Integrin alpha4beta1 antagonists - Pipeline Insight, 2022

January 2022 | 60 pages | ID: IE42261E2ED4EN
DelveInsight

Abstracts

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DelveInsight’s, “Integrin alpha4beta1 antagonists - Pipeline Insight, 2022” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Integrin alpha4beta1 antagonists pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Integrin alpha4beta1 antagonists Understanding

Integrin alpha4beta1 antagonists: Overview

Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins ?IIb?3, ?4?7/?4?1 and ?L?2 for cardiovascular diseases, inflammatory bowel disease/multiple sclerosis and dry eye disease, respectively. The related integrins ?4?7 and ?4?1 are therapeutic targets that are expressed on leukocytes and also recognize short peptide sequences, one of which is Leu–Asp–Val (LDV). There is some preclinical evidence that ?3?1 (ref.82), ?4?1 (ref.83) and ?8?1 integrins play a role in pulmonary fibrosis, and that ?v?8 is important in small airway fibrosis associated with chronic obstructive pulmonary fibrosis and asthma.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence Integrin alpha4beta1 antagonists R&D. The therapies under development are focused on novel approaches for Integrin alpha4beta1 antagonists.

Integrin alpha4beta1 antagonists Emerging Drugs Chapters

This segment of the Integrin alpha4beta1 antagonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Integrin alpha4beta1 antagonists Emerging Drugs

• Natalizumab: Biogen

Natalizumab is a monoclonal anti-integrin antibody which binds to the alpha 4 subunit of integrins to prevent migration of immune cells, and is used to treat Crohn's disease or multiple sclerosis. It Binds to the ?4-subunit of ?4b 1 and ?4b 7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the ?4-mediated adhesion of leukocytes to their counter-receptor(s). Currently, it is being evaluated in phase II stage of development to treat Graft-versus-host disease.

• AXR 159: AxeroVision

AXR-159 is being developed for the treatment of chronic Dry eyes disease (DED). AXR-270 is being developed for the short-term treatment of DED. Currently, it is in phase II stage of development to treat DED.

Further product details are provided in the report……..

Integrin alpha4beta1 antagonists: Therapeutic Assessment

This segment of the report provides insights about the different Integrin alpha4beta1 antagonists drugs segregated based on following parameters that define the scope of the report, such as:

• Major Players working on Integrin alpha4beta1 antagonists

There are approx. 5+ key companies which are developing the Integrin alpha4beta1 antagonists. The companies which have their Integrin alpha4beta1 antagonists drug candidates in the most advanced stage, i.e. Phase II include, Biogen.

• Phases

DelveInsight’s report covers around 5+ products under different phases of clinical development like

• Late-stage products (Phase III and
• Mid-stage products (Phase II and
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Integrin alpha4beta1 antagonists pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Infusion
• Intradermal
• Intramuscular
• Intranasal
• Intravaginal
• Oral
• Parenteral
• Subcutaneous
• Topical
• Molecule Type

Products have been categorized under various Molecule types such as

• Vaccines
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Integrin alpha4beta1 antagonists: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Integrin alpha4beta1 antagonists therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Integrin alpha4beta1 antagonists drugs.

Integrin alpha4beta1 antagonists Report Insights

• Integrin alpha4beta1 antagonists Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Integrin alpha4beta1 antagonists Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

• How many companies are developing Integrin alpha4beta1 antagonists drugs?
• How many Integrin alpha4beta1 antagonists drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Integrin alpha4beta1 antagonists?
• What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Integrin alpha4beta1 antagonists therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Integrin alpha4beta1 antagonists and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Biogen
• AxeroVision
• Polpharma Biologics
• EA Pharma
• BioMAS
• Feramda

Key Products

• Natalizumab
• AXR-159
• PB-006
• AJM 300
• AS 101
• BIIB 107
• SAS

Contents

Introduction
Executive Summary
Integrin alpha4beta1 antagonists: Overview
  Structure
  Mechanism of Action
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Integrin alpha4beta1 antagonists – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
  Comparative Analysis
PB-006: Polpharma Biologics
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
  Comparative Analysis
AXR 159: AxeroVision
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
  Comparative Analysis
BIIB 107: Biogen
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
  Comparative Analysis
SAS: Feramda
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
  Comparative Analysis
Integrin alpha4beta1 antagonists Key Companies
Integrin alpha4beta1 antagonists Key Products
Integrin alpha4beta1 antagonists- Unmet Needs
Integrin alpha4beta1 antagonists- Market Drivers and Barriers
Integrin alpha4beta1 antagonists- Future Perspectives and Conclusion
Integrin alpha4beta1 antagonists Analyst Views
Integrin alpha4beta1 antagonists Key Companies
Appendix