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Rheumatoid Arthritis (RA): World Drug Market 2013-2023

April 2013 | 120 pages | ID: R3AEBBAD281EN
Visiongain

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Now discover trends, opportunities and revenue prospects for treating rheumatoid arthritis

Where's the arthritic treatment market heading? Visiongain's updated report gives you forecasted revenues to 2023 for drugs treating human rheumatoid arthritis (RA). There you find R&D trends, outlooks and commercial opportunities.

Our study lets you assess sales data and predictions for the world RA medicines market, therapeutic submarkets, products and national markets. Those analyses show you that pharmaceutical field's most promising and lucrative segments.

Established and emerging anti-rheumatic technologies have potential. Read on to scan features of that industry, find what drives it, and see what its future market could be worth.

Forecasts and other analyses to help you understand the RA market

Our report gives you revenue forecasts to 2023, historical data, growth rates and market shares. It lets you discover quantitative and qualitative analysis, business outlooks and developments (R&D). You also gain 56 tables, 47 charts and three research interviews.

With our study you can stay ahead in knowledge, benefiting your research, analyses and decisions. There you find trends, innovations and opportunities for treating rheumatoid arthritis. You see what's happening, discovering possibilities.

There's rising need worldwide for drugs to treat arthritis. For RA medicines, our work helps you find business areas that can prosper most, reducing the risk of your missing out.

The following sections, then, show how you benefit from our new study.

Discover sales predictions for the world market and submarkets

Along with revenue prediction for the overall world market for treating RA, our work shows forecasts to 2023 for submarkets:
  • Biologics (biological drugs, e.g. monoclonal antibodies [mAbs])
  • Non-biologics (other therapeutic molecules).
For the non-biologics submarket, you get further revenue breakdowns to 2023:
  • NSAIDs
  • Conventional DMARDs
  • Others agents (grouped, including novel DMARDs and corticosteroids).
From 2013, how will the RA drugs market grow? Which areas will most prosper? For anti-rheumatic medicines, our report helps you identify growth potential and find opportunities.

See prospects for manufacturers of novel drugs, generics and biosimilars, including follow-on and next-generation products.

Also our investigation discusses what stimulates and restrains business. There you explore dynamics of that industry, also seeing what products can achieve the most success.

See revenue forecasts for leading drugs

How will leading anti-arthritic agents perform to 2023 at world level? Our study forecasts sales of 10 leading RA products and one emerging drug:
  • Celebrex
  • Arcoxia
  • Remicade
  • Humira
  • Enbrel
  • Orencia
  • Simponi
  • Actemra
  • Cimzia
  • Xeljanz.
There you discover how high sales can go, to 2023, finding drugs and years with highest predicted revenues and growth. Also, you see how competitors compare - assess competition. You find what's happening, understanding trends, challenges and opportunities.

Our analysis also divides its overall world RA revenue forecast into those for main geographical markets.

What prospects for leading regions and countries?

In developed and developing countries - especially India and China - there remain many opportunities for selling drugs to treat rheumatoid arthritis. There you see opportunities for developers, producers and sellers of those medicines.

Our study shows you individual revenue forecasts to 2023 for eleven national markets:
  • US
  • Japan
  • Germany, France, UK, Italy and Spain (EU5)
  • Brazil, Russia, India and China (BRIC).
There you discover progress and outlooks. That way, you assess the industry's future - hear about developments and find their significance.

Our forecasting shows revenue growth will occur in established pharma markets and in developing countries. In particular, product launches from 2013 to 2023 will change anti-rheumatic drug prescribing and the commercial landscape. See how.

Research and development - assess innovation, trends and possibilities

What about R&D - the pipeline for new RA drugs? You see developmental trends for these agents and others:
  • Biologics, including biosimilars
  • Corticosteroids
  • Other agents (e.g. JAK inhibitors).
In our work you assess innovations, hearing about developments and finding their significance. Discover progress.

See, then, what the future holds. For large companies and specialty pharma firms there exist many opportunities in treating rheumatoid arthritis. Our study explains, discussing many issues.

What affects the anti-arthritics drug sector?

Our report discusses issues and events affecting that industry and market from 2013, including these developments:
  • Current and future use of treatments
  • Unmet and under-met needs for treating rheumatoid arthritis
  • Janus kinase inhibitors and anti-TNF therapy
  • Adverse effect profiles and patient compliance
  • Regulatory challenges and developments
  • Novel small-molecule therapies
  • Demand for more-efficacious and better-tolerated drugs
  • Biosimilars - a threat to original novel products?
That way, you explore technological, economic, social and political (STEP) questions, assessing outlooks for that area of business.

Our investigation also lets you analyse the RA treatment industry's strengths, weaknesses, opportunities and threats (SWOT). See, then, what the future holds.

Leading companies and 2017 market value

What happens next? Our study predicts the overall world market for anti-arthritic drugs will reach $38.5bn in 2017. There, you also see how that market performs to 2023.

Our analyses show you what products and organisations there hold greatest potential. That work explores these leading five companies and others:
  • Abbott Laboratories (AbbVie)
  • Roche
  • Pfizer
  • Johnson & Johnson
  • Amgen.
Also, you read three interviews with authorities on that field. See what shapes it, discovering what participants think, feel, do and say.

Prospects for R&D on arthritis are encouraging, and from 2013 onwards there will arise many opportunities. Our work shows you technological, medical and commercial possibilities, helping you stay ahead.

Ten ways Rheumatoid Arthritis (RA): World Drug Market 2013-2023 helps you

In particular then, our investigation gives you the following knowledge:
  • Revenues to 2023 for the world RA drugs market - discover that industry's overall sales prospects
  • Revenues to 2023 for 5 world-level submarkets - investigate the potential of that industry's components, finding the most-promising areas for investments and revenues
  • Revenues to 2023 for 11 products - find sales outlooks for top brands, seeing how they can compete and succeed
  • Forecasts to 2023 for US, Japan, Germany, France, UK, Spain, Italy, Brazil, Russia, India and China - see national sales potentials, finding the best regions for revenues and growth
  • Review of R&D for treating rheumatoid arthritis - investigate progress in its research areas, finding technological and medical possibilities
  • Discussions of leading companies, including profiles of the top 5 players - hear about strategies, capabilities, results and outlooks
  • Interviews with authorities in that field - discover debates and opinions to help you stay ahead
  • Competition and opportunities - see what affects that industry, learning what shapes its future, esp. prospects for sustaining and developing business
  • Analysis of what stimulates and restrains the industry and market - assess challenges and strengths, helping you compete and gain advantages
  • Prospects for established competitors and firms seeking to enter the sector -explore needs, practices and outlooks for future success.
You gain information found nowhere else

That work gives independent analysis. There you receive business intelligence found only in our report, seeing where technological and financial prospects are most rewarding.

With our study you are less likely to fall behind in knowledge or miss opportunity. See there how you could benefit your research, analyses and decisions, also saving time and getting you recognition for technological and commercial insight.

Ordering now lets you discover predictions to 2023 for RA medical trends and revenues

Our investigation is for everyone needing analysis of the industry and market for anti-rheumatic medicines. There you find data, trends, opportunities and predictions. Please order that report now.

Visiongain is a trading partner with the US Federal Government
1. EXECUTIVE SUMMARY

1.1 Main Findings of the Study
1.2 Aims, Scope and Format of the Report
1.3 Chapter Outlines
1.4 Research and Analysis Methods

2. INTRODUCTION TO RHEUMATOID ARTHRITIS

2.1 What is Rheumatoid Arthritis?
2.2 Understanding Joints
2.3 What Causes Rheumatoid Arthritis?
  2.3.1 Over Active Immune System: The Immune Response and Inflammation Process
  2.3.2 Genetic Factors
  2.3.3 Environmental Trigger: Infection
  2.3.4 Other Environmental Triggers
2.4 Signs and Symptoms of RA
2.5 Similar Disorders
2.6 Risk Factors for Rheumatoid Arthritis
2.7 Prevalence of Rheumatoid Arthritis
2.8 Economic Impact of the Disease
2.9 Uncertainty on the Incidence of Rheumatoid Arthritis

3. TREATMENT OF RHEUMATOID ARTHRITIS

3.1 Drug Treatment of Rheumatoid Arthritis
3.2 Analgesics (Pain Relieving Drugs)
  3.2.1 Narcotics
  3.2.2 Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
3.3 Corticosteroids (Glucocorticoids)
3.4 DMARDs
  3.4.1 Conventional DMARDs
  3.4.2 New Oral DMARDs
  3.4.3 Biologics (Biological Drugs)

4. THE WORLD MARKET FOR RHEUMATOID ARTHRITIS DRUGS, 2013-2023

4.1 The Global Rheumatoid Arthritis Market in 2011
4.2 The Global Rheumatoid Arthritis Market: Revenue Forecast, 2012-2023
4.3 Non-Biologics for RA
  4.3.1 NSAIDs: Market, 2011-2023
  4.3.2 Conventional DMARDs: Market, 2011-2023
  4.3.3 The Others Submarket, Including Novel Oral DMARDs, is Growing in Prominence
4.4 Biologics for RA: Market Forecast, 2012-2023
4.5 Summary of the Market

5. LEADING DRUGS IN THE RHEUMATOID ARTHRITIS MARKET, 2013-2023

5.1 The Main Drugs in the RA Market, 2011
5.2 Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
  5.2.1 Celebrex: Revenue Forecast, 2012-2023
  5.2.2 Arcoxia: Revenue Forecast, 2012-2023
5.3 Biologics
  5.3.1 Remicade: Revenue Forecast, 2012-2023
  5.3.2 Humira: Revenue Forecast, 2012-2023
  5.3.3 Enbrel: Revenue Forecast, 2012-2023
  5.3.4 Rituxan: Revenue Forecast, 2012-2023
  5.3.5 Orencia: Revenue Forecast, 2012-2023
  5.3.6 Simponi: Revenue Forecast, 2012-2023
  5.3.7 Actemra: Revenue Forecast, 2012-2023
  5.3.8 Cimzia: Revenue Forecast, 2012-2023
5.4 Janus Kinase Inhibitors: Newly Approved Xeljanz
  5.4.1 Xeljanz: Revenue Forecast, 2012-2023
5.5 Summary of the Leading RA Drugs

6. LEADING NATIONAL MARKETS: RHEUMATOID ARTHRITIS DRUGS, 2013-2023

6.1 The Leading National Markets in 2011
6.2 Leading National Markets: Revenue Forecasts, 2012-2023
  6.2.1 The US RA Market: Revenue Forecast, 2012-2023
  6.2.2 The Leading European RA Markets: Revenue Forecast, 2012-2023
  6.2.3 The Japanese RA Market: Revenue Forecast, 2012-2023
  6.2.4 The Chinese RA Market: Revenue Forecast, 2012-2023
  6.2.5 The Brazilian RA Market: Revenue Forecast, 2012-2023
  6.2.6 The Indian RA Market: Revenue Forecast, 2012-2023
  6.2.7 The Russian RA Market: Revenue Forecast, 2012-2023
6.3 Summary of the Leading National Markets

7. RHEUMATOID ARTHRITIS: R&D PIPELINE, 2013

7.1 R&D Pipeline: Corticosteroids for Rheumatoid Arthritis, 2013
  7.1.1 Pfizer's PF-04171327
7.2 R&D Pipeline: New Biologics for Rheumatoid Arthritis, 2013
  7.2.1 Novartis' Secukinumab
  7.2.2 Johnson & Johnson's Sirukumab
  7.2.3 Sanofi's Sarilumab
7.3 R&D Pipeline: Biosimilars for Rheumatoid Arthritis, 2013
  7.3.1 Celltrion's Remsima
  7.3.2 EMS' Reumatocept
  7.3.3 TSH Biopharm's ENIA11
  7.3.4 Boehringer Ingelheim's BI695500
  7.3.5 Hanwha Chemical and Merck's HD 203
7.4 R&D Pipeline: Other Treatments for Rheumatoid Arthritis, 2013
  7.4.1 Eli Lilly's Baricitinib
  7.4.2 AstraZeneca's Fostamatinib
  7.4.3 AB Science's Masitinib
  7.4.4 Ablynx's ALX-0061: a Nanobody for RA
7.5 iRHOM2: A Potential New Drug Target for RA

8. LEADING COMPANIES IN THE RA DRUGS MARKET, 2013

8.1 Introduction to the Leading Companies
8.2 Abbott, Now AbbVie, Dominates the Market
8.3 Roche Markets Rituxan and Actemra
8.4 Pfizer: Xeljanz Will Maintain Strong Position in RA Drug Market
8.5 Johnson & Johnson: 24% of Revenue Generated by RA Drugs
8.6 Amgen: High Revenues from RA Drugs

9. QUALITATIVE ANALYSIS OF THE RHEUMATOID ARTHRITIS DRUG MARKET, 2013-2023

9.1 Strengths and Weaknesses of the Rheumatoid Arthritis Market, 2013
  9.1.1 Rheumatoid Arthritis: Management Rather Than Cure
  9.1.2 The Market Can Support a Wide Range of Products
  9.1.3 The Promising R&D Pipeline
  9.1.4 Adverse Effect Profiles and Poor Patient Compliance Rates
9.2 Opportunities and Threats Facing the Rheumatoid Arthritis Market, 2013-2023
  9.2.1 The Introduction of Novel Small Molecule Therapies Will Drive Market Growth
  9.2.2 The Penetration of Therapies into the Emerging Markets
  9.2.3 The Demand for Drugs With Higher Rates of Therapeutic Success
  9.2.4 The Introduction of Biosimilars: A Threat to the Market?
9.3 Social, Technological, Economic and Political Factors Affecting the Rheumatoid Arthritis Market (STEP Analysis), 2013-2023
  9.3.1 Social Factors Influencing the RA Drug Market
  9.3.2 Technological Factors Influencing the RA Drug Market
  9.3.3 Economic Factors Influencing the RA Drug Market
  9.3.4 Political Factors Influencing the RA Drug Market

10. RESEARCH INTERVIEWS

10.1 Interview with Dr Tuulikki Sokka, MD, PhD, Head of Rheumatology, Jyvдskylд Central Hospital, Finland
  10.1.1 On Current and Future Use of Treatments for RA
  10.1.2 On Unmet Needs in the RA Therapy Market
  10.1.3 On the R&D Pipeline for Rheumatoid Arthritis
  10.1.4 On Drivers of the RA Therapy Market
  10.1.5 On Prevalence of RA Around the World
10.2 Interview with Dr Yusuf Yazici, MD, Assistant Professor, Department of Medicine-Rheumatology and Hospital for Joint Diseases and Medicine, New York University
  10.2.1 Opinion on the Key Unmet Needs for RA Treatments
  10.2.2 Opinions on Current Treatments
  10.2.3 Views on Abatacept: New Biologic for RA
  10.2.4 Key Challenges: Development and Uptake of Abatacept
  10.2.5 Views on Cimzia
  10.2.6 Treatments in the R&D Pipeline
  10.2.7 Views on the Prevalence of RA
10.3 Interview with a Professor Working in Rheumatology
  10.3.1 Views on the Prevalence of RA
  10.3.2 Views on Anti-TNF Therapies for RA
  10.3.3 Opinion on Biosimilars
  10.3.4 Key Challenges in the Market
  10.3.5 Key Treatment Goals

11. CONCLUSIONS

11.1 World Market Overview to 2023
11.2 The Drug Classes
11.3 The Leading Drugs
11.4 The Leading National Markets
11.5 The Future of the RA Drug Market

LIST OF TABLES

Table 3.1 Biologic Agents and Mechanisms of Action
Table 4.1 The RA Market by Submarket, 2011
Table 4.2 The Market for RA Indications: Revenue Forecast, 2012-2023
Table 4.3 Rheumatoid Arthritis Market: Segment Revenue Forecasts, 2012-2023
Table 4.4 Non-Biologics for RA: Revenue Forecasts by Segment, 2012-2023
Table 4.5 NSAIDs: Market Forecast, 2012-2023
Table 4.6 Conventional DMARDs: Revenue Forecast, 2012-2023
Table 4.7 The Others Submarket: Revenue Forecast, 2012-2023
Table 4.8 The Biologics Submarket: Revenue Forecast, 2012-2023
Table 5.1 The Leading Drugs in the RA Market: Revenues and Market Shares, 2011
Table 5.2 The Main Drugs in the RA Market: Revenue Forecasts, 2012-2023
Table 5.3 Celebrex: Key Facts
Table 5.4 Celebrex: Revenue Forecast, 2012-2023
Table 5.5 Arcoxia: Key Facts
Table 5.6 Arcoxia: Revenue Forecast, 2012-2023
Table 5.7 Remicade: Key Facts
Table 5.8 Remicade: Revenue Forecast, 2012-2023
Table 5.9 Humira: Key Facts
Table 5.10 Humira: Revenue Forecast, 2012-2023
Table 5.11 Enbrel: Key Facts
Table 5.12 Enbrel: Revenue Forecast, 2012-2023
Table 5.13 Rituxan: Key Facts
Table 5.14 Rituxan: Revenue Forecast, 2012-2023
Table 5.15 Orencia: Key Facts
Table 5.16 Orencia: Revenue Forecast, 2012-2023
Table 5.17 Simponi: Key Facts
Table 5.18 Simponi: Revenue Forecast, 2012-2023
Table 5.19 Actemra: Key Facts
Table 5.20 Actemra: Revenue Forecast, 2012-2023
Table 5.21 Cimzia: Key Facts
Table 5.22 Cimzia: Revenue Forecast, 2012-2023
Table 5.23 Xeljanz: Key Facts
Table 5.24 Xeljanz: Revenue Forecast, 2012-2023
Table 6.1 RA: The Leading National Markets, 2011
Table 6.2 RA Drugs: Market Shares by Country, 2011 and 2023
Table 6.3 RA Drugs: Revenue Forecasts by Country, 2012-2023
Table 6.4 The US RA Drug Market: Revenue Forecast, 2012-2023
Table 6.5 The EU5 RA Drug Markets: Revenue Forecasts, 2012-2023
Table 6.6 The Japanese RA Drug Market: Revenue Forecast, 2012-2023
Table 6.7 The Chinese RA Drug Market: Revenue Forecast, 2012-2023
Table 6.8 The Brazilian RA Drug Market: Revenue Forecast, 2012-2023
Table 6.9 The Indian RA Drug Market: Revenue Forecast, 2012-2023
Table 6.10 The Russian RA Drug Market: Revenue Forecast, 2012-2023
Table 7.1 The Corticosteroid R&D Pipeline, 2013
Table 7.2 The Biologic R&D Pipeline, 2013
Table 7.3 Biosimilars R&D Pipeline, 2013
Table 7.4 Other Drugs for RA: R&D Pipeline, 2013
Table 8.1 Leading Companies in the RA Drug Market: Revenues and Market Shares, 2011
Table 8.2 Abbott Laboratories: Breakdown of Revenue from RA Drugs, 2011
Table 8.3 Roche: Breakdown of Revenue from RA Drugs, 2011
Table 8.4 Pfizer: Breakdown of Revenue from RA Drugs, 2011
Table 8.5 Johnson & Johnson: Breakdown of Revenue from RA Drugs, 2011
Table 8.6 Amgen: Breakdown of Revenue from RA Drugs, 2011
Table 10.1 Strengths and Weaknesses of the RA Drug Market, 2013
Table 10.2 Opportunities and Threats Facing the RA Drug Market, 2013-2023
Table 10.3 Social, Technological, Economic and Political Factors Influencing the RA Drug Market (STEP Analysis), 2013-2023

Rituxan: Revenue Forecast, 2012-2023

Rituxan is a monoclonal antibody which targets B cells. It is administered by intravenous infusion by a medical professional. Originally developed by Genentech and Biogen Idec, it is a chimeric mAb with murine and human constant regions which works by binding to the CD20 antigen in tumour cells. It is marketed by Genentech, a member of the Roche group. In Europe, it is marketed by Roche as MabThera. In 2011, sales of Rituxan/ MabThera generated revenue of $6.32bn(Table 5.13), an increase of 3.4% on previous year sales. In 2012, sales of Rituxan generated revenue of $6.89bn, an increase of 9% on 2011 revenue.Rituximab is also used to treat several types of non-Hodgkin lymphoma. It may also be used to treat chronic lymphocytic leukaemia. It is often given in combination with chemotherapy, but may be given on its own. Rituximab may also be given to people with follicular lymphoma who have no signs of cancer at the end of their treatment (remission). The aim is to keep the lymphoma away for as long as possible. This is called maintenance therapy and is given every three months, for up to two years.

Sales of Rituxan will show declining positive growth during the first half of the forecast period to 2017. This gradual decline in annual growth is due to the saturation of the biologics market and increased competition. Revenue for Rituxan will peak in 2017 at $8.60bn. Between 2011 and 2017, sales of Rituxan will grow at a CAGR of 5.3%. Patent protection for Rituxan in the US is expected to expire in 2018. Following this, sales of the drug will see negative annual growth; revenue from Rituxan will decrease at a CAGR of -9.4% between 2018 and 2023, visiongain predicts. In 2023, Rituxan will generate revenue of $4.99bn. A biosimilar competitor of rituximab, Reditux, from Dr. Reddy’s Laboratories is already available in India, where it has been marketed since 2007. This approval was reportedly based on a small body of evidence; more data is likely to be required before the drug will receive marketing approval in the US or the EU. However, it is likely that biosimilar competition for Rituxan will be seen following expiration. Having said this, the resulting generic erosion of revenue will be limited due to patient and physician reluctance to switch from Rituxan. Patients and rheumatologists will be likely to stick to an effective therapeutic regimen, which may have taken years of trials with different drugs to discover. Another biosimilar competitor for Rituxan, BI 695500, is reportedly being developed by Boehringer Ingelheim. It is currently in phase III clinical trials.



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