20s Proteasome Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

September 2022 | 89 pages | ID: 2CE1DD614596EN
Global Markets Direct

Abstracts

20s Proteasome Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

SUMMARY

20s Proteasome - 20S proteasome is the catalytic core of the 26S proteasome, the central protease of the ubiquitin pathway of protein degradation. It is commonly associated with regulatory complexes, which include the 19S Proteasome, the PA28 alpha/beta complex, or the PA28 gamma complex. The 20S Proteasome is composed of 28 subunits arranged into four stacked rings. Unlike the 26S proteasome, which degrades proteins in an ATP-dependent manner, the 20S proteasome is ATP-independent and only degrades entirely unfolded polypeptides.

20s Proteasome pipeline Target constitutes close to 10 molecules. Out of which approximately 6 molecules are developed by companies and remaining by the universities/institutes. The molecules developed by companies in Phase III, Phase II and Preclinical stages are 1, 2 and 3 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 1 and 3 molecules, respectively. Report covers products from therapy areas Oncology, Immunology, Infectious Disease and Metabolic Disorders which include indications Multiple Myeloma (Kahler Disease), Refractory Multiple Myeloma, Relapsed Multiple Myeloma, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Amyloidosis, Colon Cancer, Cutaneous T-Cell Lymphoma, Diffuse Large B-Cell Lymphoma, Glioblastoma Multiforme (GBM), Gliosarcoma, Kidney Transplant Rejection, Leukemia, Lung Transplant Rejection, Malignant Glioma, Metastatic Renal Cell Carcinoma, Neuroendocrine Cancer, Pancreatic Cancer, Pediatric Diffuse Intrinsic Pontine Glioma, Peripheral T-Cell Lymphomas (PTCL), Plasma Cell Neoplasm, Small-Cell Lung Cancer, Tuberculosis, Unspecified Cancer and Waldenstrom Macroglobulinemia (Lymphoplasmacytic Lymphoma).

The latest report 20s Proteasome - Drugs In Development, 2022, outlays comprehensive information on the 20s Proteasome targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. It also reviews key players involved in 20s Proteasome targeted therapeutics development with respective active and dormant or discontinued projects.

The report is built using data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Note: Certain content/sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

SCOPE

• The report provides a snapshot of the global therapeutic landscape for 20s Proteasome
• The report reviews 20s Proteasome targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
• The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
• The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
• The report reviews key players involved in 20s Proteasome targeted therapeutics and enlists all their major and minor projects
• The report assesses 20s Proteasome targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
• The report summarizes all the dormant and discontinued pipeline projects
• The report reviews latest news and deals related to 20s Proteasome targeted therapeutics

REASONS TO BUY

• Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
• Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
• Identify and understand the targeted therapy areas and indications for 20s Proteasome Identify the use of drugs for target identification and drug repurposing
• Identify potential new clients or partners in the target demographic
• Develop strategic initiatives by understanding the focus areas of leading companies
• Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
• Devise corrective measures for pipeline projects by understanding 20s Proteasome development landscape
• Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Contents

Introduction
Global Markets Direct Report Coverage
20s Proteasome - Overview
20s Proteasome - Therapeutics Development
Products under Development by Stage of Development
Products under Development by Therapy Area
Products under Development by Indication
Products under Development by Companies
Products under Development by Universities/Institutes
20s Proteasome - Therapeutics Assessment
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
20s Proteasome - Companies Involved in Therapeutics Development
Amgen Inc
Bristol-Myers Squibb Co
Centrax International Inc
HuniLife Biotechnology Inc
Jiangsu Chai Tai Fenghai Pharmaceutical Co Ltd
Zymergen Inc
20s Proteasome - Drug Profiles
carfilzomib - Drug Profile
Product Description
Mechanism Of Action
History of Events
CX-13608 - Drug Profile
Product Description
Mechanism Of Action
HuL-002 - Drug Profile
Product Description
Mechanism Of Action
History of Events
marizomib - Drug Profile
Product Description
Mechanism Of Action
History of Events
NNU-546 - Drug Profile
Product Description
Mechanism Of Action
History of Events
Ridaifen - Drug Profile
Product Description
Mechanism Of Action
History of Events
RTSV-5 - Drug Profile
Product Description
Mechanism Of Action
History of Events
Small Molecule to Inhibit 20S Proteasome for Oncology - Drug Profile
Product Description
Mechanism Of Action
History of Events
Small Molecules to Inhibit 20s Proteasome for Tuberculosis - Drug Profile
Product Description
Mechanism Of Action
History of Events
TIR-199 - Drug Profile
Product Description
Mechanism Of Action
History of Events
20s Proteasome - Dormant Products
20s Proteasome - Product Development Milestones
Featured News & Press Releases
Dec 06, 2021: Amgen announces new data on Nplate to be presented at ASH 2021
Dec 06, 2021: Amgen announces new data on KYPROLIS to be presented at ASH 2021
Jul 09, 2021: BeiGene announces the approval in China of KYPROLIS (Carfilzomib) for injection for adult patients with relapsed or refractory multiple myeloma
Mar 22, 2021: Triple therapy recommended by NICE for patients with multiple myeloma
Nov 30, 2020: Amgen announces new data on KYPROLIS At ASH 2020
Nov 12, 2020: CHMP adopts a positive opinion recommending a change to the terms of the marketing authorisation for Kyprolis
Aug 20, 2020: FDA approves new KYPROLIS (carfilzomib) combination regimen with DARZALEX (daratumumab) and Dexamethasone in both once- and twice-weekly dosing regimens
May 14, 2020: Oncolytics Biotech announces publication of abstract on Kyprolis at the 2020 American Society of Clinical Oncology Virtual Annual Meeting
May 13, 2020: Amgen presents update on KYPROLIS at ASCO 2020
May 05, 2020: KYPROLIS (carfilzomib) patents upheld against generic manufacturer
Dec 11, 2019: Amgen reports positive data in multiple myeloma study
Dec 02, 2019: Amgen announces data to be presented on KYPROLIS (carfilzomib) at ASH 2019
Sep 13, 2019: Amgen announces phase 3 CANDOR study combining KYPROLIS (carfilzomib) and DARZALEX (daratumumab) meets primary endpoint of progression-free survival
Sep 12, 2019: Amgen highlights new data From KYPROLIS (carfilzomib) and Oncology Pipeline At IMW 2019
Aug 19, 2019: Carfilzomib (Kyprolis): reminder of risk of potentially fatal cardiac events
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer

List Of Tables

LIST OF TABLES

Number of Products under Development by Stage of Development, 2022
Number of Products under Development by Therapy Areas, 2022
Number of Products under Development by Indications, 2022
Number of Products under Development by Indications, 2022 (Contd..1)
Number of Products under Development by Companies, 2022
Products under Development by Companies, 2022
Products under Development by Companies, 2022 (Contd..1)
Number of Products under Investigation by Universities/Institutes, 2022
Products under Investigation by Universities/Institutes, 2022
Number of Products by Stage and Mechanism of Actions, 2022
Number of Products by Stage and Route of Administration, 2022
Number of Products by Stage and Molecule Type, 2022
Pipeline by Amgen Inc, 2022
Pipeline by Bristol-Myers Squibb Co, 2022
Pipeline by Centrax International Inc, 2022
Pipeline by HuniLife Biotechnology Inc, 2022
Pipeline by Jiangsu Chai Tai Fenghai Pharmaceutical Co Ltd, 2022
Pipeline by Zymergen Inc, 2022
Dormant Products, 2022
Dormant Products, 2022 (Contd..1)
Dormant Products, 2022 (Contd..2)

List Of Figures

LIST OF FIGURES

Number of Products under Development by Stage of Development, 2022
Number of Products under Development by Therapy Areas, 2022
Number of Products under Development by Top 10 Indications, 2022
Number of Products by Mechanism of Actions, 2022
Number of Products by Stage and Mechanism of Actions, 2022
Number of Products by Top 10 Routes of Administration, 2022
Number of Products by Stage and Top 10 Routes of Administration, 2022