Catenin Beta 1 (Beta Catenin or CTNNB1) - Drugs in Development, 2021
Catenin Beta 1 (Beta Catenin or CTNNB1) - Drugs in Development, 2021
SUMMARY
Catenin Beta 1 (Beta Catenin or CTNNB1) - Catenin beta-1 or ?-catenin is a protein that is encoded by the CTNNB1 gene. In the presence of Wnt ligand, CTNNB1 acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. It is involved in the regulation of cell adhesion, CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. It also acts as a negative regulator of centrosome cohesion. It blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2.
Catenin Beta 1 (Beta Catenin or CTNNB1) pipeline Target constitutes close to 18 molecules. Out of which approximately 13 molecules are developed by companies and remaining by the universities/institutes. The molecules developed by companies in Phase II, Preclinical and Discovery stages are 1, 6 and 6 respectively. Similarly, the universities portfolio in Phase I, Preclinical and Discovery stages comprises 1, 2 and 2 molecules, respectively. Report covers products from therapy areas Oncology, Non Malignant Disorders, Dermatology, Gastrointestinal and Respiratory which include indications Colorectal Cancer, Melanoma, Solid Tumor, Unspecified Cancer, Breast Cancer, Hepatocellular Carcinoma, Liver Cancer, Ovarian Cancer, Pancreatic Cancer, Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Anaplastic Thyroid Cancer, Benign Tumor, Blood Cancer, Brain Cancer, Chronic Myelocytic Leukemia (CML, Chronic Myeloid Leukemia), Endometrial Cancer, Head And Neck Cancer, Hemangiomas, Hematological Tumor, Hepatic (Liver) Tumor, Idiopathic Pulmonary Fibrosis, Leukemia, Liver Cirrhosis, Lung Cancer, Neuroendocrine Tumors, Primary Biliary Cholangitis (Primary Biliary Cirrhosis), Prostate Cancer and Scar.
The latest report Catenin Beta 1 - Drugs In Development, 2021, outlays comprehensive information on the Catenin Beta 1 (Beta Catenin or CTNNB1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. It also reviews key players involved in Catenin Beta 1 (Beta Catenin or CTNNB1) targeted therapeutics development with respective active and dormant or discontinued projects.
The report is built using data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.
Note: Certain content/sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
SCOPE
SUMMARY
Catenin Beta 1 (Beta Catenin or CTNNB1) - Catenin beta-1 or ?-catenin is a protein that is encoded by the CTNNB1 gene. In the presence of Wnt ligand, CTNNB1 acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. It is involved in the regulation of cell adhesion, CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. It also acts as a negative regulator of centrosome cohesion. It blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2.
Catenin Beta 1 (Beta Catenin or CTNNB1) pipeline Target constitutes close to 18 molecules. Out of which approximately 13 molecules are developed by companies and remaining by the universities/institutes. The molecules developed by companies in Phase II, Preclinical and Discovery stages are 1, 6 and 6 respectively. Similarly, the universities portfolio in Phase I, Preclinical and Discovery stages comprises 1, 2 and 2 molecules, respectively. Report covers products from therapy areas Oncology, Non Malignant Disorders, Dermatology, Gastrointestinal and Respiratory which include indications Colorectal Cancer, Melanoma, Solid Tumor, Unspecified Cancer, Breast Cancer, Hepatocellular Carcinoma, Liver Cancer, Ovarian Cancer, Pancreatic Cancer, Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Anaplastic Thyroid Cancer, Benign Tumor, Blood Cancer, Brain Cancer, Chronic Myelocytic Leukemia (CML, Chronic Myeloid Leukemia), Endometrial Cancer, Head And Neck Cancer, Hemangiomas, Hematological Tumor, Hepatic (Liver) Tumor, Idiopathic Pulmonary Fibrosis, Leukemia, Liver Cirrhosis, Lung Cancer, Neuroendocrine Tumors, Primary Biliary Cholangitis (Primary Biliary Cirrhosis), Prostate Cancer and Scar.
The latest report Catenin Beta 1 - Drugs In Development, 2021, outlays comprehensive information on the Catenin Beta 1 (Beta Catenin or CTNNB1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. It also reviews key players involved in Catenin Beta 1 (Beta Catenin or CTNNB1) targeted therapeutics development with respective active and dormant or discontinued projects.
The report is built using data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.
Note: Certain content/sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
SCOPE
- The report provides a snapshot of the global therapeutic landscape for Catenin Beta 1 (Beta Catenin or CTNNB1)
- The report reviews Catenin Beta 1 (Beta Catenin or CTNNB1) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Catenin Beta 1 (Beta Catenin or CTNNB1) targeted therapeutics and enlists all their major and minor projects
- The report assesses Catenin Beta 1 (Beta Catenin or CTNNB1) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Catenin Beta 1 (Beta Catenin or CTNNB1) targeted therapeutics
- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Catenin Beta 1 (Beta Catenin or CTNNB1)Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Catenin Beta 1 (Beta Catenin or CTNNB1) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Introduction
Global Markets Direct Report Coverage
Catenin Beta 1 (Beta Catenin or CTNNB1) - Overview
Catenin Beta 1 (Beta Catenin or CTNNB1) - Therapeutics Development
Products under Development by Stage of Development
Products under Development by Therapy Area
Products under Development by Indication
Products under Development by Companies
Products under Development by Universities/Institutes
Catenin Beta 1 (Beta Catenin or CTNNB1) - Therapeutics Assessment
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Catenin Beta 1 (Beta Catenin or CTNNB1) - Companies Involved in Therapeutics Development
Aileron Therapeutics Inc
Circle Pharma Inc
Dicerna Pharmaceuticals Inc
Fog Pharmaceuticals Inc
iBeCa Therapeutics
MD2 Biosciences Inc
PRISM Pharma Co Ltd
Propanc Biopharma Inc
Sapience Therapeutics Inc
Stemsynergy Therapeutics Inc
Sumitomo Dainippon Pharma Oncology, Inc
Venn Therapeutics LLC
WntRx Pharmaceuticals Inc
Catenin Beta 1 (Beta Catenin or CTNNB1) - Drug Profiles
Antisense RNAi Oligonucleotide to Inhibit Beta Catenin for Oncology - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
BBI-801 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
exisulind - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
nefopam hydrochloride - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Oligonucleotides for Hepatoblastoma - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
PRI-724 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
PRP - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecule to Inhibit Beta Catenin and BCL9 for Colorectal Cancer - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecule to Inhibit Beta Catenin for Colorectal Cancer and Brain Cancer - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit Beta Catenin for Oncology - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit Beta Catenin for Unspecified Cancers - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit Beta Catenin for Unspecified Cancers - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit CTNNB1 for Unspecified Cancer - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Synthetic Peptide for Oncology - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Synthetic Peptide to Inhibit CTNNB1 for Colorectal Cancer - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Synthetic Peptides to Inhibit Beta Catenin for Oncology - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Synthetic Peptides to Inhibit Beta Catenin for Solid Tumor and Blood Cancer - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
WX-024 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Catenin Beta 1 (Beta Catenin or CTNNB1) - Dormant Products
Catenin Beta 1 (Beta Catenin or CTNNB1) - Product Development Milestones
Featured News & Press Releases
Dec 21, 2020: Propanc Biopharma receives first granted patent for method to treat cancer stem cells from Australian Patent Office
Jun 17, 2020: Sapience Therapeutics to present data on ?-catenin antagonist program at 2020 AACR Virtual Annual Meeting II
Apr 14, 2020: Propanc Biopharma receives first allowance for key patent family from Australian Patent Office
Jan 21, 2020: Propanc Biopharma receives advance overseas finding from Innovation and Science Australia
Oct 21, 2019: Propanc Biopharma illustrates novel mode of action of PRP, suppressing EMT Pathways and Metastasis in Cancer Patients
Aug 21, 2019: Propanc Biopharma receives granted US patent covering additional composition claims for PRP
Aug 12, 2019: Propanc Biopharma publishes key data in peer reviewed journal confirming anti-cancer stem cell effects of Proenzymes
Aug 08, 2019: Propanc Biopharma completes development of bio-analytical assay method to quantify PRP active ingredients in preparation for first-in-human study
Jul 15, 2019: Propanc Biopharma provides update on preparation of PRP for clinical trial application submission and recently completed reverse stock split
Jun 27, 2019: Propanc Biopharmas Intellectual Property portfolio undergoes rapid growth
May 06, 2019: Propanc Biopharma appoints Dr. Ralf Brandt to its scientific advisory board
Apr 26, 2019: Announcement of the signing of a joint R & D agreement and commencement of development activities regarding “Research and development of innovative antifibrotic drugs to improve the life prognosis of cirrhosis”
Mar 25, 2019: Propanc Biopharma initiates development of bio-analytical assay in preparation for human trials
Mar 13, 2019: Propanc Biopharma receives notice of allowance for additional claims from foundation patent in the U.S.
Dec 20, 2018: Novel development drug OP-724 (PRI-724) for the treatment of cirrhosis is published on Nature Outline
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer
Global Markets Direct Report Coverage
Catenin Beta 1 (Beta Catenin or CTNNB1) - Overview
Catenin Beta 1 (Beta Catenin or CTNNB1) - Therapeutics Development
Products under Development by Stage of Development
Products under Development by Therapy Area
Products under Development by Indication
Products under Development by Companies
Products under Development by Universities/Institutes
Catenin Beta 1 (Beta Catenin or CTNNB1) - Therapeutics Assessment
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Catenin Beta 1 (Beta Catenin or CTNNB1) - Companies Involved in Therapeutics Development
Aileron Therapeutics Inc
Circle Pharma Inc
Dicerna Pharmaceuticals Inc
Fog Pharmaceuticals Inc
iBeCa Therapeutics
MD2 Biosciences Inc
PRISM Pharma Co Ltd
Propanc Biopharma Inc
Sapience Therapeutics Inc
Stemsynergy Therapeutics Inc
Sumitomo Dainippon Pharma Oncology, Inc
Venn Therapeutics LLC
WntRx Pharmaceuticals Inc
Catenin Beta 1 (Beta Catenin or CTNNB1) - Drug Profiles
Antisense RNAi Oligonucleotide to Inhibit Beta Catenin for Oncology - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
BBI-801 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
exisulind - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
nefopam hydrochloride - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Oligonucleotides for Hepatoblastoma - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
PRI-724 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
PRP - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecule to Inhibit Beta Catenin and BCL9 for Colorectal Cancer - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecule to Inhibit Beta Catenin for Colorectal Cancer and Brain Cancer - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit Beta Catenin for Oncology - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit Beta Catenin for Unspecified Cancers - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit Beta Catenin for Unspecified Cancers - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit CTNNB1 for Unspecified Cancer - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Synthetic Peptide for Oncology - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Synthetic Peptide to Inhibit CTNNB1 for Colorectal Cancer - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Synthetic Peptides to Inhibit Beta Catenin for Oncology - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Synthetic Peptides to Inhibit Beta Catenin for Solid Tumor and Blood Cancer - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
WX-024 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Catenin Beta 1 (Beta Catenin or CTNNB1) - Dormant Products
Catenin Beta 1 (Beta Catenin or CTNNB1) - Product Development Milestones
Featured News & Press Releases
Dec 21, 2020: Propanc Biopharma receives first granted patent for method to treat cancer stem cells from Australian Patent Office
Jun 17, 2020: Sapience Therapeutics to present data on ?-catenin antagonist program at 2020 AACR Virtual Annual Meeting II
Apr 14, 2020: Propanc Biopharma receives first allowance for key patent family from Australian Patent Office
Jan 21, 2020: Propanc Biopharma receives advance overseas finding from Innovation and Science Australia
Oct 21, 2019: Propanc Biopharma illustrates novel mode of action of PRP, suppressing EMT Pathways and Metastasis in Cancer Patients
Aug 21, 2019: Propanc Biopharma receives granted US patent covering additional composition claims for PRP
Aug 12, 2019: Propanc Biopharma publishes key data in peer reviewed journal confirming anti-cancer stem cell effects of Proenzymes
Aug 08, 2019: Propanc Biopharma completes development of bio-analytical assay method to quantify PRP active ingredients in preparation for first-in-human study
Jul 15, 2019: Propanc Biopharma provides update on preparation of PRP for clinical trial application submission and recently completed reverse stock split
Jun 27, 2019: Propanc Biopharmas Intellectual Property portfolio undergoes rapid growth
May 06, 2019: Propanc Biopharma appoints Dr. Ralf Brandt to its scientific advisory board
Apr 26, 2019: Announcement of the signing of a joint R & D agreement and commencement of development activities regarding “Research and development of innovative antifibrotic drugs to improve the life prognosis of cirrhosis”
Mar 25, 2019: Propanc Biopharma initiates development of bio-analytical assay in preparation for human trials
Mar 13, 2019: Propanc Biopharma receives notice of allowance for additional claims from foundation patent in the U.S.
Dec 20, 2018: Novel development drug OP-724 (PRI-724) for the treatment of cirrhosis is published on Nature Outline
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer
LIST OF TABLES
Number of Products under Development by Stage of Development, 2021
Number of Products under Development by Therapy Areas, 2021
Number of Products under Development by Indications, 2021
Number of Products under Development by Indications, 2021 (Contd..1)
Number of Products under Development by Companies, 2021
Products under Development by Companies, 2021
Products under Development by Companies, 2021 (Contd..1)
Products under Development by Companies, 2021 (Contd..2)
Number of Products under Investigation by Universities/Institutes, 2021
Products under Investigation by Universities/Institutes, 2021
Number of Products by Stage and Mechanism of Actions, 2021
Number of Products by Stage and Route of Administration, 2021
Number of Products by Stage and Molecule Type, 2021
Pipeline by Aileron Therapeutics Inc, 2021
Pipeline by Circle Pharma Inc, 2021
Pipeline by Dicerna Pharmaceuticals Inc, 2021
Pipeline by Fog Pharmaceuticals Inc, 2021
Pipeline by iBeCa Therapeutics, 2021
Pipeline by MD2 Biosciences Inc, 2021
Pipeline by PRISM Pharma Co Ltd, 2021
Pipeline by Propanc Biopharma Inc, 2021
Pipeline by Sapience Therapeutics Inc, 2021
Pipeline by Stemsynergy Therapeutics Inc, 2021
Pipeline by Sumitomo Dainippon Pharma Oncology, Inc, 2021
Pipeline by Venn Therapeutics LLC, 2021
Pipeline by WntRx Pharmaceuticals Inc, 2021
Dormant Products, 2021
Dormant Products, 2021 (Contd..1)
Number of Products under Development by Stage of Development, 2021
Number of Products under Development by Therapy Areas, 2021
Number of Products under Development by Indications, 2021
Number of Products under Development by Indications, 2021 (Contd..1)
Number of Products under Development by Companies, 2021
Products under Development by Companies, 2021
Products under Development by Companies, 2021 (Contd..1)
Products under Development by Companies, 2021 (Contd..2)
Number of Products under Investigation by Universities/Institutes, 2021
Products under Investigation by Universities/Institutes, 2021
Number of Products by Stage and Mechanism of Actions, 2021
Number of Products by Stage and Route of Administration, 2021
Number of Products by Stage and Molecule Type, 2021
Pipeline by Aileron Therapeutics Inc, 2021
Pipeline by Circle Pharma Inc, 2021
Pipeline by Dicerna Pharmaceuticals Inc, 2021
Pipeline by Fog Pharmaceuticals Inc, 2021
Pipeline by iBeCa Therapeutics, 2021
Pipeline by MD2 Biosciences Inc, 2021
Pipeline by PRISM Pharma Co Ltd, 2021
Pipeline by Propanc Biopharma Inc, 2021
Pipeline by Sapience Therapeutics Inc, 2021
Pipeline by Stemsynergy Therapeutics Inc, 2021
Pipeline by Sumitomo Dainippon Pharma Oncology, Inc, 2021
Pipeline by Venn Therapeutics LLC, 2021
Pipeline by WntRx Pharmaceuticals Inc, 2021
Dormant Products, 2021
Dormant Products, 2021 (Contd..1)
LIST OF FIGURES
Number of Products under Development by Stage of Development, 2021
Number of Products under Development by Therapy Areas, 2021
Number of Products under Development by Top 10 Indications, 2021
Number of Products by Mechanism of Actions, 2021
Number of Products by Stage and Mechanism of Actions, 2021
Number of Products by Routes of Administration, 2021
Number of Products by Stage and Routes of Administration, 2021
Number of Products by Molecule Types, 2021
Number of Products by Stage and Molecule Types, 2021
Number of Products under Development by Stage of Development, 2021
Number of Products under Development by Therapy Areas, 2021
Number of Products under Development by Top 10 Indications, 2021
Number of Products by Mechanism of Actions, 2021
Number of Products by Stage and Mechanism of Actions, 2021
Number of Products by Routes of Administration, 2021
Number of Products by Stage and Routes of Administration, 2021
Number of Products by Molecule Types, 2021
Number of Products by Stage and Molecule Types, 2021
