Amyloid beta-protein inhibitors - Pipeline Insight, 2022

January 2022 | 60 pages | ID: A6FA2AE892D2EN
DelveInsight

Abstracts

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DelveInsight’s, “Amyloid Beta-Protein Inhibitors - Pipeline Insight, 2022” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Amyloid Beta-Protein Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Amyloid Beta-Protein Inhibitors Understanding

Amyloid Beta-Protein Inhibitors: Overview

Amyloid-? (A?) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of theamyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is being cut by certain enzymes to yield A?. Amyloid-? molecules can aggregate to form flexible soluble oligomers which may exist in several forms. Amyloid-? peptide is due to overproduction of A? and/or the failure of clearance mechanisms. Amyloid-? self-aggregates into oligomers, which can be of various sizes, and forms diffuse and neuritic plaques in the parenchyma and blood vessels.

Function – The progressive production and subsequent accumulation of ?-amyloid (A?), a proteolytic fragment of the membrane-associated amyloid precursor protein (APP), plays a central role in Alzheimer's disease (AD). A? is released in a soluble form that may be responsible for cognitive dysfunction in the early stages of the disease, then progressively forms oligomeric, multimeric and fibrillar aggregates, triggering neurodegeneration. Eventually, the aggregation and accumulation of A? culminates with the formation of extracellular plaques, one of the morphological hallmarks of the disease, detectable post-mortem in AD brains.

Amyloid Beta-Protein Inhibitors- Inhibition of the formation of these toxic polymers of A? has thus emerged as an approach to developing therapeutics for AD. Therefore, blocking the initial stages of A? peptide aggregation with small molecules could hold considerable promise as the starting point for the development of new therapies for AD.

Amyloid Beta-Protein Inhibitors Emerging Drugs Chapters

This segment of the Amyloid Beta-Protein Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Amyloid Beta-Protein Inhibitors Emerging Drugs

• Aducanumab: Biogen

Biogen’s aducanumab — a monoclonal antibody is currently under review by the U.S. Food and Drug Administration. If ultimately approved, it is predicted that the drug, which only showed modest efficacy in phase III clinical trial, could become the best-selling drug of all time.

• Crenezumab: Hoffman-La-Roche

Crenezumab (RG7412) is a humanized monoclonal antibody, which binds to amyloid beta (Abeta). Abeta is the main constituent of amyloid plaque in the brains of patients with Alzheimer's disease and is proposed to be causative in the development of the disease. A phase II clinical trial is evaluating Crenezumab in healthy individuals with a history of familial Alzheimer’s disease. Roche plans to submit regulatory applications for marketing Crenezumab for Alzheimer's disease by 2023.

Further product details are provided in the report……..

Amyloid Beta-Protein Inhibitors: Therapeutic Assessment

This segment of the report provides insights about the different Amyloid Beta-Protein Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:

• Major Players working on Amyloid Beta-Protein Inhibitors

There are approx. 10+ key companies which are developing the Amyloid Beta-Protein Inhibitors. The companies which have their Amyloid Beta-Protein Inhibitors drug candidates in the most advanced stage, i.e. preregistration include Biogen.

• Phases

DelveInsight’s report covers around 10+ products under different phases of clinical development like

• Late-stage products (Phase III )
• Mid-stage products (Phase II )
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Amyloid Beta-Protein Inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Infusion
• Intravenous
• Intramuscular
• Oral
• Parenteral
• Subcutaneous
• Molecule Type

Products have been categorized under various Molecule types such as

• Vaccines
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Amyloid Beta-Protein Inhibitors: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Amyloid Beta-Protein Inhibitors therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Amyloid Beta-Protein Inhibitors drugs.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence Amyloid Beta-Protein Inhibitors R&D.
• The therapies under development are focused on novel approaches for Amyloid Beta-Protein Inhibitors.

Amyloid Beta-Protein Inhibitors Report Insights

• Amyloid Beta-Protein Inhibitors Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Amyloid Beta-Protein Inhibitors Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

• How many companies are developing Amyloid Beta-Protein Inhibitors drugs?
• How many Amyloid Beta-Protein Inhibitors drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for Amyloid Beta-Protein Inhibitors?
• What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Amyloid Beta-Protein Inhibitors therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Amyloid Beta-Protein Inhibitors and their status?
• What are the key designations that have been granted to the emerging drugs?

Contents

Introduction
Executive Summary
Amyloid Beta-Protein Inhibitors: Overview
  Structure
  Mechanism of Action
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Amyloid Beta-Protein Inhibitors – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
  Amyloid Beta-Protein Inhibitors companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Amyloid Beta-Protein Inhibitors Collaboration Deals
  Company-Company Collaborations (Licensing / Partnering) Analysis
  Company-University Collaborations (Licensing / Partnering) Analysis
late Stage Products (Preregistration)
  Comparative Analysis
Aducanumab: Biogen
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
  Comparative Analysis
R-phenserine: Annovis Bio
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
  Comparative Analysis
Fol PRI 002: Priavoid
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
  Comparative Analysis
Amyloid Beta-Protein Inhibitors Key Companies
Amyloid Beta-Protein Inhibitors Key Products
Amyloid Beta-Protein Inhibitors- Unmet Needs
Amyloid Beta-Protein Inhibitors- Market Drivers and Barriers
Amyloid Beta-Protein Inhibitors- Future Perspectives and Conclusion
Amyloid Beta-Protein Inhibitors Analyst Views
Amyloid Beta-Protein Inhibitors Key Companies
Appendix

List Of Tables

LIST OF TABLES

Table 1 Total Products for Amyloid Beta-Protein Inhibitors
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products

List Of Figures

LIST OF FIGURES

Figure 1 Total Products for Amyloid Beta-Protein Inhibitors
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products