Hormone Replacement Therapy (HRT): Market Research Report

Date: January 5, 2016
Pages: 198
Price:
US$ 4,950.00
Publisher: Global Industry Analysts, Inc
Report type: Strategic Report
Delivery: E-mail Delivery (PDF)
ID: H9FFE488A85EN
Leaflet:

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Hormone Replacement Therapy (HRT): Market Research Report
This report analyzes the worldwide markets for Hormone Replacement Therapy (HRT) in US$ Thousand. The report provides separate comprehensive analytics for the US, Canada, Europe, Asia-Pacific, Latin America, and Rest of World. Annual estimates and forecasts are provided for the period 2015 through 2022. Also, a six-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 40 companies including many key and niche players such as -
  • Abbott Laboratories
  • AbbVie, Inc.
  • Allergan plc
  • Bayer Pharma AG
  • Hisamitsu Pharmaceutical Co., Inc.
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations
Disclaimers
Data Interpretation & Reporting Level
Quantitative Techniques & Analytics
Product Definition and Scope of Study

II. EXECUTIVE SUMMARY

1. OUTLOOK

Amid Controversies, Confusion and Competition, Demand for HRT Continues to Rise
The HRT Controversy – An Insight
Current and Future Analysis
The Regional Divide
Increasing Number of Women in Menopause – A Major Market Driver
Dearth in Safe Drugs is Hurting the Market, and Women

2. INDUSTRY OVERVIEW

An Introduction to Menopause and Hormone Replacement Therapy
An Overview of Select Estrogen Therapy Approaches
WHI Study- A Major Blow to the HRT Market
The HRT Controversy Evolution in the New Millennium
Reappraisal of Data from Previous Studies – A Hope for Resurgence in HRT Demand
IMS Consensus Guidelines Paving Way for More Clarity of HRT
Menopause Statistics – An Opportunity Indicator
Ethnic Differences Exist in Menopausal Symptoms

3. MARKET TRENDS & ISSUES

Market Size Restricted by Lesser Number of Women Opting for Treatment
Safety Issues: A Major Deterrent to the HRT Market
Manufacturers to Face Legal Challenges
Unmet Needs in the Combination Therapies for HRT drive Research for New Medicines
Topical Estrogens – More Safe and Effective
Transdermal HRT Products Present Exciting Opportunities
Phytoestrogens – The New Panacea for Menopausal Symptoms?
Diet Link to Menopause Symptoms Raises Interest
Impact of Soy and Other Phytoestrogens – A Reality Check
Select Botanical Treatments Studied for Menopause Symptoms Treatment and Identified Risks and Limitations
EstroG – A Successful Herbal Health Supplement in Alleviating Menopausal Symptoms
The Growing Buzz around Bioidentical Drugs
Bio-identical Hormones – A Natural and Safe Substitute to Synthetic HRT?
List of Bio-identical Products Used in Conventional HRT
Pellet Therapy – A New Innovation Downsizes Conventional Issues with Bioidentical HRT
Direct-to-Consumer Advertising for HRT – A Mixed Bag

4. COMPETITIVE LANDSCAPE

Intense Competition Marks the Global HRT Market

Table 1. Global Sales of Select HRT Products (in US$ Million): 2014 & 2015 (includes corresponding Graph/Chart)

The Premarin Saga
Health Risks Tarnish Premarin’s Image

Table 2. Annual Sales of Premarin Family: 2002-2015 (includes corresponding Graph/Chart)

Pfizer Seeks Refuge in Line Extensions
Better Safety Profile for Duavee – A Shot in the Arm for Pfizer
Estrace Cream Drives Revenue Gains in Allergan’s HRT Portfolio

Table 3. Annual Sales of Estrace Cream: 2010-2015 (includes corresponding Graph/Chart)

New Drug Buoys Novo Nordisk’s HRT Portfolio
Estriol: The Next Generation Estrogen Therapy?
What Makes Estriol Work?
Topical Estriol – More Promising in Safety
Estriol – Used More Commonly Outside the US
Entry of Generics Threatens Market Growth Prospects
Select Hormone Therapies for Post-Menopausal Women by Year of Patent Expiry: 2015 to 2022
Generic Incursion in Hormone Replacement Therapy - List of Drugs With and Without Approved Generic Versions
Select Hormone Therapies for Treatment of Postmenopausal Symptoms by Generic Manufacturers
Are Non-Hormonal Therapies A Threat to HRT?
Earlier Failures Induce Lethargy in Non-Hormonal Therapies
Menerba: A Promising Non-Hormone Therapy for Menopausal Hot Flashes

5. THERAPY PROFILE – A REVIEW OF SELECT RECENT STUDIES CONDUCTED

New Meta-Analysis Positively Links Ovarian Cancer to Use of HRT, Albeit Modest
Nanotechnology for HRT – New Drug under Development Eyes Better Absorption and Safety
Researchers at Yale University Discover Discontinuation HRT May Lead to Premature Deaths
Bioidenticals versus Synthetic Hormone Replacement Therapy Agents
Studies at University of Sydney Researchers Reveal the Safety of Short-Term Unopposed Estrogens
US Researchers Reveal HRT Risks May be Dependent on Weight and Other Factors
Studies Prove HRT to Lower Risk of Pancreatic Cancer
University of Texas Reveal HRT Linked to Risks of Kidney Stones
Researchers at the Sundsvall Hospital Demonstrate Increased Incidence of Cataract Development in Women Undergoing HRT
Researchers at University of Southern California Demonstrate Estrogen Replacement Therapies Lower Stress Levels in Older Women
Studies at Uppsala University Hospital Demonstrate HRT is Associated with Improved Muscle Functioning in Postmenopausal women
Finnish Study Reveals HRT Usage Assist in the Treatment of Hot Flashes in Post-Menopausal Women
Researchers at Johns Hopkins University Demonstrate Women Undergoing Hormone Therapy Less Prone to Alzheimer's Disease
French Study Reveals Hormone Replacement Pills May Affect Gall Bladder
Danish Studies Proves HRT Lowers Risk of Heart Attack and Heart Failure

6. PRODUCT OVERVIEW

What are Hormones?
What is Menopause?
Menopause Symptoms and Complaints
Introduction to Hormone Replacement Therapy
HRT Products
Estrogen
Progestins
Types of HRT
Why HRT?
Milestones and Downfalls in the Hormone Replacement Therapy (HRT) Market
Contraindications of HRT
Historical Progression
Advantages and Disadvantages of Using HRT
Benefits of Hormone Therapy
Relief from Vasomotor Symptoms
Vaginal Symptoms
Improvement in Sexual Functioning
Urinary Health
Management of Variations in Body Weight/ Mass
Ensuring Quality of Life
Osteoporosis
Diabetes Mellitus (DM)
Impact on Overall Mortality
Treatment of Premature Menopause
Risks Involved in Hormone Therapy
Hormone Therapies in HRT and their Effect
Potential Benefits and Risks of HRT in Menopausal Symptoms
Common and Less Common Side Effects of Using Estrogen-alone, Progesterone-alone or Combination Therapies
Potential Issues
Cardiovascular Problems
Coronary Heart Disease (CHD)
Stroke
Venous Thromboembolism (VTE)
Endometrial Cancer
Breast Cancer
Estrogen-Progestogen Therapy
Estrogen Therapy
Lung Cancer
Depression and Mood Swings
Ovarian Cancer
Routes of Administration
Systemic Treatment
Pills
Advantages and Disadvantages of Oral HRT
Vaginal Estrogen Ring
Transdermal Estrogen Skin Patches
Localized Treatment
Vaginal Estrogen Tablets
Estrogen Creams
Intrauterine Progestin System (IUS)
Lower Dose Vaginal Estrogen Ring
Vaginal Progesterone Gel
Implants
Advantages and Disadvantages of HRT Implants
Bioidentical Hormone Replacement Therapy (BHRT)
Historical Background
More Claims than Evidence
Other Alternatives
Prescription Medication
Gabapentin
Clonidine
SNRIs and SSRIs
Botanicals
Black Cohosh
Phytoestrogens (Isoflavones)
Other Botanical Products
Non-botanical Supplements
Mind/Body therapies
Exercise and Diet

7. PRODUCT INTRODUCTIONS/APPROVALS

Acrux and Gedeon Richter Announce European Approval for Lenzetto
Noven Launches New Lose Dose-Strength Minivelle for Treating Postmenopausal Osteoporosis
Mylan Launches Generic Vivelle-DOT
Sandoz Rolls Out Authorized Generic for Vivelle-Dot in the US
Amneal Launches Lopreeza - Authorized Generic Form of Activella
Hisamitsu Secures Extended Dosage and Indication for Estrana Tape Estradiol Transdermal Patch

8. RECENT INDUSTRY ACTIVITY

TherapeuticsMD Completes Patient Enrolment for Replenish Trial for TX-001HR
Actavis Changes Name to Allergan
Actavis Takes Over Allergan
Perrigo to Acquire Evamist from Lumara Health
Trimel Acquires Canadian Rights to Estrace from Shire
Upsher-Smith Inks Deal to Sell Divigel to Vertical Pharmaceuticals
Meda Inks Promotion Agreement with Mission Pharmacal for Elestrin
IDT Australia Inks Agreement with Perrigo to Acquire Conjugated Estrogens ANDA Filing

9. FOCUS ON SELECT GLOBAL PLAYERS

Abbott Laboratories (US)
AbbVie, Inc. (US)
Allergan plc (Ireland)
Bayer Pharma AG (Germany)
Hisamitsu Pharmaceutical Co., Inc. (Japan)
Noven Pharmaceuticals, Inc. (US)
Novartis AG (Switzerland)
Novo Nordisk A/S (Denmark)
Orion Pharma AB (Finland)
Pfizer, Inc. (US)
Rottapharm Madaus (Italy)
Teva Pharmaceutical Industries Ltd. (Israel)
TherapeuticsMD, Inc. (US)

10. GLOBAL MARKET PERSPECTIVE

Table 4. World Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) by Geographic Region - US, Canada, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 5. World Historic Review for Hormone Replacement Therapy (HRT) by Geographic Region - US, Canada, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)
Table 6. World 14-Year Perspective for Hormone Replacement Therapy (HRT) by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Europe, Asia-Pacific, Latin America and Rest of World Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)

III. MARKET

1. THE UNITED STATES

A. Market Analysis
Current & Future Analysis
HRT Market in the US – An Overview
Select FDA Drug Approvals for Treatment of Menopause Symptoms by Year of Approval
List of Approved Oral Estrogen Therapy Products
List of Approved Transdermal Estrogen Therapy Products
List of Approved Vaginal Estrogen Therapy Products
List of Approved Combination Estrogen Products
The Menopause Opportunity

Table 7. US Female Population Percentage Distribution by Age Group: 2015 (includes corresponding Graph/Chart)

Impact of the WHI Study
Increasing Preference for Topical Vaginal Products
Rising Interest in Low-Dose Hormone Therapies to Lead Market Growth
Low-Dose Hormone Replacement Therapy Formulations of Estrogens and Estrogen- Progestin Combinations Available in the United States
Are Custom Compounded Bioidenticals Products Better?
List of FDA-Approved Bioidentical Hormones
Bioidenticals Remains a Lethargic Market in the US
Regulatory Scenario for BHRT in the US
Issues with Approved Bioidenticals
VVA Market Remains Underpenetrated
FDA Appealed to Make Changes to Boxed Warnings on Low-Dose Vaginal Estrogen to Drive Adoption
Growing Pharmacy Compounding of HRT Raises Concerns; Proposed Bill to Put Shackles
Product Approvals/Launches
Strategic Corporate Developments
Select Key Players
B. Market Analytics

Table 8. The US Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 9. The US Historic Review for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)

2. CANADA

A. Market Analysis
Canada – The Birth Place of Estrogens
Current Market Scenario
The Fallout of the WHI Study

Table 10. Canadian Female Population Estimates by Age Group: 2015 (includes corresponding Graph/Chart)

List of Approved Oral Estrogen Therapy Products
List of Approved Transdermal Estrogen Therapy Products
List of Approved Vaginal Estrogen Therapy Products
List of Approved Combination Estrogen Products
Strategic Corporate Development
B. Market Analytics

Table 11. Canadian Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 12. Canadian Historic Review for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)

3. EUROPE

A. Market Analysis
Current & Future Analysis
Growing Demand for Topical and Transdermal HRT
European Medicines Agency Imposes New Restrictions on Linoladiol HN and Linoladiol N Estradiol Creams
B. Market Analytics

Table 13. European Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) by Geographic Region - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 14. European Historic Review for Hormone Replacement Therapy (HRT) by Geographic Region - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)
Table 15. European 14-Year Perspective for Hormone Replacement Therapy (HRT) by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK, Spain and Rest of Europe Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)

3A. FRANCE

A. Market Analysis
Current & Future Analysis
A Peek into the HRT Prescription Practices in France
B. Market Analytics

Table 16. French Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 17. French Historic Review for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)

3B. GERMANY

A. Market Analysis
Current & Future Analysis
Bayer Pharma AG – A Major Germany-Based Player
B. Market Analytics

Table 18. German Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 19. German Historic Review for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)

3C. ITALY

A. Market Analysis
Current & Future Analysis
Rottapharm Madaus – A Major Italy-Based Regional Player
B. Market Analytics

Table 20. Italian Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 21. Italian Historic Review for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)

3D. THE UNITED KINGDOM

A. Market Analysis
Current & Future Analysis
Post-Menopausal Symptoms in British Women
British Menopause Society and Women’s Health Concern Revises Recommendations on HRT
List of the Hormone Replacement Therapy Products Available in the UK
List of HRT Products Available in the UK by Format
New Guidelines from NHS May Improve Uptake of HRT
B. Market Analytics

Table 22. The UK Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 23. The UK Historic Review for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)

3E. SPAIN

A. Market Analysis
Current & Future Analysis
HRT Prescription Status in Spain
B. Market Analytics

Table 24. Spanish Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 25. Spanish Historic Review for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)

3F. REST OF EUROPE

A. Market Analysis
Current & Future Analysis
Product Approval
Strategic Corporate Development
Select Key Players
B. Market Analytics

Table 26. Rest of Europe Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 27. Rest of Europe Historic Review for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)

4. ASIA-PACIFIC

A. Market Analysis
Current and Future Analysis
Focus on Select Regional Markets
Australia
Dwindling Options for Estrogen Patients – A Growing Concern
Japan
Japan – A Small yet Growing Market for HRT
Menopausal Characteristics and Impact of Diet
Product Approval
Hisamitsu Pharmaceutical Co., Inc. – A Major Japan-Based HRT Manufacturer
B. Market Analytics

Table 28. Asia-Pacific Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 29. Asia-Pacific Historic Review for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)

5. LATIN AMERICA

Market Analysis

Table 30. Latin American Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 31. Latin American Historic Review for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)

6. REST OF WORLD

A. Market Analysis
Current & Future Analysis
Teva Pharmaceutical Industries Ltd. – A Key Player Israel-based Player
B. Market Analytics

Table 32. Rest of World Recent Past, Current & Future Analysis for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 33. Rest of World Historic Review for Hormone Replacement Therapy (HRT) Market - Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 40 (including Divisions/Subsidiaries - 47)
The United States (22)
Canada (3)
Japan (3)
Europe (12)
  Germany (1)
  The United Kingdom (5)
  Rest of Europe (6)
Asia-Pacific (Excluding Japan) (6)
Middle East (1)
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