Viral core protein inhibitors - Pipeline Insight, 2022

January 2022 | 60 pages | ID: VDD22A6C99A0EN
DelveInsight

Abstracts

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DelveInsight’s, “Viral core protein inhibitors - Pipeline Insight, 2022” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Viral core protein inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Viral core protein inhibitors Understanding

Viral core protein inhibitors: Overview

The core or capsid protein is essential to virion assembly and structure, interacts with several host cell proteins, and is the most conserved of all of the viral proteins across the six major genotypes. The core protein oligomerizes during the process of viral assembly, and a screen evaluating dimerization, a process mediated by the N-terminal domain, identified small-molecule inhibitors from a library of indoline derivatives. Core inhibitors, also known as capsid assembly modulators or core protein allosteric modulators, are a novel class of HBV replication inhibitors that have been shown to act at multiple steps in the HBV lifecycle.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence Viral core protein inhibitors R&D. The therapies under development are focused on novel approaches for Viral core protein inhibitors.

Viral core protein inhibitors Emerging Drugs Chapters

This segment of the Viral core protein inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Viral core protein inhibitors Emerging Drugs

• Vebicorvir: Assembly Biosciences

Vebicorvir, first-generation core inhibitor is being developed by Assembly Biosciences. In Phase 2 clinical trials, first-generation core inhibitor vebicorvir (VBR) administered with nucleos(t)ide analogue reverse transcriptase inhibitor (NrtI) therapy demonstrated a favorable safety profile and led to greater viral suppression of both HBV DNA and HBV pgRNA than NrtI therapy alone. VBR is advancing in multiple Phase 2 combination studies. Vebicorvir have been granted Fast Track designation by the U.S. Food and Drug Administration for the treatment of chronic HBV infection.

• Morphothiadine: HEC Pharm

Morphothiadine (GLS4), a HAP (heteroaryl-di-hydro-pyrimidines) compound is being developed by HEC Pharm Group, for the oral treatment of hepatitis B.

Further product details are provided in the report……..

Viral core protein inhibitors: Therapeutic Assessment

This segment of the report provides insights about the different Viral core protein inhibitors drugs segregated based on following parameters that define the scope of the report, such as:

• Major Players working on Viral core protein inhibitors

There are approx. 5+ key companies which are developing the Viral core protein inhibitors. The companies which have their Viral core protein inhibitors drug candidates in the most advanced stage, i.e. Phase II include, Assembly Biosciences.

• Phases

DelveInsight’s report covers around 5+ products under different phases of clinical development like

• Late-stage products (Phase III and
• Mid-stage products (Phase II and
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Viral core protein inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Infusion
• Intradermal
• Intramuscular
• Intranasal
• Intravaginal
• Oral
• Parenteral
• Subcutaneous
• Topical
• Molecule Type

Products have been categorized under various Molecule types such as

• Vaccines
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Viral core protein inhibitors: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Viral core protein inhibitors therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Viral core protein inhibitors drugs.

Viral core protein inhibitors Report Insights

• Viral core protein inhibitors Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Viral core protein inhibitors Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

• How many companies are developing Viral core protein inhibitors drugs?
• How many Viral core protein inhibitors drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Viral core protein inhibitors?
• What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Viral core protein inhibitors therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Viral core protein inhibitors and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Assembly Biosciences
• HEC Pharm
• Janssen Sciences Ireland
• Enanta Pharmaceuticals
• Fujian Cosunter Pharmaceutical
• Door Pharmaceuticals

Key Products

• Vebicorvir
• GLS4
• Bersacapavir
• EDP 514
• GST HG141
• ABI H3733
• ABI 4334
• Research programme: HBV core protein modulators

Contents

Introduction
Executive Summary
Viral core protein inhibitors: Overview
  Structure
  Mechanism of Action
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Viral core protein inhibitors – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
  Comparative Analysis
Drug name: Company name
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
  Comparative Analysis
Vebicorvir: Assembly Biosciences
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I and I/II)
  Comparative Analysis
EDP 514: Enanta Pharmaceuticals
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
  Comparative Analysis
ABI 4334: Assembly Biosciences
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
  Comparative Analysis
Viral core protein inhibitors Key Companies
Viral core protein inhibitors Key Products
Viral core protein inhibitors- Unmet Needs
Viral core protein inhibitors- Market Drivers and Barriers
Viral core protein inhibitors- Future Perspectives and Conclusion
Viral core protein inhibitors Analyst Views
Viral core protein inhibitors Key Companies
Appendix
Introduction
Executive Summary
Viral core protein inhibitors: Overview
  Structure
  Mechanism of Action
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Viral core protein inhibitors – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
  Comparative Analysis
Drug name: Company name
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
  Comparative Analysis
Vebicorvir: Assembly Biosciences
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I and I/II)
  Comparative Analysis
EDP 514: Enanta Pharmaceuticals
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
  Comparative Analysis
ABI 4334: Assembly Biosciences
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
  Comparative Analysis
Viral core protein inhibitors Key Companies
Viral core protein inhibitors Key Products
Viral core protein inhibitors- Unmet Needs
Viral core protein inhibitors- Market Drivers and Barriers
Viral core protein inhibitors- Future Perspectives and Conclusion
Viral core protein inhibitors Analyst Views
Viral core protein inhibitors Key Companies
Appendix