Furure Italian Nucleic Acid Testing Market Outlook

Date: February 14, 2012
Pages: 850
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US$ 5,900.00 US$ 5,015.00
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Publisher: VPGMarketResearch.com
Report type: Strategic Report
Delivery: E-mail Delivery (PDF)
ID: I5E86B2B32FEN
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Furure Italian Nucleic Acid Testing Market Outlook
Highlights
  • Comprehensive 850-page market segmentation analysis of the Italian NAT market.
  • Major issues pertaining to the Italian NAT laboratory practice, as well as key economic, regulatory, demographic, social and technological trends with significant market impact during the next ten years.
  • An extensive review of DNA probe and biochip technologies, test formats, detection methodologies, trends in testing automation and amplification methods.
  • Ten-year test volume and reagent sales forecasts for the following categories:
    • Infectious Diseases
    • Cancer
    • Forensic Testing
    • Genetic Diseases
    • Paternity Testing/HLA Typing
  • Review of testing methodologies and instrumentation technologies.
  • Feature comparison of automated and semiautomated analyzers.
  • Sales and market shares of leading suppliers.
  • Over 60 specific opportunities for NAT instruments, test systems, IT and auxiliary products.
  • Profiles of major suppliers, and emerging market entrants, including their sales, product portfolios, marketing tactics, technological know-how, new products in R&D, collaborative arrangements and business strategies.
  • Alternative market penetration strategies.
  • Potential market entry barriers and risks.
  • Business planning issues and concerns.
Contains 850 pages and 36 tables
INTRODUCTION

WORLDWIDE MARKET AND TECHNOLOGY OVERVIEW

A. DNA SEQUENCING


1. Introduction
2. Sequencing Methods
3. Autoradiography
4. The Human Genome Project
5. Sequencing Automation
6. Image Scanners
7. Fluorescent Detection
8. Gene Profiling
9. Gene Expression
10. Polymorphism Screening
11. Protein Interaction Networks

B. DNA AND RNA PROBE TECHNOLOGY

1. Basic Principles
2. Probe Preparation
3. The DNA Probe Test
  a. Sample Preparation
  b. Hybridization
  c. Separation
  d. Detection/Measurement
4. Test Formats
  a. Filter Hybridization
  b. Southern Blot
  c. Northern Blot
  d. In Situ Hybridization
  e. Others
5. Labeling Techniques
6. Amplification Methods
  Polymerase Chain Reaction
    Temperature Cyclers
    PCR Variations
      Immuno-PCR
      QC-PCR
      DAP-PCR
  Strand Displacement Activation
  TMA
  Ligase Chain Reaction
  Branched DNA
    Hybridization Protection Assay
  Nucleic-Acid Sequence-Based Amplification
  Self-Sustained Sequence Replicase
  Others
    Ampliprobe
    CAR
    CAS
    CPT
    Dendritic Polymer Technology
    ISO-CR
    LAT
    Probe Networks
    RAMP
    Repair Chain Reaction
    Rolling Circles
    Sequence Independent Gene Amplification
    Sequence Initiation Reaction
    SISPA
    Solid Phase Amplification

C. DETECTION TECHNOLOGIES

1. Radioactive Methods
  a. Overview
  b. Major Isotopes
  P-32
  S-35
  H-3
  I-125
2. Non-Isotopic Methods
  a. Enzymatic Labels
  b. Chemical Labeling
  Indirect Chemical Labeling
  Direct Chemical Labeling
  c. Fluorescence
  d. Chemiluminescence
  e. Electrical Conductivity

D. INSTRUMENTATION REVIEW

1. Abbott LCx
2. Beckman Coulter/Biomek FK
3. Becton Dickinson SDA
4. Bio-Rad GeneScope
5. Gen-Probe Tigris
6. Roche Cobas Amplicor
7. Tecan LS Series

E. BIOCHIPS: GENOSENSORS, MICROARRAYS, AND LABS-ON-THE-CHIP

    Liquid Transportation and Mixing
    Separation
    Reaction
    Detection

F. PHARMACOGENOMICS

G. MAJOR APPLICATIONS


1. Microbiology/Infectious Diseases
  a. Overview
  b. Major Infectious Diseases
      AIDS
  Structure and Composition
  Classification
  AIDS Origins
  Animal Lentivirus Systems
  Virus Receptors
  HIV Infections in Humans
    Pathogenesis and Pathology
  CD4T Lymphocytes and Memory Cells
  Monocytes and Macrophages
  Lymphoid Organs
  Neural Cells
  Viral Coinfections
    Clinical Findings
  Plasma Viral Load
  Pediatric AIDS
    Neurologic Disease
    Opportunistic Infections
    Cancer
  Immunity
    Virus Isolation
    Serology
    Viral Nucleic Acid/Antigen Detection
  Epidemiology
    Worldwide Spread of AIDS
    United States
    Routes of Transmission
  DNA Probes
    Overview
    Quantitative PCR
    In Situ PCR
    Needed Improvements
  Viral Load/Drug Resistance Testing
  Genotype and Phenotype Testing
  Blood Banking Considerations
      Adenovirus
  Background
  Diagnostic Tests
  Vaccines and Drugs
  Adeno-Associated Viruses (AAV)
      Anthrax/Bacillus Anthracis
  Background
  Diagnostic Tests
  Vaccines and Drugs
      Babesiosis
  Background
      BEA and Other Bartonella Diseases
  Background
  Diagnostic Tests
  Vaccines and Drugs
      Chagas Disease
  Background
      Campylobacter
  Background
  Diagnostic Tests
    Culture Identification
  Vaccines and Drugs
      Chlamydia
  Background
    Chlamydia psittaci
    Chlmaydia pneumoniae
    Chlamydia trachomatis
  Diagnostic Tests
  Vaccines and Drugs
      Creutzfeldt-Jakob’s Disease
  Background
  Blood Transmission
  Diagnostic Tests
  Major Commercial and Academic Players
    Bayer
    Disease Sciences/Bio Tec Global
    Imperial College School of Medicine
    Ortho-Clinical Diagnostics
    Pall
    ProMetic Life Sciences
    Proteome Sciences/Idexx
    Q-One Biotech
    Serono
    U.S. Agricultural Research Service
  Drugs
  Vaccines
      Cytomegalovirus
  Background
    Chorioretinitis
    Gastrointestinal
    Central Nervous System Disease
  Diagnostic Tests
  Vaccines and Drugs
      Ebola Virus
  Background
    Epidemiology
    Clinical Syndromes
  Diagnostic Tests
  Vaccines and Drugs
      EchoVirus
  Background
    Acute Aseptic Meningitisis
    Encephalitis
    Exanthems
    Respiratory Disease
    Myopericarditis
    Neonatal Infections
  Diagnostic Tests
  Vaccines and Drugs
      Encephalitis
  Background
  Diagnostic Tests
  Vaccines and Drugs
      Enteroviruses
  Background
  Diagnostic Tests
    Viral Isolation and Identification
    Antibody Tests
  Vaccines and Drugs
      Epstein-Barr Virus
  Background
  Diagnostic Tests
  Vaccines and Drugs
      Gonorrhea
  Background
  Diagnostic Tests
  Vaccines and Drugs
      Hepatitis
  Hepatitis A
  Hepatitis B
    Structure and Composition
    Replication
  Hepatitis C
  Hepatitis D (Delta)
  Hepatitis E
  Hepatitis G
  Hepatitis Infections Pathology
  Clinical Findings
  Laboratory Tests
    Hepatitis A
    Hepatitis B
    Hepatitis C
    Hepatitis D
    Hepatitis E
  Virus-Host Immune Reactions
  Epidemiology
    Hepatitis A
    Hepatitis B
    Hepatitis C
    Hepatitis D (Delta)
  Vaccines and Drugs
      Herpes Simplex Virus
  Background
  Diagnostic Tests
  Vaccines and Drugs
      Legionella
  Background
  Diagnostic Tests
  Vaccines and Drugs
      Lyme Disease
  Background
    Clinical Description
    Clinical Case Definition
    Laboratory Criteria for Diagnosis
    Case Classification
  Diagnostic Tests
  Vaccines and Drugs
      Malaria
      Mycoplasma
  Background
    Ureaplasma Urealyticum & Mycoplasma Hominis
  Diagnostic Tests
  Vaccines and Drugs
      Papillomaviruses/HPV
  Background
    HPV in Cancer
    Cervical Neoplasm
  Diagnostic Tests
  Vaccines and Drugs
    Prevention
      Parvovirus B19
  Background
    Microbiology
    Epidemiology
    Clinical Syndromes
    Erythema Infectiosum (Slapped Cheek)
    Adult Polyarthropathy
    Transient Aplastic Crisis
    Transient Pancytopenia
    Red Cell Aplasia in Immunocompromised
    Perinatal Infections
  Diagnostic Test
  Vaccines and Drugs
      Pneumonia
  Background
  Diagnostic Tests
  Vaccines and Drugs
      Polyomaviruses
  Background
  Diagnostic Tests
  Vaccines and Drugs
      Salmonellosis
  Background
  Diagnostic Tests
  Vaccines and Drugs
      Shigellosis
  Background
  Diagnostic Tests
  Vaccines and Drugs
      Streptococci
  Background
  Diagnostic Tests
  Vaccines and Drugs
    Group A Streptococci
    Group B Streptococci
      Toxoplasmosis
  Background
  Diagnostic Tests
  Vaccines and Drugs
      Tuberculosis
  Background
  Diagnostic Tests
    Microscopic Characteristics
    Cultural Characteristics
    Skin Tests
    MDRTB
  Vaccines and Drugs
      West Nile Virus
  Background
    Clinical Syndromes
  Diagnostic Tests
  Vaccines and Drugs
      Yersinia
  Background
  Diagnostic Tests
  Vaccines and Drugs
  c. Antibiotic Susceptibility
2. Cancer Testing
  a. Overview
  b. Major Cancer Types
      Prostate
      Lung
      Colon and Rectum
      Breast
      Skin
      Uterine
      Leukemia
      Oral
  c. Oncogenes
  Abl/abl-bcr
  AIB1
  BCL-2
  BRCA1
  CD44
  C-fos
  C-myb
  C-myc
  CYP17
  Erb-B
  HPC1
  N-myc
  P40
  P51
  P53
  PIK3CA
  PTI-1
  Ras
  Reg
  Sis
  Src
3. Genetic Diseases
  a. Overview
  b. Nucleic Acid Amplification
  c. Chromosome Imaging
  d. Genomics Technologies
  e. Proteomics Technologies
  f. Current Pharmacogenomic Tests
  g. Future Pharmacogenomic Testing
  h. Major Diseases
      Achondroplasia
      Autosomal Dominant Polycystic Kidney Disease
      Cancer
      Cosmetogenomics
      Cystic Fibrosis
      Down's Syndrome
      Duchenne and Becker Muscular Dystrophy
      Factor V (Leiden)
      Factor IX Deficiency
      Fragile X Syndrome
      Heart Disease
      Hemochomatosis
      Hemophilia
      Huntington's Disease
      Maternal-Fetal Incompatibility
      Multiple Endocrine Neoplasia
      Phenylketonuria (PKU)
      Polycystic Kidney Disease (PKD)
      Prenatal Screening
      Retinitis Pigmentosa
      Retinoblastoma
      Sickle Cell Anemia
      Spinal Muscular Atrophy
      Vitamin B12 Metabolism
  i. Social Issues and Concerns
4. Forensic Testing
  a. Overview
  b. Multilocus and Single Locus Probes
      Multilocus Probes
      Single Locus Probes
      PCR and RFLP
  c. The FBI
  d. DNA Profile Data Banks
      U.S.A.
      U.K.
  e. Judicial Implementation
  f. Major Crime Categories
  g. Factors Contributing to the DNA Probe Market Expansion
      Technology Availability
      Use of Hair as Evidence
  h. Wildlife Forensics
5. Paternity Testing/HLA Typing
6. Other Applications
  a. Disease Susceptibility Testing
  b. Cardiovascular Diseases
  c. Diabetes
  d. Alzheimer's Disease
  e. Periodontal Disease
  f. Plasma Purification
  g. Organ Transplantation
  h. Water Contamination
  i. Other

H. COMPETING/COMPLEMENTING TECHNOLOGIES

1. Monoclonal Antibodies/Immunoassays
2. RNA Probes
3. Two-Dimensional Electrophoresis
4. Flow Cytometry

I. WORLDWIDE MARKET OVERVIEW

1. Business Environment
2. Market Structure
3. Market Size and Growth
  Italy
    A. Executive Summary
    B. Business Environment
    C. Market Structure
    D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
  Major Product Development Opportunities
    A. Instrumentation
    B. Reagent Kits and Test Systems/panels
    C. Computers, Software and Automation
    D. Auxiliary Products
  Design Criteria For Decentralized Testing Products
  Alternative Market Penetration Strategies
    A. Internal Development
    B. Collaborative Arrangements
    C. University Contracts
    D. Distribution Strategies For Decentralized Testing
  Markets
    1. Marketing Approaches
    2. Product Complexity
    3. Customer Preference
    4. Established Suppliers
    5. Emerging Suppliers
    6. Major Types Of Distributors
    7. Market Segmentation
  Potential Market Entry Barriers And Risks
    A. Market Maturity
    B. Cost Containment
    C. Competition
    D. Technological Edge And Limitations
    E. Patent Protection
    F. Regulatory Constraints
    G. Decentralized Testing Market Challenges
  Competitive Profiles
    Abbott
    Affymetrix
    Agilent
    Applied Gene Technologies
    Arca
    Beckman Coulter/Danaher
    Becton Dickinson
    Biokit
    BioMerieux
    Bio-Rad
    Biotest
    Caliper
    Cepheid
    Decode
    Diadexus
    Eiken
    Enzo
    Exact Sciences
    Fujirebio
    Gen-Probe
    Hologic
    Illumina
    Innogenetics/Solvay
    Kreatech
    Li-Cor Biosciences
    Life Technologies
    Monogram Biosciences
    Myriad Genetics
    Nanogen/Elitech
    Novartis
    Orchid CellMark
    Ortho-Clinical Diagnostics
    Proteome Sciences
    Qiagen
    Roche
    Scienion
    Sequenom
    Shimadzu
    Siemens
    Sierra Molecular
    Takara Bio
    Tecan Group

APPENDIXES

Appendix I: Major Universities and Research Centers Developing NAT Technology
Appendix II: Glossary of Terms
Appendix III: Currency Exchange Rates

LIST OF TABLES

Major Companies Developing or Marketing AIDS NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Adenovirus NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Campylobacter NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Chlamydia NAT And Other Direct Identification Tests
Major Companies Developing or Marketing CMV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing EBV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Gonorrhea NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Hepatitis NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Herpes NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Legionella NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Lyme Disease NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Mycoplasma NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Papilloma Virus NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Pneumonia NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Salmonella NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Shigella NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Streptococci NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Toxoplasmosis NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Tuberculosis NAT And Other Direct Identification Tests
Oncogenes Potential Application in Cancer Diagnosis
Major Companies Developing or Marketing Cancer NAT Tests
Major Companies Developing or Marketing NAT Assays For Genetic Diseases
Summary Table Italy, NAT Test Volume And Sales Forecast by Major Application
Italy, Laboratories Performing DNA Sequencing by Market Segment
Italy, NAT Market Potential Laboratory Universe by Market Segment
Italy, NAT Test Volume Forecast By Major Application
Italy, Major Infectious NAT Test Volume Forecast
Italy, Infectious Disease Screening NAT Volume Forecast
Italy, NAT Market Forecast By Major Application
Italy, Infectious Disease Screening NAT Reagent Market Forecast by Test
Italy, NAT Market By Major Supplier
Italy, HIV/Hepatitis NAT Market By Major Supplier
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