[email protected] +44 20 8123 2220 (UK) +1 732 587 5005 (US) Contact Us | FAQ |

Stargardt Disease - Pipeline Insight, 2021

July 2021 | 60 pages | ID: S1692A26E80EEN
DelveInsight

US$ 1,500.00

E-mail Delivery (PDF)

Download PDF Leaflet

Accepted cards
Wire Transfer
Checkout Later
Need Help? Ask a Question
This report can be delivered to the clients within 72 Hours

DelveInsight’s, “Stargardt Disease - Pipeline Insight, 2021,” report provides comprehensive insights about 18+ companies and 18+ pipeline drugs in Stargardt Disease pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
Stargardt Disease Understanding

Stargardt Disease: Overview

Stargardt disease is an inherited disorder of the retina — the tissue at the back of the eye that senses light. The disease typically causes vision loss during childhood or adolescence, although in some forms, vision loss may not be noticed until later in adulthood. It is rare for people with the disease to become completely blind. For most people, vision loss progresses slowly over time to 20/200 or worse. (Normal vision is 20/20). The most common symptom of Stargardt disease is variable, often slow loss of central vision in both eyes. People with the disease might notice gray, black, or hazy spots in the center of their vision, or that it takes longer than usual for their eyes to adjust when moving from light to dark environments. Their eyes may be more sensitive to bright light. Some people also develop color blindness later in the disease.

'Stargardt Disease - Pipeline Insight, 2021' report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Stargardt Disease pipeline landscape is provided which includes the disease overview and Stargardt Disease treatment guidelines. The assessment part of the report embraces, in depth Stargardt Disease commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Stargardt Disease collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence Stargardt Disease R&D. The therapies under development are focused on novel approaches to treat/improve Stargardt Disease.
Stargardt Disease Emerging Drugs Chapters

This segment of the Stargardt Disease report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Stargardt Disease Emerging Drugs
  • Emixustat hydrochloride: Kubota Vision
Emixustat modulates the visual cycle by inhibiting a critical enzyme of this pathway, retinal pigment epithelium protein 65 (RPE65). The visual cycle is the process by which vitamin A is recycled in the eye; vitamin A is crucial to the visual process. Slowing the visual cycle reduces the availability of vitamin A derivatives (11-cis- and all-trans-retinal) to form precursors of toxic A2E and related compounds. In addition, reducing the availability of 11-cis-retinal decreases retinal metabolic demands under dark conditions. Currently, it is in Phase III stage of clinical trial evaluation to treat Stargardt Disease.
  • ALK-001: Alkeus Pharmaceuticals
ALK-001 is a chemically-modified vitamin A being investigated for the prevention and treatment of Stargardt disease and age-related macular degeneration (AMD). ALK-001 is taken once a day by mouth. Toxic vitamin A aggregates (“dimers”) have been implicated in the pathophysiology of Stargardt and dry-AMD. Vitamin A dimers form when two molecules of vitamin A are combined. ALK-001 is a form of vitamin A that has been chemically-modified to slow the formation of toxic vitamin A dimers in the eye.

Further product details are provided in the report……..

Stargardt Disease: Therapeutic Assessment

This segment of the report provides insights about the different Stargardt Disease drugs segregated based on following parameters that define the scope of the report, such as:
  • Major Players in Stargardt Disease
There are approx. 18+ key companies which are developing the therapies for Stargardt Disease. The companies which have their Stargardt Disease drug candidates in the most advanced stage, i.e. phase III include, Kubota Vision.
  • Phases
DelveInsight’s report covers around 18+ products under different phases of clinical development like
  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
Stargardt Disease pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Oral
  • Parenteral
  • intravitreal
  • Subretinal
  • Topical.
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Stargardt Disease: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Stargardt Disease therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Stargardt Disease drugs.

Stargardt Disease Report Insights
  • Stargardt Disease Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
Stargardt Disease Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions

Current Treatment Scenario and Emerging Therapies:
  • How many companies are developing Stargardt Disease drugs?
  • How many Stargardt Disease drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Stargardt Disease?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Stargardt Disease therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Stargardt Disease and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • Kubota Vision
  • Alkeus Pharmaceuticals
  • IVERIC bio
  • Generation Bio
  • Nanoscope Therapeutics
  • Stargazer Pharmaceuticals, Inc.
  • Astellas Pharma
  • Spark Therapeutics
  • Katairo
  • Vitrisa Therapeutics
  • Biophytis
  • Belite Bio
  • Biogen
  • ReVision Therapeutics
  • Applied Genetic Technologies Corporation
  • Beam Therapeutics
  • Curative Biotechnology
  • ProQR Therapeutics
  • 4P-Pharma
  • Coave Therapeutics
  • Abeona Therapeutics
  • Connectyx
Key Products
  • Emixustat hydrochloride
  • ALK-001
  • Avacincaptad pegol
  • MCO 010
  • STG-001
  • MA09-hRPE
  • Soraprazan
  • Macuneos
  • BPN-14967
  • NSR-BEST1
  • CVZ 002
  • AAV2/5-GRK1-hRPGRco
  • Metformin
  • 4P-020
  • CTx-ABCA4
  • REV-0100
Introduction
Executive Summary
Stargardt Disease: Overview
  Causes
  Mechanism of Action
  Signs and Symptoms
  Diagnosis
  Disease Management
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Late Stage Products (Phase III)
  Comparative Analysis
Emixustat hydrochloride: Kubota Vision
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
  Comparative Analysis
ALK-001: Alkeus Pharmaceuticals
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..

Early Stage Products (Phase I/II)
  Comparative Analysis
BPN-14967: Belite Bio
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
  Comparative Analysis
REV-0100: ReVision Therapeutics
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..

Inactive Products
  Comparative Analysis
Stargardt Disease Key Companies
Stargardt Disease Key Products
Stargardt Disease- Unmet Needs
Stargardt Disease- Market Drivers and Barriers
Stargardt Disease- Future Perspectives and Conclusion
Stargardt Disease Analyst Views
Stargardt Disease Key Companies
Appendix


LIST OF TABLES

Table 1 Total Products for Stargardt Disease
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products


LIST OF FIGURES

Figure 1 Total Products for Stargardt Disease
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products


More Publications