Global Bone Marrow Transplant Market Professional Survey Report 2017

December 2017 | 116 pages | ID: G05654863C2EN
QYResearch

Abstracts

This report studies Bone Marrow Transplant in Global market, especially in North America, China, Europe, Southeast Asia, Japan and India, with production, revenue, consumption, import and export in these regions, from 2012 to 2016, and forecast to 2022.

This report focuses on top manufacturers in global market, with production, price, revenue and market share for each manufacturer, covering

• AllCells (USA)
• Lonza (Switzerland)
• Merck (USA)
• Sanofi (France)
• Translational Biosciences (USA)
• Athersys (USA)
• Beike Biotechnology (China)
• BioTime (USA)
• Bluebird Bio (USA)
• Caladrius (USA)
• Cellular Biomedicine Group (USA)
• Cesca Therapeutics (USA)
• TiGenix (Belgium)
• CHA Biotech (Korea)
• Chugai Pharmaceutical (UK)
• CORESTEM (Korea)
• Gamida Cell (USA)
• Histocell (Spain)
• Hemostemix (Canada)

On the basis of product, this report displays the production, revenue, price, market share and growth rate of each type, primarily split into

• Autologous Hematopoietic Stem Cell Transplantation
• Syngeneic Hematopoietic Stem Cell Transplantation
• Allo-HSCT

By Application, the market can be split into

• Acute Leukemia
• Chronic Leukemia

By Regions, this report covers (we can add the regions/countries as you want)

• North America
• China
• Europe
• Southeast Asia
• Japan
• India

If you have any special requirements, please let us know and we will offer you the report as you want.

Contents

Global Bone Marrow Transplant Market Professional Survey Report 2017

1 INDUSTRY OVERVIEW OF BONE MARROW TRANSPLANT

1.1 Definition and Specifications of Bone Marrow Transplant
  1.1.1 Definition of Bone Marrow Transplant
  1.1.2 Specifications of Bone Marrow Transplant
1.2 Classification of Bone Marrow Transplant
  1.2.1 Autologous Hematopoietic Stem Cell Transplantation
  1.2.2 Syngeneic Hematopoietic Stem Cell Transplantation
  1.2.3 Allo-HSCT
1.3 Applications of Bone Marrow Transplant
  1.3.1 Acute Leukemia
  1.3.2 Chronic Leukemia
  1.3.3 Application
1.4 Market Segment by Regions
  1.4.1 North America
  1.4.2 China
  1.4.3 Europe
  1.4.4 Southeast Asia
  1.4.5 Japan
  1.4.6 India

2 MANUFACTURING COST STRUCTURE ANALYSIS OF BONE MARROW TRANSPLANT

2.1 Raw Material and Suppliers
2.2 Manufacturing Cost Structure Analysis of Bone Marrow Transplant
2.3 Manufacturing Process Analysis of Bone Marrow Transplant
2.4 Industry Chain Structure of Bone Marrow Transplant

3 TECHNICAL DATA AND MANUFACTURING PLANTS ANALYSIS OF BONE MARROW TRANSPLANT

3.1 Capacity and Commercial Production Date of Global Bone Marrow Transplant Major Manufacturers in 2016
3.2 Manufacturing Plants Distribution of Global Bone Marrow Transplant Major Manufacturers in 2016
3.3 R&D Status and Technology Source of Global Bone Marrow Transplant Major Manufacturers in 2016
3.4 Raw Materials Sources Analysis of Global Bone Marrow Transplant Major Manufacturers in 2016

4 GLOBAL BONE MARROW TRANSPLANT OVERALL MARKET OVERVIEW

4.1 2012-2017E Overall Market Analysis
4.2 Capacity Analysis
  4.2.1 2012-2017E Global Bone Marrow Transplant Capacity and Growth Rate Analysis
  4.2.2 2016 Bone Marrow Transplant Capacity Analysis (Company Segment)
4.3 Sales Analysis
  4.3.1 2012-2017E Global Bone Marrow Transplant Sales and Growth Rate Analysis
  4.3.2 2016 Bone Marrow Transplant Sales Analysis (Company Segment)
4.4 Sales Price Analysis
  4.4.1 2012-2017E Global Bone Marrow Transplant Sales Price
  4.4.2 2016 Bone Marrow Transplant Sales Price Analysis (Company Segment)

5 BONE MARROW TRANSPLANT REGIONAL MARKET ANALYSIS

5.1 North America Bone Marrow Transplant Market Analysis
  5.1.1 North America Bone Marrow Transplant Market Overview
  5.1.2 North America 2012-2017E Bone Marrow Transplant Local Supply, Import, Export, Local Consumption Analysis
  5.1.3 North America 2012-2017E Bone Marrow Transplant Sales Price Analysis
  5.1.4 North America 2016 Bone Marrow Transplant Market Share Analysis
5.2 China Bone Marrow Transplant Market Analysis
  5.2.1 China Bone Marrow Transplant Market Overview
  5.2.2 China 2012-2017E Bone Marrow Transplant Local Supply, Import, Export, Local Consumption Analysis
  5.2.3 China 2012-2017E Bone Marrow Transplant Sales Price Analysis
  5.2.4 China 2016 Bone Marrow Transplant Market Share Analysis
5.3 Europe Bone Marrow Transplant Market Analysis
  5.3.1 Europe Bone Marrow Transplant Market Overview
  5.3.2 Europe 2012-2017E Bone Marrow Transplant Local Supply, Import, Export, Local Consumption Analysis
  5.3.3 Europe 2012-2017E Bone Marrow Transplant Sales Price Analysis
  5.3.4 Europe 2016 Bone Marrow Transplant Market Share Analysis
5.4 Southeast Asia Bone Marrow Transplant Market Analysis
  5.4.1 Southeast Asia Bone Marrow Transplant Market Overview
  5.4.2 Southeast Asia 2012-2017E Bone Marrow Transplant Local Supply, Import, Export, Local Consumption Analysis
  5.4.3 Southeast Asia 2012-2017E Bone Marrow Transplant Sales Price Analysis
  5.4.4 Southeast Asia 2016 Bone Marrow Transplant Market Share Analysis
5.5 Japan Bone Marrow Transplant Market Analysis
  5.5.1 Japan Bone Marrow Transplant Market Overview
  5.5.2 Japan 2012-2017E Bone Marrow Transplant Local Supply, Import, Export, Local Consumption Analysis
  5.5.3 Japan 2012-2017E Bone Marrow Transplant Sales Price Analysis
  5.5.4 Japan 2016 Bone Marrow Transplant Market Share Analysis
5.6 India Bone Marrow Transplant Market Analysis
  5.6.1 India Bone Marrow Transplant Market Overview
  5.6.2 India 2012-2017E Bone Marrow Transplant Local Supply, Import, Export, Local Consumption Analysis
  5.6.3 India 2012-2017E Bone Marrow Transplant Sales Price Analysis
  5.6.4 India 2016 Bone Marrow Transplant Market Share Analysis

6 GLOBAL 2012-2017E BONE MARROW TRANSPLANT SEGMENT MARKET ANALYSIS (BY TYPE)

6.1 Global 2012-2017E Bone Marrow Transplant Sales by Type
6.2 Different Types of Bone Marrow Transplant Product Interview Price Analysis
6.3 Different Types of Bone Marrow Transplant Product Driving Factors Analysis
  6.3.1 Autologous Hematopoietic Stem Cell Transplantation of Bone Marrow Transplant Growth Driving Factor Analysis
  6.3.2 Syngeneic Hematopoietic Stem Cell Transplantation of Bone Marrow Transplant Growth Driving Factor Analysis
  6.3.3 Allo-HSCT of Bone Marrow Transplant Growth Driving Factor Analysis

7 GLOBAL 2012-2017E BONE MARROW TRANSPLANT SEGMENT MARKET ANALYSIS (BY APPLICATION)

7.1 Global 2012-2017E Bone Marrow Transplant Consumption by Application
7.2 Different Application of Bone Marrow Transplant Product Interview Price Analysis
7.3 Different Application of Bone Marrow Transplant Product Driving Factors Analysis
  7.3.1 Acute Leukemia of Bone Marrow Transplant Growth Driving Factor Analysis
  7.3.2 Chronic Leukemia of Bone Marrow Transplant Growth Driving Factor Analysis

8 MAJOR MANUFACTURERS ANALYSIS OF BONE MARROW TRANSPLANT

8.1 AllCells (USA)
  8.1.1 Company Profile
  8.1.2 Product Picture and Specifications
    8.1.2.1 Product A
    8.1.2.2 Product B
  8.1.3 AllCells (USA) 2016 Bone Marrow Transplant Sales, Ex-factory Price, Revenue, Gross Margin Analysis
  8.1.4 AllCells (USA) 2016 Bone Marrow Transplant Business Region Distribution Analysis
8.2 Lonza (Switzerland)
  8.2.1 Company Profile
  8.2.2 Product Picture and Specifications
    8.2.2.1 Product A
    8.2.2.2 Product B
  8.2.3 Lonza (Switzerland) 2016 Bone Marrow Transplant Sales, Ex-factory Price, Revenue, Gross Margin Analysis
  8.2.4 Lonza (Switzerland) 2016 Bone Marrow Transplant Business Region Distribution Analysis
8.3 Merck (USA)
  8.3.1 Company Profile
  8.3.2 Product Picture and Specifications
    8.3.2.1 Product A
    8.3.2.2 Product B
  8.3.3 Merck (USA) 2016 Bone Marrow Transplant Sales, Ex-factory Price, Revenue, Gross Margin Analysis
  8.3.4 Merck (USA) 2016 Bone Marrow Transplant Business Region Distribution Analysis
8.4 Sanofi (France)
  8.4.1 Company Profile
  8.4.2 Product Picture and Specifications
    8.4.2.1 Product A
    8.4.2.2 Product B
  8.4.3 Sanofi (France) 2016 Bone Marrow Transplant Sales, Ex-factory Price, Revenue, Gross Margin Analysis
  8.4.4 Sanofi (France) 2016 Bone Marrow Transplant Business Region Distribution Analysis
8.5 Translational Biosciences (USA)
  8.5.1 Company Profile
  8.5.2 Product Picture and Specifications
    8.5.2.1 Product A
    8.5.2.2 Product B
  8.5.3 Translational Biosciences (USA) 2016 Bone Marrow Transplant Sales, Ex-factory Price, Revenue, Gross Margin Analysis
  8.5.4 Translational Biosciences (USA) 2016 Bone Marrow Transplant Business Region Distribution Analysis
8.6 Athersys (USA)
  8.6.1 Company Profile
  8.6.2 Product Picture and Specifications
    8.6.2.1 Product A
    8.6.2.2 Product B
  8.6.3 Athersys (USA) 2016 Bone Marrow Transplant Sales, Ex-factory Price, Revenue, Gross Margin Analysis
  8.6.4 Athersys (USA) 2016 Bone Marrow Transplant Business Region Distribution Analysis
8.7 Beike Biotechnology (China)
  8.7.1 Company Profile
  8.7.2 Product Picture and Specifications
    8.7.2.1 Product A
    8.7.2.2 Product B
  8.7.3 Beike Biotechnology (China) 2016 Bone Marrow Transplant Sales, Ex-factory Price, Revenue, Gross Margin Analysis
  8.7.4 Beike Biotechnology (China) 2016 Bone Marrow Transplant Business Region Distribution Analysis
8.8 BioTime (USA)
  8.8.1 Company Profile
  8.8.2 Product Picture and Specifications
    8.8.2.1 Product A
    8.8.2.2 Product B
  8.8.3 BioTime (USA) 2016 Bone Marrow Transplant Sales, Ex-factory Price, Revenue, Gross Margin Analysis
  8.8.4 BioTime (USA) 2016 Bone Marrow Transplant Business Region Distribution Analysis
8.9 Bluebird Bio (USA)
  8.9.1 Company Profile
  8.9.2 Product Picture and Specifications
    8.9.2.1 Product A
    8.9.2.2 Product B
  8.9.3 Bluebird Bio (USA) 2016 Bone Marrow Transplant Sales, Ex-factory Price, Revenue, Gross Margin Analysis
  8.9.4 Bluebird Bio (USA) 2016 Bone Marrow Transplant Business Region Distribution Analysis
8.10 Caladrius (USA)
  8.10.1 Company Profile
  8.10.2 Product Picture and Specifications
    8.10.2.1 Product A
    8.10.2.2 Product B
  8.10.3 Caladrius (USA) 2016 Bone Marrow Transplant Sales, Ex-factory Price, Revenue, Gross Margin Analysis
  8.10.4 Caladrius (USA) 2016 Bone Marrow Transplant Business Region Distribution Analysis
8.11 Cellular Biomedicine Group (USA)
8.12 Cesca Therapeutics (USA)
8.13 TiGenix (Belgium)
8.14 CHA Biotech (Korea)
8.15 Chugai Pharmaceutical (UK)
8.16 CORESTEM (Korea)
8.17 Gamida Cell (USA)
8.18 Histocell (Spain)
8.19 Hemostemix (Canada)

9 DEVELOPMENT TREND OF ANALYSIS OF BONE MARROW TRANSPLANT MARKET

9.1 Global Bone Marrow Transplant Market Trend Analysis
  9.1.1 Global 2017-2022 Bone Marrow Transplant Market Size (Volume and Value) Forecast
  9.1.2 Global 2017-2022 Bone Marrow Transplant Sales Price Forecast
9.2 Bone Marrow Transplant Regional Market Trend
  9.2.1 North America 2017-2022 Bone Marrow Transplant Consumption Forecast
  9.2.2 China 2017-2022 Bone Marrow Transplant Consumption Forecast
  9.2.3 Europe 2017-2022 Bone Marrow Transplant Consumption Forecast
  9.2.4 Southeast Asia 2017-2022 Bone Marrow Transplant Consumption Forecast
  9.2.5 Japan 2017-2022 Bone Marrow Transplant Consumption Forecast
  9.2.6 India 2017-2022 Bone Marrow Transplant Consumption Forecast
9.3 Bone Marrow Transplant Market Trend (Product Type)
9.4 Bone Marrow Transplant Market Trend (Application)

10 BONE MARROW TRANSPLANT MARKETING TYPE ANALYSIS

10.1 Bone Marrow Transplant Regional Marketing Type Analysis
10.2 Bone Marrow Transplant International Trade Type Analysis
10.3 Traders or Distributors with Contact Information of Bone Marrow Transplant by Region
10.4 Bone Marrow Transplant Supply Chain Analysis

11 CONSUMERS ANALYSIS OF BONE MARROW TRANSPLANT

11.1 Consumer 1 Analysis
11.2 Consumer 2 Analysis
11.3 Consumer 3 Analysis
11.4 Consumer 4 Analysis

12 CONCLUSION OF THE GLOBAL BONE MARROW TRANSPLANT MARKET PROFESSIONAL SURVEY REPORT 2017

Methodology
Analyst Introduction
Data Source


The report requires updating with new data and is sent in 2-3 business days after order is placed.

List Of Tables

LIST OF TABLES AND FIGURES

Figure Picture of Bone Marrow Transplant
Table Product Specifications of Bone Marrow Transplant
Table Classification of Bone Marrow Transplant
Figure Global Production Market Share of Bone Marrow Transplant by Type in 2016
Figure Autologous Hematopoietic Stem Cell Transplantation Picture
Table Major Manufacturers of Autologous Hematopoietic Stem Cell Transplantation
Figure Syngeneic Hematopoietic Stem Cell Transplantation Picture
Table Major Manufacturers of Syngeneic Hematopoietic Stem Cell Transplantation
Figure Allo-HSCT Picture
Table Major Manufacturers of Allo-HSCT
Table Applications of Bone Marrow Transplant
Figure Global Consumption Volume Market Share of Bone Marrow Transplant by Application in 2016
Figure Acute Leukemia Examples
Table Major Consumers in Acute Leukemia
Figure Chronic Leukemia Examples
Table Major Consumers in Chronic Leukemia
Figure Market Share of Bone Marrow Transplant by Regions
Figure North America Bone Marrow Transplant Market Size (Million USD) (2012-2022)
Figure China Bone Marrow Transplant Market Size (Million USD) (2012-2022)
Figure Europe Bone Marrow Transplant Market Size (Million USD) (2012-2022)
Figure Southeast Asia Bone Marrow Transplant Market Size (Million USD) (2012-2022)
Figure Japan Bone Marrow Transplant Market Size (Million USD) (2012-2022)
Figure India Bone Marrow Transplant Market Size (Million USD) (2012-2022)
Table Bone Marrow Transplant Raw Material and Suppliers
Table Manufacturing Cost Structure Analysis of Bone Marrow Transplant in 2016
Figure Manufacturing Process Analysis of Bone Marrow Transplant
Figure Industry Chain Structure of Bone Marrow Transplant
Table Capacity and Commercial Production Date of Global Bone Marrow Transplant Major Manufacturers in 2016
Table Manufacturing Plants Distribution of Global Bone Marrow Transplant Major Manufacturers in 2016
Table R&D Status and Technology Source of Global Bone Marrow Transplant Major Manufacturers in 2016
Table Raw Materials Sources Analysis of Global Bone Marrow Transplant Major Manufacturers in 2016
Table Global Capacity, Sales, Price, Cost, Sales Revenue (M USD) and Gross Margin of Bone Marrow Transplant 2012-2017
Figure Global 2012-2017E Bone Marrow Transplant Market Size (Volume) and Growth Rate
Figure Global 2012-2017E Bone Marrow Transplant Market Size (Value) and Growth Rate
Table 2012-2017E Global Bone Marrow Transplant Capacity and Growth Rate
Table 2016 Global Bone Marrow Transplant Capacity (K Units) List (Company Segment)
Table 2012-2017E Global Bone Marrow Transplant Sales (K Units) and Growth Rate
Table 2016 Global Bone Marrow Transplant Sales (K Units) List (Company Segment)
Table 2012-2017E Global Bone Marrow Transplant Sales Price (USD/Unit)
Table 2016 Global Bone Marrow Transplant Sales Price (USD/Unit) List (Company Segment)
Figure North America Capacity Overview
Table North America Supply, Import, Export and Consumption (K Units) of Bone Marrow Transplant 2012-2017E
Figure North America 2012-2017E Bone Marrow Transplant Sales Price (USD/Unit)
Figure North America 2016 Bone Marrow Transplant Sales Market Share
Figure China Capacity Overview
Table China Supply, Import, Export and Consumption (K Units) of Bone Marrow Transplant 2012-2017E
Figure China 2012-2017E Bone Marrow Transplant Sales Price (USD/Unit)
Figure China 2016 Bone Marrow Transplant Sales Market Share
Figure Europe Capacity Overview
Table Europe Supply, Import, Export and Consumption (K Units) of Bone Marrow Transplant 2012-2017E
Figure Europe 2012-2017E Bone Marrow Transplant Sales Price (USD/Unit)
Figure Europe 2016 Bone Marrow Transplant Sales Market Share
Figure Southeast Asia Capacity Overview
Table Southeast Asia Supply, Import, Export and Consumption (K Units) of Bone Marrow Transplant 2012-2017E
Figure Southeast Asia 2012-2017E Bone Marrow Transplant Sales Price (USD/Unit)
Figure Southeast Asia 2016 Bone Marrow Transplant Sales Market Share
Figure Japan Capacity Overview
Table Japan Supply, Import, Export and Consumption (K Units) of Bone Marrow Transplant 2012-2017E
Figure Japan 2012-2017E Bone Marrow Transplant Sales Price (USD/Unit)
Figure Japan 2016 Bone Marrow Transplant Sales Market Share
Figure India Capacity Overview
Table India Supply, Import, Export and Consumption (K Units) of Bone Marrow Transplant 2012-2017E
Figure India 2012-2017E Bone Marrow Transplant Sales Price (USD/Unit)
Figure India 2016 Bone Marrow Transplant Sales Market Share
Table Global 2012-2017E Bone Marrow Transplant Sales (K Units) by Type
Table Different Types Bone Marrow Transplant Product Interview Price
Table Global 2012-2017E Bone Marrow Transplant Sales (K Units) by Application
Table Different Application Bone Marrow Transplant Product Interview Price
Table AllCells (USA) Information List
Table Product A Overview
Table Product B Overview
Table 2016 AllCells (USA) Bone Marrow Transplant Revenue (Million USD), Sales (K Units), Ex-factory Price (USD/Unit)
Figure 2016 AllCells (USA) Bone Marrow Transplant Business Region Distribution
Table Lonza (Switzerland) Information List
Table Product A Overview
Table Product B Overview
Table 2016 Lonza (Switzerland) Bone Marrow Transplant Revenue (Million USD), Sales (K Units), Ex-factory Price (USD/Unit)
Figure 2016 Lonza (Switzerland) Bone Marrow Transplant Business Region Distribution
Table Merck (USA) Information List
Table Product A Overview
Table Product B Overview
Table 2015 Merck (USA) Bone Marrow Transplant Revenue (Million USD), Sales (K Units), Ex-factory Price (USD/Unit)
Figure 2016 Merck (USA) Bone Marrow Transplant Business Region Distribution
Table Sanofi (France) Information List
Table Product A Overview
Table Product B Overview
Table 2016 Sanofi (France) Bone Marrow Transplant Revenue (Million USD), Sales (K Units), Ex-factory Price (USD/Unit)
Figure 2016 Sanofi (France) Bone Marrow Transplant Business Region Distribution
Table Translational Biosciences (USA) Information List
Table Product A Overview
Table Product B Overview
Table 2016 Translational Biosciences (USA) Bone Marrow Transplant Revenue (Million USD), Sales (K Units), Ex-factory Price (USD/Unit)
Figure 2016 Translational Biosciences (USA) Bone Marrow Transplant Business Region Distribution
Table Athersys (USA) Information List
Table Product A Overview
Table Product B Overview
Table 2016 Athersys (USA) Bone Marrow Transplant Revenue (Million USD), Sales (K Units), Ex-factory Price (USD/Unit)
Figure 2016 Athersys (USA) Bone Marrow Transplant Business Region Distribution
Table Beike Biotechnology (China) Information List
Table Product A Overview
Table Product B Overview
Table 2016 Beike Biotechnology (China) Bone Marrow Transplant Revenue (Million USD), Sales (K Units), Ex-factory Price (USD/Unit)
Figure 2016 Beike Biotechnology (China) Bone Marrow Transplant Business Region Distribution
Table BioTime (USA) Information List
Table Product A Overview
Table Product B Overview
Table 2016 BioTime (USA) Bone Marrow Transplant Revenue (Million USD), Sales (K Units), Ex-factory Price (USD/Unit)
Figure 2016 BioTime (USA) Bone Marrow Transplant Business Region Distribution
Table Bluebird Bio (USA) Information List
Table Product A Overview
Table Product B Overview
Table 2016 Bluebird Bio (USA) Bone Marrow Transplant Revenue (Million USD), Sales (K Units), Ex-factory Price (USD/Unit)
Figure 2016 Bluebird Bio (USA) Bone Marrow Transplant Business Region Distribution
Table Caladrius (USA) Information List
Table Product A Overview
Table Product B Overview
Table 2016 Caladrius (USA) Bone Marrow Transplant Revenue (Million USD), Sales (K Units), Ex-factory Price (USD/Unit)
Figure 2016 Caladrius (USA) Bone Marrow Transplant Business Region Distribution
Table Cellular Biomedicine Group (USA) Information List
Table Cesca Therapeutics (USA) Information List
Table TiGenix (Belgium) Information List
Table CHA Biotech (Korea) Information List
Table Chugai Pharmaceutical (UK) Information List
Table CORESTEM (Korea) Information List
Table Gamida Cell (USA) Information List
Table Histocell (Spain) Information List
Table Hemostemix (Canada) Information List
Figure Global 2017-2022 Bone Marrow Transplant Market Size (K Units) and Growth Rate Forecast
Figure Global 2017-2022 Bone Marrow Transplant Market Size (Million USD) and Growth Rate Forecast
Figure Global 2017-2022 Bone Marrow Transplant Sales Price (USD/Unit) Forecast
Figure North America 2017-2022 Bone Marrow Transplant Consumption Volume (K Units) and Growth Rate Forecast
Figure China 2017-2022 Bone Marrow Transplant Consumption Volume (K Units) and Growth Rate Forecast
Figure Europe 2017-2022 Bone Marrow Transplant Consumption Volume (K Units) and Growth Rate Forecast
Figure Southeast Asia 2017-2022 Bone Marrow Transplant Consumption Volume (K Units) and Growth Rate Forecast
Figure Japan 2017-2022 Bone Marrow Transplant Consumption Volume (K Units) and Growth Rate Forecast
Figure India 2017-2022 Bone Marrow Transplant Consumption Volume (K Units) and Growth Rate Forecast
Table Global Sales Volume (K Units) of Bone Marrow Transplant by Type 2017-2022
Table Global Consumption Volume (K Units) of Bone Marrow Transplant by Application 2017-2022
Table Traders or Distributors with Contact Information of Bone Marrow Transplant by Region