Syndromes
        Diagnostic Tests
        Vaccines and Drugs
      EchoVirus
        Background
          Acute Aseptic Meningitisis
          Encephalitis
          Exanthems
          Respiratory Disease
          Myopericarditis
          Neonatal Infections
        Diagnostic Tests
        Vaccines and Drugs
      Encephalitis
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Enteroviruses
        Background
        Diagnostic Tests
          Viral Isolation and Identification
          Antibody Tests
        Vaccines and Drugs
      Epstein-Barr Virus
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Gonorrhea
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Hepatitis
        Hepatitis A
        Hepatitis B
          Structure and Composition
          Replication
        Hepatitis C
        Hepatitis D (Delta)
        Hepatitis E
        Hepatitis G
        Hepatitis Infections Pathology
        Clinical Findings
        Laboratory Tests
          Hepatitis A
          Hepatitis B
          Hepatitis C
          Hepatitis D
          Hepatitis E
        Virus-Host Immune Reactions
        Epidemiology
          Hepatitis A
          Hepatitis B
          Hepatitis C
          Hepatitis D (Delta)
        Vaccines and Drugs
      Herpes Simplex Virus
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Legionella
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Lyme Disease
        Background
          Clinical Description
          Clinical Case Definition
          Laboratory Criteria for Diagnosis
          Case Classification
        Diagnostic Tests
        Vaccines and Drugs
      Malaria
      Mycoplasma
        Background
          Ureaplasma Urealyticum & Mycoplasma Hominis
        Diagnostic Tests
        Vaccines and Drugs
      Papillomaviruses/HPV
        Background
          HPV in Cancer
          Cervical Neoplasm
        Diagnostic Tests
        Vaccines and Drugs
          Prevention
      Parvovirus B19
        Background
          Microbiology
          Epidemiology
          Clinical Syndromes
          Erythema Infectiosum (Slapped Cheek)
          Adult Polyarthropathy
          Transient Aplastic Crisis
          Transient Pancytopenia
          Red Cell Aplasia in Immunocompromised
          Perinatal Infections
        Diagnostic Test
        Vaccines and Drugs
      Pneumonia
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Polyomaviruses
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Salmonellosis
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Shigellosis
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Streptococci
        Background
        Diagnostic Tests
        Vaccines and Drugs
          Group A Streptococci
          Group B Streptococci
      Toxoplasmosis
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Tuberculosis
        Background
        Diagnostic Tests
          Microscopic Characteristics
          Cultural Characteristics
          Skin Tests
          MDRTB
        Vaccines and Drugs
      West Nile Virus
        Background
          Clinical Syndromes
        Diagnostic Tests
        Vaccines and Drugs
      Yersinia
        Background
        Diagnostic Tests
        Vaccines and Drugs
    c. Antibiotic Susceptibility
  2. Cancer Testing
    a. Overview
    b. Major Cancer Types
      Prostate
      Lung
      Colon and Rectum
      Breast
      Skin
      Uterine
      Leukemia
      Oral
      c. Oncogenes
        Abl/abl-bcr
        AIB1
        BCL-2
        BRCA1
        CD44
        C-fos
        C-myb
        C-myc
        CYP17
        Erb-B
        HPC1
        N-myc
        P40
        P51
        P53
        PIK3CA
        PTI-1
        Ras
        Reg
        Sis
        Src
  3. Genetic Diseases
    a. Overview
    b. Nucleic Acid Amplification
    c. Chromosome Imaging
    d. Genomics Technologies
    e. Proteomics Technologies
    f. Current Pharmacogenomic Tests
    g. Future Pharmacogenomic Testing
    h. Major Diseases
      Achondroplasia
      Autosomal Dominant Polycystic Kidney Disease
      Cancer
      Cosmetogenomics
      Cystic Fibrosis
      Down's Syndrome
      Duchenne and Becker Muscular Dystrophy
      Factor V (Leiden)
      Factor IX Deficiency
      Fragile X Syndrome
      Heart Disease
      Hemochomatosis
      Hemophilia
      Huntington's Disease
      Maternal-Fetal Incompatibility
      Multiple Endocrine Neoplasia
      Phenylketonuria (PKU)
      Polycystic Kidney Disease (PKD)
      Prenatal Screening
      Retinitis Pigmentosa
      Retinoblastoma
      Sickle Cell Anemia
      Spinal Muscular Atrophy
      Vitamin B12 Metabolism
    i. Social Issues and Concerns
  4. Forensic Testing
    a. Overview
    b. Multilocus and Single Locus Probes
      Multilocus Probes
      Single Locus Probes
      PCR and RFLP
    c. The FBI
    d. DNA Profile Data Banks
      U.S.A.
      U.K.
    e. Judicial Implementation
    f. Major Crime Categories
    g. Factors Contributing to the DNA Probe Market Expansion
      Technology Availability
      Use of Hair as Evidence
    h. Wildlife Forensics
  5. Paternity Testing/HLA Typing
  6. Other Applications
    a. Disease Susceptibility Testing
    b. Cardiovascular Diseases
    c. Diabetes
    d. Alzheimer's Disease
    e. Periodontal Disease
    f. Plasma Purification
    g. Organ Transplantation
    h. Water Contamination
    i. Other
H. Competing/complementing Technologies
  1. Monoclonal Antibodies/Immunoassays
  2. RNA Probes
  3. Two-Dimensional Electrophoresis
  4. Flow Cytometry

GERMANY

A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares

MAJOR PRODUCT DEVELOPMENT OPPORTUNITIES

A. Instrumentation
B. Reagent Kits and Test Systems/panels
C. Computers, Software and Automation
D. Auxiliary Products

DESIGN CRITERIA FOR DECENTRALIZED TESTING PRODUCTS

ALTERNATIVE MARKET PENETRATION STRATEGIES

A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies For Decentralized Testing Markets
  1. Marketing Approaches
  2. Product Complexity
  3. Customer Preference
  4. Established Suppliers
  5. Emerging Suppliers
  6. Major Types Of Distributors
  7. Market Segmentation

POTENTIAL MARKET ENTRY BARRIERS AND RISKS

A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge And Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges

COMPETITIVE PROFILES

Abbott
Affymetrix
Agilent
Applied Gene Technologies
Arca
Beckman Coulter/Danaher
Becton Dickinson
Biokit
BioMerieux
Bio-Rad
Biotest
Caliper
Cepheid
Decode
Diadexus
Eiken
Enzo
Exact Sciences
Fujirebio
Gen-Probe
Hologic
Illumina
Innogenetics/Solvay
Kreatech
Li-Cor Biosciences
Life Technologies
Monogram Biosciences
Myriad Genetics
Nanogen/Elitech
Novartis
Orchid CellMark
Ortho-Clinical Diagnostics
Proteome Sciences
Qiagen
Roche
Scienion
Sequenom
Shimadzu
Siemens
Sierra Molecular
Takara Bio
Tecan Group

APPENDIXES

Appendix I: Major Universities and Research Centers Developing Molecular Diagnostic Technology
Appendix II: Glossary of Terms
Appendix III: Currency Exchange Rates

List Of Tables

LIST OF TABLES

Major Companies Developing or Marketing AIDS Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Adenovirus Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Campylobacter Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Chlamydia Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing CMV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing EBV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Gonorrhea Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Hepatitis Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Herpes Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Legionella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Lyme Disease Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Mycoplasma Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Papilloma Virus Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Pneumonia Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Salmonella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Shigella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Streptococci Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Toxoplasmosis Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Tuberculosis Molecular Diagnostic And Other Direct Identification Tests
Oncogenes Potential Application in Cancer Diagnosis Major Companies Developing or Marketing Cancer
Molecular Diagnostic Tests
Major Companies Developing or Marketing Molecular Diagnostic Test For Genetic Diseases
Summary Table Germany, Molecular Diagnostics Test Volume And Sales Forecast by Major Application
Germany, Laboratories Performing DNA Sequencing by Market Segment
Germany, Molecular Diagnostics Market Potential Laboratory Universe by Market Segment
Germany, Molecular Diagnostics Test Volume Forecast By Major Application
Germany, Major Infectious Disease Molecular Diagnostics Test Volume Forecast
Germany, Infectious Disease Screening NAT Volume Forecast
Germany, Molecular Diagnostics Market Forecast By Major Application
Germany, Infectious Disease Screening NAT Reagent Market Forecast by Test
Germany, Molecular Diagnostics Market by Major Supplier
Germany, HIV/Hepatitis NAT Market Reagent Sales by Major Supplier