Hematopoietic progenitor kinase 1 inhibitors - Pipeline Insight, 2022

January 2022 | 60 pages | ID: H66867300A01EN
DelveInsight

Abstracts

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DelveInsight’s, “Hematopoietic progenitor kinase 1 inhibitors - Pipeline Insight, 2022” report provides comprehensive insights about 6+ companies and 6+ pipeline drugs in Hematopoietic progenitor kinase 1 inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Hematopoietic progenitor kinase 1 inhibitors Understanding

Hematopoietic progenitor kinase 1 inhibitors: Overview

Hematopoietic progenitor kinase 1 (HPK1) is a protein kinase that reduces the T cell response to tumor cells. Specifically, HPK1 is a negative regulator of T cell receptor (TCR) signaling. Active HPK1 phosphorylates a protein in the TCR complex, flagging it for degradation, and blocking the TCR signaling important for mounting an immune response against tumor cells. By inhibiting HPK1 with a small molecule compound it may be possible to enhance T cell function and antitumor responses.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence Hematopoietic progenitor kinase 1 inhibitors R&D. The therapies under development are focused on novel approaches for Hematopoietic progenitor kinase 1 inhibitors.

Hematopoietic progenitor kinase 1 inhibitors Emerging Drugs Chapters

This segment of the Hematopoietic progenitor kinase 1 inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Hematopoietic progenitor kinase 1 inhibitors Emerging Drugs

• CFI-40241: Treadwell Therapeutics

CFI-402411 is a novel, highly orally available immunomodulatory small molecule inhibitor of HPK1 (Hematopoietic Progenitor Kinase 1), a critical regulator of immune cell activation, antigen presentation, and T cell responses to immunosuppressive factors. CFI-402411 has the potential to be an effective treatment in a wide range of cancers as a monotherapy, and in combination with other agents including checkpoint inhibitors.

• BGB-15025: Beigene

BGB-15025 is an investigational hematopoietic progenitor kinase 1 (HPK1) inhibitor discovered and being developed by BeiGene. HPK1 is a key negative feedback regulator of T-cell receptor signaling, which is believed to play a key role in antitumor immune response. In preclinical studies, the inhibition of HPK1 enhanced T-cell activation, which is expected to enhance the anti-tumor activity of anti-PD-1 inhibitors such as BeiGene’s tislelizumab.

Further product details are provided in the report……..

Hematopoietic progenitor kinase 1 inhibitors: Therapeutic Assessment

This segment of the report provides insights about the different Hematopoietic progenitor kinase 1 inhibitors drugs segregated based on following parameters that define the scope of the report, such as:

• Major Players working on Hematopoietic progenitor kinase 1 inhibitors

There are approx. 6+ key companies which are developing the Hematopoietic progenitor kinase 1 inhibitors. The companies which have their Hematopoietic progenitor kinase 1 inhibitors drug candidates in the most advanced stage, i.e. Phase I/II include, Treadwell Therapeutics.

• Phases

DelveInsight’s report covers around 6+ products under different phases of clinical development like

• Late-stage products (Phase III and
• Mid-stage products (Phase II and
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Hematopoietic progenitor kinase 1 inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Infusion
• Intradermal
• Intramuscular
• Intranasal
• Intravaginal
• Oral
• Parenteral
• Subcutaneous
• Topical
• Molecule Type

Products have been categorized under various Molecule types such as

• Vaccines
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Hematopoietic progenitor kinase 1 inhibitors: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Hematopoietic progenitor kinase 1 inhibitors therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Hematopoietic progenitor kinase 1 inhibitors drugs.

Hematopoietic progenitor kinase 1 inhibitors Report Insights

• Hematopoietic progenitor kinase 1 inhibitors Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Hematopoietic progenitor kinase 1 inhibitors Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

• How many companies are developing Hematopoietic progenitor kinase 1 inhibitors drugs?
• How many Hematopoietic progenitor kinase 1 inhibitors drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Hematopoietic progenitor kinase 1 inhibitors?
• What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Hematopoietic progenitor kinase 1 inhibitors therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Hematopoietic progenitor kinase 1 inhibitors and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Treadwell Therapeutics
• BeiGene
• Nimbus Therapeutics
• Blueprint Medicines
• RAPT Therapeutics
• Ryvu Therapeutics
• Arvinas

Key Products

• CFI-40241
• BGB 15025
• Research programme: small molecule HPK1 inhibitors
• BLU 2069
• NMBS 1

Contents

Introduction
Executive Summary
Hematopoietic progenitor kinase 1 inhibitors: Overview
  Structure
  Mechanism of Action
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Hematopoietic progenitor kinase 1 inhibitors – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
  Comparative Analysis
Drug name: Company name
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
  Comparative Analysis
Drug name: Company name
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I and I/II)
  Comparative Analysis
CFI-40241: Treadwell Therapeutics
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
  Comparative Analysis
BLU 2069: Blueprint Medicines
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
  Comparative Analysis
Hematopoietic progenitor kinase 1 inhibitors Key Companies
Hematopoietic progenitor kinase 1 inhibitors Key Products
Hematopoietic progenitor kinase 1 inhibitors- Unmet Needs
Hematopoietic progenitor kinase 1 inhibitors- Market Drivers and Barriers
Hematopoietic progenitor kinase 1 inhibitors- Future Perspectives and Conclusion
Hematopoietic progenitor kinase 1 inhibitors Analyst Views
Hematopoietic progenitor kinase 1 inhibitors Key Companies
Appendix
Introduction
Executive Summary
Hematopoietic progenitor kinase 1 inhibitors: Overview
  Structure
  Mechanism of Action
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Hematopoietic progenitor kinase 1 inhibitors – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
  Comparative Analysis
Drug name: Company name
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
  Comparative Analysis
Drug name: Company name
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I and I/II)
  Comparative Analysis
CFI-40241: Treadwell Therapeutics
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
  Comparative Analysis
BLU 2069: Blueprint Medicines
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
  Comparative Analysis
Hematopoietic progenitor kinase 1 inhibitors Key Companies
Hematopoietic progenitor kinase 1 inhibitors Key Products
Hematopoietic progenitor kinase 1 inhibitors- Unmet Needs
Hematopoietic progenitor kinase 1 inhibitors- Market Drivers and Barriers
Hematopoietic progenitor kinase 1 inhibitors- Future Perspectives and Conclusion
Hematopoietic progenitor kinase 1 inhibitors Analyst Views
Hematopoietic progenitor kinase 1 inhibitors Key Companies
Appendix