Interleukin 6 inhibitors - Pipeline Insight, 2022

January 2022 | 60 pages | ID: I3EB00E27756EN
DelveInsight

Abstracts

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DelveInsight’s, “Interleukin 6 inhibitors - Pipeline Insight, 2022” report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in Interleukin 6 inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Interleukin 6 inhibitors Understanding

Interleukin 6 inhibitors: Overview

Interleukin-6 (IL-6) is a protein produced by various cells. It helps regulate immune responses, which makes the IL-6 test potentially useful as a marker of immune system activation. IL-6 can be elevated with inflammation, infection, autoimmune disorders, cardiovascular diseases, and some cancers. The test measures the amount of IL-6 in the blood. Interleukin-6 is one of a large group of molecules called cytokines. Cytokines have multiple roles to play within the body and act especially within the immune system to help direct the body’s immune response. They are a part of the “inflammatory cascade” that involves the coordinated, sequential activation of immune response pathways. Anti-interleukin-6 agents are a class of therapeutics. Interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers. Hence, anti-IL6 agents have been sought. In rheumatoid arthritis they can help patients unresponsive to TNF inhibitors.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence Interleukin 6 inhibitors R&D. The therapies under development are focused on novel approaches for Interleukin 6 inhibitors.

Interleukin 6 inhibitors Emerging Drugs Chapters

This segment of the Interleukin 6 inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Interleukin 6 inhibitors Emerging Drugs

• Ziltivekimab: Novo Nordisk

Ziltivekimab is a fully human monoclonal antibody designed to lower systemic inflammation through inhibition of IL-6 (a pro-inflammatory cytokine with a causal role in atherosclerosis). With its extended half-life technology, ziltivekimab has been designed to enable once-monthly administration by subcutaneous (SC) injection. Ziltivekimab is being developed by Novo Nordisk following the acquisition of Corvidia Therapeutics, announced in June 2020.

• Siltuximab: EUSA Pharma

Siltuximab is a monoclonal antibody that directly neutralizes interleukin (IL)-6, an inflammatory cytokine detected at elevated levels in multiple inflammatory conditions, of which potentially there may be a role in patients with COVID-19. It is currently approved by the FDA and the European Medicines Agency (EMA) as well as regulatory bodies in a number of other jurisdictions worldwide, for the treatment of patients with multicentric Castleman disease (MCD). Currently, it is in phase 3 stage of clinical trial evaluation to treat SARS-CoV-2 acute respiratory disease.

Further product details are provided in the report……..

Interleukin 6 inhibitors: Therapeutic Assessment

This segment of the report provides insights about the different Interleukin 6 inhibitors drugs segregated based on following parameters that define the scope of the report, such as:

• Major Players working on Interleukin 6 inhibitors

There are approx. 15+ key companies which are developing the Interleukin 6 inhibitors. The companies which have their Interleukin 6 inhibitors drug candidates in the most advanced stage, i.e. Phase III include, Novo Nordisk.

• Phases

DelveInsight’s report covers around 15+ products under different phases of clinical development like

• Late-stage products (Phase III and
• Mid-stage products (Phase II and
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Interleukin 6 inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Infusion
• Intradermal
• Intramuscular
• Intranasal
• Intravaginal
• Oral
• Parenteral
• Subcutaneous
• Topical
• Molecule Type

Products have been categorized under various Molecule types such as

• Vaccines
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Interleukin 6 inhibitors: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Interleukin 6 inhibitors therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Interleukin 6 inhibitors drugs.

Interleukin 6 inhibitors Report Insights

• Interleukin 6 inhibitors Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Interleukin 6 inhibitors Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

• How many companies are developing Interleukin 6 inhibitors drugs?
• How many Interleukin 6 inhibitors drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Interleukin 6 inhibitors?
• What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Interleukin 6 inhibitors therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Interleukin 6 inhibitors and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Novo Nordisk
• EUSA Pharma
• Celgene Corporation
• R-Pharm
• Emphycorp
• Fountain BioPharma
• Hutchison MediPharma
• Kodiak Sciences
• NeurMedix
• Kodiak Sciences
• Starton Therapeutics
• Peptinov
• Biocad
• Qyuns Therapeutics
• Bio-Thera Solutions
• Janssen Biotech
• Signpath Pharma
• CSL Behring

Key Products

• Ziltivekimab
• Siltuximab
• Pomalidomide
• Clazakizumab
• Olokizumab
• N115
• FB 704A
• HMPL 004
• CNTO-136
• BAT-1806
• KSI 501
• QX-003S
• Lenalidomide
• BCD-089
• PPV 06
• Lipocurcumin

Contents

Introduction
Executive Summary
Interleukin 6 inhibitors: Overview
  Structure
  Mechanism of Action
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Interleukin 6 inhibitors – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
  Comparative Analysis
Ziltivekimab: Novo Nordisk
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
  Comparative Analysis
FB 704A: Fountain BioPharma
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
  Comparative Analysis
PPV 06: Peptinov
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
  Comparative Analysis
KSI 501: Kodiak Sciences
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
  Comparative Analysis
Interleukin 6 inhibitors Key Companies
Interleukin 6 inhibitors Key Products
Interleukin 6 inhibitors- Unmet Needs
Interleukin 6 inhibitors- Market Drivers and Barriers
Interleukin 6 inhibitors- Future Perspectives and Conclusion
Interleukin 6 inhibitors Analyst Views
Interleukin 6 inhibitors Key Companies
Appendix