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Vertigo - Pipeline Insight, 2021

May 2021 | 60 pages | ID: VFCBA47E398AEN
DelveInsight

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DelveInsight’s, “Vertigo - Pipeline Insight, 2021,” report provides comprehensive insights about 3+ companies and 3+ pipeline drugs in Vertigo pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
Vertigo Understanding

Vertigo: Overview

Vertigo is a symptom, rather than a condition itself. It's the sensation that you, or the environment around you, is moving or spinning. This feeling may be barely noticeable, or it may be so severe that you find it difficult to keep your balance and do everyday tasks. Attacks of vertigo can develop suddenly and last for a few seconds, or they may last much longer. If you have severe vertigo, your symptoms may be constant and last for several days, making normal life very difficult. Vertigo is commonly caused by a problem with the way balance works in the inner ear, although it can also be caused by problems in certain parts of the brain. Some cases of vertigo improve over time, without treatment. However, some people have repeated episodes for many months, or even years, such as those with Mйni?re's disease. There are specific treatments for some causes of vertigo. A series of simple head movements (known as the Epley manoeuvre) is used to treat BPPV. Medicines, such as prochlorperazine and some antihistamines, can help in the early stages or most cases of vertigo.

'Vertigo - Pipeline Insight, 2021' report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Vertigo pipeline landscape is provided which includes the disease overview and Vertigo treatment guidelines. The assessment part of the report embraces, in depth Vertigo commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Vertigo collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence Vertigo R&D. The therapies under development are focused on novel approaches to treat/improve Vertigo.
Vertigo Emerging Drugs Chapters

This segment of the Vertigo report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Vertigo Emerging Drugs
  • AM-125: Auris Medical
Auris Medical is developing AM-125, an intranasal formulation of betahistine, for the treatment of vertigo. The intranasal delivery of AM-125 is intended to bypass the effects of first-pass metabolism found with oral delivery of betahistine. This is expected to offer significant additional benefits in terms of efficacy and tolerability. Betahistine is a small molecule drug that acts as a partial histamine H1-receptor agonist and a H3-receptor antagonist. The compound has demonstrated increased cochlear, vestibular and cerebral blood flow, vestibular compensation and the ability to inhibit neuronal firing in the vestibular nuclei. In the case of vertigo, the objective is to restore balance. AM-125 is currently in Phase 2 development
  • Seliforant: Sensorion
Seliforant (formerly SENS-111) is the first representative candidate of the histamine type 4 receptor antagonist class to be tested for the symptomatic treatment of vertigo crises. Displaying a neuromodulation effect of the sensorineural inner ear cell function, Seliforant is a small molecule that can be taken orally or via a standard injection, and is currently in a separate Phase 2 clinical trial.

Further product details are provided in the report

Vertigo: Therapeutic Assessment

This segment of the report provides insights about the different Vertigo drugs segregated based on following parameters that define the scope of the report, such as:
  • Major Players in Vertigo
There are approx. 3+ key companies which are developing the therapies for Vertigo. The companies which have their Vertigo drug candidates in the most advanced stage, i.e. phase II include, Auris Medical.
  • Phases
DelveInsight’s report covers around 3+ products under different phases of clinical development like
  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
Vertigo pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Oral
  • Parenteral
  • intravitreal
  • Subretinal
  • Topical.
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Vertigo: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Vertigo therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Vertigo drugs.

Vertigo Report Insights
  • Vertigo Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
Vertigo Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions

Current Treatment Scenario and Emerging Therapies:
  • How many companies are developing Vertigo drugs?
  • How many Vertigo drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Vertigo?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Vertigo therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Vertigo and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • Auris Medical
  • Sensorion
  • Apsen Farmaceutica
  • Otonomy
  • Sound Pharmaceuticals
Key Products
  • AM-125
  • Seliforant
  • APSLXR
  • OTO-104
  • SPI-1005
Introduction
Executive Summary
Vertigo: Overview
  Causes
  Mechanism of Action
  Signs and Symptoms
  Diagnosis
  Disease Management
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Vertigo – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
  Vertigo companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Vertigo Collaboration Deals
  Company-Company Collaborations (Licensing / Partnering) Analysis
  Company-University Collaborations (Licensing / Partnering) Analysis
Mid Stage Products (Phase II)
  Comparative Analysis
AM-125: Auris Medical
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report
Early Stage Products (Phase I)
  Comparative Analysis
APSLXR: Apsen Farmaceutica
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report
Inactive Products
  Comparative Analysis
Vertigo Key Companies
Vertigo Key Products
Vertigo- Unmet Needs
Vertigo- Market Drivers and Barriers
Vertigo- Future Perspectives and Conclusion
Vertigo Analyst Views
Vertigo Key Companies
Appendix

LIST OF TABLES

Table 1 Total Products for Vertigo
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products

LIST OF FIGURES

Figure 1 Total Products for Vertigo
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products


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