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Synthetic Biology: Global Markets

February 2022 | 344 pages | ID: SA5AC8E81C5EN
BCC Research

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Report Scope:

The study scope includes core synthetic biology products (e.g., oligonucleotides, synthetic genes, BioBrick parts, delivery plasmids, chassis organisms, synthetic cells, cell-based and cell-free production systems), enabling technologies (e.g., DNA sequencing, DNA synthesis, gene editing, bioinformatics, specialty media) and enabled technologies (e.g., healthcare, industrial chemicals, consumer products, food and beverage, agriculture) that are already commercialized or are forecast to be commercialized through 2026.

Key synthetic biology technologies and products are analyzed to determine present and future market status, as well as forecasted growth from 2021 to 2026. An in-depth discussion of strategic alliances, industry structures, competitive dynamics, patents and market-driving forces is also provided.

BCC Research examines the synthetic biology industry by market segment, including DNA sequencing, DNA synthesis, gene editing, synthetic biology foundries and software; as well as the agriculture; consumer products, cosmetics and skin care, food and beverage, healthcare and industrial chemicals enable product sectors.

The role of key strategic alliances and acquisitions from 2018 to 2020 is discussed. Emerging markets, including synthetic genes, synthetic-biology-enabled drugs and vaccines, genome-edited crops and chassis organisms; as well as metabolically engineered factories for producing synthetic fuels and specialty chemicals, are analyzed, and more than 215 companies in these fields are highlighted.

Report Includes:
  • 30 data tables and 99 additional tables
  • An up-to-date review and analysis of the global market for synthetic biology within the life science industry
  • Analyses of the global market trends, with data from 2019 to 2021, and projections of compound annual growth rates (CAGRs) through 2026
  • Evaluation and forecast the global synthetic biology market size, forecasted growth trends, and corresponding market share analysis by product type, end-user industry, and region
  • Highlights of the current and future market potential for synthetic biology products and technologies, and areas of focus to forecast this market into various segments and sub-segments
  • Description of core synthetic biology products, key enabling technologies, and identify commercial opportunities for product development and competitive strategies
  • In-depth assessment of the synthetic biology industry structure, competitors review, and intellectual property landscape
  • Information on synthetic biology industry M&A deals, development of commercially viable products and technologies, and other strategic alliances within the industry
  • Patent review and analysis of patents granted for synthetic biology technologies, liquid biopsy and sequencing, and gene-editing industry
  • Detailed profiles of about 185+ companies within synthetic biology industry. Major players include Agilent Technologies Inc., Eurofins Scientific, GenScript, Merck KGaA, Novozymes A/S, Thermo Fisher Scientific Inc., and Twist Bioscience
CHAPTER 1 INTRODUCTION

Study Goals and Objectives
Reasons for Doing the Study
Contribution of the Study and for Whom
What's New in This Update?
Scope and Format
Methodology
Information Sources
Geographical Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports

CHAPTER 2 SUMMARY AND HIGHLIGHTS

CHAPTER 3 OVERVIEW

Synthetic Biology Technologies Covered in this Report
Value Chain Analysis
Synthetic Biology Overview
Development Stage of Synthetic Biology
Forces Driving the Growth of the Market for Synthetic Biology
Global Market for Synthetic Biology by End-User Industry
Product and Technology Life Cycles
Synthetic Biology Industry
Impact of COVID-19 on the Global Market for Synthetic Biology

CHAPTER 4 TECHNOLOGY BACKGROUND

Introduction
Synthetic Biology Defined
Synthetic Biology History
Unique Commercially Available Synthetic Biology Products
Leghemoglobin
Sitgaliptin
Hyaline
PROVEN, a Biological Nitrogen Fertilizer for Corn by Pivot Bio
Kymriah
Calyno
Paradigm Shift in Biology
Synthetic Biology Technology Overview
Enabling Technologies
DNA-Synthesis and DNA-Sequencing Cost Trends
DNA-Synthesis Technologies
Microfluidic Technologies
Next-Generation Sequencing Technologies
Gene Editing
Gene Drives
Bioinformatics Technologies
Biologic Components and Integrated Systems Technologies
Synthetic DNA
BioBrick Parts
Minimal Genomes and Chassis Organisms
Enabled Products
Pathway Engineering
Research and Development Applications
Synthetic Biology and the Microbiome
Synthetic Biology in Biofuels Feedstocks
Synthetic Biology Microbiome Initiatives
Current Governance and Regulations
U.S. Regulations
International Regulations

CHAPTER 5 SYNTHETIC BIOLOGY APPLICATIONS

Enabling Technologies Applications
Biologic Components and Integrated Systems Applications
Synthetic Genes
BioBrick Parts
Integrated Systems
Enabled Products Applications
Pharmaceuticals
Industrial Biotechnology Applications
Agricultural Applications
Data Storage Applications

CHAPTER 6 SYNTHETIC BIOLOGY INDUSTRY

Investment in Synthetic Biology Industry
Industrial Biotechnology Value Chain
Industry Structural Forces
Products and Technology Life Cycle
Sequencing Instruments Industry
Long-Read Sequencing Industry
DNA Synthesis Industry
Oligos as Therapeutics
Gene Synthesis Workflow
Gene Synthesis Value Chain
Synthetic Gene Market Segments
Gene-Editing Industry
Synthetic Biology Organism Design and Foundries Industry
Software Industry
Agriculture Industry
Consumer Products Industry
Cosmetics and Skin Care Industry
Food and Beverage Industry
Healthcare Industry
Industrial Chemicals Industry
Cell-Free System Industry
Industry Acquisitions and Strategic Alliances

CHAPTER 7 GLOBAL MARKET FOR SYNTHETIC BIOLOGY

Industry Growth-Driving Forces
DNA Read, Write and Edit Technologies
Growing Role of Designer Organisms
Speeding up of Commercialization Pathways
Growth in Synthetic Biology Foundries
Increasing Research and Development Investment by Pharma Companies
Global Market for Synthetic Biology by End-User Industry
Research Market
Healthcare Market
Industrial Chemicals Market
Agriculture Market
Consumer Market
Food and Beverage Market
Global Market for Synthetic Biology by Product Type
Enabling Products Market
Synthetic Biologic Components Market
Integrated Systems Market
Enabled Products Market
Geographic Markets
Synthetic Biology Products by Region
Enabling Products Market by Region
Core Products Market by Region
Enabled Products Market by Region

CHAPTER 8 PATENTS

Introduction
Foundational Patents
Synthetic Biology Patent Analysis
Sequencing-Related Patent Issues
Gene Editing-Related Patents
Gene Editing Patents: Sangamo Case Study

CHAPTER 9 COMPANY PROFILES

Key Market Players
AGILENT TECHNOLOGIES INC.
AMYRIS INC.
CODEXIS INC.
EUROFINS SCIENTIFIC
GENSCRIPT
GINKGO BIOWORKS
MERCK KGAA
NOVOZYMES A/S
THERMO FISHER SCIENTIFIC INC.
TWIST BIOSCIENCE
VIRIDOS
Other Players
20N LABS INC.
ABEONA THERAPEUTICS LLC
ACTIVE MOTIF
AEMETIS INC.
AGRIVIDA INC.
AJINOMOTO CO., INC.
ALGENUITY
AMBRX INC.
AMFORA INC.
ANSA BIOTECHNOLOGIES INC.
ANTHEIA INC.
ARBOR BIOTECHNOLOGIES INC.
ARCADIA BIOSCIENCES INC.
ARCTURUS THERAPEUTICS INC.
ARDRA BIO INC.
ARZEDA CORP.
ASTRAZENECA PLC
ATG BIOSYNTHETICS GMBH
ATUM
AVECIA
AZARGEN BIOTECHNOLOGIES PTY., LTD.
AZITRA INC.
BASF AG
BAYER AG
BEAM THERAPEUTICS INC.
BENCHLING
BENSON HILL BIOSYSTEMS INC.
BIO BASIC INC.
BIOGEN INC.
BIOMAX INFORMATICS AG
BIOMX LTD.
BIONEER CORP.
BIO S&T INC.
BIOSYNTIA APS
BLUEBIRD BIO INC.
BOLT THREADS INC.
BRISTOL-MYERS SQUIBB CO.
CALYSTA INC.
CALYXT INC.
CARGILL INC.
CARIBOU BIOSCIENCES INC.
CRISPR THERAPEUTICS
CASZYME
CATALOG TECHNOLOGIES, INC.
CELLECTIS SA
CENTRIENT PHARMACEUTICALS
CHAIN BIOTECHNOLOGY LTD.
CIBUS INC.
C-LECTA GMBH
CODAGENIX INC.
COLORIFIX LTD.
CORBION
CRONOS GROUP
CROWN LABORATORIES INC.
DANAHER CORP.
DEMURIS LTD.
DNA SCRIPT
DOVETAIL GENOMICS LLC
DOWDUPONT INC.
EDIGENE INC.
EDITAS MEDICINE INC.
ELIGO BIOSCIENCE SAS
ENDLESS WEST
ENEVOLV INC.
EPOCH LIFE SCIENCE INC.
EVONETIX
EVOLVA SA
EXXONMOBIL CORP.
G+FLAS LIFE SCIENCES INC.
GEA ENZYMES
GELTOR INC.
GENEMED SYNTHESIS INC.
GENERAY BIOTECH CO., LTD.
GENOMATICA
GENUS PLC
GEVO INC.
GILEAD SCIENCES INC.
GLAXOSMITHKLINE PLC
GLOBAL BIOENERGIES
GLOWEE- UNREASONABLE GROUP
GLYCOSBIO FOOD SCIENCES
GLYCOSYN LLC
GOODYEAR TIRE & RUBBER CO.
HELIXWORKS TECHNOLOGIES LTD.
HOMOLOGY MEDICINES INC.
HORIZON DISCOVERY GROUP PLC
HUVEPHARMA
ILLUMINA INC.
IMPOSSIBLE FOODS INC.
INDUSTRIAL MICROBES INC.
INGENZA LTD.
INOVIO PHARMACEUTICALS INC.
INSCRIPTA INC.
INTELLIA THERAPEUTICS INC.
INTERNATIONAL BUSINESS MACHINES
JOYN BIO
KANEKA CORP.
KWS SAAT SE
LABGENIUS LTD.
LANZATECH
LATTICE AUTOMATION INC.
LC SCIENCES
LCY CHEMICAL CORP.
LGC GROUP
LOCUS BIOSCIENCES
LOGICBIO THERAPEUTICS
LUMEN BIOSCIENCE
LYGOS INC.
MEISSA VACCINES, INC.
MICROSYNBIOTIX
MICROBYRE, INC.
MICROSOFT CORP.
MILIS BIO LTD.
MODERN MEADOW
MODULAR GENETICS INC.
MOLECULAR ASSEMBLIES INC.
MORPHOSYS AG
MOTIF INGREDIENTS
NEW ENGLAND BIOLABS
NOVARTIS PHARMA AG
NOVOME BIOTECHNOLOGIES INC.
NOVVI LLC
NUCELIS LLC
NUCLERA NUCLEICS LTD.
OMEGA BIO-TEK INC.
ORAGENICS INC.
OXFORD BIOMEDICA PLC
PAIRWISE PLANTS INC.
PFIZER INC.
PHIO PHARMACEUTICALS CORP.
PHYTOWELT GREEN TECHNOLOGIES GMBH
PIVOT BIO
POSEIDA THERAPEUTICS INC.
PRECISION BIOSCIENCES INC.
PROKARIUM HOLDINGS LTD.
PROMEGA CORP.
PTC THERAPEUTICS INC.
RECOMBINETICS INC.
ROQUETTE FRERES
ROYAL DSM NV
SANGAMO THERAPEUTICS INC.
SAREPTA THERAPEUTICS INC.
SCARAB GENOMICS LLC
SENTI BIOSCIENCES
SHINEGENE MOLECULAR BIO-TECHNOLOGIES INC.
SIGMA ALDRICH CORP.
SHERLOCK BIOSCIENCES
SILICOLIFE LDA.
SOCATI CORP.
SPIBER INC.
STRING BIO
SUGARLOGIX
SYNBIO TECHNOLOGIES INC.
SYNGENTA AG (CHEMCHINA)
SYNTHEGO CORP.
SYNLOGIC THERAPEUTICS
SYNTHACE LTD.
SYNTHETIC BIOLOGICS INC.
TAKARA BIO
TEPHA INC.
TESELAGEN BIOTECHNOLOGY INC.
TIERRA BIOSCIENCES
TOOLGEN
TRANSCRIPTIC INC.
TROPIC BIOSCIENCES U.K. LTD.
TRITON ALGAE INNOVATIONS LTD.
VEDANTA BIOSCIENCES
VERSALIS SPA
VERTEX PHARMACEUTICALS INC.
VIR BIOTECHNOLOGY INC.
XYPHOS BIOSCIENCES, INC.
YIELD10 BIOSCIENCES INC.
ZIOPHARM ONCOLOGY, INC.
ZYMERGEN
ZYMOCHEM INC.

LIST OF TABLES

Summary Table: Global Market for Synthetic Biology, by Product Type, Through 2026
Table 1: Report Scope
Table 2: Synthetic Biology Paradigm
Table 3: Driving Forces of the Market for Synthetic Biology, 2021-2026
Table 4: Global Market for Synthetic Biology, by End-User Industry, Through 2026
Table 5: Synthetic Biology Products and Technology Life Cycle Stage
Table 6: Synthetic Biology Industry, by Market Segment
Table 7: Synthetic Biology Definitions
Table 8: Synthetic Biology History, 1970-2019
Table 9: Paradigm Shift Caused by Synthetic Biology
Table 10: Genetic Engineering and Synthetic Biology Comparison
Table 11: Synthetic Biology Applications, by Technology
Table 12: Importance of Enabling Technologies
Table 13: Single Human Genome Sequence Cost, 2001-2021
Table 14: DNA-Synthesis Costs, 2006-2019
Table 15: Pros and Cons of Gene-Synthesis Technologies
Table 16: Importance of Microfluidics Technologies in Synthetic Biology
Table 17: Next-Generation Sequencing Technologies, by Company, 2019
Table 18: Gene-Editing Therapeutic Interventions
Table 19: Gene-Editing Technology Approaches
Table 20: Comparison of the Major Gene-Editing Technologies
Table 21: Comparison of CRISPR Enzyme Technology
Table 22: Gene Drive Modified Organisms Potential Market Applications
Table 23: Synthetic Biology Bioinformatics Technologies
Table 24: Comparison of Nucleic Acids, Genes and Genomes
Table 25: Synthetic DNA Types
Table 26: Synthetic Genes as Molecular-Biology Tools
Table 27: Synthetic Genes Versus Traditional Polymerase Chain Reaction Cloning
Table 28: Mechanism of DNA Constructs
Table 29: Minimal Genome Key Attributes
Table 30: Enabled Technologies, by Near-Term Application
Table 31: Metabolic Engineering for Artemisinic Acid
Table 32: Research and Development Applications for Synthetic Biology Products
Table 33: Microbiomes: Approaches of Incorporation of Synthetic Biology
Table 34: Contribution of Synthetic Biology to Biofuels
Table 35: Synthetic Biology Initiatives Relating to the Microbiome
Table 36: Synthetic Biology Biosafety Governance Regulations
Table 37: Synthetic Biology Products Impacted by Enabling Technologies
Table 38: Biologic Components and Integrated Systems Near-Term Applications
Table 39: Synthetic Gene Near-Term Applications, by End User
Table 40: E Coli as a Chassis Organism
Table 41: Drug Discovery and Development Applications for Synthetic Biology Products
Table 42: Gene-Editing Clinical Pipeline, by Company, 2019
Table 43: CAR-T Cell Alliances and Synthetic Biology Platforms
Table 44: Industrial Biotechnology Applications
Table 45: Synthetic Biology Enabled Biofuel Applications
Table 46: Growth Status of Specialty versus Drop-in Biofuels, 2000–2020
Table 47: Synthetic Biology Enabled Agriculture and Animal Applications
Table 48: U.S. and European Approaches to Regulation of Gene-Edited Crops
Table 49: Synthetic Biology Industry Structural Forces
Table 50: Synthetic Biology Products and Technology Life Cycle Stages
Table 51: Advanced Sequencing Industry Company Positioning, 2020
Table 52: End-to-End Sequencing Approaches
Table 53: Next Generation Sequencing History
Table 54: Long-Read Sequencing Industry, by Company, 2020
Table 55: Nucleic Acid Synthesis Key Competitor Strategies, by Company, 2020
Table 56: RNA Therapy Segments
Table 57: RNA Therapies Industry
Table 58: Gene Synthesis Workflow
Table 59: Gene Synthesis Market Factors of Differentiation
Table 60: Gene-Editing Industry, 2020
Table 61: Regulatory Situation of Gene-Edited Crops, by Country or Region
Table 62: Clinical-Stage Gene-Editing Industry, 2020
Table 63: Competitive Platforms: ?-Thalassemia
Table 64: Competitive Platforms: LCA, 2019
Table 65: Organism Design and Automation Industry, 2020
Table 66: Market Focus for Selected Synthetic Biology Software Companies, 2020
Table 67: Market Segment of Synthetic Biology Agriculture Industry, by Company, 2020
Table 68: Consumer Products Industry Market Segment, by Company, 2020
Table 69: Cosmetic and Skin Care Industry, 2020
Table 70: Food and Beverage Industry, 2020
Table 71: Synthetic Biology-Based Healthcare Industry, 2020
Table 72: Microbiome Therapeutic Industry, 2020
Table 73: Synthetic Biology-Based Industrial Chemicals Industry, 2020
Table 74: Leading Companies in the Cell-Free Synthetic Biology Industry, 2020
Table 75: Synthetic Biology Industry Acquisitions, 2018–2021
Table 76: Strategic Alliances, 2018–2020
Table 77: Forces Driving Growth in the Market for Synthetic Biology
Table 78: Global Market for Synthetic Biology in Research End Uses, by Product Type, Through 2026
Table 79: Global Market for Synthetic Biology in Healthcare End Uses, by Product Type, Through 2026
Table 80: Global Market for Synthetic Biology in Industrial Chemical End Uses, by Product Type, Through 2026
Table 81: Global Market for Synthetic Biology in Agricultural End Uses, by Product Type, Through 2026
Table 82: Global Market for Synthetic Biology in Consumer End Uses, by Product Type, Through 2026
Table 83: Global Market for Synthetic Biology in Food and Beverage End Uses, by Product Type, Through 2026
Table 84: Global Market for Synthetic Biology, by Product Type, Through 2026
Table 85: Global Market for Synthetic Biology Enabling Products, by Type, Through 2026
Table 86: Global Market for Synthetic Biology Enabling Products, by End-User Industry, Through 2026
Table 87: Global Market for Synthetic Biologic Components, by Type, Through 2026
Table 88: Global Market for Synthetic Biologic Components, by End-User Industry, Through 2026
Table 89: Global Market for Synthetic Biology Integrated Systems, by Type, Through 2026
Table 90: Synthetic Biology Microbe Engineering Workflow
Table 91: Global Market for Synthetic Biology Integrated Systems, by End-User Industry, Through 2026
Table 92: Biodiesel Fuel Performance Comparison
Table 93: Artemisinin Drug Production Comparison
Table 94: Sweetener Product Comparison
Table 95: Global Market for Synthetic Biology Enabled Products, by End-User Industry, Through 2026
Table 96: Global Market for Synthetic Biology Enabled Products in Healthcare End-Use, by Segment, Through 2026
Table 97: Gene-Editing Clinical Pipeline, by Company, 2019
Table 98: Global Market for Synthetic Biology Enabled Products in Consumer End-Use, by Type, Through 2026
Table 99: Global Market for Synthetic Biology Enabled Products in Food and Beverage End-Use, by Type, Through 2026
Table 100: Synthetic Biology-Based Chemical Process Factors
Table 101: Global Market for Synthetic Biology Enabled Products in Industrial Chemical End-Use, by Type, Through 2026
Table 102: Advanced Biofuel Growth Factors
Table 103: Crude Oil Prices, 2011-2020
Table 104: Strategic Shifts in Biofuels, by Company, 2012–2018
Table 105: Global Market for Synthetic Biology Enabled Products in Agriculture End-Use, by Type, Through 2026
Table 106: Mosquito-Control Methods
Table 107: Aedes Aegypti Initial Markets, 2019
Table 108: Advantages of Gene Editing for Crop Enhancement
Table 109: Gene-Edited Crop Market Landscape, 2020
Table 110: Gene Edited Crops Commercialization Pathway
Table 111: Global Market for Synthetic Biology, by Region, Through 2026
Table 112: Global Market for Synthetic Biology Enabling Products, by Region, Through 2026
Table 113: Global Market for Synthetic Biologic Components, by Region, Through 2026
Table 114: Global Market for Synthetic Biology Integrated Systems, by Region, Through 2026
Table 115: Global Market for Synthetic Biology Enabled Products, by Region, Through 2026
Table 116: Patents on Synthetic Biology Technologies
Table 117: Foundational Patents on Synthetic Biology Technolgies
Table 118: Synthetic Biology Representative Patent Grouping, by Tier
Table 119: Patent Description, by Company
Table 120: Status of Liquid Biopsy and Sequencing-Related Patent Disputes, 2019
Table 121: CRISPR-Cas9 Patent Groups
Table 122: CRISPR-Cas9 Patent Licensing Fields, by Company
Table 123: Sangamo Collaboration Agreements Relating to ZFN Technology
Table 124: Sangamo Therapeutics Patent Position
Table 125: Ginkgo Bioworks Engineered-Organism Workflow
Table 126: Agrivida Technical Approach
Table 127: Arcturus Therapeutics Inc.: Multiple mRNA Vaccine and Therapeutic Programs in Clinical Development
Table 128: Gene-Editing Versus Gene-Therapy Approach

LIST OF FIGURES

Summary Figure: Global Market for Synthetic Biology, by Product Type, 2019-2026
Figure 1: Value Chain Analysis
Figure 2: Synthetic Biology Value Added Chain
Figure 3: Evolution of Synthetic Biology from Natural to Artificial Systems
Figure 4: Conventional Versus Synthetic Biology Approach to Gene Synthesis
Figure 5: Synthetic Biology Scale
Figure 6: Conventional DNA-Synthesis Technology Schematic
Figure 7: Microarrays in DNA Synthesis
Figure 8: Promoter and Reporter Roles in Synthetic Biology Systems
Figure 9: Creation of Enabled Products Through Synthetic Biology
Figure 10: Total Synthetic Biology Funding, 2017–2020
Figure 11: Industrial Biotechnology Value Chain with Synthetic Biology Leverage Points
Figure 12: Synthetic Biology Patent Documents Granted, Filed and Published, 2018–2021
Figure 13: Agilent Technologies: Annual Revenue, 2018–2020
Figure 14: Agilent Technologies: Revenue Share, by Segment, 2020
Figure 15: Agilent Technologies: Revenue Share, by Region, 2020
Figure 16: Amyris Inc.: Annual Revenue, 2018–2020
Figure 17: Amyris Inc.: Revenue Share, by Region, 2020
Figure 18: Codexis Inc.: Annual Revenue, 2018–2020
Figure 19: Codexis Inc.: Revenue Share, by Segment, 2020
Figure 20: Codexis Inc.: Revenue Share, by Region, 2020
Figure 21: Eurofins Scientific: Annual Revenue, 2018–2020
Figure 22: Eurofins Scientific: Revenue Share, by Region, 2020
Figure 23: GenScript: Annual Revenue, 2018–2020
Figure 24: GenScript: Revenue Share, by Segment, 2020
Figure 25: GenScript: Revenue Share, by Region, 2020
Figure 26: Merck KGaA: Annual Revenue, 2018–2020
Figure 27: Merck KGaA: Revenue Share, by Business Segment, 2020
Figure 28: Merck KGaA: Revenue Share, by Region, 2020
Figure 29: Novozymes A/S: Annual Revenue, 2018–2020
Figure 30: Novozymes A/S: Revenue Share, by Business Segment, 2020
Figure 31: Novozymes A/S: Revenue Share, by Region, 2020
Figure 32: Thermo Fisher Scientific: Annual Revenue, 2018–2020
Figure 33: Thermo Fisher Scientific: Revenue Share, by Business Segment, 2020
Figure 34: Thermo Fisher Scientific: Revenue Share, by Region, 2020
Figure 35: Twist Bioscience: Annual Revenue, 2018–2020
Figure 36: Twist Bioscience: Revenue Share, by Products, 2020
Figure 37: Twist Bioscience: Revenue Share, by Region, 2020


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