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Tinnitus - Pipeline Insight, 2021

May 2021 | 60 pages | ID: T40066FD316EN
DelveInsight

US$ 1,500.00

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DelveInsight’s, “Tinnitus - Pipeline Insight, 2021,” report provides comprehensive insights about 8+ companies and 9+ pipeline drugs in Tinnitus pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
Tinnitus Understanding

Tinnitus: Overview

Tinnitus is commonly described as a ringing in the ears, but it also can sound like roaring, clicking, hissing, or buzzing. It may be soft or loud, high pitched or low pitched. Tinnitus represents one of the most common and distressing otologic problems, and it causes various somatic and psychological disorders that interfere with the quality of life. The most common associated symptoms or subjective discomforts involve concentration difficulties, insomnia, and decreased speech discrimination. Tinnitus does not represent a disease itself but instead is a symptom of a variety of underlying diseases. Otologic causes include noise-induced hearing loss, presbycusis, otosclerosis, otitis, impacted cerumen, sudden deafness, Meniere's disease, and other causes of hearing loss. The most effective treatment for tinnitus is to work on the underlying cause. The underlying cause can be treatable by medical and/or surgical treatment. Approaches for tinnitus management and treatment include medications, vitamin therapy, biofeedback, hypnosis, electrical stimulation, relaxation therapy, counselling, habituation therapies, tinnitus retraining therapy [TRT], cognitive behavioural therapy [CBT], tinnitus maskers and hearing aid.

'Tinnitus - Pipeline Insight, 2021' report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Tinnitus pipeline landscape is provided which includes the disease overview and Tinnitus treatment guidelines. The assessment part of the report embraces, in depth Tinnitus commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Tinnitus collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence Tinnitus R&D. The therapies under development are focused on novel approaches to treat/improve Tinnitus.
Tinnitus Emerging Drugs Chapters

This segment of the Tinnitus report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Tinnitus Emerging Drugs
  • AM-101: Auris Medical
AM-101 is an NMDA receptor antagonist that is being developed for treatment of acute inner ear tinnitus. The NMDA (N-methyl-D-aspartate) receptor is a glutamate receptor on the neuron leading to the auditory cortex that is communicated to by the hair cells of the inner ear. The drug is in Phase III clinical development for the treatment of Tinnitus.
  • OTO-313: Otonomy
OTO-313 is a sustained-exposure formulation of gacyclidine, a potent and selective NMDA receptor antagonist, in development for the treatment of tinnitus. OTO-313 utilizes a novel, patent-protected formulation technology to provide several weeks of gacyclidine drug exposure in the inner ear compartment following a single intratympanic injection. The drug is currently under Phase II clinical evaluation for the treatment of Tinnitus.

Further product details are provided in the report

Tinnitus: Therapeutic Assessment

This segment of the report provides insights about the different Tinnitus drugs segregated based on following parameters that define the scope of the report, such as:
  • Major Players in Tinnitus
There are approx. 8+ key companies which are developing the therapies for Tinnitus. The companies which have their Tinnitus drug candidates in the most advanced stage, i.e. Phase III include, Auris Medical.
  • Phases
DelveInsight’s report covers around 9+ products under different phases of clinical development like
  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
Tinnitus pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Oral
  • Parenteral
  • Intravitreal
  • Subretinal
  • Topical
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Tinnitus: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Tinnitus therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Tinnitus drugs.

Tinnitus Report Insights
  • Tinnitus Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
Tinnitus Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions

Current Treatment Scenario and Emerging Therapies:
  • How many companies are developing Tinnitus drugs?
  • How many Tinnitus drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Tinnitus?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Tinnitus therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Tinnitus and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • Auris Medical
  • Sound Pharmaceuticals
  • Otonomy
  • Knopp Biosciences
  • Otologic Pharmaceutics
  • Decibel Therapeutics
Key Products
  • AM-101
  • Ebselen
  • OTO-313
  • AM 102
  • Research programme: potassium channel activators
  • NHPN-1010
  • DB-XX5
Introduction
Executive Summary
Tinnitus: Overview
  Causes
  Mechanism of Action
  Signs and Symptoms
  Diagnosis
  Disease Management
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Tinnitus – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
  Tinnitus companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Tinnitus Collaboration Deals
  Company-Company Collaborations (Licensing / Partnering) Analysis
  Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Preregistration)
  Comparative Analysis
Drug name: Company name
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report
Late Stage Products (Phase III)
  Comparative Analysis
AM-101: Auris Medical
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report
Mid Stage Products (Phase II)
  Comparative Analysis
OTO-313: Otonomy
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report
Preclinical and Discovery Stage Products
  Comparative Analysis
Research programme: potassium channel activators - Knopp Biosciences
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report
Inactive Products
  Comparative Analysis
Tinnitus Key Companies
Tinnitus Key Products
Tinnitus- Unmet Needs
Tinnitus- Market Drivers and Barriers
Tinnitus- Future Perspectives and Conclusion
Tinnitus Analyst Views
Tinnitus Key Companies
Appendix

LIST OF TABLES

Table 1 Total Products for Tinnitus
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products

LIST OF FIGURES

Figure 1 Total Products for Tinnitus
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products


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