Epidermal growth factor receptor antagonists - Pipeline Insight, 2022
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DelveInsight’s, “Epidermal Growth Factor Receptor Antagonists - Pipeline Insight, 2022” report provides comprehensive insights about 30+ companies and 30+ pipeline drugs in Epidermal Growth Factor Receptor Antagonists pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Epidermal Growth Factor Receptor Antagonists: Overview
Epidermal growth factor (EGF) is a 53-amino-acid cytokine which is proteolytically cleaved from a large integral membrane protein precursor. EGF acts to stimulate growth of epithelial cells, accelerates tooth eruption and eyelid opening in mice, inhibits gastric acid secretion and is involved in wound healing.
Function - The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors carry out both redundant and restricted functions in mammalian development and in the maintenance of tissues in the adult mammal. Loss of regulation of the ErbB receptors underlies many human diseases, most notably cancer.
Epidermal Growth Factor Receptor Antagonists - EGFR inhibitor was the first agent developed as a target cancer therapy. Two classes of EGFR inhibitors are in current use: the monoclonal antibodies that target the extracellular ligand-binding domain and small-molecule tyrosine kinase inhibitors (which target intracellular domain. EGFR inhibitors have been approved for the treatment of metastatic non-small-cell lung cancer, colorectal cancer, pancreatic cancer, and squamous cell carcinoma of the head and neck. When the expression of EGFR is decreased, inhibition of downstream signaling occurs in malignant tumor cells. This results in inhibition of metastasis, growth, proliferation, differentiation, and angiogenesis and causing apoptosis of cancer cells.
Epidermal Growth Factor Receptor Antagonists Emerging Drugs Chapters
This segment of the Epidermal Growth Factor Receptor Antagonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Epidermal Growth Factor Receptor Antagonists Emerging Drugs
Further product details are provided in the report……..
Epidermal Growth Factor Receptor Antagonists: Therapeutic Assessment
This segment of the report provides insights about the different Epidermal Growth Factor Receptor Antagonists drugs segregated based on following parameters that define the scope of the report, such as:
Epidermal Growth Factor Receptor Antagonists: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Epidermal Growth Factor Receptor Antagonists therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Epidermal Growth Factor Receptor Antagonists drugs.
Report Highlights
Current Scenario and Emerging Therapies:
DelveInsight’s, “Epidermal Growth Factor Receptor Antagonists - Pipeline Insight, 2022” report provides comprehensive insights about 30+ companies and 30+ pipeline drugs in Epidermal Growth Factor Receptor Antagonists pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
Epidermal Growth Factor Receptor Antagonists: Overview
Epidermal growth factor (EGF) is a 53-amino-acid cytokine which is proteolytically cleaved from a large integral membrane protein precursor. EGF acts to stimulate growth of epithelial cells, accelerates tooth eruption and eyelid opening in mice, inhibits gastric acid secretion and is involved in wound healing.
Function - The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors carry out both redundant and restricted functions in mammalian development and in the maintenance of tissues in the adult mammal. Loss of regulation of the ErbB receptors underlies many human diseases, most notably cancer.
Epidermal Growth Factor Receptor Antagonists - EGFR inhibitor was the first agent developed as a target cancer therapy. Two classes of EGFR inhibitors are in current use: the monoclonal antibodies that target the extracellular ligand-binding domain and small-molecule tyrosine kinase inhibitors (which target intracellular domain. EGFR inhibitors have been approved for the treatment of metastatic non-small-cell lung cancer, colorectal cancer, pancreatic cancer, and squamous cell carcinoma of the head and neck. When the expression of EGFR is decreased, inhibition of downstream signaling occurs in malignant tumor cells. This results in inhibition of metastasis, growth, proliferation, differentiation, and angiogenesis and causing apoptosis of cancer cells.
Epidermal Growth Factor Receptor Antagonists Emerging Drugs Chapters
This segment of the Epidermal Growth Factor Receptor Antagonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Epidermal Growth Factor Receptor Antagonists Emerging Drugs
- Nazartinib: Novartis Oncology
- Zorifertinib: AstraZeneca
Further product details are provided in the report……..
Epidermal Growth Factor Receptor Antagonists: Therapeutic Assessment
This segment of the report provides insights about the different Epidermal Growth Factor Receptor Antagonists drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players working on Epidermal Growth Factor Receptor Antagonists
- Phases
- Late-stage products (Phase III and
- Mid-stage products (Phase II and
- Early-stage products (Phase I/II and Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Infusion
- Intradermal
- Intramuscular
- Intranasal
- Intravaginal
- Oral
- Parenteral
- Subcutaneous
- Topical.
- Molecule Type
- Vaccines
- Monoclonal Antibody
- Peptides
- Polymer
- Small molecule
- Product Type
Epidermal Growth Factor Receptor Antagonists: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Epidermal Growth Factor Receptor Antagonists therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Epidermal Growth Factor Receptor Antagonists drugs.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Epidermal Growth Factor Receptor Antagonists R&D. The therapies under development are focused on novel approaches for Epidermal Growth Factor Receptor Antagonists.
- Epidermal Growth Factor Receptor Antagonists Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Scenario and Emerging Therapies:
- How many companies are developing Epidermal Growth Factor Receptor Antagonists drugs?
- How many Epidermal Growth Factor Receptor Antagonists drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for Epidermal Growth Factor Receptor Antagonists?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Epidermal Growth Factor Receptor Antagonists therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Epidermal Growth Factor Receptor Antagonists and their status?
- What are the key designations that have been granted to the emerging drugs?
- Novartis Oncology
- AstraZeneca
- Voronoi
- Blueprint Medicines
- Symphogen
- Hutchison Medipharma
- Beta Pharma
- Checkpoint Therapeutics
- InventisBio
- XuanZhu Pharma
- Allist Pharmaceuticals
- ACEA Therapeutics
- Astellas Pharma
- Sunshine Lake Pharma
- Hangzhou ACEA Pharmaceutical Research
- Black Diamond Therapeutics
- Zentalis Pharmaceuticals
- Glycotope
- Sinocelltech
- Pfizer
- Cullinan Oncology
- Merus
- ARIAD Pharmaceuticals
- Jiangsu Hengrui Medicine
- Tianjin Hemay Biotech
- Shanghai Henlius Biotech
- Sichuan Kelun Pharmaceutical Research Institute
- Nazartinib
- Zorifertinib
- ORIC 114
- BLU 945
- Futuximab/modotuximab
- Epitinib
- Rezivertinib
- Olafertinib
- D 0316
- Pirotinib
- Alflutinib
- Abivertinib
- Osimertinib
- Erlotinib
- Gefitinib
- Larotinib
- Avitinib
- BDTX 189
- ZN e4
- Tomuzotuximab
- SCT 200
- Dacomitinib
- CLN 081
- MCLA 129
- Mobocertinib
- Pyrotinib
- PB 357
- Hemay 022
- Cetuximab biosimilar
- KL 140
Introduction
Executive Summary
Epidermal Growth Factor Receptor Antagonists: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Epidermal Growth Factor Receptor Antagonists – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Epidermal Growth Factor Receptor Antagonists companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Epidermal Growth Factor Receptor Antagonists Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
Comparative Analysis
Nazartinib: Novartis Oncology
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Pirotinib: XuanZhu Pharma
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I/II)
Comparative Analysis
BLU 945: Blueprint Medicines
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
ORIC 114: Voronoi
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Epidermal Growth Factor Receptor Antagonists Key Companies
Epidermal Growth Factor Receptor Antagonists Key Products
Epidermal Growth Factor Receptor Antagonists- Unmet Needs
Epidermal Growth Factor Receptor Antagonists- Market Drivers and Barriers
Epidermal Growth Factor Receptor Antagonists- Future Perspectives and Conclusion
Epidermal Growth Factor Receptor Antagonists Analyst Views
Epidermal Growth Factor Receptor Antagonists Key Companies
Appendix
Executive Summary
Epidermal Growth Factor Receptor Antagonists: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Epidermal Growth Factor Receptor Antagonists – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Epidermal Growth Factor Receptor Antagonists companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Epidermal Growth Factor Receptor Antagonists Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
Comparative Analysis
Nazartinib: Novartis Oncology
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Pirotinib: XuanZhu Pharma
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I/II)
Comparative Analysis
BLU 945: Blueprint Medicines
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
ORIC 114: Voronoi
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Epidermal Growth Factor Receptor Antagonists Key Companies
Epidermal Growth Factor Receptor Antagonists Key Products
Epidermal Growth Factor Receptor Antagonists- Unmet Needs
Epidermal Growth Factor Receptor Antagonists- Market Drivers and Barriers
Epidermal Growth Factor Receptor Antagonists- Future Perspectives and Conclusion
Epidermal Growth Factor Receptor Antagonists Analyst Views
Epidermal Growth Factor Receptor Antagonists Key Companies
Appendix