Toll-Like Receptor 3 (TLR-3) Agonist - Pipeline Insight, 2022

January 2022 | 60 pages | ID: TD03C610B2BCEN
DelveInsight

Abstracts

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DelveInsight’s, “Toll-Like Receptor 3 (TLR-3) Agonist - Pipeline Insight, 2022” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Toll-Like Receptor 3 (TLR-3) Agonist pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Toll-Like Receptor 3 (TLR-3) Agonist Understanding

Toll-Like Receptor 3 (TLR-3) Agonist: Overview

TLR3 is a member of the toll-like receptor (TLR) family. It plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR3 agonist formulation are the most extensively tested as a single agent in humans with infectious diseases and cancers including glioblastoma, renal cell cancer, melanoma, leukemia, ovarian cancer, and breast cancer. In studies, TLR3 signaling is activated by a synthetic dsRNA agonist, polyriboinosinic: polyribocytidylic acid, a potent immune stimulant that has been shown to induce protective immunity against influenza, HBV, a few HIV strains and coronaviruses.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence Toll-Like Receptor 3 (TLR-3) Agonist R&D. The therapies under development are focused on novel approaches for Toll-Like Receptor 3 (TLR-3) Agonist.

Toll-Like Receptor 3 (TLR-3) Agonist Emerging Drugs Chapters

This segment of the Toll-Like Receptor 3 (TLR-3) Agonist report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Toll-Like Receptor 3 (TLR-3) Agonist Emerging Drugs

• Rintatolimod: AIM ImmunoTech

Rintatolimod is a synthetic derivative of inosinic acid with antiretroviral and immunomodulatory properties. Rintatolimod is a mismatched double stranded polymer of RNA. It is a restricted Toll-Like Receptor 3 (TLR3) agonist lacking activation of other primary cellular inducers of innate immunity (e.g. cytosolic helicases). Rintatolimod was granted Orphan Drug Designation by the US Food and Drug Administration (FDA) for the treatment of pancreatic cancer in December 2020.

• PrEP-001: PrEP Biopharm

PrEP-001 is a nasal powder, a proprietary formulation of polyriboinosinic and polyribocytidylic acid effectively that elicits a cellular innate immune response in nasal epithelium. It is in Phase 2 for the prevention of influenza, influenza-like-illness and the common cold. PrEP-001, triggers the innate immune system through the Rig-I, MDA5 and TLR3 receptors and is expected to provide a rapid, broad-spectrum prophylaxis against ~200 respiratory viruses.

Further product details are provided in the report……..

Toll-Like Receptor 3 (TLR-3) Agonist: Therapeutic Assessment

This segment of the report provides insights about the different Toll-Like Receptor 3 (TLR-3) Agonist drugs segregated based on following parameters that define the scope of the report, such as:

• Major Players working on Toll-Like Receptor 3 (TLR-3) Agonist

There are approx. 5+ key companies which are developing the Toll-Like Receptor 3 (TLR-3) Agonist. The companies which have their Toll-Like Receptor 3 (TLR-3) Agonist drug candidates in the most advanced stage, i.e. Phase II include, AIM ImmunoTech.

• Phases

DelveInsight’s report covers around 5+ products under different phases of clinical development like

• Late-stage products (Phase III and
• Mid-stage products (Phase II and
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Toll-Like Receptor 3 (TLR-3) Agonist pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Infusion
• Intradermal
• Intramuscular
• Intranasal
• Intravaginal
• Oral
• Parenteral
• Subcutaneous
• Topical
• Molecule Type

Products have been categorized under various Molecule types such as

• Vaccines
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Toll-Like Receptor 3 (TLR-3) Agonist: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Toll-Like Receptor 3 (TLR-3) Agonist therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Toll-Like Receptor 3 (TLR-3) Agonist drugs.

Toll-Like Receptor 3 (TLR-3) Agonist Report Insights

• Toll-Like Receptor 3 (TLR-3) Agonist Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Toll-Like Receptor 3 (TLR-3) Agonist Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

• How many companies are developing Toll-Like Receptor 3 (TLR-3) Agonist drugs?
• How many Toll-Like Receptor 3 (TLR-3) Agonist drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for Toll-Like Receptor 3 (TLR-3) Agonist?
• What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Toll-Like Receptor 3 (TLR-3) Agonist therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Toll-Like Receptor 3 (TLR-3) Agonist and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• AIM ImmunoTech
• PrEP Biopharm
• Oncovir
• Bioncotech Therapeutics

Key Products

• Rintatolimod
• PrEP-001
• Poly ICLC
• BO-112

Contents

Introduction
Executive Summary
Toll-Like Receptor 3 (TLR-3) Agonist: Overview
  Structure
  Mechanism of Action
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Toll-Like Receptor 3 (TLR-3) Agonist – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
  Toll-Like Receptor 3 (TLR-3) Agonist companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Toll-Like Receptor 3 (TLR-3) Agonist Collaboration Deals
  Company-Company Collaborations (Licensing / Partnering) Analysis
  Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
  Comparative Analysis
Drug name: Company name
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
  Comparative Analysis
Rintatolimod: AIM ImmunoTech
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
  Comparative Analysis
Drug name: Company name
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
  Comparative Analysis
Drug name: Company name
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
  Comparative Analysis
Toll-Like Receptor 3 (TLR-3) Agonist Key Companies
Toll-Like Receptor 3 (TLR-3) Agonist Key Products
Toll-Like Receptor 3 (TLR-3) Agonist- Unmet Needs
Toll-Like Receptor 3 (TLR-3) Agonist- Market Drivers and Barriers
Toll-Like Receptor 3 (TLR-3) Agonist- Future Perspectives and Conclusion
Toll-Like Receptor 3 (TLR-3) Agonist Analyst Views
Toll-Like Receptor 3 (TLR-3) Agonist Key Companies
Appendix

List Of Tables

LIST OF TABLES

Table 1 Total Products for Toll-Like Receptor 3 (TLR-3) Agonist
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products

List Of Figures

LIST OF FIGURES

Figure 1 Total Products for Toll-Like Receptor 3 (TLR-3) Agonist
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products