Cell-Based Assays: Market Research Report

Date: January 9, 2014
Pages: 242
Price:
US$ 4,500.00
Publisher: Global Industry Analysts, Inc
Report type: Strategic Report
Delivery: E-mail Delivery (PDF)
ID: C7B8AC7F8AAEN
Leaflet:

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Cell-Based Assays: Market Research Report
This report analyzes the worldwide markets for Cell-Based Assays in US$ Million by the following Applications: Basic Research, ADME Testing, and Drug Discovery. The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2013 through 2020. Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 74 companies including many key and niche players such as -
  • BD Biosciences
  • Beckman Coulter, Inc.
  • BioVision, Inc.
  • Cisbio Bioassays
  • DiscoveRx Corporation
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations
Disclaimers
Data Interpretation & Reporting Level
Quantitative Techniques & Analytics
Product Definitions and Scope of Study
Basic Research
ADME Testing
Drug Discovery

II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW

Cell-based Assays: A Most Promising Area in Cellular Biology

Table 1. Global Market for Cell-based Assays (2013): Percentage Share Breakdown of Value Sales by Segment (includes corresponding Graph/Chart)
Table 2. Global Market for Cell-based Assays (2013): Percentage Share Breakdown of Value Sales by End-User (includes corresponding Graph/Chart)

Developed Markets Dominate, While Asia-Pacific Lends Growth Momentum
Major Trends, Growth Drivers and Restraints
Trends
Growth Drivers
Growth Restraints
Growing Prominence of Cell-based Assays in Drug Discovery
Cell-Based Assays Emerge as a Popular Tool in Basic Research
Use of Cell-based Assays in ADME-Toxicity Testing Gains Traction
Hepatotoxicity Testing Occupies Largest Market Share
Cell-based Assays in HTS and UHTS
Major Types of Cell-Based HTS Assays for Drug Screening
High-Content Screening (HCS) - A Rapidly Expanding Screening Technology in Cell-Based Assays
High Content Screening - Key Application Areas
HCS vs. HTS
Outsourcing of Pharma R&D Gathers Momentum

Table 3. Worldwide Annual Spending on Drugs by Category (2011 & 2015): Percentage Breakdown of Dollar Sales for Branded Drugs, Generic Drugs, and Others (includes corresponding Graph/Chart)

Drug Discovery Outsourcing and Type of Services Outsourced

2. MAJOR TRENDS & ISSUES

Growing Inclination towards In-vitro Assays for Toxicology Studies
Time and Cost Benefits Drive Use of Cell-Based Assays over Other Techniques
Rising Number of Drug Targets Surge Demand for Cell-Based Assays
Growing Focus on the Development of Reproducible and Robust Cell-based Assays
Stem Cells Exude Great Potential in Drug Toxicity Testing
Stem Cell Research in Cardiovascular Repair Rife with Hurdles
Increasing Use of Cell-Based Assays over Other Methods in Toxicity Testing
Functional Assays: An Effective Way of Predicting Specific Toxic Effects
GPCR Targets to Drive Growth in Functional Cell Assay Market
Innovation in Screening Guarantees Success for Drug Discovery Programs

3D CELL CULTURE TECHNOLOGY TO PUT A NEW SPIN ON IN VITRO CELL ANALYSES

3D-CRT WITH CAPABILITY OF TRACKING REAL TIME 3D POSITION OF DIFFUSING NANOPARTICLES

Automated Multiplexing Platforms Present Growth Opportunities
Miniaturized Cell-based Assays on the Horizon
Rising Interest in Cell-based Assays Propels Development of Improved Products
Automation of Cell-based Assays: A Growing Trend
Technology Advances in Drug Discovery Processes Spurs Cell-Based Assay Market
Development of Label-free Cell-based Assays: A Recent Trend in Biological Assays
Microfluidics Systems in Cell-based Assays
Cell-Based Assays Likely to Gain from Microfluidic Devices
Other Trends
Raman Spectroscopy: An Attractive Analytical Tool for Pharmaceutical Industry
Fluorescence Spectroscopy for Cellular Imaging Analyses
Cell-based Immunoassays: Novel Assay Technology for Autoantibodies Detection
Shift Away from Established Cell Lines to Primary Cells
Role of Cell-based Assays in Personalized Medicine: A Research Focus

3. CELL-BASED ASSAYS - APPLICATION AREAS

Cell-Based Assays in Drug Discovery

Table 4. Global Drug Discovery Market (2013): Percentage Share Breakdown of Revenues by Segment (includes corresponding Graph/Chart)

Drug Target Validation
Lead Identification
Lead Optimization
Sources and Types of Cells Available for Drug Screening
Cell-Based Assays in ADME Testing

Table 5. Leading Causes of Failure During New Drug Development: Percentage Share Breakdown by ADME/Tox Issues, Insufficient Efficacy, Adverse Side Effects, and Commercial Viability (includes corresponding Graph/Chart)

Need for Better Models: A Major Factor Driving Innovation in the Market

4. CELL-BASED ASSAYS: AN OVERVIEW

What Drives Advances in Cell-based Assays?
Cell Culture Fundamentals
An Insight into Cell Biology
Cell-based Assays: Basic Facts
Defining Cell-based Assays
Assays
Biological Assays
Quantification of Biological Activity
Cell-based Assays
Cell Based Assays: Prerequisites for Proof of Concept
List of Factors to be considered in Cell-Based Assays
Contamination with Mycoplasma: A Critical Factor
Modes of Contamination
Prevention
Uses of Cell-Based Assays
Challenges
Transient Transfection Cells
Limitations
Cell-based Assays: Product Segmentation
Assay Kits
Cell Function-Associated Assays
Cell Growth-Associated Assays
Select Methods of Evaluating Cell-Growth
Various Types of Cell Growth Associated Assays:
Cell Death-Associated Assays
Lab Automation

MIACA

5. PRODUCT INTRODUCTIONS/INNOVATIONS

InSphero Releases 3D InSight™ Cytotoxicity Assay Kit
Clinigene Introduces Cell-Based Biomarker Assay
BioVision Launches EZViable™ Calcein AM Cell Viability Assay Kit and MTS Cell Proliferation Assay Kit
Hepregen Rolls Out First Rat Hepatopactm Assay Kit for Toxicology Applications
Labstract Launches Cell-Based Assay Services
Hepregen Unveils Human HepatoMune™ Assay Kit
Molecular Devices Launches EarlyTox™ Cell Integrity Kit
LGC Introduces cGMP Cell-based Assay Capability
SymCel Rolls Out Commercial Label-Free Cell-Based Assay
Platypus Technologies Introduces Oris™ Pro 96-Well Invasion Assay
BioVision Launches Cell-Based Cholesterol Efflux Fluorometric Assay Kit
Promega Rolls Out GloMax® Discover Multimode Detection Plate Reader System
Hepregen Launches First Monkey Hepatopac™ Assay Kits
DiscoveRx Launches New Human Primary Cell-Based T Cell Autoimmune Panel
Hepregen Introduces Multi-Donor Human Hepatopac™ Assay
Hurel Introduces Cell-Based In Vitro Testing Product Suite
Thermo Fisher Scientific Releases Three New High Content Analysis Products
Thermo Fisher Scientific Launches Novel Incubation Solution for Cell-Based Research
DiscoveRx Introduces InCELL Hunter™ Platform
Cellectricon Launches Advanced Cell-Based Assay Systems
BioTek Launches Gas Controller for Synergy™ Hybrid Multi-Mode Microplate Readers
Intertek Releases cGMP Cell-Based Assays

6. RECENT INDUSTRY ACTIVITY

Promethera Biosciences Collaborates with EMD Millipore
Axxam and Cellectis Partner to Provide New Generation of Cell-Based Assays
TGR BioSciences and Abcam Enter into Licensing Agreement
Viradux Research Enters into JV Partnership with Benalli
Cellectricon Introduces Discovery Services Division
PPD Announces Expansion of cGMP Cell-based Assay Laboratory
Oxford Immunotec Enters into Licensing and Partnership Agreements with Lophius Biosciences
Evotec Takes Over Cell Culture Service
GE Healthcare Inks Sublicense Agreement with Cellular Dynamics for Cellular Assay Patents
Discoverx Acquires BioSeek®
CEVEC and CSS Enter into License Agreement
Cyprotex Enters into Licensing Deal with Sigma® Life Science
Medicyte to Collaborate with Reinnervate to Develop 3D Cell Toxicity Assays
Affymetrix Acquires eBioscience Holding Company
SGS Inaugurates New Cell-Based Assay Laboratory
Corning Acquires Majority of BD's Discovery Labware Unit

7. FOCUS ON SELECT GLOBAL PLAYERS

BD Biosciences (US)
Beckman Coulter, Inc. (US)
BioVision, Inc. (US)
Cisbio Bioassays (US)
DiscoveRx Corporation (US)
EMD Millipore Corp. (US)
Enzo Life Sciences, Inc. (US)
Evotec AG (Germany)
GE Healthcare Life Sciences (UK)
New England Biolabs, Inc. (US)
PerkinElmer, Inc. (US)
Promega Corporation (US)
ProQinase GmbH (Germany)
Qiagen NV (The Netherlands)
Sigma-Aldrich Corporation (US)
StemCells, Inc. (US)
Thermo Fisher Scientific, Inc. (US)
Life Technologies Corp. (US)
Xenometrix AG (Switzerland)

8. GLOBAL MARKET PERSPECTIVE

Table 6. World Recent Past, Current and Future Analysis for Cell-Based Assays by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table 7. World Historic Review for Cell-Based Assays by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table 8. World 15-Year Perspective for Cell-Based Assays by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)

Cell-Based Assays Market by Application

Table 9. World Recent Past, Current and Future Analysis for Cell-Based Assays for Basic Research by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table 10. World Historic Review for Cell-Based Assays for Basic Research by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table 11. World 15-Year Perspective for Cell-Based Assays for Basic Research by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)
Table 12. World Recent Past, Current and Future Analysis for Cell-Based Assays for ADME Testing by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table 13. World Historic Review for Cell-Based Assays for ADME Testing by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table 14. World 15-Year Perspective for Cell-Based Assays for ADME Testing by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)
Table 15. World Recent Past, Current and Future Analysis for Cell-Based Assays for Drug Discovery by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table 16. World Historic Review for Cell-Based Assays for Drug Discovery by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table 17. World 15-Year Perspective for Cell-Based Assays for Drug Discovery by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)

III. MARKET

1. THE UNITED STATES

A. Market Analysis
Cell-Based Assay Market to Witness Significant Growth
Functional Cell Assays – A Key Segment
Increased Usage Drives Growth of Cell-based Assays
Impact of Automation & High-Throughput Screening on CBA Market
Custom Designed Assays to Drive the US Cell-based Assay Market
Clinical Trials Market in the US
Competitive Scenario

Table 18. Leading Players in the US Cell-Based Assays Market (2013): Percentage Breakdown of Revenues for Millipore, Promega, EMD Biosciences, BD Biosciences, New England Biolabs and Others (includes corresponding Graph/Chart)

Product Launches
Strategic Corporate Developments
Focus on Select Players
B. Market Analytics

Table 19. US Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table 20. US Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table 21. US 15-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)

2. JAPAN

Market Analysis

Table 22. Japanese Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table 23. Japanese Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table 24. Japanese 15-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)

3. EUROPE

A. Market Analysis
Current and Future Analysis
Pharmaceutical Companies Opt for Cell-Based Assays in Drug Discovery
Rising Number of Drug Targets Surge Demand for Cell-Based Assays
GPCR Targets to Drive Growth in Functional Cell Assay Market
Cell Growth-Based Assay Kits Market Makes Progress
Cell Death Based Assays: Efficiency Improvements in Development Programs Favor Growth
Cell-based Assays Represent the Primary Drug Discovery Tool in HTS Laboratories
Advances in Technology, Identification Methods, and Lab Disciplines in CBA Market
Regulatory Requirements in Cell-Based Assays Market
Validation Assays for Compliance with ICH Guidelines
Outsourcing of Validation Studies to CTOs
Growth of European Drug Discovery CRO Market: Opportunities for CBA Market
Clinical Trials Market in Europe
Competitive Landscape
Product Launches
Strategic Corporate Developments
Focus on Select Players
B. Market Analytics

Table 25. European Recent Past, Current and Future Analysis for Cell-Based Assays by Geographic Region - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table 26. European Historic Review for Cell-Based Assays by Geographic Region - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table 27. European 15-Year Perspective for Cell-Based Assays by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK, Spain and Rest of Europe Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)
Table 28. European Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table 29. European Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table 30. European 15-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)

4. REST OF WORLD

A. Market Analysis
Current and Future Analysis
Emerging Nations Capitalize on the Outsourcing Trend
China
Life Sciences Market in China Continues to Thrive Despite Recession
China Emerges as the Major Outsourcer for Drug Discovery
China Begins Implementation of GLP Standard
Use of Non-Human Primates- A Key Feature of Chinese Pharmaceutical Sector
Going Ahead
India
A Thriving Clinical Trials Market

Table 31. Cost of Conducting Clinical Trials: India Vs. US (In US$ Million) (includes corresponding Graph/Chart)

Strategic Corporate Developments
B. Market Analytics

Table 32. Rest of World Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table 33. Rest of World Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table 34. Rest of World 15-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 74 (including Divisions/Subsidiaries - 79)
The United States (47)
Japan (1)
Europe (29)
  France (3)
  Germany (6)
  The United Kingdom (10)
  Italy (1)
  Rest of Europe (9)
Asia-Pacific (Excluding Japan) (2)
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