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2020 COVID-19 Clinical Trials Guide- Companies, Drugs, Phases, Subjects, Current Status and Outlook to 2025

September 2020 | 1800 pages | ID: 27A75DEB8FE4EN
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Report Description

The September updated COVID-19 clinical trials report presents a comprehensive 1800 page analysis on all clinical trials across 96 countries worldwide. The report provides phase wise analysis, region wise clinical trials, trials sponsored directly by companies and through universities, drugs under development, trials in emerging economies and developed countries, and subjects enrolled across phases, geographies, companies, trial status, trial types and countries.

Potential Drugs under analysis in COVID-19 clinical trials

Abatacept, Abidole , Abivertinib, ABX464, Acalabrutinib, ACE inhibitor, Acetaminophen, acetylsalicylic acid, adalimumab, Aescinate , AG0301, Alafenamide , Alendronic Acid , Alkaline phosphatase, Almitrine, alpha-Interferon, Alteplase, Ambrisentan, Amiodarone, Amlodipine besilate, Ampion, AMY-101, ANAKINRA, ANG-3777, Angiotensin 1-7, Angiotensin receptor blocker, Anluohuaxian, AOIM - Z , Apilimod Dimesylate , Apixaban, APL-9, apocynin, Apremilast, Aprepitant, APROTININ, Arbidol Hydrochloride, ARCT-021, Argatroban, ARGX-117, ArtemiC, Artemisinin, ascorbic acid, Aspirin, Astegolimab, ASUNERCEPT, AT-001, AT-527, Atazanavir , ATI-450, Atorvastatin, Atovaquone, ATYR1923, avdoralimab, Avigan, Aviptadil, AVM0703, AZD1656, AZD7442, AZD7986, Azithromycin, Azivudine, azoximer bromide, Babaodan, Bactek-R, Baidu Duan Fang, Baloxavir Marboxil, Bardoxolone methyl, BARICITINIB, BAT2020, BBV152, BDB-001 , bemcentinib, Bemiparin, Berberine, betafron, Bevacizumab, Bicalutamide, BIO 300, BIO101, Biomodulina T, bismuth potassium citrate, Bivalirudin , BLD-2660, BMS-986253, BNT162, Botulinum Neurotoxin, Bovine Lipid Extract Surfactant, Brensocatib, Brequinar, BRII-196, BRII-198, bromelain, Bromhexine, Bucillamine, Budesonide, Calcifediol, Camostate mesylate, Camrelizumab, Canakinumab , Candesartan, Carrimycin, Ceftriaxone, Celebrex , Cenicriviroc, CERC-002, chloroquine , Chloroquine Diphosphate, Chloroquine phosphate, Chlorpromazine, Cholecalciferol, Ciclesonide, CICLOSPORIN, CIGB 2020 vaccine, CIGB 300 , CIGB-258 Peptide , CK0802, Clarithromycin, clavulanate, Clazakizumab, CLEVIRA , Clevudine, Clindamycin, Clofazimine, Clopidogrel, Cobicistat, Colchicine, corticosteroid , Cospherunate, CPI-006, Crizanlizumab, Crocetin, CSA0001, cyclosporin, CYNK-001, CYP-001, CYT107, Daclatasvir, Dalteparin, Danoprevir, Dapagliflozin, DARUNAVIR, DAS181, Decitabine, Deferiprone, Deferoxamine, Defibrotide, Degarelix, Dendrobium candidum, Desferal, Desidustat, Dexamethasone, dextrose, DFV890, diltiazem, Diphenhydramine, Dipyridamole, Disulfiram, Dociparastat sodium, Dolquine, Dornase Alfa, Doxycycline, DUR-928, Dutasteride, Duvelisib, ebastine, Ebselen, EC-18, Eculizumab, edaravone, EDP1815, EIDD-2801, Emapalumab, Emtricitabine, Enoxaparin, Enzalutamide, EPARINA, Estradiol, Etoposide, F-652, Famotidine, Favipiravir, Febuxostat, Fingolimod, Fisetin, Fluoxetine, Fluvoxamine, Folic Acid, Fondapariniux, Formoterol, fostamatinib disodium hexahydrate, FT516, Galidesivir, Garadacimab, Gemtuzumab ozogamicin, Gimsilumab, GLS-1200, GS-5734, GX-19, HA330, Heberon Alfa R , Heparin, Hesperidin, hydrocortisone, Hyperbaric Oxygen, Ibrutinib, Ibudilast, Ibuprofen, Icatibant, Icosapent ethyl, IFX-1, Iloprost , ILT101, Imatinib, IMM-101, IMU-838, Indomethacin, Infliximab, INM005, INO-4800, Interferon Alfa, interferon beta, Isoflurane, Isoprinosine, Isotretinoin , itolizumab, ITRACONAZOLE, Ivermectin, Ixekizumab , Jakotinib hydrochloride, JS016, KB109 , KBP-201 , Ketamine, Khorasan asafoetida, kolimycin, Lactoferrin, lanadelumab, Lariam, L-ascorbic acid, LAU-7b, LB1148, L-cysteine, Ledipasvir, Leflunomide, Lenalidomide, Lenzilumab, Leronlimab, Levamisole, Levilimab, Lianhua Qingwen , Linagliptin, Lipoic acid, Losartan , Losmapimod , Lucinactant, LY3127804, LY3819253, M5049, Maraviroc, MAS825, Masitinib mesilate, mavrilimumab, MEDI3506, MEFLOQUINE, Melatonin, Melphalan, Meplazumab , Merimepodib, metenkefalin, Metformin, Methotrexate, methylprednisolone , metoprolol tartrate, metronidazole, midazolam, minocycline, MK-5475, Moxibustion , mRNA-1273, MRx-4DP0004, Mucodentol, MultiStem, MVC-COV1901, Mycobacterium w, N acetylcysteine, N-803, NA-831, N-Acetyl cysteine, NADROPARIN, Nafamostat Mesylate, Naltrexone, Namilumab, nangibotide, nanocurcumin, Naproxen, NasoVAX, Nebulised heparin, Nelfinavir, Niacin-Tannin, Niclosamide, Nifedipine, Nintedanib , Nitazoxanide , Nivolumab , Noscapine, Novaferon, NP-120 , NT-I7, OctaplasLG, olchicine/Statins, Olokizumab, Omegaven, Omeprazole, OP-101, Opaganib, Oseltamivir, Otilimab, Ozanimod, Pamrevlumab, PB1046, Pegylated interferon lambda, Pembrolizumab, Pentaglobin, Pentoxifylline, Pertuzumab, PH94B, PHR160, Piclidenoson, Pioglitazone, Pirfenidone, Plitidepsin, PLX-PAD, Povidone-iodine, Prasugrel Hydrochloride, Prazosin, Prednisolone, Previfenon, Probiorinse, Progesterone, Prolongin, Propranolol Hydrochloride, Proxalutamide, PSC-04, PTC299, PUL-042, Pulmozyme, Pyramax, Pyridostigmine, qingfei detoxification, raltagravir, Ramelteon, Ramipril, Rapamycin, Ravulizumab, Razuprotafib, RBT-9, rednisolone, Reginmune , REGN10933, REGN10987, Remdesivir, Remestemcel-L, RESP301, resveratrol, Ribavirin, RITONAVIR, Ritonavir , Rivaroxaban, RPH-104, RTB101, Ruxolitinib, SAB-185, SAR443122, SARILUMAB, SBI-101, SCB-2019, SCTA01, Secukinumab, Secuquinumab, selenium, Selinexor, Septimeb, Sevoflurane, Shenfu, Sildenafil, Silibinin, Siltuximab, Silymarin, simvastatin, Sirolimus, Sirukumab, Sitagliptin, SivoMixx , Sofosbuvir, Spironolactone, STI-1499, sulfamethoxazole, sulfate, Sulodexide, TAK-671, Tamiflu, Tamoxifen, Tanacetum parthenium, Tannin, Tanreqing, TD-0903, TD139, Teicoplanin IV, Telmisartan, Tenecteplase, Tenofovir, Teprenone, Tetrandrine, thalidomide, Thymalfasin, Thymoquinone, Thymosin Alpha 1 , Tinzaparin , Tirofiban, TJ003234, TL-895, TMV-083, Tociliuzumab, Tradipitant, Tramadol, Tranexamic acid, Tranilast, Trastuzumab, Triazavirin, Tricholoma, tridecactide, Trifluoperazine, TRV027, TXA127, TY027, Ulinastatin, Umnifenovir, V591, vadadustat, VAFIDEMSTAT, Valsartan (Diovan), Vancomycin, Vazegepant , Velpatasvir, Veru-111, Videsil, Vidofludimus calcium, Virazole, VPM1002, XAV-19, XC221, Xinguan-1 , Xinguan-2 , Xiyanping , XPro1595, Xuebijing , yohimbine, Zanubrutinib, Zilucoplan, ZingiVir H, ?-Globulin

Key companies included in the research-

Novartis Pharmaceuticals, Azidus Brasil, Eli Lilly and Company, Hamad Medical Corporation, Gilead Sciences, Genentech, Inc., ProgenaBiome, Revimmune, Regeneron Pharmaceuticals, AstraZeneca, Romark Laboratories L.C., Ridgeback Biotherapeutics, LP, Cadila Pharnmaceuticals, NeuroRx, Inc., Hoffmann-La Roche, Hope Biosciences, China National Biotec Group Company Limited, Medicine Invention Design, Inc, Azienda Ospedaliero-Universitaria di Parma, Merck Sharp & Dohme Corp., Kaleido Biosciences, Pulmotect, Inc., Beijing TIL Therapeutics, CanSino Biologics Inc., Vakzine Projekt Management GmbH, Intermountain Health Care, Inc., ModernaTX, Inc., Incyte Corporation, Sorrento Therapeutics, Inc., IRCCS San Raffaele, Sina Darou Laboratories Company, Sanofi, Max Healthcare Insititute Limited, CytoDyn, Inc., World Medicine ILAC SAN. ve TIC. A.S., Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A., Implicit Bioscience, Karyopharm Therapeutics Inc, Octapharma, Kiniksa Pharmaceuticals, Ltd., Atabay Kimya Sanayi Ticaret A.S., R-Pharm, Instituto Grifols, S.A., Cadila Healthcare Limited, Jiangxi Qingfeng Pharmaceutical Co. Ltd., Brii Biosciences Limited, NeuroActiva, Inc., Bristol-Myers Squibb, SAb Biotherapeutics, Inc., Theravance Biopharma, Sound Pharmaceuticals, Incorporated, Sinovac Research and Development Co., Ltd., Glenmark Pharmaceuticals Ltd, Laboratorio Elea Phoenix S.A., CinnaGen Company, Inmunotek S.L., Alexion Pharmaceuticals, RedHill Biopharma Limited, Shire, Dr Reddys Laboratories Limited, Generon (Shanghai) Corporation Ltd., Hamilton Health Sciences Corporation, Durect Corp, CAR-T (Shanghai) Biotechnology Co., Ltd., BioCryst Pharmaceuticals, Janssen Research & Development, LLC, Oryzon Genomics S. A., Humanigen, Inc., Hunan yuanpin Cell Biotechnology Co., Ltd, Kinevant Sciences GmbH, I-Mab Biopharma Co. Ltd., AbbVie, Perseverance Research Center, LLC, Regeneris Medical, Personalized Stem Cells, Inc., UnitedHealth Group, Janssen Pharmaceutical K.K., BeiGene, International Stemcell Services Ltd, Bausch Health Americas, Inc., Barakat Pharmaceutical Group, BioAegis Therapeutics Inc., Genexine, Inc., Fujifilm Pharmaceuticals U.S.A., Inc., Staidson (Beijing) Biopharmaceuticals Co., Ltd, Azienda USL Toscana Nord Ovest, Ampio Pharmaceuticals. Inc., 4D pharma plc, AnGes, Inc., GlaxoSmithKline, Biophytis, Renibus Therapeutics, Inc., Rapa Therapeutics LLC, Celularity Incorporated, Evelo Biosciences, Inc., IBSA Institut Biochimique SA, Chiesi Farmaceutici S.p.A., AVM Biotechnology LLC, Firebrick Pharma Pty Ltd, Athersys, Inc, Pharmamel S.L., BioNTech SE, Shree Dhootapapeshwar Limited, Novavax, Kimera Labs, OncoImmune, Inc., Burnasyan Federal Medical Biophysical Center, Inmune Bio, Inc., Northside Hospital, Inc., Swedish Orphan Biovitrum, AI Therapeutics, Inc., Bosnalijek D.D, Appili Therapeutics Inc., Covis Pharma S.?.r.l., Baylx Inc., Vanda Pharmaceuticals, Vaxine Pty Ltd, Immunic AG, AO GENERIUM, TASK Applied Science, Pulmoquine Therapeutics, Inc, R-Pharm International, LLC, Corvus Pharmaceuticals, Inc., Immunitor LLC, Heron Therapeutics, BioNTech RNA Pharmaceuticals GmbH, Shin Poong Pharmaceutical Co. Ltd., Janssen Pharmaceutica N.V., Belgium, Arcturus Therapeutics, Inc., NPO Petrovax, Alfasigma S.p.A., MGC Pharmaceuticals d.o.o, RSV Therapeutics LLC, PharmaMar, Restem, LLC., Qu?mica Luar SRL, Enzychem Lifesciences Corporation, Algernon Pharmaceuticals, Amarin Corporation, Synairgen Research Ltd., Aerpio Therapeutics, ImmunityBio, Inc., Cynata Therapeutics Limited, Canadian Cancer Trials Group, argenx BV, InflaRx GmbH, Klinikum St. Georg gGmbH, Veru Inc., Biohaven Pharmaceuticals, Inc., Pluristem Ltd., Apex Laboratories Pvt Ltd, Windtree Therapeutics, Sun Pharmaceutical Industries Limited, Chimerix Inc, Darmanara .Co, BioXcellerator, Hilton Pharma Pvt. Ltd., Leading BioSciences, Inc, DEY Company, Can-Fite BioPharma, Capricor Inc., Blade Therapeutics, Sentien Biotechnologies, Inc., TriHealth Inc., Bayside Health, Abivax S.A., Applied Biology, Inc., Lifefactors Zona Franca, SAS, Sharp HealthCare, Amyndas Pharmaceuticals S.A., CureVac AG, Atea Pharmaceuticals, Inc., Medicago Inc, Biocad, Vicore Pharma AB, NantKwest, Inc., Chugai Pharmaceutical Co., Ltd., Aspire Health Science, Beyond Air Ltd, Aivita Biomedical, Inc., Orpheris, Inc., Novelfarma Ila? San. ve Tic. Ltd. Sti., Angion Biomedica Corp, Hope Pharmaceuticals, Thirty Respiratory Limited, Apellis Pharmaceuticals, Inc., Laboratorios Roemmers S.A.I.C.F., Arch Biopartners Inc., Ansun Biopharma, Inc., Cardiologia Assistencial e de Pesquisa LTDA, Takeda, Benefic?ncia Portuguesa de S?o Paulo, Cellenkos, Inc., VistaGen Therapeutics, Inc., Bharat Biotech International Limited, Symvivo Corporation, Kentucky BioProcessing, Inc., Clover Biopharmaceuticals AUS Pty Ltd, Biocon Limited, S.L.A. Pharma AG, Grifols Therapeutics LLC, Biofarma, Humanetics Corporation, Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V., Sinocelltech Ltd., GeneOne Life Science, Inc., Thomas Benfield, Restorbio Inc., Medigen Vaccine Biologics Corp., CSL Behring, Regenexx, LLC, Mesoblast International S?rl, Nutrin GmbH, Partner Therapeutics, Inc., Inmunova S.A., Aevi Genomic Medicine, LLC, Biopharma Plasma LLC, aTyr Pharma, Inc., NeoImmuneTech, Apeiron Biologics, Revive Therapeutics, Ltd., CTI BioPharma, PT Bio Farma, Laurent Pharmaceuticals Inc., Orthosera Kft., Telios Pharma, Inc., Fulcrum Therapeutics, Bellerophon Pulse Technologies, Accelagen Pty Ltd, Clear Creek Bio, Inc., Erasmus MC, Zhejiang Hisun Pharmaceutical Co. Ltd., AB Science, HeNan Sincere Biotech Co., Ltd, Charit? Research Organisation GmbH, Celltex Therapeutics Corporation, DRK-Bluspendedienst Baden-W?rttemberg - Hessen gGmbH, Inotrem, St George Street Capital Ltd, Tychan Pte Ltd., WIN MEDICARE PVTLTD, MediciNova, Intas Pharmaceuticals Ltd, Trustem, Wockhardt Ltd, FibroGen, Cipla Ltd, Inovio Pharmaceuticals, Cadila Healthcare Limited Zydus Research Center, Bio-Thera Solutions, PHARCO CORPORATE, PhaseBio Pharmaceuticals Inc., FUJIFILM Toyama Chemical Co., Ltd., Deutsches Rotes Kreuz DRK-Blutspendedienst Baden-Wurttemberg-Hessen, Chistasazan Notash Fartak Company Limited., Chromis LLC, Zist Daru Danesh Company, First Wave Bio, Inc., Middle East Gene Therapy corporation, PTC Therapeutics, Tuohua Biological Technology Co. Ltd, Sanotize Research and Development corp., Health Medicine Chemistry Company, Immunovative Therapies, Ltd., Bukwang Pharmaceutical, Shanghai Junshi Bioscience Co., Ltd., AdventHealth, Altimmune, Inc., Kocak Farma, ViralClear Pharmaceuticals, Inc.

Executive Summary

During the 2019 to August 2020 observation period, 1194 COVID-19 trials have been initated and an additional 503 clinical trials are planned to commence. Of the total 1697 trials studied in the research, 726 trials are in Phase 2, 549 trials are in Phase 3, 220 trials in Phase 0 and Phase 1, and 183 trials in Phase 4. In terms of enrollment, 62% of subjects are recruited/planned for Phase 3.

Around 84% of trials are recruiting or planning to recruit subjects for their pipeline product development. Over 21% of trials are directly sponsored by pharmaceutical companies with the remaining 79% being sponsored indirectly by companies or sponsored by institutions.

Among countries, the US stood the largest market worldwide, accounting for 441 clinical trials. Among economy types, advanced and emerging economies share an almost equal volume of trials with the former accounting for 53% of trial count.

Overall, during the period under consideration, new clinical trial count has been steadily increasing. Further, with robust market outlook, the number of clinical trials and enrolment is also expected to increase steadily through 2022.
1 TABLE OF CONTENTS

1.1 List of Figures
1.2 List of Tables

2 EXECUTIVE SUMMARY

2.1 COVID-19 Clinical Trials Overview, 2020
2.2 Premium Insights into Clinical Trials
  2.2.1 United States is the largest country in COVID-19 Clinical Trials
  2.2.2 COVID-19 Clinical Trials by Region
  2.2.3 One-Fifth of trials are directly sponsored by Companies
  2.2.4 Companies participating in Trials
  2.2.5 Major Drugs under Development in COVID-19 Clinical Trials
  2.2.6 Trials in Emerging and Developing Economies

3 REGION-WISE COVID-19 CLINICAL TRIALS

3.1 North America COVID-19 Clinical Trials by Country
3.2 Europe COVID-19 Clinical Trials by Country
3.3 Eastern Mediterranean COVID-19 Clinical Trials by Country
3.4 Africa COVID-19 Clinical Trials by Country
3.5 South and Central America COVID-19 Clinical Trials by Country
3.6 South East Asia COVID-19 Clinical Trials by Country
3.7 Western Pacific COVID-19 Clinical Trials by Country

4 CLINICAL TRIALS TRENDS TO 2022

4.1 Phase wise COVID-19 Clinical Trials
4.2 COVID-19 Trials by Recruitment Status
4.3 Trial Type wise COVID-19 Clinical Trials

5 COVID-19 AVERAGE ENROLLMENT TRENDS

5.1 Enrollment in COVID-19 Trials by Region
5.2 Enrollment in Top 10 Countries- COVID-19 Trials
5.3 Enrollment in COVID-19 Trials by Phase
5.4 Enrollment in COVID-19 Trials by Status
5.5 Enrollment in COVID-19 Trials by Type of Trial

6 COMPANY LEVEL ANALYSIS

6.1 COVID-19 Trials by Sponsor Type
6.2 COVID-19 Average Enrollment by Sponsor Type
  6.2.1 Subjects Recruited by Leading Sponsors
  6.2.2 Leading Institutes participating in Clinical Trials

7 RECENT CLINICAL TRIALS- SNAPSHOTS

7.1 Phase 0 Trials
7.2 Phase 1 Trials
7.3 Phase 2 Trials
7.4 Phase 3 Trials
7.5 Phase 4 Trials

8 APPENDIX

8.1 ABOUT VPA RESEARCH
8.2 SOURCES AND RESEARCH METHODOLOGY

LIST OF FIGURES

Figure 1: Epidemic curve of confirmed COVID-19 Cases, December 2019- July 2020
Figure 2: COVID-19- Clinical Trials by Country, 2020
Figure 3: COVID-19- Clinical Trials by Region, 2020
Figure 4: COVID-19- Ongoing Clinical Trials by Type of Economy
Figure 5: COVID-19- Clinical Trials by Phase of Development
Figure 6: COVID-19- Clinical Trials by Status
Figure 7: COVID-19- Clinical Trials by Type
Figure 8: Enrollment in COVID-19 Trials by Region
Figure 9: COVID-19- Trials by Sponsor Type
Figure 10: COVID-19- Trials by Sponsor Type

LIST OF TABLES

Table 1: COVID-19- Unique Clinical Trials by Sponsor Type
Table 2: North America- COVID-19 Clinical Trials by Country
Table 3: Europe - COVID-19 Clinical Trials by Country
Table 4: Europe - COVID-19 Clinical Trials by Country (Continued)
Table 5: Eastern Mediterranean - COVID-19 Clinical Trials by Country
Table 6: Africa - COVID-19 Clinical Trials by Country
Table 7: South and Central America - COVID-19 Clinical Trials by Country
Table 8: South East Asia - COVID-19 Clinical Trials by Country
Table 9: Western Pacific - COVID-19 Clinical Trials by Country
Table 10: Enrollment in COVID-19 Trials by Region
Table 11: COVID-19- Top 10 Countries with Enrollment
Table 12: COVID-19- Enrollment by Phase
Table 13: COVID-19- Enrollment by Phase
Table 14: COVID-19- Enrollment by Trial Type
Table 15: COVID-19- Subjects Recruited by Leading Sponsors
Table 16: COVID-19 Phase 0 Trial Snapshots
Table 17: COVID-19 Phase 0 Trial Snapshots
Table 18: COVID-19 Phase 0 Trial Snapshots
Table 19: COVID-19 Phase 0 Trial Snapshots
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