Acute respiratory distress syndrome (ARDS) – Pipeline Insight, 2020
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DelveInsight’s, “Acute respiratory distress syndrome (ARDS) – Pipeline Insight, 2020,” report provides comprehensive insights about 50+ companies and 50+ pipeline drugs in Acute respiratory distress syndrome pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Acute respiratory distress syndrome (ARDS): Overview
Acute respiratory distress syndrome (ARDS) is a life-threatening condition of seriously ill patients, characterized by poor oxygenation, pulmonary infiltrates, and acuity of onset. On a microscopic level, the disorder is associated with capillary endothelial injury and diffuse alveolar damage. Acute respiratory distress syndrome is defined as an acute disorder that starts within 7 days of the inciting event and is characterized by bilateral lung infiltrates and severe progressive hypoxemia in the absence of any evidence of cardiogenic pulmonary edema. ARDS is defined by the patient's oxygen in arterial blood (PaO2) to the fraction of the oxygen in the inspired air (FiO2). These patients have a PaO2/FiO2 ratio of less than 300.
Symptoms
Acute respiratory distress syndrome usually develops within 24 to 48 hours of the original injury or disease but may take as long as 4 or 5 days to occur. The person first has shortness of breath, usually with rapid, shallow breathing.
Common symptoms and signs of ARDS include:
A doctor can diagnose ARDS in several different ways. There’s no one definitive test for diagnosing this condition. The doctor may take a blood pressure reading, perform a physical exam, and recommend any of the following tests:
No drug has proved beneficial in the prevention or management of acute respiratory distress syndrome. The chief treatment strategy is supportive care and focuses on 1) reducing shunt fraction, 2) increasing oxygen delivery, 3) decreasing oxygen consumption, and 4) avoiding further injury. Early administration of corticosteroids to septic patients does not prevent the development of acute respiratory distress syndrome.
Acute respiratory distress syndrome Emerging Drugs Chapters
This segment of the Acute respiratory distress syndrome report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Acute respiratory distress syndrome Emerging Drugs
Further product details are provided in the report……..
Acute respiratory distress syndrome: Therapeutic Assessment
This segment of the report provides insights about the different Acute respiratory distress syndrome drugs segregated based on following parameters that define the scope of the report, such as:
Phases
DelveInsight’s report covers around 50+ products under different phases of clinical development like
Acute respiratory distress syndrome: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Acute respiratory distress syndrome therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Acute respiratory distress syndrome drugs.
Report Highlights
Current Treatment Scenario and Emerging Therapies:
DelveInsight’s, “Acute respiratory distress syndrome (ARDS) – Pipeline Insight, 2020,” report provides comprehensive insights about 50+ companies and 50+ pipeline drugs in Acute respiratory distress syndrome pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
Acute respiratory distress syndrome (ARDS): Overview
Acute respiratory distress syndrome (ARDS) is a life-threatening condition of seriously ill patients, characterized by poor oxygenation, pulmonary infiltrates, and acuity of onset. On a microscopic level, the disorder is associated with capillary endothelial injury and diffuse alveolar damage. Acute respiratory distress syndrome is defined as an acute disorder that starts within 7 days of the inciting event and is characterized by bilateral lung infiltrates and severe progressive hypoxemia in the absence of any evidence of cardiogenic pulmonary edema. ARDS is defined by the patient's oxygen in arterial blood (PaO2) to the fraction of the oxygen in the inspired air (FiO2). These patients have a PaO2/FiO2 ratio of less than 300.
Symptoms
Acute respiratory distress syndrome usually develops within 24 to 48 hours of the original injury or disease but may take as long as 4 or 5 days to occur. The person first has shortness of breath, usually with rapid, shallow breathing.
Common symptoms and signs of ARDS include:
- labored and rapid breathing
- muscle fatigue and general weakness
- low blood pressure
- discolored skin or nails
- a dry, hacking cough
- a fever
- headaches
- a fast pulse rate
- mental confusion
A doctor can diagnose ARDS in several different ways. There’s no one definitive test for diagnosing this condition. The doctor may take a blood pressure reading, perform a physical exam, and recommend any of the following tests:
- a blood test
- a chest X-ray
- a CT scan
- throat and nose swabs
- an electrocardiogram
- an echocardiogram
- an airway examination
No drug has proved beneficial in the prevention or management of acute respiratory distress syndrome. The chief treatment strategy is supportive care and focuses on 1) reducing shunt fraction, 2) increasing oxygen delivery, 3) decreasing oxygen consumption, and 4) avoiding further injury. Early administration of corticosteroids to septic patients does not prevent the development of acute respiratory distress syndrome.
Acute respiratory distress syndrome Emerging Drugs Chapters
This segment of the Acute respiratory distress syndrome report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Acute respiratory distress syndrome Emerging Drugs
- HCR040: Histocell, S.L.
- HLCM051(MultiStem): Healios
Further product details are provided in the report……..
Acute respiratory distress syndrome: Therapeutic Assessment
This segment of the report provides insights about the different Acute respiratory distress syndrome drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Acute respiratory distress syndrome
Phases
DelveInsight’s report covers around 50+ products under different phases of clinical development like
- Mid-stage products (Phase II and Phase I/II)
- Early-stage products (Phase I/II and Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Subcutaneous
- Intramuscular
- Intravenous
- Molecule Type
- Monoclonal antibodies
- Stem cell therapies
- Immunoproteins
- Peptides
- Proteins
- Product Type
Acute respiratory distress syndrome: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Acute respiratory distress syndrome therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Acute respiratory distress syndrome drugs.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Acute respiratory distress syndrome R&D. The therapies under development are focused on novel approaches to treat/improve Acute respiratory distress syndrome.
- Several trials are currently ongoing evaluating experimental therapies for Acute respiratory distress syndrome, including human mesenchymal stem cells and extracorporeal membrane oxygenation (ECMO).
- Acute respiratory distress syndrome Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Acute respiratory distress syndrome drugs?
- How many Acute respiratory distress syndrome drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Acute respiratory distress syndrome?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Acute respiratory distress syndrome therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Acute respiratory distress syndrome and their status?
- What are the key designations that have been granted to the emerging drugs?
- Athersys, Inc
- Histocell
- BioXcellerator
- Altor BioScience
- Cartesian Therapeutics
- Meridigen Biotech Co., Ltd.
- Sage Therapeutics
- Healios K.K.
- Chiesi Farmaceutici
- Bayer
- Altor BioScience
- Faron Pharmaceuticals Ltd
- AVM Biotechnology LLC
- Amyndas Pharmaceuticals S.A.
- Kinevant Sciences GmbH
- Eli Lilly and Company
- Suntory Pharmaceutical
- MultiStem
- HCR040
- Wharton's jelly derived Mesenchymal stem cells.
- TNX-832
- Descartes 30
- UMC119-06
- HLCM051
- CUROSURF
- BAY1097761
- ALT-836
- Interferon Beta
- AMY-101
Introduction
Executive Summary
Acute respiratory distress syndrome: Overview
Causes
Mechanism of Action
Signs and Symptoms
Diagnosis
Disease Management
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Acute respiratory distress syndrome – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Acute respiratory distress syndrome companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Acute respiratory distress syndrome Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
Comparative Analysis
Ravulizumab: Alexion Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
HLCM051: Healios
Product Description
Research and Development
Product Development Activities
Poractant alfa: Chiesi Farmaceutici
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
Research programme: cell-based lung disorder therapeutics: Northern Therapeutics
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Acute respiratory distress syndrome Key Companies
Acute respiratory distress syndrome Key Products
Acute respiratory distress syndrome- Unmet Needs
Acute respiratory distress syndrome- Market Drivers and Barriers
Acute respiratory distress syndrome- Future Perspectives and Conclusion
Acute respiratory distress syndrome Analyst Views
Acute respiratory distress syndrome Key Companies
Appendix
Executive Summary
Acute respiratory distress syndrome: Overview
Causes
Mechanism of Action
Signs and Symptoms
Diagnosis
Disease Management
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Acute respiratory distress syndrome – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Acute respiratory distress syndrome companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Acute respiratory distress syndrome Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
Comparative Analysis
Ravulizumab: Alexion Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
HLCM051: Healios
Product Description
Research and Development
Product Development Activities
Poractant alfa: Chiesi Farmaceutici
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
Research programme: cell-based lung disorder therapeutics: Northern Therapeutics
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Acute respiratory distress syndrome Key Companies
Acute respiratory distress syndrome Key Products
Acute respiratory distress syndrome- Unmet Needs
Acute respiratory distress syndrome- Market Drivers and Barriers
Acute respiratory distress syndrome- Future Perspectives and Conclusion
Acute respiratory distress syndrome Analyst Views
Acute respiratory distress syndrome Key Companies
Appendix
LIST OF TABLES
Table 1 Total Products for Acute respiratory distress syndrome
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products
Table 1 Total Products for Acute respiratory distress syndrome
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products
LIST OF FIGURES
Figure 1 Total Products for Acute respiratory distress syndrome
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products
Figure 1 Total Products for Acute respiratory distress syndrome
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products