Genetic Engineering: Market Research Report
The global outlook series on Genetic Engineering provides a collection of market briefs and concise summaries of research findings.
The report offers an aerial view of the industry, highlights latest developments, and discusses demand drivers, issues and concerns, and regulatory environment.
Discussion on the industry’s most noteworthy regional market, the US, is amply detailed with unbiased research commentary to provide the reader a rudimentary understanding of the prevailing market climate.
Market discussions in the report are punctuated with fact-rich market data tables.
Regional markets elaborated upon include United States, Canada, India, China, and South Africa among others.
Also included is an indexed, easy-to-refer, fact-finder directory listing the addresses, and contact details of 153 companies active in the market.
The report offers an aerial view of the industry, highlights latest developments, and discusses demand drivers, issues and concerns, and regulatory environment.
Discussion on the industry’s most noteworthy regional market, the US, is amply detailed with unbiased research commentary to provide the reader a rudimentary understanding of the prevailing market climate.
Market discussions in the report are punctuated with fact-rich market data tables.
Regional markets elaborated upon include United States, Canada, India, China, and South Africa among others.
Also included is an indexed, easy-to-refer, fact-finder directory listing the addresses, and contact details of 153 companies active in the market.
1.INDUSTRY OVERVIEW
Genetic Engineering: A Prelude
Genetic Engineering: Not the Same As Biotechnology
The Evolution and Progress of GM Crops
M Crops Gain Global Acceptance
GM Cultivation Gains Prominence in Developing Nations
Rising Prices, Food Shortage Make Biotech Grains Attractive
Socio-Economic Impacts of Biotech Crops
Impact of GM Crops on Biodiversity
Challenges to GM Crops Adoption
Biotech Regulatory Measures Hinder Crop Domestication
Genetic Modification of Forest Trees and Associated Issues
Biosafety: a Key Criterion Associated
Governments Not to Give Up on GM Hope
US - The Largest Producer of GM Crops
Leading Countries by Biotech Crop Area (2009)
Major Market Participants
2.MARKET DYNAMICS
Global Food Demand to Drive Need for GM Crops
Developing Countries: Major Share Holders for Biotech Crop Production
Status of Biotech Rice in the World
Genetic Engineering – A Solution for Food Crisis!
Harmful or Healthy: Breaking The Myth About GM Crops
Non-food Sectors to Benefit from GE Technology
Genetic Engineering and Enzymes
GE to Help Starch and Sugar Processing Enzyme Market
GE to Drive Demand for Bakery Enzymes
Genetic Engineering Revolutionizes Vaccines
Plant Expression Systems to Replace Traditional Expression Systems
Approved Gene Therapies Fail to Gather Momentum
P53 Gene Therapy – A Novel Approach in Cancer Treatment
3.ISSUES AND CONCERNS
The GM Food Issue Continues
Nations at Crossroads to Accept or Object GE Crops
Nations Set Global Agenda to Settle GM Crop Controversies
Challenges Confronting the Biotechs
Efficacy – The Key Challenge for Gene Therapy
Key Factors Affecting the Indian Biotechnology Industry
4.REGIONAL TRENDS
Genetic Engineering: A Fast Catching Trend in Developing Countries
Future of GE Technologies
US: Owns a Lion’s Share of the World Biotech Produce
GM Crops Fail to Live up to Expectations in the US
US Soybean and Corn Crop to Witness Robust Growth
FDA Compliance to Spur Growth in the US Biotech Industry
Canada Reaches Million Acres Mark
Small and Medium Sized Biotech Enterprises to Grow in Europe
Germany and UK- The Hub of European Gene Therapy Market
Spain Garners Leading Spot in Europe’s GM Maize Market
GMO Crops’ Future Hinges on Co-Existence Measures in EU
European Commission Downplays Impact of GM Crops
Biotech Crops Remain in a Political Standstill in Europe
European Nations Ban GM Potato and Maize
UK Government’s GM Crops Proposal Faces Rebuff
Spanish Transgenic Corn Plantation Increases
Ireland: A GM-free Zone
Gene Therapy Pipeline Strengthens in Asia
GM Foods Trends in Asia
Bt Cotton Fails in Asia
Chinese Biopharmaceutical Market to Continue its Growth Spurt
Government to Support Biopharmaceutical Innovation
Biotech Crop Research Gains Momentum in India
The Great Indian Bt Brinjal Controversy
India – The Leading Cultivator of Bt Cotton
India Ousts China in Bt Cotton Cultivation
Indian Agri-Bio Industry on a Roll
India: Ban on Genetically Engineered Crops?
Legalization of Genetic Engineering in Indonesia
GM Crops to Earn Good Returns for Australia
Biotechnology - A Boon for Agriculture in Malaysia
Poor Biotech Crops Adoption in Africa
Biotech Crops Cultivation Zooms in South Africa
Uruguayan Community Resist GM Plants
GM Crop Adoption Rate Grows Exponentially in Brazil
5.GENETIC ENGINEERING: AN OVERVIEW
The Concept…
Molecular Basics – The Gene
Genome – The Information Pool
Evolution of Genetic Engineering
Historical Developments in Genetic Engineering:
The Human Genome Project
Significant Events in the Past
Gene Therapy
Types of Gene Therapy
Monogenic Gene Therapy
Suicide Gene Therapy
Antisense Gene Therapy
Human Genetic Engineering
Genetic Engineering in Animals
Role of Biotechnology in Agriculture
Insect Resistant Crops Vs. Herbicide Tolerant Crops
Some Interesting GM Crop Facts
Myths and Fads Associated to Genetically Engineered Crops
Improvement of Genetic Characters in Wheat
Agrobacterium tumifaciens Mediated Transformation
The Biolistic Transformation Method
Genetically Modified Foods
GM Food Faces Worldwide Criticism During Initial Years
Benefits of Genetically Modified Foods
Pest Resistance
Cold Tolerance
Herbicide Tolerance
Drought and Salinity Tolerance
Disease Resistance
Phytoremediation
Nutrition
Pharmaceuticals
Negative Impacts of GM Foods
Possibility of Crosspollination
Decreased Pesticides Effectiveness
Unintentional Destruction of Other Species
Health Concerns Related to GM Foods
Cost Concerns Related to GM Foods
Genetic Engineering and Food Processing
Genetic Engineering and Regulatory Environment
Patents - An Overview
6.GENE THERAPY – A REVIEW
Factors Influencing Gene Therapy’s Future Development
Human Genome Analysis
Gene Therapy - The Next Generation Cardiovascular Therapy
Public Support for Gene Therapy
RNAi Bode Bright Prospects
Factors Hampering Gene Therapy Future Development
Stringent US and European Regulatory Laws Prolongs Gene Therapy Development
Identifying Genetic Fault
Immune Response
Delivering Genetic Materials into Patient Cells
Multigene Disorders
Side Effects
Push Towards Germline Gene Transfer
Technical Limitations
Commercialization: A Road Uphill
Time Line in Gene Therapy Drug Development
Select Gene Therapy Products in Phase III Development (2010)
Select Gene Therapy Products in Phase II Development (2010)
Select Gene Therapy Products in Phase I and Pre-Clinical Development (2010)
Target Diseases and Players Involved
Key Players by Application Area
Gene Therapy Industry in Europe and the US – A Comparison
7.GENE AMPLIFICATION TECHNOLOGY
Definition of Gene Amplification
Target vs. Signal Amplification
Available Types of Gene Amplification Technologies
Polymerase Chain Reaction
The PCR comprises four major components:
Reagents and Equipment Required for PCR
Reaction Steps
Denaturation
Annealing
Extension
Detection of Amplified Product/DNA
(Q&Q) PCR
Reverse Transcriptase PCR (RT-PCR)
Alternative Technologies to PCR
OmniPlex
Genome-wide disease association studies
Pharmacogenomics studies
Molecular diagnostics and forensics
Additional OmniPlex Applications in Development
Strand Displacement Amplification
Ligase Chain Reaction
LCR Involves a Cyclic two-Step Reaction
Gene Amplification Technology (GAT)
Hybrid Capture
Isothermal DNA Amplification Techniques
Rolling Circle Amplification in Diagnostics
Ican Isothermal Gene Amplification Technology
BioHelix HDA Technology
Other Amplification Technologies
Signal Amplification Technology
Transcription Mediated Amplification
DNA Cleavage-based Signal Amplification
Ramification Amplification Method
End Use Market Analysis
Medical and Diagnostics
Role of Amplification Technology in the Diagnoses of Infectious Diseases
Diagnosis of Infectious Diseases by PCR
Detection of Antimicrobial Resistance
PCR Based Nucleic Acid Amplification for Detection of Antimicrobial Agents
Nucleic Acid Amplification Testing (NAT)
Nucleic Acid Amplification Methods
DNA Amplification Technology in the Diagnosis of Infectious Diseases
Advantages
Limitations
Forensic and Paternity Testing
Food Safety
8.RESEARCH AND DEVELOPMENT
9.MERGERS & ACQUISITIONS
10.RECENT INDUSTRY ACTIVITY
11.PRODUCT/SERVICE LAUNCHES
Global Directory
Genetic Engineering: A Prelude
Genetic Engineering: Not the Same As Biotechnology
The Evolution and Progress of GM Crops
M Crops Gain Global Acceptance
GM Cultivation Gains Prominence in Developing Nations
Rising Prices, Food Shortage Make Biotech Grains Attractive
Socio-Economic Impacts of Biotech Crops
Impact of GM Crops on Biodiversity
Challenges to GM Crops Adoption
Biotech Regulatory Measures Hinder Crop Domestication
Genetic Modification of Forest Trees and Associated Issues
Biosafety: a Key Criterion Associated
Governments Not to Give Up on GM Hope
US - The Largest Producer of GM Crops
Leading Countries by Biotech Crop Area (2009)
Table 1. Current and Future Analysis of the Global Biotech Crops Market By Geographic Region for the US, Canada, Asia-Pacific, Latin America and Rest of World Independently Analyzed with Annual Sales Figures in US$ Million for 2010 through 2015
Major Market Participants
2.MARKET DYNAMICS
Global Food Demand to Drive Need for GM Crops
Developing Countries: Major Share Holders for Biotech Crop Production
Status of Biotech Rice in the World
Genetic Engineering – A Solution for Food Crisis!
Harmful or Healthy: Breaking The Myth About GM Crops
Non-food Sectors to Benefit from GE Technology
Genetic Engineering and Enzymes
GE to Help Starch and Sugar Processing Enzyme Market
GE to Drive Demand for Bakery Enzymes
Genetic Engineering Revolutionizes Vaccines
Plant Expression Systems to Replace Traditional Expression Systems
Approved Gene Therapies Fail to Gather Momentum
P53 Gene Therapy – A Novel Approach in Cancer Treatment
3.ISSUES AND CONCERNS
The GM Food Issue Continues
Nations at Crossroads to Accept or Object GE Crops
Nations Set Global Agenda to Settle GM Crop Controversies
Challenges Confronting the Biotechs
Efficacy – The Key Challenge for Gene Therapy
Key Factors Affecting the Indian Biotechnology Industry
4.REGIONAL TRENDS
Genetic Engineering: A Fast Catching Trend in Developing Countries
Future of GE Technologies
US: Owns a Lion’s Share of the World Biotech Produce
Table 2. US Biotech Crop Produce By Year in Millions of Hectares
GM Crops Fail to Live up to Expectations in the US
US Soybean and Corn Crop to Witness Robust Growth
FDA Compliance to Spur Growth in the US Biotech Industry
Canada Reaches Million Acres Mark
Table 3. Canadian Biotech Crop Produce by Leading Crops (2011)
Table 4. Biotech Maize in Canada: Percentage Share Breakdown by Varieties with Single Stacked gene, Two Stacked genes, and Triple Stacked genes (2011)
Small and Medium Sized Biotech Enterprises to Grow in Europe
Germany and UK- The Hub of European Gene Therapy Market
Spain Garners Leading Spot in Europe’s GM Maize Market
Table 5. Biotech Maize Hectarage in Europe (2011)
GMO Crops’ Future Hinges on Co-Existence Measures in EU
European Commission Downplays Impact of GM Crops
Biotech Crops Remain in a Political Standstill in Europe
European Nations Ban GM Potato and Maize
UK Government’s GM Crops Proposal Faces Rebuff
Spanish Transgenic Corn Plantation Increases
Ireland: A GM-free Zone
Gene Therapy Pipeline Strengthens in Asia
GM Foods Trends in Asia
Bt Cotton Fails in Asia
Chinese Biopharmaceutical Market to Continue its Growth Spurt
Government to Support Biopharmaceutical Innovation
Biotech Crop Research Gains Momentum in India
The Great Indian Bt Brinjal Controversy
India – The Leading Cultivator of Bt Cotton
India Ousts China in Bt Cotton Cultivation
Indian Agri-Bio Industry on a Roll
India: Ban on Genetically Engineered Crops?
Legalization of Genetic Engineering in Indonesia
GM Crops to Earn Good Returns for Australia
Biotechnology - A Boon for Agriculture in Malaysia
Poor Biotech Crops Adoption in Africa
Biotech Crops Cultivation Zooms in South Africa
Table 6. Percentage Share Breakdown of Biotech Maize by Type (2011) in South Africa
Table 7. Percentage Share Breakdown of Biotech Cotton by Type (2011) in South Africa
Uruguayan Community Resist GM Plants
GM Crop Adoption Rate Grows Exponentially in Brazil
5.GENETIC ENGINEERING: AN OVERVIEW
The Concept…
Molecular Basics – The Gene
Genome – The Information Pool
Evolution of Genetic Engineering
Historical Developments in Genetic Engineering:
The Human Genome Project
Significant Events in the Past
Gene Therapy
Types of Gene Therapy
Monogenic Gene Therapy
Suicide Gene Therapy
Antisense Gene Therapy
Human Genetic Engineering
Genetic Engineering in Animals
Role of Biotechnology in Agriculture
Insect Resistant Crops Vs. Herbicide Tolerant Crops
Some Interesting GM Crop Facts
Myths and Fads Associated to Genetically Engineered Crops
Improvement of Genetic Characters in Wheat
Agrobacterium tumifaciens Mediated Transformation
The Biolistic Transformation Method
Genetically Modified Foods
GM Food Faces Worldwide Criticism During Initial Years
Benefits of Genetically Modified Foods
Pest Resistance
Cold Tolerance
Herbicide Tolerance
Drought and Salinity Tolerance
Disease Resistance
Phytoremediation
Nutrition
Pharmaceuticals
Negative Impacts of GM Foods
Possibility of Crosspollination
Decreased Pesticides Effectiveness
Unintentional Destruction of Other Species
Health Concerns Related to GM Foods
Cost Concerns Related to GM Foods
Genetic Engineering and Food Processing
Genetic Engineering and Regulatory Environment
Patents - An Overview
6.GENE THERAPY – A REVIEW
Factors Influencing Gene Therapy’s Future Development
Human Genome Analysis
Gene Therapy - The Next Generation Cardiovascular Therapy
Public Support for Gene Therapy
RNAi Bode Bright Prospects
Factors Hampering Gene Therapy Future Development
Stringent US and European Regulatory Laws Prolongs Gene Therapy Development
Identifying Genetic Fault
Immune Response
Delivering Genetic Materials into Patient Cells
Multigene Disorders
Side Effects
Push Towards Germline Gene Transfer
Technical Limitations
Commercialization: A Road Uphill
Time Line in Gene Therapy Drug Development
Table 8. Gene Therapy Clinical Trials (2011): Percentage Breakdown by Geographic Region for the US, Europe, Canada, Japan and Rest of World
Table 9. Gene Therapy Clinical Development (2011): Percentage Share Breakdown by Stage
Select Gene Therapy Products in Phase III Development (2010)
Select Gene Therapy Products in Phase II Development (2010)
Select Gene Therapy Products in Phase I and Pre-Clinical Development (2010)
Target Diseases and Players Involved
Key Players by Application Area
Table 10. Clinical Development of Gene Therapy by Targeted Indication (2011): Percentage Breakdown of Number of Trials for Cancer Diseases, Cardiovascular Diseases, Infectious Diseases, Monogenic Diseases, Neurological Diseases and Others
Table 11. Gene Therapy Clinical Trials Worldwide (2011): Percentage Breakdown by Gene Type Transferred - Antigen, Cytokine, Tumor Suppressor, Growth Factor, Deficiency, Suicide, and Others
Table 12. Gene Therapy Clinical Development by Vectors Used (2011): Percentage Breakdown of Number of Trials for Adenovirus, Retrovirus, Plasmid DNA, Vaccinia Virus, Lipofection and Others
Gene Therapy Industry in Europe and the US – A Comparison
7.GENE AMPLIFICATION TECHNOLOGY
Definition of Gene Amplification
Target vs. Signal Amplification
Available Types of Gene Amplification Technologies
Polymerase Chain Reaction
The PCR comprises four major components:
Reagents and Equipment Required for PCR
Reaction Steps
Denaturation
Annealing
Extension
Detection of Amplified Product/DNA
(Q&Q) PCR
Reverse Transcriptase PCR (RT-PCR)
Alternative Technologies to PCR
OmniPlex
Genome-wide disease association studies
Pharmacogenomics studies
Molecular diagnostics and forensics
Additional OmniPlex Applications in Development
Strand Displacement Amplification
Ligase Chain Reaction
LCR Involves a Cyclic two-Step Reaction
Gene Amplification Technology (GAT)
Hybrid Capture
Isothermal DNA Amplification Techniques
Rolling Circle Amplification in Diagnostics
Ican Isothermal Gene Amplification Technology
BioHelix HDA Technology
Other Amplification Technologies
Signal Amplification Technology
Transcription Mediated Amplification
DNA Cleavage-based Signal Amplification
Ramification Amplification Method
End Use Market Analysis
Medical and Diagnostics
Role of Amplification Technology in the Diagnoses of Infectious Diseases
Diagnosis of Infectious Diseases by PCR
Detection of Antimicrobial Resistance
PCR Based Nucleic Acid Amplification for Detection of Antimicrobial Agents
Nucleic Acid Amplification Testing (NAT)
Nucleic Acid Amplification Methods
DNA Amplification Technology in the Diagnosis of Infectious Diseases
Advantages
Limitations
Forensic and Paternity Testing
Food Safety
Table 13. Current and Future Analysis for Global Gene Amplification Technology Market by Segment Independently Analyzed with Annual Sales Figures in US$ Million for 2010 Through 2015
Table 14. Global Gene Amplification Market (2012): Percentage Breakdown of Value Sales by Geographic Region- the US, Canada, Japan, Europe and Rest of World
8.RESEARCH AND DEVELOPMENT
9.MERGERS & ACQUISITIONS
10.RECENT INDUSTRY ACTIVITY
11.PRODUCT/SERVICE LAUNCHES
Global Directory
