Placenta growth factor inhibitors - Pipeline Insight, 2022

January 2022 | 60 pages | ID: P95BC9649EBDEN
DelveInsight

Abstracts

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DelveInsight’s, “Placenta Growth Factor Inhibitors - Pipeline Insight, 2022” report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in Placenta Growth Factor Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Placenta Growth Factor Inhibitors Understanding

Placenta Growth Factor Inhibitors: Overview

Placental Growth Factor (PlGF) is a pleiotropic cytokine, similar to vascular endothelial growth factor (VEGF), which binds to its membrane bound receptor—fms tyrosine kinase 1 (Flt-1) to stimulate angiogenesis.

Function - The placental growth factor (PGF) gene is a protein-coding gene and a member of the vascular endothelial growth factor (VEGF) family. The PGF gene is expressed only in human umbilical vein endothelial cells (HUVE) and the placenta. PGF is ultimately associated with angiogenesis. Specifically, PGF plays a role in trophoblast growth and differentiation. Trophoblast cells, specifically extravillous trophoblast cells, are responsible for invading the uterine wall and the maternal spiral arteries. The extravillous trophoblast cells produce a blood vessel of larger diameter for the developing fetus that is independent of maternal vasoconstriction. This is essential for increased blood flow and reduced resistance.

Placenta Growth Factor Inhibitors - PlGF plays a significant role in experimental CNV. Increased levels of PlGF have also been reported in eyes of patients with diabetes and interference with its receptor during oxygen-induced ischemic retinopathy (OIR) inhibits neovascularization. Therefore, targeting PlGF may be a promising strategy for treatment of eye diseases with a neovascular component including diabetic retinopathy, retinopathy of prematurity and exudative AMD.

Placenta Growth Factor Inhibitors Emerging Drugs Chapters

This segment of the Placenta Growth Factor Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Placenta Growth Factor Inhibitors Emerging Drugs

• FYB203: Bioeq

FYB203 is a biosimilar of aflibercept (Eylea®) which was licensed by Santo Holding from Formycon AG in May 2015. Similarly to Lucentis®, Eylea® is prescribed for the treatment of neovascular age-related macular degeneration (neovascular AMD) and other serious eye conditions. Currently, it is in phase 3 of development stage for the treatment of Wet age-related macular degeneration.

• ABP 938: Amgen

ABP 938 (aflibercept), a biosimilar candidate to EYLEA, is a vascular endothelial growth factor receptor (VEGFR) Fc fusion protein. Currently, it is in phase 3 of development stage for the treatment of Wet age-related macular degeneration.

Further product details are provided in the report……..

Placenta Growth Factor Inhibitors: Therapeutic Assessment

This segment of the report provides insights about the different Placenta Growth Factor Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:

• Major Players working on Placenta Growth Factor Inhibitors

There are approx. 15+ key companies which are developing the Placenta Growth Factor Inhibitors. The companies which have their Placenta Growth Factor Inhibitors drug candidates in the most advanced stage, i.e. phase III include, Bioeq.

• Phases

DelveInsight’s report covers around 15+ products under different phases of clinical development like

• Late-stage products (Phase III and
• Mid-stage products (Phase II and
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Placenta Growth Factor Inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Infusion
• Intradermal
• Intramuscular
• Intranasal
• Intravaginal
• Oral
• Parenteral
• Subcutaneous
• Topical.
• Molecule Type

Products have been categorized under various Molecule types such as

• Vaccines
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Placenta Growth Factor Inhibitors: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Placenta Growth Factor Inhibitors therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Placenta Growth Factor Inhibitors drugs.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence Placenta Growth Factor Inhibitors R&D. The therapies under development are focused on novel approaches for Placenta Growth Factor Inhibitors.

Placenta Growth Factor Inhibitors Report Insights

• Placenta Growth Factor Inhibitors Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Placenta Growth Factor Inhibitors Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

• How many companies are developing Placenta Growth Factor Inhibitors drugs?
• How many Placenta Growth Factor Inhibitors drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for Placenta Growth Factor Inhibitors?
• What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Placenta Growth Factor Inhibitors therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Placenta Growth Factor Inhibitors and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Regeneron
• Ocular Therapeutix
• Alteogen
• 4D Molecular Therapeutics
• Celltrion
• Amgen
• Sam Chun Dang Pharm
• Samsung Bioepis
• Bioeq
• Prestige Biopharma
• Luye Pharma
• GlycoNex
• Momenta Pharmaceuticals
• Alteogen
• HEXAL
• Bayer

Key Products

• OTX-AFS
• ALT L9
• 4D 150
• CT-P42
• ABP 938
• SCD-411
• SB-15
• FYB203
• PBP 1602
• LY-09004
• SEA Aflibercept Biosimilar
• M-710
• REGN 910-3
• ALT L9
• SOK583A1
• BAY-865321

Contents

Introduction
Executive Summary
Placenta Growth Factor Inhibitors: Overview
  Structure
  Mechanism of Action
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Placenta Growth Factor Inhibitors – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
  Placenta Growth Factor Inhibitors companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Placenta Growth Factor Inhibitors Collaboration Deals
  Company-Company Collaborations (Licensing / Partnering) Analysis
  Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
  Comparative Analysis
FYB203: Bioeq
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
  Comparative Analysis
REGN 910-3: Regeneron Pharmaceuticals
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
  Comparative Analysis
ALT L9: Alteogen
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
  Comparative Analysis

4D 150: 4D MOLECULAR THERAPEUTICS

  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
  Comparative Analysis
Placenta Growth Factor Inhibitors Key Companies
Placenta Growth Factor Inhibitors Key Products
Placenta Growth Factor Inhibitors- Unmet Needs
Placenta Growth Factor Inhibitors- Market Drivers and Barriers
Placenta Growth Factor Inhibitors- Future Perspectives and Conclusion
Placenta Growth Factor Inhibitors Analyst Views
Placenta Growth Factor Inhibitors Key Companies
Appendix