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Chronic Hepatitis B Virus Infection - Pipeline Insight, 2021

July 2021 | 60 pages | ID: CC3D4F4AF35AEN
DelveInsight

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DelveInsight’s, “Chronic Hepatitis B Virus Infection - Pipeline Insight, 2021,” report provides comprehensive insights about 45+ companies and 45+ pipeline drugs in Chronic Hepatitis B Virus Infection pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
Chronic Hepatitis B Virus Infection Understanding

Chronic Hepatitis B Virus Infection: Overview

Chronic hepatitis B virus infection is a global public health threat that causes considerable liver-related morbidity and mortality. It is acquired at birth or later via person-to-person transmission. Vaccination effectively prevents infection and chronic hepatitis B virus carriage. In chronically infected patients, an elevated serum hepatitis B virus DNA concentration is the main risk factor for disease progression, although there are other clinical and viral parameters that influence disease outcomes. In addition to liver biochemistry, virological markers, and abdominal ultrasonography, non-invasive assessment of liver fibrosis is emerging as an important assessment modality. Long-term nucleos(t)ide-analogue therapy is safe and well tolerated, achieves potent viral suppression, and reduces the incidence of liver-related complications. However, a need to optimise management remains. Promising novel therapies are at the developmental stage.

'Chronic Hepatitis B Virus Infection - Pipeline Insight, 2021' report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Chronic Hepatitis B Virus Infection pipeline landscape is provided which includes the disease overview and Chronic Hepatitis B Virus Infection treatment guidelines. The assessment part of the report embraces, in depth Chronic Hepatitis B Virus Infection commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Chronic Hepatitis B Virus Infection collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence Chronic Hepatitis B Virus Infection R&D. The therapies under development are focused on novel approaches to treat/improve Chronic Hepatitis B Virus Infection.
Chronic Hepatitis B Virus Infection Emerging Drugs Chapters

This segment of the Chronic Hepatitis B Virus Infection report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Chronic Hepatitis B Virus Infection Emerging Drugs
  • AB-729 (GalNAc-RNAi): Arbutus Biopharma
AB-729 is a subcutaneously-delivered RNAi therapeutic targeted to hepatocytes that inhibits viral replication and reduces all HBV antigens using our novel covalently conjugated GalNAc delivery technology. Currently, it is in Phase II stage of development to treat Chronic Hepatitis B virus infection.
  • VIR-2218: Vir Biotechnology
VIR-2218, an HBV-targeting siRNA, is designed to inhibit the production of all HBV proteins, including hepatitis B virus surface antigen (HBsAg), which in turn is hypothesized to remove the inhibition of T cell activity directed against HBV. We believe that achieving a functional cure for many HBV patients may be enabled by using VIR-2218 in combination with other agents. Currently, it is in Phase II stage of development to treat Chronic Hepatitis B virus infection.

Further product details are provided in the report……..

Chronic Hepatitis B Virus Infection: Therapeutic Assessment

This segment of the report provides insights about the different Chronic Hepatitis B Virus Infection drugs segregated based on following parameters that define the scope of the report, such as:
  • Major Players in Chronic Hepatitis B Virus Infection
There are approx. 45+ key companies which are developing the therapies for Chronic Hepatitis B Virus Infection. The companies which have their Chronic Hepatitis B Virus Infection drug candidates in the most advanced stage, i.e. phase II include, Vir Biotechnology.
  • Phases
DelveInsight’s report covers around 45+ products under different phases of clinical development like
  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
Chronic Hepatitis B Virus Infection pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Oral
  • Parenteral
  • intravenous
  • Subcutaneous
  • Topical.
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Chronic Hepatitis B Virus Infection: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Chronic Hepatitis B Virus Infection therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Chronic Hepatitis B Virus Infection drugs.

Chronic Hepatitis B Virus Infection Report Insights
  • Chronic Hepatitis B Virus Infection Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
Chronic Hepatitis B Virus Infection Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions

Current Treatment Scenario and Emerging Therapies:
  • How many companies are developing Chronic Hepatitis B Virus Infection drugs?
  • How many Chronic Hepatitis B Virus Infection drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Chronic Hepatitis B Virus Infection?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Chronic Hepatitis B Virus Infection therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Chronic Hepatitis B Virus Infection and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • Arbutus Biopharma
  • Vir Biotechnology
  • Ascentage Pharma Group Inc.
  • Assembly Biosciences
  • Nucorion Pharmaceuticals, Inc.
  • Hoffmann-La Roche
  • Enyo Pharma
  • Qilu Pharmaceutical Co., Ltd.
  • Ascletis Pharmaceuticals Co., Ltd.
  • Xiamen Amoytop Biotech
  • Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
  • Romark Laboratories L.C.
  • Alios Biopharma Inc.
  • Antios Therapeutics, Inc
  • Jiangsu HengRui Medicine Co., Ltd.
  • Enanta Pharmaceuticals
  • Janssen Pharmaceuticals
  • Gilead Sciences
  • Replicor Inc.
  • Golden Biotechnology Corporation
  • Hepatera Ltd.
  • PharmaEssentia
  • Chong Kun Dang Pharmaceutical
  • Green Cross Corporation
  • Aligos Therapeutics
  • Sunshine Lake Pharma Co., Ltd.
  • Transgene
  • Tasly Tianjin Biopharmaceutical Co., Ltd.
  • GlaxoSmithKline
  • Henlix, Inc
  • Ionis Pharmaceuticals, Inc.
  • Altimmune, Inc.
  • Shanghai HEP Pharmaceutical
  • Dong-A ST Co., Ltd.
  • Enyo Pharma
  • CHA Vaccine Institute Co., Ltd.
  • Dicerna Pharmaceuticals, Inc.
  • Vaccitech (UK) Limited
  • Fujian Cosunter Pharmaceutical Co. Ltd
  • Regeneron Pharmaceuticals
  • VenatoRx Pharmaceuticals
  • ISA Pharmaceuticals
  • Finch Therapeutics Group, Inc
  • Zhimeng Biopharma
  • VBI Vaccines Inc
  • GlobeImmune
Key Products
  • AB-729 (GalNAc-RNAi)
  • VIR-2218
  • APG-1387
  • ABI-H2158
  • NCO-48
  • RO7062931
  • EYP001a
  • QL-007
  • ASC22
  • Ypeginterferon alpha-2b
  • TQ-A3334
  • Nitazoxanide
  • JNJ-440
  • ATI-2173
  • HRS5091
  • EDP-514
  • JNJ-73763989
  • Selgantolimod
  • REP 2139-Mg
  • Antroquinonol
  • Myrcludex B
  • P1101
  • CKD-390
  • GC1102
  • ALG-000184
  • GLS4
  • TG1050
  • T101
  • ChAd155-hIi-HBV
  • Serplulimab
  • IONIS-HBVRx
  • HepTcell
  • Hepalatide
  • DA-2802
  • EYP001a
  • CVI-HBV-002
  • DCR-HBVS
  • ChAdOx1-HBV
  • GST-HG141
  • Cemiplimab
  • VNRX-9945
  • ISA104
  • CP101
  • ZM-H1505R
  • VBI-2601
  • GS-4774
Introduction
Executive Summary
Chronic Hepatitis B Virus Infection: Overview
  Causes
  Mechanism of Action
  Signs and Symptoms
  Diagnosis
  Disease Management
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Late Stage Products (Phase III)
  Comparative Analysis
Ypeginterferon alpha-2b: Xiamen Amoytop Biotech
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
  Comparative Analysis
AB-729: Arbutus Biopharma
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..

Early Stage Products (Phase I)
  Comparative Analysis
NCO-48: Nucorion Pharmaceuticals
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
  Comparative Analysis
Drug name: Company name
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..

Inactive Products
  Comparative Analysis
Chronic Hepatitis B Virus Infection Key Companies
Chronic Hepatitis B Virus Infection Key Products
Chronic Hepatitis B Virus Infection- Unmet Needs
Chronic Hepatitis B Virus Infection- Market Drivers and Barriers
Chronic Hepatitis B Virus Infection- Future Perspectives and Conclusion
Chronic Hepatitis B Virus Infection Analyst Views
Chronic Hepatitis B Virus Infection Key Companies
Appendix


LIST OF TABLES

Table 1 Total Products for Chronic Hepatitis B Virus Infection
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products


LIST OF FIGURES

Figure 1 Total Products for Chronic Hepatitis B Virus Infection
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products


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