Immunoglobulin inhibitors - Pipeline Insight, 2022
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DelveInsight’s, “Immunoglobulin inhibitors - Pipeline Insight, 2022” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Immunoglobulin inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Immunoglobulin inhibitors: Overview
The interactions between immunoglobulin E (IgE) and its two receptors, Fc?RI and CD23 (Fc?RII), play pivotal roles in allergic disease. Fc?RI is principally expressed on the surface of mast cells and basophils. Allergen mediated cross-linking of Fc?RI-bound IgE on the surface of these IgE-sensitized cells triggers degranulation and release of inflammatory mediators. CD23 is expressed in membrane-bound (mCD23) and soluble forms, the latter existing as monomeric or trimeric fragments. Inhibiting the interaction between IgE and Fc?RI, but not CD23, is thus a potentially promising therapeutic approach in the treatment of allergic disease.
The importance of immunoglobulin E (IgE) in atopic disorders such as asthma, allergic rhinitis, food allergies, and atopic dermatitis is well established. Elevation of total serum IgE is typically found in many atopic patients, and in predisposed individuals, allergen-specific IgE is produced. The availability of humanized monoclonal antibodies against IgE has provided a new therapeutic option and tool to explore the role IgE in allergic diseases and the effects of inhibiting IgE itself. Clinically, anti-IgE therapy has already been proven to be useful in the treatment of asthma and allergic rhinitis.
Report Highlights
This segment of the Immunoglobulin inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Immunoglobulin inhibitors Emerging Drugs
It is currently in Phase III stage of development and is being developed by Novartis.
Further product details are provided in the report……..
Immunoglobulin inhibitors: Therapeutic Assessment
This segment of the report provides insights about the different Immunoglobulin inhibitors drugs segregated based on following parameters that define the scope of the report, such as:
Immunoglobulin inhibitors: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Immunoglobulin inhibitors therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Immunoglobulin inhibitors drugs.
Immunoglobulin inhibitors Report Insights
Current Scenario and Emerging Therapies:
DelveInsight’s, “Immunoglobulin inhibitors - Pipeline Insight, 2022” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Immunoglobulin inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
Immunoglobulin inhibitors: Overview
The interactions between immunoglobulin E (IgE) and its two receptors, Fc?RI and CD23 (Fc?RII), play pivotal roles in allergic disease. Fc?RI is principally expressed on the surface of mast cells and basophils. Allergen mediated cross-linking of Fc?RI-bound IgE on the surface of these IgE-sensitized cells triggers degranulation and release of inflammatory mediators. CD23 is expressed in membrane-bound (mCD23) and soluble forms, the latter existing as monomeric or trimeric fragments. Inhibiting the interaction between IgE and Fc?RI, but not CD23, is thus a potentially promising therapeutic approach in the treatment of allergic disease.
The importance of immunoglobulin E (IgE) in atopic disorders such as asthma, allergic rhinitis, food allergies, and atopic dermatitis is well established. Elevation of total serum IgE is typically found in many atopic patients, and in predisposed individuals, allergen-specific IgE is produced. The availability of humanized monoclonal antibodies against IgE has provided a new therapeutic option and tool to explore the role IgE in allergic diseases and the effects of inhibiting IgE itself. Clinically, anti-IgE therapy has already been proven to be useful in the treatment of asthma and allergic rhinitis.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Immunoglobulin inhibitors R&D. The therapies under development are focused on novel approaches for Immunoglobulin inhibitors.
This segment of the Immunoglobulin inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Immunoglobulin inhibitors Emerging Drugs
- Ligelizumab: Novartis
It is currently in Phase III stage of development and is being developed by Novartis.
Further product details are provided in the report……..
Immunoglobulin inhibitors: Therapeutic Assessment
This segment of the report provides insights about the different Immunoglobulin inhibitors drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players working on Immunoglobulin inhibitors
- Phases
- Late-stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage products (Phase I/II and Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Infusion
- Intradermal
- Intramuscular
- Intranasal
- Intravaginal
- Oral
- Parenteral
- Subcutaneous
- Topical
- Molecule Type
- Vaccines
- Monoclonal Antibody
- Peptides
- Polymer
- Small molecule
- Product Type
Immunoglobulin inhibitors: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Immunoglobulin inhibitors therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Immunoglobulin inhibitors drugs.
Immunoglobulin inhibitors Report Insights
- Immunoglobulin inhibitors Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Scenario and Emerging Therapies:
- How many companies are developing Immunoglobulin inhibitors drugs?
- How many Immunoglobulin inhibitors drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for Immunoglobulin inhibitors?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Immunoglobulin inhibitors therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Immunoglobulin inhibitors and their status?
- What are the key designations that have been granted to the emerging drugs?
- Novartis
- Yuhan
- Hansa Biopharma
- Epsilogen
- Ligelizumab
- YH-35324
- Imlifidase
- MOv18 IgE
Introduction
Executive Summary
Immunoglobulin inhibitors: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Late Stage Products (Phase III)
Comparative Analysis
Ligelizumab: Novartis
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Drug Name: Company Name
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
MOv18 IgE: Epsilogen
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
Comparative Analysis
YH-35324: Yuhan
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Immunoglobulin inhibitors Key Companies
Immunoglobulin inhibitors Key Products
Immunoglobulin inhibitors- Unmet Needs
Immunoglobulin inhibitors- Market Drivers and Barriers
Immunoglobulin inhibitors- Future Perspectives and Conclusion
Immunoglobulin inhibitors Analyst Views
Immunoglobulin inhibitors Key Companies
Appendix
Executive Summary
Immunoglobulin inhibitors: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Late Stage Products (Phase III)
Comparative Analysis
Ligelizumab: Novartis
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Drug Name: Company Name
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
MOv18 IgE: Epsilogen
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
Comparative Analysis
YH-35324: Yuhan
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Immunoglobulin inhibitors Key Companies
Immunoglobulin inhibitors Key Products
Immunoglobulin inhibitors- Unmet Needs
Immunoglobulin inhibitors- Market Drivers and Barriers
Immunoglobulin inhibitors- Future Perspectives and Conclusion
Immunoglobulin inhibitors Analyst Views
Immunoglobulin inhibitors Key Companies
Appendix