Future Nucleic Acid Testing Market - New Product Development Opportunities and Business Expansion Strategies for Instrument and Reagent Suppliers
This comprehensive seven-country, 1,050-page report is designed to help current suppliers and potential market entrants identify and evaluate major business opportunities emerging in the NAT market during this decade.
Highlights
Highlights
- Business and technological trends in seven major markets
- Five- and ten-year test volume and sales forecasts
- Market shares of leading competitors
- Feature comparison of major analyzers
- Profiles of market players and start-up firms developing innovative technologies and products
- Specific product and business opportunities for instrument and consumable suppliers.
INTRODUCTION
WORLDWIDE MARKET AND TECHNOLOGY OVERVIEW
A. DNA SEQUENCING
1. Introduction
2. Sequencing Methods
3. Autoradiography
4. The Human Genome Project
5. Sequencing Automation
6. Image Scanners
7. Fluorescent Detection
8. Gene Profiling
9. Gene Expression
10. Polymorphism Screening
11. Protein Interaction Networks
B. DNA AND RNA PROBE TECHNOLOGY
1. Basic Principles
2. Probe Preparation
3. The DNA Probe Test
a. Sample Preparation
b. Hybridization
c. Separation
d. Detection/Measurement
4. Test Formats
a. Filter Hybridization
b. Southern Blot
c. Northern Blot
d. In Situ Hybridization
e. Others
5. Labeling Techniques
6. Amplification Methods
Polymerase Chain Reaction
Temperature Cyclers
PCR Variations
Immuno-PCR
QC-PCR
DAP-PCR
Strand Displacement Activation
TMA
Ligase Chain Reaction
Branched DNA
Hybridization Protection Assay
Nucleic-Acid Sequence-Based Amplification
Self-Sustained Sequence Replicase
Others
Ampliprobe
CAR
CAS
CPT
Dendritic Polymer Technology
ISO-CR
LAT
Probe Networks
RAMP
Repair Chain Reaction
Rolling Circles
Sequence Independent Gene Amplification
Sequence Initiation Reaction
SISPA
C. DETECTION TECHNOLOGIES
1. Radioactive Methods
a. Overview
b. Major Isotopes
P-32
S-35
H-3
I-125
2. Non-Isotopic Methods
a. Enzymatic Labels
b. Chemical Labeling
Indirect Chemical Labeling
Direct Chemical Labeling
c. Fluorescence
d. Chemiluminescence
e. Electrical Conductivity
D. INSTRUMENTATION REVIEW
1. Abbott LCx
2. Autogenomics Infinity
3. Beckman Coulter/Biomek FK
4. Becton Dickinson SDA
5. Bio-Rad GeneScope
6. Gen-Probe Tigris
7. Nanosphere Verigen Series
8. Roche Cobas Amplicor
9. Tecan LS Series
E. BIOCHIPS: GENOSENSORS, MICROARRAYS, AND LABS-ON-THE-CHIP
Liquid Transportation and Mixing
Separation
Reaction
Detection
F. PHARMACOGENOMICS
G. MAJOR APPLICATIONS
1. Microbiology/Infectious Diseases
a. Overview
b. Major Infectious Diseases
AIDS
Structure and Composition
Classification
AIDS Origins
Animal Lentivirus Systems
Virus Receptors
HIV Infections in Humans
Pathogenesis and Pathology
CD4T Lymphocytes and Memory Cells
Monocytes and Macrophages
Lymphoid Organs
Neural Cells
Viral Coinfections
Clinical Findings
Plasma Viral Load
Pediatric AIDS
Neurologic Disease
Opportunistic Infections
Cancer
Immunity
Laboratory Diagnosis
Virus Isolation
Serology
Viral Nucleic Acid/Antigen Detection
Epidemiology
Worldwide Spread of AIDS
United States
Routes of Transmission
Prevention, Treatment, And Control
Antiviral Drugs
Vaccines
Transmission HIV in Blood Products
HIV Transmission in Transplant and Artificial Insemination Recipients
Diagnostic Tests
Enzyme Immunoassay Interpretation
Specificity, Sensitivity and Predictive Value
Competition Assays
Western Blot Technique
Immuno-Fluorescence Assays (IFA)
Radioimmunoprecipitation
HIV-1/HIV-2 Combination Testing
Methods of HIV-Antigen Detection
Antigen Assays and Blood Screening
Urine Tests
DNA Probes
Overview
Quantitative PCR
In Situ PCR
Needed Improvements
Viral Load/Drug Resistance Testing
Genotype and Phenotype Testing
Blood Banking Considerations
Adenovirus
Background
Diagnostic Tests
Vaccines and Drugs
Adeno-Associated Viruses (AAV)
Anthrax/Bacillus Anthracis
Background
Diagnostic Tests
Vaccines and Drugs
Babesiosis
Background
BEA and Other Bartonella Diseases
Background
Diagnostic Tests
Vaccines and Drugs
Chagas Disease
Background
Campylobacter
Background
Diagnostic Tests
Culture Identification
Vaccines and Drugs
Chlamydia
Background
Chlamydia psittaci
Chlmaydia pneumoniae
Chlamydia trachomatis
Diagnostic Tests
Vaccines and Drugs
Creutzfeldt-Jakob’s Disease
Background
Blood Transmission
Diagnostic Tests
Major Commercial and Academic Players
Bayer
Disease Sciences/Bio Tec Global
Imperial College School of Medicine
Ortho-Clinical Diagnostics
Pall
ProMetic Life Sciences
Proteome Sciences/Idexx
Q-One Biotech
Serono
U.S. Agricultural Research Service
Drugs
Vaccines
Cytomegalovirus
Background
Chorioretinitis
Gastrointestinal
Central Nervous System Disease
Diagnostic Tests
Vaccines and Drugs
Ebola Virus
Background
Epidemiology
Clinical Syndromes
Diagnostic Tests
Vaccines and Drugs
EchoVirus
Background
Acute Aseptic Meningitisis
Encephalitis
Exanthems
Respiratory Disease
Myopericarditis
Neonatal Infections
Diagnostic Tests
Vaccines and Drugs
Encephalitis
Background
Diagnostic Tests
Vaccines and Drugs
Enteroviruses
Background
Diagnostic Tests
Viral Isolation and Identification
Antibody Tests
Vaccines and Drugs
Epstein-Barr Virus
Background
Diagnostic Tests
Vaccines and Drugs
Gonorrhea
Background
Diagnostic Tests
Vaccines and Drugs
Hepatitis
Hepatitis A
Hepatitis B
Structure and Composition
Replication
Hepatitis C
Hepatitis D (Delta)
Hepatitis E
Hepatitis G
Hepatitis Infections Pathology
Clinical Findings
Laboratory Tests
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D
Hepatitis E
Virus-Host Immune Reactions
Epidemiology
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D (Delta)
Vaccines and Drugs
Herpes Simplex Virus
Background
Diagnostic Tests
Vaccines and Drugs
Legionella
Background
Diagnostic Tests
Vaccines and Drugs
Lyme Disease
Background
Clinical Description
Clinical Case Definition
Laboratory Criteria for Diagnosis
Case Classification
Diagnostic Tests
Vaccines and Drugs
Malaria
Mycoplasma
Background
Ureaplasma Urealyticum & Mycoplasma Hominis
Diagnostic Tests
Vaccines and Drugs
Papillomaviruses/HPV
Background
HPV in Cancer
Cervical Neoplasm
Diagnostic Tests
Vaccines and Drugs
Prevention
Parvovirus B19
Background
Microbiology
Epidemiology
Clinical Syndromes
Erythema Infectiosum (Slapped Cheek)
Adult Polyarthropathy
Transient Aplastic Crisis
Transient Pancytopenia
Red Cell Aplasia in Immunocompromised
Perinatal Infections
Diagnostic Test
Vaccines and Drugs
Pneumonia
Background
Diagnostic Tests
Vaccines and Drugs
Polyomaviruses
Background
Diagnostic Tests
Vaccines and Drugs
Salmonellosis
Background
Diagnostic Tests
Vaccines and Drugs
Shigellosis
Background
Diagnostic Tests
Vaccines and Drugs
Streptococci
Background
Diagnostic Tests
Vaccines and Drugs
Group A Streptococci
Group B Streptococci
Toxoplasmosis
Background
Diagnostic Tests
Vaccines and Drugs
Tuberculosis
Background
Diagnostic Tests
Microscopic Characteristics
Cultural Characteristics
Skin Tests
MDRTB
Vaccines and Drugs
West Nile Virus
Background
Clinical Syndromes
Diagnostic Tests
Vaccines and Drugs
Yersinia
Background
Diagnostic Tests
Vaccines and Drugs
c. Antibiotic Susceptibility
2. Cancer Testing
a. Overview
b. Major Cancer Types
Prostate
Lung
Colon and Rectum
Breast
Skin
Uterine
Leukemia
Oral
c. Oncogenes
Abl/abl-bcr
AIB1
BRCA1
CD44
C-fos
C-myb
C-myc
CYP17
Erb-B
HPC1
N-myc
P40
P51
P53
PIK3CA
PTI-1
Ras
Reg
Sis
Src
3. Genetic Diseases
a. Overview
b. Nucleic Acid Amplification
c. Chromosome Imaging
d. Genomics Technologies
e. Proteomics Technologies
f. Current Pharmacogenomic Tests
g. Future Pharmacogenomic Testing
h. Major Diseases
Achondroplasia
Autosomal Dominant Polycystic Kidney Disease
Cancer
Cosmetogenomics
Cystic Fibrosis
Down's Syndrome
Duchenne and Becker Muscular Dystrophy
Factor V (Leiden)
Factor IX Deficiency
Fragile X Syndrome
Heart Disease
Hemochomatosis
Hemophilia
Huntington's Disease
Maternal-Fetal Incompatibility
Multiple Endocrine Neoplasia
Phenylketonuria (PKU)
Polycystic Kidney Disease (PKD)
Prenatal Screening
Retinitis Pigmentosa
Retinoblastoma
Sickle Cell Anemia
Spinal Muscular Atrophy
Vitamin B12 Metabolism
i. Social Issues and Concerns
4. Forensic Testing
a. Overview
b. Multilocus and Single Locus Probes
Multilocus Probes
Single Locus Probes
PCR and RFLP
c. The FBI
d. DNA Profile Data Banks
U.S.A.
U.K.
e. Judicial Implementation
f. Major Crime Categories
g. Factors Contributing to the DNA Probe Market Expansion
Technology Availability
Use of Hair as Evidence
h. Wildlife Forensics
5. Paternity Testing/HLA Typing
6. Other Applications
a. Disease Susceptibility Testing
b. Cardiovascular Diseases
c. Diabetes
d. Alzheimer's Disease
e. Plasma Purification
f. Organ Transplantation
g. Water Contamination
h. Others
G. COST ANALYSIS
1. Equipment
2. Consumables
H. COMPETING/COMPLEMENTING TECHNOLOGIES
1. Monoclonal Antibodies/Immunoassays
2. RNA Probes
3. Two-Dimensional Electrophoresis
4. Flow Cytometry
I. REIMBURSEMENT ISSUES
J. WORLDWIDE MARKET OVERVIEW
1. Business Environment
2. Market Structure
3. Market Size and Growth
France
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
Germany
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
Italy
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
Japan
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
Spain
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
U.K.
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
U.S.A.
A. Executive Summary
B. Business Environment
1. Health Care Expenditures
2. Cost Consciousness
3. Reimbursement
4. Industry Consolidation
5. Managed Care
a. HMO
b. PPO
6. Hospitals
7. Admissions
8. Length of Stay
9. Industry Diversification
10. Physician Demographics
11. Population Aging
a. Chronic Illness
b. Disease Incidence
c. Susceptibility to Iatrogenesis
d. Multiple Illness Cases
12. Laboratory Regulations
13. FDA Reform
C. Market Structure
1. Hospitals
2. Commercial/Private Laboratories
3. Blood Banks
D. Market Size, Growth and Major Suppliers’ Sales and Market Shares
Major Product Development Opportunities
A. Instrumentation
B. Reagent Kits and Test Systems/panels
C. Computers, Software and Automation
D. Auxiliary Products
Design Criteria For Decentralized Testing Products
Alternative Market Penetration Strategies
A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies For Decentralized Testing Markets
1. Marketing Approaches
2. Product Complexity
3. Customer Preference
4. Established Suppliers
5. Emerging Suppliers
6. Major Types Of Distributors
7. Market Segmentation
Potential Market Entry Barriers And Risks
A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge And Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges
Competitive Profiles
Abbott
Aclara
Affymetrix
Agilent
Ambion
Applera
Applied Gene Technologies
Beckman Coulter
Becton Dickinson
Biokit
BioMerieux
Biotest
Boston Biomedica
Caliper
Cepheid
Chiron
Decode
Diadexus
Digene
Eiken
Enzo
Exact Sciences
Fujirebio
Gen-Probe
Gene Tec
Illumina
Innogenetics
Kreatech
Li-Cor
Molecular Diagnostics
Myriad Genetics
Nanogen
Nuvelo
Orchid Biosciences
Qiagen
Roche
Sangtec
Sequenom
Scienion
Sierra Diagnostics
Shimadzu
Takara Bio
Tepnel Life Sciences
Tecan Group
Third Wave
APPENDIXES
Appendix I: Major Companies Developing or Marketing NAT Reagents and Test Kits
Appendix II: Major Universities and Research Centers Developing NAT Technologies
Appendix III: Glossary of Terms
Appendix IV: Currency Exchange Rates
WORLDWIDE MARKET AND TECHNOLOGY OVERVIEW
A. DNA SEQUENCING
1. Introduction
2. Sequencing Methods
3. Autoradiography
4. The Human Genome Project
5. Sequencing Automation
6. Image Scanners
7. Fluorescent Detection
8. Gene Profiling
9. Gene Expression
10. Polymorphism Screening
11. Protein Interaction Networks
B. DNA AND RNA PROBE TECHNOLOGY
1. Basic Principles
2. Probe Preparation
3. The DNA Probe Test
a. Sample Preparation
b. Hybridization
c. Separation
d. Detection/Measurement
4. Test Formats
a. Filter Hybridization
b. Southern Blot
c. Northern Blot
d. In Situ Hybridization
e. Others
5. Labeling Techniques
6. Amplification Methods
Polymerase Chain Reaction
Temperature Cyclers
PCR Variations
Immuno-PCR
QC-PCR
DAP-PCR
Strand Displacement Activation
TMA
Ligase Chain Reaction
Branched DNA
Hybridization Protection Assay
Nucleic-Acid Sequence-Based Amplification
Self-Sustained Sequence Replicase
Others
Ampliprobe
CAR
CAS
CPT
Dendritic Polymer Technology
ISO-CR
LAT
Probe Networks
RAMP
Repair Chain Reaction
Rolling Circles
Sequence Independent Gene Amplification
Sequence Initiation Reaction
SISPA
C. DETECTION TECHNOLOGIES
1. Radioactive Methods
a. Overview
b. Major Isotopes
P-32
S-35
H-3
I-125
2. Non-Isotopic Methods
a. Enzymatic Labels
b. Chemical Labeling
Indirect Chemical Labeling
Direct Chemical Labeling
c. Fluorescence
d. Chemiluminescence
e. Electrical Conductivity
D. INSTRUMENTATION REVIEW
1. Abbott LCx
2. Autogenomics Infinity
3. Beckman Coulter/Biomek FK
4. Becton Dickinson SDA
5. Bio-Rad GeneScope
6. Gen-Probe Tigris
7. Nanosphere Verigen Series
8. Roche Cobas Amplicor
9. Tecan LS Series
E. BIOCHIPS: GENOSENSORS, MICROARRAYS, AND LABS-ON-THE-CHIP
Liquid Transportation and Mixing
Separation
Reaction
Detection
F. PHARMACOGENOMICS
G. MAJOR APPLICATIONS
1. Microbiology/Infectious Diseases
a. Overview
b. Major Infectious Diseases
AIDS
Structure and Composition
Classification
AIDS Origins
Animal Lentivirus Systems
Virus Receptors
HIV Infections in Humans
Pathogenesis and Pathology
CD4T Lymphocytes and Memory Cells
Monocytes and Macrophages
Lymphoid Organs
Neural Cells
Viral Coinfections
Clinical Findings
Plasma Viral Load
Pediatric AIDS
Neurologic Disease
Opportunistic Infections
Cancer
Immunity
Laboratory Diagnosis
Virus Isolation
Serology
Viral Nucleic Acid/Antigen Detection
Epidemiology
Worldwide Spread of AIDS
United States
Routes of Transmission
Prevention, Treatment, And Control
Antiviral Drugs
Vaccines
Transmission HIV in Blood Products
HIV Transmission in Transplant and Artificial Insemination Recipients
Diagnostic Tests
Enzyme Immunoassay Interpretation
Specificity, Sensitivity and Predictive Value
Competition Assays
Western Blot Technique
Immuno-Fluorescence Assays (IFA)
Radioimmunoprecipitation
HIV-1/HIV-2 Combination Testing
Methods of HIV-Antigen Detection
Antigen Assays and Blood Screening
Urine Tests
DNA Probes
Overview
Quantitative PCR
In Situ PCR
Needed Improvements
Viral Load/Drug Resistance Testing
Genotype and Phenotype Testing
Blood Banking Considerations
Adenovirus
Background
Diagnostic Tests
Vaccines and Drugs
Adeno-Associated Viruses (AAV)
Anthrax/Bacillus Anthracis
Background
Diagnostic Tests
Vaccines and Drugs
Babesiosis
Background
BEA and Other Bartonella Diseases
Background
Diagnostic Tests
Vaccines and Drugs
Chagas Disease
Background
Campylobacter
Background
Diagnostic Tests
Culture Identification
Vaccines and Drugs
Chlamydia
Background
Chlamydia psittaci
Chlmaydia pneumoniae
Chlamydia trachomatis
Diagnostic Tests
Vaccines and Drugs
Creutzfeldt-Jakob’s Disease
Background
Blood Transmission
Diagnostic Tests
Major Commercial and Academic Players
Bayer
Disease Sciences/Bio Tec Global
Imperial College School of Medicine
Ortho-Clinical Diagnostics
Pall
ProMetic Life Sciences
Proteome Sciences/Idexx
Q-One Biotech
Serono
U.S. Agricultural Research Service
Drugs
Vaccines
Cytomegalovirus
Background
Chorioretinitis
Gastrointestinal
Central Nervous System Disease
Diagnostic Tests
Vaccines and Drugs
Ebola Virus
Background
Epidemiology
Clinical Syndromes
Diagnostic Tests
Vaccines and Drugs
EchoVirus
Background
Acute Aseptic Meningitisis
Encephalitis
Exanthems
Respiratory Disease
Myopericarditis
Neonatal Infections
Diagnostic Tests
Vaccines and Drugs
Encephalitis
Background
Diagnostic Tests
Vaccines and Drugs
Enteroviruses
Background
Diagnostic Tests
Viral Isolation and Identification
Antibody Tests
Vaccines and Drugs
Epstein-Barr Virus
Background
Diagnostic Tests
Vaccines and Drugs
Gonorrhea
Background
Diagnostic Tests
Vaccines and Drugs
Hepatitis
Hepatitis A
Hepatitis B
Structure and Composition
Replication
Hepatitis C
Hepatitis D (Delta)
Hepatitis E
Hepatitis G
Hepatitis Infections Pathology
Clinical Findings
Laboratory Tests
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D
Hepatitis E
Virus-Host Immune Reactions
Epidemiology
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D (Delta)
Vaccines and Drugs
Herpes Simplex Virus
Background
Diagnostic Tests
Vaccines and Drugs
Legionella
Background
Diagnostic Tests
Vaccines and Drugs
Lyme Disease
Background
Clinical Description
Clinical Case Definition
Laboratory Criteria for Diagnosis
Case Classification
Diagnostic Tests
Vaccines and Drugs
Malaria
Mycoplasma
Background
Ureaplasma Urealyticum & Mycoplasma Hominis
Diagnostic Tests
Vaccines and Drugs
Papillomaviruses/HPV
Background
HPV in Cancer
Cervical Neoplasm
Diagnostic Tests
Vaccines and Drugs
Prevention
Parvovirus B19
Background
Microbiology
Epidemiology
Clinical Syndromes
Erythema Infectiosum (Slapped Cheek)
Adult Polyarthropathy
Transient Aplastic Crisis
Transient Pancytopenia
Red Cell Aplasia in Immunocompromised
Perinatal Infections
Diagnostic Test
Vaccines and Drugs
Pneumonia
Background
Diagnostic Tests
Vaccines and Drugs
Polyomaviruses
Background
Diagnostic Tests
Vaccines and Drugs
Salmonellosis
Background
Diagnostic Tests
Vaccines and Drugs
Shigellosis
Background
Diagnostic Tests
Vaccines and Drugs
Streptococci
Background
Diagnostic Tests
Vaccines and Drugs
Group A Streptococci
Group B Streptococci
Toxoplasmosis
Background
Diagnostic Tests
Vaccines and Drugs
Tuberculosis
Background
Diagnostic Tests
Microscopic Characteristics
Cultural Characteristics
Skin Tests
MDRTB
Vaccines and Drugs
West Nile Virus
Background
Clinical Syndromes
Diagnostic Tests
Vaccines and Drugs
Yersinia
Background
Diagnostic Tests
Vaccines and Drugs
c. Antibiotic Susceptibility
2. Cancer Testing
a. Overview
b. Major Cancer Types
Prostate
Lung
Colon and Rectum
Breast
Skin
Uterine
Leukemia
Oral
c. Oncogenes
Abl/abl-bcr
AIB1
BRCA1
CD44
C-fos
C-myb
C-myc
CYP17
Erb-B
HPC1
N-myc
P40
P51
P53
PIK3CA
PTI-1
Ras
Reg
Sis
Src
3. Genetic Diseases
a. Overview
b. Nucleic Acid Amplification
c. Chromosome Imaging
d. Genomics Technologies
e. Proteomics Technologies
f. Current Pharmacogenomic Tests
g. Future Pharmacogenomic Testing
h. Major Diseases
Achondroplasia
Autosomal Dominant Polycystic Kidney Disease
Cancer
Cosmetogenomics
Cystic Fibrosis
Down's Syndrome
Duchenne and Becker Muscular Dystrophy
Factor V (Leiden)
Factor IX Deficiency
Fragile X Syndrome
Heart Disease
Hemochomatosis
Hemophilia
Huntington's Disease
Maternal-Fetal Incompatibility
Multiple Endocrine Neoplasia
Phenylketonuria (PKU)
Polycystic Kidney Disease (PKD)
Prenatal Screening
Retinitis Pigmentosa
Retinoblastoma
Sickle Cell Anemia
Spinal Muscular Atrophy
Vitamin B12 Metabolism
i. Social Issues and Concerns
4. Forensic Testing
a. Overview
b. Multilocus and Single Locus Probes
Multilocus Probes
Single Locus Probes
PCR and RFLP
c. The FBI
d. DNA Profile Data Banks
U.S.A.
U.K.
e. Judicial Implementation
f. Major Crime Categories
g. Factors Contributing to the DNA Probe Market Expansion
Technology Availability
Use of Hair as Evidence
h. Wildlife Forensics
5. Paternity Testing/HLA Typing
6. Other Applications
a. Disease Susceptibility Testing
b. Cardiovascular Diseases
c. Diabetes
d. Alzheimer's Disease
e. Plasma Purification
f. Organ Transplantation
g. Water Contamination
h. Others
G. COST ANALYSIS
1. Equipment
2. Consumables
H. COMPETING/COMPLEMENTING TECHNOLOGIES
1. Monoclonal Antibodies/Immunoassays
2. RNA Probes
3. Two-Dimensional Electrophoresis
4. Flow Cytometry
I. REIMBURSEMENT ISSUES
J. WORLDWIDE MARKET OVERVIEW
1. Business Environment
2. Market Structure
3. Market Size and Growth
France
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
Germany
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
Italy
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
Japan
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
Spain
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
U.K.
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
U.S.A.
A. Executive Summary
B. Business Environment
1. Health Care Expenditures
2. Cost Consciousness
3. Reimbursement
4. Industry Consolidation
5. Managed Care
a. HMO
b. PPO
6. Hospitals
7. Admissions
8. Length of Stay
9. Industry Diversification
10. Physician Demographics
11. Population Aging
a. Chronic Illness
b. Disease Incidence
c. Susceptibility to Iatrogenesis
d. Multiple Illness Cases
12. Laboratory Regulations
13. FDA Reform
C. Market Structure
1. Hospitals
2. Commercial/Private Laboratories
3. Blood Banks
D. Market Size, Growth and Major Suppliers’ Sales and Market Shares
Major Product Development Opportunities
A. Instrumentation
B. Reagent Kits and Test Systems/panels
C. Computers, Software and Automation
D. Auxiliary Products
Design Criteria For Decentralized Testing Products
Alternative Market Penetration Strategies
A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies For Decentralized Testing Markets
1. Marketing Approaches
2. Product Complexity
3. Customer Preference
4. Established Suppliers
5. Emerging Suppliers
6. Major Types Of Distributors
7. Market Segmentation
Potential Market Entry Barriers And Risks
A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge And Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges
Competitive Profiles
Abbott
Aclara
Affymetrix
Agilent
Ambion
Applera
Applied Gene Technologies
Beckman Coulter
Becton Dickinson
Biokit
BioMerieux
Biotest
Boston Biomedica
Caliper
Cepheid
Chiron
Decode
Diadexus
Digene
Eiken
Enzo
Exact Sciences
Fujirebio
Gen-Probe
Gene Tec
Illumina
Innogenetics
Kreatech
Li-Cor
Molecular Diagnostics
Myriad Genetics
Nanogen
Nuvelo
Orchid Biosciences
Qiagen
Roche
Sangtec
Sequenom
Scienion
Sierra Diagnostics
Shimadzu
Takara Bio
Tepnel Life Sciences
Tecan Group
Third Wave
APPENDIXES
Appendix I: Major Companies Developing or Marketing NAT Reagents and Test Kits
Appendix II: Major Universities and Research Centers Developing NAT Technologies
Appendix III: Glossary of Terms
Appendix IV: Currency Exchange Rates
LIST OF TABLES
Major Companies Developing or Marketing Thermocyclers
Major Companies Developing or Marketing AIDS NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Adenovirus NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Campylobacter NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Chlamydia NAT And Other Direct Identification Tests
Major Companies Developing or Marketing CMV NAT And Other Direct Identification Tests
Major Companies Developing or Marketing EBV NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Gonorrhea NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Hepatitis NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Herpes NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Legionella NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Lyme Disease NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Mycoplasma NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Papilloma Virus NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Pneumonia NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Salmonella NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Shigella NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Streptococci NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Toxoplasmosis NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Tuberculosis NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Cancer NAT Tests
Major Companies Developing or Marketing NAT Assays For Genetic Diseases
Worldwide, Laboratories Performing DNA Sequencing By Country
Worldwide, NAT Market, Potential Laboratory Universe by Country
Worldwide, NAT Volume Forecast by Country
Worldwide, NAT Market Forecast by Country
Summary Table France, NAT Volume And Sales Forecast by Major Application
France, Laboratories Performing DNA Sequencing By Market Segment
France, NAT Market Potential Laboratory Universe by Market Segment
France, NAT Volume Forecast By Major Application
France, Major Infectious Disease NAT Volume Forecast
France, Infectious Disease Screening NAT Volume Forecast
France, NAT Market Forecast By Major Application
France, Infectious Disease Screening NAT Reagent Market Forecast by Test
France, NAT Market By Major Supplier
France, HIV/Hepatitis NAT Market By Major Supplier
Summary Table Germany, NAT Volume And Sales Forecast by Major Application
Germany, Laboratories Performing DNA Sequencing by Market Segment
Germany, NAT Market Potential Laboratory Universe By Market Segment
Germany, NAT Volume Forecast By Major Application
Germany, Major Infectious Disease NAT Volume Forecast
Germany, Infectious Disease Screening NAT Volume Forecast
Germany, NAT Market Forecast By Major Application
Germany, Infectious Disease Screening NAT Reagent Market Forecast by Test
Germany, NAT Market by Major Supplier
Germany, HIV/Hepatitis NAT Market by Major Supplier
Summary Table Italy, NAT Volume And Sales Forecast by Major Application
Italy, Laboratories Performing DNA Sequencing by Market Segment
Italy, NAT Market Potential Laboratory Universe by Market Segment
Italy, NAT Volume Forecast By Major Application
Italy, Major Infectious Disease NAT Volume Forecast
Italy, Infectious Disease Screening NAT Volume Forecast
Italy, NAT Market Forecast By Major Application
Italy, Infectious Disease Screening NAT Reagent Market Forecast by Test
Italy, NAT Market By Major Supplier
Italy, HIV/Hepatitis NAT Market By Major Supplier
Summary Table Japan, NAT Volume And Sales Forecast by Major Application
Japan, Laboratories Performing DNA Sequencing by Market Segment
Japan, NAT Market Potential Laboratory Universe by Market Segment
Japan, NAT Volume Forecast By Major Application
Japan, Major Infectious Disease NAT Volume Forecast
Japan, Infectious Disease Screening NAT Volume Forecast
Japan, NAT Market Forecast By Major Application
Japan, Infectious Disease Screening NAT Market Forecast by Test
Japan, NAT Market By Major Supplier
Japan, HIV/Hepatitis NAT Market by Major Supplier
Summary Table Spain, NAT Volume And Sales Forecast by Major Application
Spain, Laboratories Performing DNA Sequencing by Market Segment
Spain, NAT Market, Potential Laboratory Universe by Market Segment
Spain, NAT Volume Forecast by Major Application
Spain, Major Infectious Disease NAT Volume Forecast
Spain, Infectious Disease Screening NAT Volume Forecast
Spain, NAT Market Forecast By Major Application
Spain, Infectious Disease Screening NAT Reagent Market Forecast by Test
Spain, NAT Market By Major Supplier
Spain, HIV/Hepatitis NAT Market by Major Supplier
Summary Table U.K., NAT Volume And Sales Forecast by Major Application
U.K., Laboratories Performing DNA Sequencing by Market Segment
U.K., NAT Market Potential Laboratory Universe by Market Segment
U.K., NAT Volume Forecast By Major Application
U.K., Major Infectious Disease NAT Volume Forecast
U.K., Infectious Disease Screening NAT Volume Forecast
U.K., NAT Market Forecast By Major Application
U.K., Infectious Disease Screening NAT Reagent Market Forecast by Test
U.K., NAT Market by Major Supplier
Summary Table U.S.A., NAT Volume And Sales Forecast by Major Application
U.S.A., Laboratories Performing DNA Sequencing by Market Segment
U.S.A., NAT Market, Potential Laboratory Universe by Market Segment
U.S.A., NAT Volume Forecast By Major Application
U.S.A., Major Infectious Disease NAT Volume Forecast
U.S.A., Infectious Disease Screening NAT Volume by Test Forecast
U.S.A., NAT Market Forecast By Major Application
U.S.A., Infectious Disease Screening NAT Reagent Market Forecast by Test
U.S.A., NAT Market by Major Supplier
U.S.A., HIV/Hepatitis C NAT Market By Major Supplier
U.S.A., West Nile Virus NAT Market By Major Supplier
Major Companies Developing or Marketing Thermocyclers
Major Companies Developing or Marketing AIDS NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Adenovirus NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Campylobacter NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Chlamydia NAT And Other Direct Identification Tests
Major Companies Developing or Marketing CMV NAT And Other Direct Identification Tests
Major Companies Developing or Marketing EBV NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Gonorrhea NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Hepatitis NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Herpes NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Legionella NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Lyme Disease NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Mycoplasma NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Papilloma Virus NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Pneumonia NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Salmonella NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Shigella NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Streptococci NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Toxoplasmosis NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Tuberculosis NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Cancer NAT Tests
Major Companies Developing or Marketing NAT Assays For Genetic Diseases
Worldwide, Laboratories Performing DNA Sequencing By Country
Worldwide, NAT Market, Potential Laboratory Universe by Country
Worldwide, NAT Volume Forecast by Country
Worldwide, NAT Market Forecast by Country
Summary Table France, NAT Volume And Sales Forecast by Major Application
France, Laboratories Performing DNA Sequencing By Market Segment
France, NAT Market Potential Laboratory Universe by Market Segment
France, NAT Volume Forecast By Major Application
France, Major Infectious Disease NAT Volume Forecast
France, Infectious Disease Screening NAT Volume Forecast
France, NAT Market Forecast By Major Application
France, Infectious Disease Screening NAT Reagent Market Forecast by Test
France, NAT Market By Major Supplier
France, HIV/Hepatitis NAT Market By Major Supplier
Summary Table Germany, NAT Volume And Sales Forecast by Major Application
Germany, Laboratories Performing DNA Sequencing by Market Segment
Germany, NAT Market Potential Laboratory Universe By Market Segment
Germany, NAT Volume Forecast By Major Application
Germany, Major Infectious Disease NAT Volume Forecast
Germany, Infectious Disease Screening NAT Volume Forecast
Germany, NAT Market Forecast By Major Application
Germany, Infectious Disease Screening NAT Reagent Market Forecast by Test
Germany, NAT Market by Major Supplier
Germany, HIV/Hepatitis NAT Market by Major Supplier
Summary Table Italy, NAT Volume And Sales Forecast by Major Application
Italy, Laboratories Performing DNA Sequencing by Market Segment
Italy, NAT Market Potential Laboratory Universe by Market Segment
Italy, NAT Volume Forecast By Major Application
Italy, Major Infectious Disease NAT Volume Forecast
Italy, Infectious Disease Screening NAT Volume Forecast
Italy, NAT Market Forecast By Major Application
Italy, Infectious Disease Screening NAT Reagent Market Forecast by Test
Italy, NAT Market By Major Supplier
Italy, HIV/Hepatitis NAT Market By Major Supplier
Summary Table Japan, NAT Volume And Sales Forecast by Major Application
Japan, Laboratories Performing DNA Sequencing by Market Segment
Japan, NAT Market Potential Laboratory Universe by Market Segment
Japan, NAT Volume Forecast By Major Application
Japan, Major Infectious Disease NAT Volume Forecast
Japan, Infectious Disease Screening NAT Volume Forecast
Japan, NAT Market Forecast By Major Application
Japan, Infectious Disease Screening NAT Market Forecast by Test
Japan, NAT Market By Major Supplier
Japan, HIV/Hepatitis NAT Market by Major Supplier
Summary Table Spain, NAT Volume And Sales Forecast by Major Application
Spain, Laboratories Performing DNA Sequencing by Market Segment
Spain, NAT Market, Potential Laboratory Universe by Market Segment
Spain, NAT Volume Forecast by Major Application
Spain, Major Infectious Disease NAT Volume Forecast
Spain, Infectious Disease Screening NAT Volume Forecast
Spain, NAT Market Forecast By Major Application
Spain, Infectious Disease Screening NAT Reagent Market Forecast by Test
Spain, NAT Market By Major Supplier
Spain, HIV/Hepatitis NAT Market by Major Supplier
Summary Table U.K., NAT Volume And Sales Forecast by Major Application
U.K., Laboratories Performing DNA Sequencing by Market Segment
U.K., NAT Market Potential Laboratory Universe by Market Segment
U.K., NAT Volume Forecast By Major Application
U.K., Major Infectious Disease NAT Volume Forecast
U.K., Infectious Disease Screening NAT Volume Forecast
U.K., NAT Market Forecast By Major Application
U.K., Infectious Disease Screening NAT Reagent Market Forecast by Test
U.K., NAT Market by Major Supplier
Summary Table U.S.A., NAT Volume And Sales Forecast by Major Application
U.S.A., Laboratories Performing DNA Sequencing by Market Segment
U.S.A., NAT Market, Potential Laboratory Universe by Market Segment
U.S.A., NAT Volume Forecast By Major Application
U.S.A., Major Infectious Disease NAT Volume Forecast
U.S.A., Infectious Disease Screening NAT Volume by Test Forecast
U.S.A., NAT Market Forecast By Major Application
U.S.A., Infectious Disease Screening NAT Reagent Market Forecast by Test
U.S.A., NAT Market by Major Supplier
U.S.A., HIV/Hepatitis C NAT Market By Major Supplier
U.S.A., West Nile Virus NAT Market By Major Supplier
