Adenosine A2B receptor antagonists - Pipeline Insight, 2022
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DelveInsight’s, “Adenosine A2B receptor antagonists - Pipeline Insight, 2022” report provides comprehensive insights about 7+ companies and 7+ pipeline drugs in Adenosine A2B receptor antagonists pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Adenosine A2B receptor antagonists: Overview
Adenosine is generated mainly via the degradation of adenosine 5?-triphosphate (ATP) released under stress conditions, to protect cells and tissues locally. Adenosine and ATP acting at different classes of receptors often have opposite effects in cell proliferation or cell death. ATP and other adenine nucleotides have antitumor effects via the activation of the P2Y1 receptor (P2Y1R) subtype, whereas adenosine induces cancer cell proliferation and growth of many types of tumors via the activation of the A2B adenosine receptor (AR) .
A2BAR activation leads to dissociation of the G?s and G?? subunits and subsequent activation of the adenylyl cyclases, which in turn hydrolyze intracellular ATP into cyclic AMP (cAMP), which activates protein kinase A (PKA) and many downstream signaling molecules. The Gs-cAMP-PKA axis is an important A2BAR-mediated signaling pathway.
A2BAR signaling is a major pathway contributing to cancer cell proliferation and solid tumor growth, angiogenesis and metastasis, and immune suppression. Thus, A2BAR antagonists are potentially a novel anticancer therapy, either in combination with other anticancer drugs or as a mono-therapy.
Report Highlights
This segment of the Adenosine A2B receptor antagonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Adenosine A2B receptor antagonists Emerging Drugs
A2bR is also upregulated by certain cancer cells, such as in prostate cancer and KRAS-mutated cancers. As a result, etrumadenant may uniquely block adenosine’s immunosuppressive and cancer cell-intrinsic effects.
It is currently in Phase II stage of development and is being developed by Arcus Biosciences.
Further product details are provided in the report……..
Adenosine A2B receptor antagonists: Therapeutic Assessment
This segment of the report provides insights about the different Adenosine A2B receptor antagonists drugs segregated based on following parameters that define the scope of the report, such as:
Adenosine A2B receptor antagonists: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Adenosine A2B receptor antagonists therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Adenosine A2B receptor antagonists drugs.
Adenosine A2B receptor antagonists Report Insights
Current Scenario and Emerging Therapies:
DelveInsight’s, “Adenosine A2B receptor antagonists - Pipeline Insight, 2022” report provides comprehensive insights about 7+ companies and 7+ pipeline drugs in Adenosine A2B receptor antagonists pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
Adenosine A2B receptor antagonists: Overview
Adenosine is generated mainly via the degradation of adenosine 5?-triphosphate (ATP) released under stress conditions, to protect cells and tissues locally. Adenosine and ATP acting at different classes of receptors often have opposite effects in cell proliferation or cell death. ATP and other adenine nucleotides have antitumor effects via the activation of the P2Y1 receptor (P2Y1R) subtype, whereas adenosine induces cancer cell proliferation and growth of many types of tumors via the activation of the A2B adenosine receptor (AR) .
A2BAR activation leads to dissociation of the G?s and G?? subunits and subsequent activation of the adenylyl cyclases, which in turn hydrolyze intracellular ATP into cyclic AMP (cAMP), which activates protein kinase A (PKA) and many downstream signaling molecules. The Gs-cAMP-PKA axis is an important A2BAR-mediated signaling pathway.
A2BAR signaling is a major pathway contributing to cancer cell proliferation and solid tumor growth, angiogenesis and metastasis, and immune suppression. Thus, A2BAR antagonists are potentially a novel anticancer therapy, either in combination with other anticancer drugs or as a mono-therapy.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Adenosine A2B receptor antagonists R&D. The therapies under development are focused on novel approaches for Adenosine A2B receptor antagonists.
This segment of the Adenosine A2B receptor antagonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Adenosine A2B receptor antagonists Emerging Drugs
- Etrumadenant: Arcus Biosciences
A2bR is also upregulated by certain cancer cells, such as in prostate cancer and KRAS-mutated cancers. As a result, etrumadenant may uniquely block adenosine’s immunosuppressive and cancer cell-intrinsic effects.
It is currently in Phase II stage of development and is being developed by Arcus Biosciences.
Further product details are provided in the report……..
Adenosine A2B receptor antagonists: Therapeutic Assessment
This segment of the report provides insights about the different Adenosine A2B receptor antagonists drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players working on Adenosine A2B receptor antagonists
- Phases
- Late-stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage products (Phase I/II and Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Infusion
- Intradermal
- Intramuscular
- Intranasal
- Intravaginal
- Oral
- Parenteral
- Subcutaneous
- Topical
- Molecule Type
- Vaccines
- Monoclonal Antibody
- Peptides
- Polymer
- Small molecule
- Product Type
Adenosine A2B receptor antagonists: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Adenosine A2B receptor antagonists therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Adenosine A2B receptor antagonists drugs.
Adenosine A2B receptor antagonists Report Insights
- Adenosine A2B receptor antagonists Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Scenario and Emerging Therapies:
- How many companies are developing Adenosine A2B receptor antagonists drugs?
- How many Adenosine A2B receptor antagonists drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for Adenosine A2B receptor antagonists?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Adenosine A2B receptor antagonists therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Adenosine A2B receptor antagonists and their status?
- What are the key designations that have been granted to the emerging drugs?
- Palobiofarma
- Arcus Biosciences
- Incyte Corporation
- Teon Therapeutics
- Corvus Pharmaceuticals
- Tarus Therapeutics
- AdoRx Therapeutics
- PBF-1129
- Etrumadenant
- INCB106385
- TT-702
- CPI-935
- TT-4
- Research Programme: A2A/A2B receptors antagonists
Introduction
Executive Summary
Adenosine A2B receptor antagonists: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Late Stage Products (Phase III)
Comparative Analysis
Drug Name: Company Name
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Etrumadenant: Arcus Biosciences
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
INCB106385: Incyte Corporation
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
Comparative Analysis
CPI-935: Corvus Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Adenosine A2B receptor antagonists Key Companies
Adenosine A2B receptor antagonists Key Products
Adenosine A2B receptor antagonists- Unmet Needs
Adenosine A2B receptor antagonists- Market Drivers and Barriers
Adenosine A2B receptor antagonists- Future Perspectives and Conclusion
Adenosine A2B receptor antagonists Analyst Views
Adenosine A2B receptor antagonists Key Companies
Appendix
Executive Summary
Adenosine A2B receptor antagonists: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Late Stage Products (Phase III)
Comparative Analysis
Drug Name: Company Name
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Etrumadenant: Arcus Biosciences
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
INCB106385: Incyte Corporation
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
Comparative Analysis
CPI-935: Corvus Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Adenosine A2B receptor antagonists Key Companies
Adenosine A2B receptor antagonists Key Products
Adenosine A2B receptor antagonists- Unmet Needs
Adenosine A2B receptor antagonists- Market Drivers and Barriers
Adenosine A2B receptor antagonists- Future Perspectives and Conclusion
Adenosine A2B receptor antagonists Analyst Views
Adenosine A2B receptor antagonists Key Companies
Appendix
