2012 Italy Molecular Diagnostics Market Strategic Analysis: Supplier Shares and Sales Forecasts for 35 Tests/Applications

Date: June 19, 2012
Pages: 850
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2012 Italy Molecular Diagnostics Market Strategic Analysis: Supplier Shares and Sales Forecasts for 35 Tests/Applications
Thisreport presents a comprehensive analysis of the Italian molecular diagnostics market, including:
  • Major issues pertaining to the Italian molecular diagnostics laboratory practice, as well as key economic, regulatory, demographic, social and technological trends with significant market impact during the next ten years.
  • An extensive review of DNA probe and biochip technologies, test formats, detection methodologies, trends in testing automation and amplification methods.
  • Ten-year test volume and reagent sales forecasts for the following categories:
    • Infectious Diseases
    • Genetic Diseases
    • Cancer
    • Paternity Testing/HLA Typing
    • Forensic Testing
  • Review of testing methodologies an instrumentation technologies.
  • Feature comparison of automated and semiautomated analyzers.
  • Sales and market shares of leading suppliers.
  • Over 60 specific opportunities for molecular diagnostic instruments, test systems, IT and auxiliary products.
  • Profiles of major suppliers, and emerging market entrants, including their sales, product portfolios, marketing tactics, technological know-how, new products in R&D, collaborative arrangements and business strategies.
  • Alternative market penetration strategies.
  • Potential market entry barriers and risks.
  • Business planning issues and concerns.
Contains 850 pages and 36 tables
INTRODUCTION

WORLDWIDE MARKET AND TECHNOLOGY OVERVIEW


A. DNA Sequencing
  1. Introduction
  2. Sequencing Methods
  3. Autoradiography
  4. The Human Genome Project
  5. Sequencing Automation
  6. Image Scanners
  7. Fluorescent Detection
  8. Gene Profiling
  9. Gene Expression
  10. Polymorphism Screening
  11. Protein Interaction Networks
B. DNA And RNA Probe Technology
  1. Basic Principles
  2. Probe Preparation
  3. The DNA Probe Test
    a. Sample Preparation
    b. Hybridization
    c. Separation
    d. Detection/Measurement
  4. Test Formats
    a. Filter Hybridization
    b. Southern Blot
    c. Northern Blot
    d. In Situ Hybridization
    e. Others
  5. Labeling Techniques
  6. Amplification Methods
      Polymerase Chain Reaction
        Temperature Cyclers
        PCR Variations
          Immuno-PCR
          QC-PCR
          DAP-PCR
      Strand Displacement Activation
      TMA
      Ligase Chain Reaction
      Branched DNA
        Hybridization Protection Assay
      Nucleic-Acid Sequence-Based Amplification
      Self-Sustained Sequence Replicase
      Others
        Ampliprobe
        CAR
        CAS
        CPT
        Dendritic Polymer Technology
        ISO-CR
        LAT
        Probe Networks
        RAMP
        Repair Chain Reaction
        Rolling Circles
        Sequence Independent Gene Amplification
        Sequence Initiation Reaction
        SISPA
        Solid Phase Amplification
C. Detection Technologies
  1. Radioactive Methods
    a. Overview
    b. Major Isotopes
      P-32
      S-35
      H-3
      I-125
  2. Non-Isotopic Methods
    a. Enzymatic Labels
    b. Chemical Labeling
      Indirect Chemical Labeling
      Direct Chemical Labeling
    c. Fluorescence
    d. Chemiluminescence
    e. Electrical Conductivity
D. Instrumentation Review
  1. Abbott LCx
  2. Beckman Coulter/Biomek FK
  3. Becton Dickinson SDA
  4. Bio-Rad GeneScope
  5. Gen-Probe Tigris
  6. Roche Cobas Amplicor
  7. Tecan LS Series
E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip
        Liquid Transportation and Mixing
        Separation
        Reaction
        Detection
F. Pharmacogenomics
G. Major Applications
  1. Microbiology/Infectious Diseases
    a. Overview
    b. Major Infectious Diseases
          AIDS
      Structure and Composition
      Classification
      AIDS Origins
      Animal Lentivirus Systems
      Virus Receptors
      HIV Infections in Humans
        Pathogenesis and Pathology
      CD4T Lymphocytes and Memory Cells
      Monocytes and Macrophages
      Lymphoid Organs
      Neural Cells
      Viral Coinfections
        Clinical Findings
      Plasma Viral Load
      Pediatric AIDS
        Neurologic Disease
        Opportunistic Infections
        Cancer
      Immunity
        Virus Isolation
        Serology
        Viral Nucleic Acid/Antigen Detection
      Epidemiology
        Worldwide Spread of AIDS
        United States
        Routes of Transmission
      DNA Probes
        Overview
        Quantitative PCR
        In Situ PCR
        Needed Improvements
      Viral Load/Drug Resistance Testing
      Genotype and Phenotype Testing
      Blood Banking Considerations
          Adenovirus
      Background
      Diagnostic Tests
      Vaccines and Drugs
      Adeno-Associated Viruses (AAV)
          Anthrax/Bacillus Anthracis
      Background
      Diagnostic Tests
      Vaccines and Drugs
          Babesiosis
      Background
          BEA and Other Bartonella Diseases
      Background
      Diagnostic Tests
      Vaccines and Drugs
          Chagas Disease
      Background
          Campylobacter
      Background
      Diagnostic Tests
        Culture Identification
      Vaccines and Drugs
          Chlamydia
      Background
        Chlamydia psittaci
        Chlmaydia pneumoniae
        Chlamydia trachomatis
      Diagnostic Tests
      Vaccines and Drugs
          Creutzfeldt-Jakob’s Disease
      Background
      Blood Transmission
      Diagnostic Tests
      Major Commercial and Academic Players
        Bayer
        Disease Sciences/Bio Tec Global
        Imperial College School of Medicine
        Ortho-Clinical Diagnostics
        Pall
        ProMetic Life Sciences
        Proteome Sciences/Idexx
        Q-One Biotech
        Serono
        U.S. Agricultural Research Service
      Drugs
      Vaccines
          Cytomegalovirus
      Background
        Chorioretinitis
        Gastrointestinal
        Central Nervous System Disease
      Diagnostic Tests
      Vaccines and Drugs
          Ebola Virus
      Background
        Epidemiology
        Clinical Syndromes
      Diagnostic Tests
      Vaccines and Drugs
          EchoVirus
      Background
        Acute Aseptic Meningitisis
        Encephalitis
        Exanthems
        Respiratory Disease
        Myopericarditis
        Neonatal Infections
      Diagnostic Tests
      Vaccines and Drugs
          Encephalitis
      Background
      Diagnostic Tests
      Vaccines and Drugs
          Enteroviruses
      Background
      Diagnostic Tests
        Viral Isolation and Identification
        Antibody Tests
      Vaccines and Drugs
          Epstein-Barr Virus
      Background
      Diagnostic Tests
      Vaccines and Drugs
          Gonorrhea
      Background
      Diagnostic Tests
      Vaccines and Drugs
          Hepatitis
      Hepatitis A
      Hepatitis B
        Structure and Composition
        Replication
      Hepatitis C
      Hepatitis D (Delta)
      Hepatitis E
      Hepatitis G
      Hepatitis Infections Pathology
      Clinical Findings
      Laboratory Tests
        Hepatitis A
        Hepatitis B
        Hepatitis C
        Hepatitis D
        Hepatitis E
      Virus-Host Immune Reactions
      Epidemiology
        Hepatitis A
        Hepatitis B
        Hepatitis C
        Hepatitis D (Delta)
      Vaccines and Drugs
          Herpes Simplex Virus
      Background
      Diagnostic Tests
      Vaccines and Drugs
          Legionella
      Background
      Diagnostic Tests
      Vaccines and Drugs
          Lyme Disease
      Background
        Clinical Description
        Clinical Case Definition
        Laboratory Criteria for Diagnosis
        Case Classification
      Diagnostic Tests
      Vaccines and Drugs
          Malaria
          Mycoplasma
      Background
        Ureaplasma Urealyticum & Mycoplasma Hominis
      Diagnostic Tests
      Vaccines and Drugs
          Papillomaviruses/HPV
      Background
        HPV in Cancer
        Cervical Neoplasm
      Diagnostic Tests
      Vaccines and Drugs
        Prevention
          Parvovirus B19
      Background
        Microbiology
        Epidemiology
        Clinical Syndromes
        Erythema Infectiosum (Slapped Cheek)
        Adult Polyarthropathy
        Transient Aplastic Crisis
        Transient Pancytopenia
        Red Cell Aplasia in Immunocompromised
        Perinatal Infections
      Diagnostic Test
      Vaccines and Drugs
          Pneumonia
      Background
      Diagnostic Tests
      Vaccines and Drugs
          Polyomaviruses
      Background
      Diagnostic Tests
      Vaccines and Drugs
          Salmonellosis
      Background
      Diagnostic Tests
      Vaccines and Drugs
          Shigellosis
      Background
      Diagnostic Tests
      Vaccines and Drugs
          Streptococci
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Group A Streptococci
        Group B Streptococci
          Toxoplasmosis
      Background
      Diagnostic Tests
      Vaccines and Drugs
          Tuberculosis
      Background
      Diagnostic Tests
        Microscopic Characteristics
        Cultural Characteristics
        Skin Tests
        MDRTB
      Vaccines and Drugs
          West Nile Virus
      Background
        Clinical Syndromes
      Diagnostic Tests
      Vaccines and Drugs
          Yersinia
      Background
      Diagnostic Tests
      Vaccines and Drugs
    c. Antibiotic Susceptibility
  2. Cancer Testing
    a. Overview
    b. Major Cancer Types
          Prostate
          Lung
          Colon and Rectum
          Breast
          Skin
          Uterine
          Leukemia
          Oral
    c. Oncogenes
      Abl/abl-bcr
      AIB1
      BCL-2
      BRCA1
      CD44
      C-fos
      C-myb
      C-myc
      CYP17
      Erb-B
      HPC1
      N-myc
      P40
      P51
      P53
      PIK3CA
      PTI-1
      Ras
      Reg
      Sis
      Src
  3. Genetic Diseases
    a. Overview
    b. Nucleic Acid Amplification
    c. Chromosome Imaging
    d. Genomics Technologies
    e. Proteomics Technologies
    f. Current Pharmacogenomic Tests
    g. Future Pharmacogenomic Testing
    h. Major Diseases
          Achondroplasia
          Autosomal Dominant Polycystic Kidney Disease
          Cancer
          Cosmetogenomics
          Cystic Fibrosis
          Down's Syndrome
          Duchenne and Becker Muscular Dystrophy
          Factor V (Leiden)
          Factor IX Deficiency
          Fragile X Syndrome
          Heart Disease
          Hemochomatosis
          Hemophilia
          Huntington's Disease
          Maternal-Fetal Incompatibility
          Multiple Endocrine Neoplasia
          Phenylketonuria (PKU)
          Polycystic Kidney Disease (PKD)
          Prenatal Screening
          Retinitis Pigmentosa
          Retinoblastoma
          Sickle Cell Anemia
          Spinal Muscular Atrophy
          Vitamin B12 Metabolism
    i. Social Issues and Concerns
  4. Forensic Testing
    a. Overview
    b. Multilocus and Single Locus Probes
          Multilocus Probes
          Single Locus Probes
          PCR and RFLP
    c. The FBI
    d. DNA Profile Data Banks
          U.S.A.
          U.K.
    e. Judicial Implementation
    f. Major Crime Categories
    g. Factors Contributing to the DNA Probe Market Expansion
          Technology Availability
          Use of Hair as Evidence
    h. Wildlife Forensics
  5. Paternity Testing/HLA Typing
  6. Other Applications
    a. Disease Susceptibility Testing
    b. Cardiovascular Diseases
    c. Diabetes
    d. Alzheimer's Disease
    e. Periodontal Disease
    f. Plasma Purification
    g. Organ Transplantation
    h. Water Contamination
    i. Other
H. Competing/complementing Technologies
  1. Monoclonal Antibodies/Immunoassays
  2. RNA Probes
  3. Two-Dimensional Electrophoresis
  4. Flow Cytometry

ITALY

A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares

MAJOR PRODUCT DEVELOPMENT OPPORTUNITIES

A. Instrumentation
B. Reagent Kits and Test Systems/panels
C. Computers, Software and Automation
D. Auxiliary Products

DESIGN CRITERIA FOR DECENTRALIZED TESTING PRODUCTS

ALTERNATIVE MARKET PENETRATION STRATEGIES


A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies For Decentralized Testing Markets
  1. Marketing Approaches
  2. Product Complexity
  3. Customer Preference
  4. Established Suppliers
  5. Emerging Suppliers
  6. Major Types Of Distributors
  7. Market Segmentation

POTENTIAL MARKET ENTRY BARRIERS AND RISKS

A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge And Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges

COMPETITIVE PROFILES

        Abbott
        Affymetrix
        Agilent
        Applied Gene Technologies
        Arca
        Beckman Coulter/Danaher
        Becton Dickinson
        Biokit
        BioMerieux
        Bio-Rad
        Biotest
        Caliper
        Cepheid
        Decode
        Diadexus
        Eiken
        Enzo
        Exact Sciences
        Fujirebio
        Gen-Probe
        Hologic
        Illumina
        Innogenetics/Solvay
        Kreatech
        Li-Cor Biosciences
        Life Technologies
        Monogram Biosciences
        Myriad Genetics
        Nanogen/Elitech
        Novartis
        Orchid CellMark
        Ortho-Clinical Diagnostics
        Proteome Sciences
        Qiagen
        Roche
        Scienion
        Sequenom
        Shimadzu
        Siemens
        Sierra Molecular
        Takara Bio
        Tecan Group

APPENDIXES

Appendix I: Major Universities and Research Centers Developing Molecular Diagnostic Technology
Appendix II: Glossary of Terms
Appendix III: Currency Exchange Rates

LIST OF TABLES

Major Companies Developing or Marketing AIDS Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Adenovirus Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Campylobacter Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Chlamydia Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing CMV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing EBV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Gonorrhea Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Hepatitis Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Herpes Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Legionella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Lyme Disease Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Mycoplasma Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Papilloma Virus Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Pneumonia Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Salmonella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Shigella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Streptococci Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Toxoplasmosis Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Tuberculosis Molecular Diagnostic And Other Direct Identification Tests
Oncogenes Potential Application in Cancer Diagnosis
Major Companies Developing or Marketing Cancer Molecular Diagnostic Tests
Major Companies Developing or Marketing Molecular Diagnostic Test For Genetic Diseases
Summary Table Italy, Molecular Diagnostics Test Volume And Sales Forecast by Major Application
Italy, Laboratories Performing DNA Sequencing by Market Segment
Italy, Molecular Diagnostics Market Potential Laboratory Universe by Market Segment
Italy, Molecular Diagnostics Test Volume Forecast By Major Application
Italy, Major Infectious Disease Molecular Diagnostics Test Volume Forecast
Italy, Infectious Disease Screening NAT Volume Forecast
Italy, Molecular Diagnostics Market Forecast By Major Application
Italy, Infectious Disease Screening Nat Reagent Market Forecast by Test
Italy, Molecular Diagnostics Market By Major Supplier
Italy, HIV/Hepatitis NAT Market By Major Supplier
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