[email protected] +44 20 8123 2220 (UK) +1 732 587 5005 (US) Contact Us | FAQ |

RCC: KOL Insight [2017]

June 2017 | | ID: R99575EF017EN
FirstWord

US$ 8,145.00

E-mail Delivery (PDF)

Download PDF Leaflet

Accepted cards
Wire Transfer
Checkout Later
Need Help? Ask a Question
How will new combination regimens impact the RCC treatment landscape?

The treatment of advanced RCC has been transformed in recent years as VEGF, TKI and mTOR inhibitors have taken centre stage. KOLs now argue that the first-line treatment of advanced RCC is on the cusp of a second wave of change. At the forefront is a multitude of immunotherapy-based combination regimens that look set to transform first-line therapy, including Keytruda/Inlyta, Bavencio/Inlyta, Tecentriq/Avastin, Cabometyx/Opdivo±Yervoy and Keytruda/Lenvima. The adjuvant setting is also set to become a key battleground with multiple agents in Phase III trials. What will be the critical factors for success as the rapidly evolving treatment armamentarium leads to ever more complex decision making for oncologists? In this report six US and six EU KOLs offer their candid insights on ten marketed therapies and five pipeline drugs.

Take a tour of the report now:
  • Methodology
  • Research Objectives
  • Questions Asked
  • See the RCC therapies covered
  • Find out who the 6 US and 6 European KOLs are
  • Sample Pages
Top Takeaways
  • How is the future use of immunotherapies for the treatment of RCC likely to evolve and how will their use impact current treatment strategies?
  • A host of Phase III trials are evaluating dual immunotherapy and immunotherapy/VEGF-TKI combination regimens in the first-line setting. How do KOLs view the potential for these combinations to be used in first-line treatment?
  • How are Pfizer’s Sutent and Novartis’ Votrient viewed as first-line monotherapies and what will the future hold for them as competition escalates?
  • How do KOLs view the results of the Phase II IMmotion 150 trial comparing Tecentriq in combination with Avastin versus Sutent, and the overall potential for this combination?
  • How convinced are KOLs by the Phase II CABOSUN data, and do they view the potential for Cabometyx in the frontline setting?
  • Bristol-Myers Squibb’s Opdivo has gained momentum in the second-line setting. What do KOLs perceive as the advantages and disadvantages of Opdivo, and how do these influence its usage?
  • There is currently a lack of effective adjuvant therapies, but a number of agents are under clinical evaluation in this setting. How do KOLs view the potential for VEGF TKIs and immunotherapies to be used as adjuvant therapy?
Quotes

“We will treat in a more diverse way, and in five years’ time we should be able to tell which patients should receive a more intense immunotherapy combination versus those that might receive a TKI/ immunotherapy combination, versus those [candidates] for single-agent, less intense, treatment.” EU Key Opinion Leader

“What we need to address is the question of a cure for patients; it is good to improve survival, it is good to improve PFS, but what we want to improve is the cure rate. That is what we should try to achieve with these combinations, with two or even three agents.” US Key Opinion Leader

Sample of therapies covered

Marketed Therapies
  • Sutent (sunitinib; Pfizer)
  • Votrient (pazopanib; Novartis)
  • Nexavar (sorafenib; Amgen/Bayer)
  • Inlyta (axitinib; Pfizer)
  • Cabometyx (cabozantinib; Exelixis)
  • Lenvima/Kisplyx (lenvatinib; Eisai)
  • Avastin (bevacizumab; Roche)
  • Afinitor (everolimus; Novartis)
  • Torisel (temsirolimus; Pfizer)
  • Opdivo (nivolumab; Bristol-Myers Squibb)
Pipeline Therapies
  • Tivozanib (Tivopath; AVEO Oncology)
  • Pembrolizumab (Keytruda; Merck & Co.)
  • Atezolizumab (Tecentriq; Roche)
  • Avelumab (Bavencio; Merck Group/Pfizer)
  • Rocapuldencel-T (AGS 003; Argos Therapeutics)
KOLs from North America
  • Neeraj Agarwal, Associate Professor in the Division of Oncology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT
  • Ronald M Bukowski, Professor of Medical Oncology, Bukowski Consulting, OH (previously, Cleveland Clinic, Cleveland, OH)
  • Robert A Figlin, Professor of Hematology/Oncology, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA
  • Eric Jonasch, Professor, Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX
  • Robert Motzer, Professor of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
  • Brian Rini, Professor of Medicine, Lerner College of Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH
KOLs from Europe
  • Bernard Escudier, Professor of Medical Oncology, Institut Gustave Roussy, Villejuif, France
  • Stephane Oudard, Professor of Medical Oncology, Georges Pompidou Hospital, Paris, France
  • Giuseppe Procopio, Professor of Medicine, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan
  • Anonymous KOL, Professor of Haematology and Oncology, major university medical centre, Germany
  • Anonymous KOL, Professor of Haematology and Oncology, major university hospital, Germany
  • Anonymous KOL, Professor and Chairman of the Department of Urology, major university hospital, Germany
Money Back Guarantee

At FirstWord, we stand behind our reports. If you're not completely satisfied, we’ll refund your money. Guaranteed.

About FirstWord

FirstWord is an innovative industry intelligence leader serving over 240,000 Pharma and MedTech professionals worldwide. FirstWord offers a range of products and services designed to help your company gain a competitive edge by making key business decisions with speed and confidence.

FirstWord Pharma PLUS is a personalised and comprehensive intelligence service delivering up-to-the-minute pharma news, insight, analysis and expert views of importance to your company’s success.

FirstWord Reports deliver timely, need-to-know intelligence about your products, your competitors and your markets. Covering biosimilars, market access, medical affairs, sales & marketing, technology and therapy areas, FirstWord Reports provide expert views and intelligence on the challenges facing pharma today.
1.EXECUTIVE SUMMARY

2.RESEARCH OBJECTIVES

3.RESEARCH FOCUS

4.REPORT FOCUS

5.UNMET NEEDS

6.VEGF INHIBITORS

6.1 Overview
6.2 Marketed drugs
  6.2.1 Sutent (sunitinib; Pfizer)
  6.2.2 Votrient (pazopanib; Novartis)
  6.2.3 Nexavar (sorafenib; Amgen/Bayer)
  6.2.4 Inlyta (axitinib; Pfizer)
  6.2.5 Cabometyx (cabozantinib; Exelixis)
  6.2.6 Lenvima/Kisplyx (lenvatinib; Eisai)
  6.2.7 Avastin (bevacizumab; Roche)
6.3 Pipeline drugs
  6.3.1 Tivopath (tivozanib; AVEO Oncology)

7.MTOR INHIBITORS

7.1 Overview
7.2 Marketed drugs
  7.2.1 Afinitor (everolimus; Novartis)
  7.2.2 Torisel (temsirolimus; Pfizer)

8.IMMUNOTHERAPIES

8.1 Marketed drugs
  8.1.1 Opdivo (nivolumab; Bristol-Myers Squibb)
8.2 Pipeline drugs
  8.2.1 Keytruda (pembrolizumab; Merck & Co.)
  8.2.2 Tecentriq (atezolizumab; Roche)
  8.2.3 Bavencio (avelumab; Merck Group/Pfizer)
  8.2.4 Rocapuldencel-T (AGS-003; Argos Therapeutics)

9. CONCLUSION

10. APPENDIX

10.1 KOL details
  10.1.1 KOLs from North America
  10.1.2 KOLs from Europe


More Publications