TRAIL receptor 2 agonists - Pipeline Insight, 2022

January 2022 | 60 pages | ID: TB3BB3E6D6FDEN
DelveInsight

Abstracts

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DelveInsight’s, “TRAIL receptor 2 agonists - Pipeline Insight, 2022” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in TRAIL receptor 2 agonists pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

TRAIL receptor 2 agonists Understanding

TRAIL receptor 2 agonists: Overview

TRAIL receptor 2 (TRAILR2), also known as Death receptor 5 (DR5), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in neoplastic cells upon binding to its receptors TRAIL-R1 and TRAIL-R2. This biological principle has been adopted for the development of cancer-selective therapies. However, many tumor cells are resistant to TRAIL and moreover TRAIL-R1/R2 can activate pro-inflammatory pathways thereby promoting invasion, migration, and metastasis

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence TRAIL receptor 2 agonists R&D. The therapies under development are focused on novel approaches for TRAIL receptor 2 agonists.

TRAIL receptor 2 agonists Emerging Drugs Chapters

This segment of the TRAIL receptor 2 agonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

TRAIL receptor 2 agonists Emerging Drugs

• INBRX-109: Inhibrx

INBRX-109 is a tetravalent DR5 agonistic antibody, is designed to exploit tumor-biased direct cell death induction by DR5 activation in numerous cancer types. With a valency of four, it has the ability to potently agonize DR5 through efficient receptor clustering, causing cell death, but by way of our sdAb platform, also eliminates recognition by pre-existing anti-drug antibodies (ADAs) to lessen the potential for hyper-clustering. In January 2021, the U.S. Food and Drug Administration (FDA) granted Fast Track designation to INBRX-109 for the treatment of patients with unresectable or metastatic conventional chondrosarcoma.

• BI 905711: Travere Therapeutics

BI 905711 is a tetravalent bispecific antibody that cross-links the pro-apoptotic tumor necrosis factor (TNF)-related apoptosis-inducing ligand receptor 2 (TRAILR2) with the tumor cell anchor cadherin 17 (CDH17). CDH17-dependent clustering of TRAILR2 allows BI 905711 to induce selective apoptosis in CDH17-expressing tumor cells. BI 905711 is currently being investigated in patients with advanced gastrointestinal (GI) cancers.

Further product details are provided in the report……..

TRAIL receptor 2 agonists: Therapeutic Assessment

This segment of the report provides insights about the different TRAIL receptor 2 agonists drugs segregated based on following parameters that define the scope of the report, such as:

• Major Players working on TRAIL receptor 2 agonists

There are approx. 5+ key companies which are developing the TRAIL receptor 2 agonists. The companies which have their TRAIL receptor 2 agonists drug candidates in the most advanced stage, i.e. Phase II include, Inhibrx.

• Phases

DelveInsight’s report covers around 5+ products under different phases of clinical development like

• Late-stage products (Phase III and
• Mid-stage products (Phase II and
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

TRAIL receptor 2 agonists pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Infusion
• Intradermal
• Intramuscular
• Intranasal
• Intravaginal
• Oral
• Parenteral
• Subcutaneous
• Topical
• Molecule Type

Products have been categorized under various Molecule types such as

• Vaccines
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

TRAIL receptor 2 agonists: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses TRAIL receptor 2 agonists therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging TRAIL receptor 2 agonists drugs.

TRAIL receptor 2 agonists Report Insights

• TRAIL receptor 2 agonists Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

TRAIL receptor 2 agonists Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

• How many companies are developing TRAIL receptor 2 agonists drugs?
• How many TRAIL receptor 2 agonists drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of TRAIL receptor 2 agonists?
• What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the TRAIL receptor 2 agonists therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for TRAIL receptor 2 agonists and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Inhibrx
• Boehringer Ingelheim
• IGM Biosciences
• Amgen
• Genmab
• Theraly Fibrosis
• IGM Biosciences

Key Products

• INBRX-109
• BI 905711
• IGM 8444
• Conatumumab
• Benufutamab
• TLY 012
• Anti-DR5 IgM antibody

Contents

Introduction
Executive Summary
TRAIL receptor 2 agonists: Overview
  Structure
  Mechanism of Action
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
TRAIL receptor 2 agonists – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
  Comparative Analysis
Drug name: Company name
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
  Comparative Analysis
INBRX-109: Inhibrx
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
  Comparative Analysis
BI 905711: Boehringer Ingelheim
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
  Comparative Analysis
TLY 012: Theraly Fibrosis
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
  Comparative Analysis
TRAIL receptor 2 agonists Key Companies
TRAIL receptor 2 agonists Key Products
TRAIL receptor 2 agonists- Unmet Needs
TRAIL receptor 2 agonists- Market Drivers and Barriers
TRAIL receptor 2 agonists- Future Perspectives and Conclusion
TRAIL receptor 2 agonists Analyst Views
TRAIL receptor 2 agonists Key Companies
Appendix