Complement C5 inhibitors - Pipeline Insight, 2022
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DelveInsight’s, “Complement C5 Inhibitors - Pipeline Insight, 2022” report provides comprehensive insights about 12+ companies and 12+ pipeline drugs in Complement C5 Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Complement C5 Inhibitors: Overview
Complement component C5 is the initiator of the effector terminal phase of the complement system and shares the molecular structure consisting of two chains-? and ?, linked by disulfide bonds, with C3 and C4, with the only difference being that complement component C5 does not contain an internal thio-ester bond. The terminal phase is similar for the classical, lectin, and alternative pathways. Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes.
Function - Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Complement C5 Inhibitors - The complement inhibitor that has achieved the widest attention as a therapeutic agent is a monoclonal antibody to C5. The advantage to this strategy is that it prevents the generation of C5a, the most potent of the anaphylatoxins, and of the MAC. The generation of C3b and C4b opsonins still would occur, allowing proper clearance of pathogens and immune complexes even if C5 conversion were inhibited chronically. Because there is evidence that activation of early complement components is important for the maintenance of tolerance to self-antigens, inhibition of C5 activation may be less worrisome than inhibition of C3 activation.
Complement C5 Inhibitors Emerging Drugs Chapters
This segment of the Complement C5 Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Complement C5 Inhibitors Emerging Drugs
Further product details are provided in the report……..
Complement C5 Inhibitors: Therapeutic Assessment
This segment of the report provides insights about the different Complement C5 Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:
Complement C5 Inhibitors: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Complement C5 Inhibitors therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Complement C5 Inhibitors drugs.
Report Highlights
Current Scenario and Emerging Therapies:
DelveInsight’s, “Complement C5 Inhibitors - Pipeline Insight, 2022” report provides comprehensive insights about 12+ companies and 12+ pipeline drugs in Complement C5 Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
Complement C5 Inhibitors: Overview
Complement component C5 is the initiator of the effector terminal phase of the complement system and shares the molecular structure consisting of two chains-? and ?, linked by disulfide bonds, with C3 and C4, with the only difference being that complement component C5 does not contain an internal thio-ester bond. The terminal phase is similar for the classical, lectin, and alternative pathways. Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes.
Function - Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Complement C5 Inhibitors - The complement inhibitor that has achieved the widest attention as a therapeutic agent is a monoclonal antibody to C5. The advantage to this strategy is that it prevents the generation of C5a, the most potent of the anaphylatoxins, and of the MAC. The generation of C3b and C4b opsonins still would occur, allowing proper clearance of pathogens and immune complexes even if C5 conversion were inhibited chronically. Because there is evidence that activation of early complement components is important for the maintenance of tolerance to self-antigens, inhibition of C5 activation may be less worrisome than inhibition of C3 activation.
Complement C5 Inhibitors Emerging Drugs Chapters
This segment of the Complement C5 Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Complement C5 Inhibitors Emerging Drugs
- Ravulizumab: Alexion Pharmaceuticals
- Pozelimab: Regeneron Pharmaceuticals
Further product details are provided in the report……..
Complement C5 Inhibitors: Therapeutic Assessment
This segment of the report provides insights about the different Complement C5 Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players working on Complement C5 Inhibitors
- Phases
- Late-stage products (Phase III and
- Mid-stage products (Phase II and
- Early-stage products (Phase I/II and Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Infusion
- Intradermal
- Intramuscular
- Intranasal
- Intravaginal
- Oral
- Parenteral
- Subcutaneous
- Topical.
- Molecule Type
- Vaccines
- Monoclonal Antibody
- Peptides
- Polymer
- Small molecule
- Product Type
Complement C5 Inhibitors: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Complement C5 Inhibitors therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Complement C5 Inhibitors drugs.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Complement C5 Inhibitors R&D. The therapies under development are focused on novel approaches for Complement C5 Inhibitors.
- Complement C5 Inhibitors Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Scenario and Emerging Therapies:
- How many companies are developing Complement C5 Inhibitors drugs?
- How many Complement C5 Inhibitors drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for Complement C5 Inhibitors?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Complement C5 Inhibitors therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Complement C5 Inhibitors and their status?
- What are the key designations that have been granted to the emerging drugs?
- Alexion Pharmaceuticals
- Regeneron Pharmaceuticals
- Chugai Pharmaceutical
- Swedish Orphan Biovitrum
- Ra Pharmaceuticals
- Amgen
- Biocad
- MorphoSys
- UCB
- ISU Abxis
- Samsung Bioepis
- Alexion Pharmaceuticals
- Alnylam Pharmaceuticals
- IVERIC bio
- Ravulizumab
- Pozelimab
- Crovalimab
- RLYB 116
- RA 101295
- ABP 959
- BCD-148
- Tesidolumab
- Zilucoplan
- ISU 305
- SB12
- 5G1-1
- Cemdisiran
- Avacincaptad pegol
Introduction
Executive Summary
Complement C5 Inhibitors: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Complement C5 Inhibitors – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Complement C5 Inhibitors companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Complement C5 Inhibitors Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
Comparative Analysis
Pozelimab: Regeneron Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Cemdisiran: Alnylam Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
ISU 305: ISU Abxis
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
RA 101295: Ra Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Complement C5 Inhibitors Key Companies
Complement C5 Inhibitors Key Products
Complement C5 Inhibitors- Unmet Needs
Complement C5 Inhibitors- Market Drivers and Barriers
Complement C5 Inhibitors- Future Perspectives and Conclusion
Complement C5 Inhibitors Analyst Views
Complement C5 Inhibitors Key Companies
Appendix
Executive Summary
Complement C5 Inhibitors: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Complement C5 Inhibitors – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Complement C5 Inhibitors companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Complement C5 Inhibitors Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
Comparative Analysis
Pozelimab: Regeneron Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Cemdisiran: Alnylam Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
ISU 305: ISU Abxis
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
RA 101295: Ra Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Complement C5 Inhibitors Key Companies
Complement C5 Inhibitors Key Products
Complement C5 Inhibitors- Unmet Needs
Complement C5 Inhibitors- Market Drivers and Barriers
Complement C5 Inhibitors- Future Perspectives and Conclusion
Complement C5 Inhibitors Analyst Views
Complement C5 Inhibitors Key Companies
Appendix