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Protein Expression Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Expression System (Prokaryotic, Mammalian Cell, Insect Cell, Yeast, Others), By Product (Reagents, Competent Cells, Expression Vectors, Services, Instruments), By End user (Pharmaceutical and Biotechnological Companies, Academic Research, Contract research organizations, Others), By Region and Competition, 2019-2029F

June 2024 | 185 pages | ID: P51F0991935BEN
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Global Protein Expression Market was valued at USD 3.52 Billion in 2023 and is anticipated t%lI%project steady growth in the forecast period with a CAGR of 9.25% through 2029. Protein expression, a fundamental process in molecular biology, plays a pivotal role in the biotechnology and pharmaceutical industries. It involves the synthesis of specific proteins in cells, enabling scientists t%lI%study and utilize them for various purposes, from understanding biological mechanisms t%lI%producing therapeutic proteins. The global protein expression market is witnessing remarkable growth as it evolves t%lI%meet the demands of research, diagnostics, and drug development. The global protein expression market has seen substantial growth in recent years and is expected t%lI%continue t%lI%expand in the foreseeable future. Factors contributing t%lI%this growth include advancements in genetic engineering techniques, increasing demand for biopharmaceuticals, rising investments in research and development, and the expanding biotechnology and pharmaceutical sectors.

The increasing demand for biologics, driven by their effectiveness in treating various diseases, provides a significant growth opportunity for the protein expression market. This includes both established biologics and emerging therapies like gene and cell therapies. Protein expression technologies are finding applications beyond drug development, such as in diagnostics, industrial biotechnology, and research. Diversifying application areas will open up new markets and opportunities. Ongoing research and development efforts are likely t%lI%yield more advanced and cost-effective protein expression systems. Innovations in gene editing and synthetic biology will enhance the precision and control of protein expression. Collaborations between academic institutions, research organizations, and biotech companies can accelerate the development and commercialization of novel protein expression technologies and products.

Key Market Drivers

Growing Biopharmaceutical Industry

The biopharmaceutical industry has seen tremendous growth in recent years, with a surge in demand for innovative therapeutic solutions, and the global protein expression market is reaping the benefits of this expansion. Protein expression is a fundamental process in biotechnology that involves the production of proteins for various applications, including drug development, diagnostics, and research. As the demand for biopharmaceuticals continues t%lI%rise, the protein expression market is experiencing robust growth, driven by advancements in biotechnology and the need for efficient and cost-effective protein production methods. The biopharmaceutical industry has become a vital component of the healthcare landscape, offering therapies and treatments for a wide range of diseases, including cancer, autoimmune disorders, and rare genetic conditions. Unlike traditional pharmaceuticals, biopharmaceuticals are produced using living cells, which allow for the creation of highly specific and potent therapeutic agents.

Advances in genomics and precision medicine have opened the door for personalized treatments, which often require the development of highly specific biologics tailored t%lI%an individual's genetic makeup. The global population is aging, leading t%lI%a rise in age-related diseases and a greater need for biopharmaceuticals. Continuous innovation in biotechnology, including gene editing and CRISPR-Cas9 technology, has accelerated the development of biologics and gene therapies. Government bodies around the world are increasingly recognizing the importance of biopharmaceuticals, resulting in streamlined approval processes and investments in research and development.

The global protein expression market is witnessing significant growth due t%lI%its essential role in the biopharmaceutical industry. The rising demand for biopharmaceuticals, including monoclonal antibodies, vaccines, and gene therapies, has led t%lI%an increased need for efficient protein expression systems. Continuous advancements in protein expression technologies, such as cell-free systems, mammalian expression systems, and yeast expression systems, have made protein production faster, more cost-effective, and scalable. Both established pharmaceutical companies and startups are investing heavily in biotechnology and protein expression, driving research and development efforts in this field. Contract Manufacturing Organizations (CMOs) are playing a crucial role in the protein expression market by offering specialized expertise and resources for biopharmaceutical production. This trend is expected t%lI%continue, further driving the market's growth. Beyond biopharmaceuticals, protein expression technologies are finding applications in industrial biotechnology, agriculture, and academic research.

Increased Investment in Research and Development

In today's rapidly evolving world of science and biotechnology, the global protein expression market is experiencing a surge in growth. This growth is primarily attributed t%lI%increased investment in research and development (R&D) across various sectors, including pharmaceuticals, biotechnology, and academic institutions. Protein expression is a fundamental process in the biotechnology industry, serving as a cornerstone for the development of therapeutic proteins, vaccines, and diagnostic tools. The expansion of R&D activities has paved the way for innovation and the application of cutting-edge technologies in the field, propelling the global protein expression market t%lI%new heights.

The biotechnology industry has witnessed remarkable advancements in recent years. Innovations such as CRISPR-Cas9 gene editing, high-throughput sequencing, and the development of sophisticated bioprocessing techniques have expanded the scope of protein expression research. These breakthroughs have fueled R&D investments, enabling the exploration of novel therapeutic proteins and biopharmaceuticals. The demand for biopharmaceuticals, such as monoclonal antibodies, vaccines, and gene therapies, has surged. Biopharmaceuticals often rely on recombinant protein expression systems for their production. With a growing emphasis on precision medicine and personalized therapies, R&D investments are essential t%lI%meet the increasing need for innovative biopharmaceutical products.

Governments around the world recognize the importance of R&D in the biotechnology sector. As a result, they have been increasing funding and offering incentives t%lI%research institutions, startups, and established biotechnology companies. These financial resources stimulate protein expression research, driving market growth. Collaborative efforts between academic institutions and industrial players have become more prevalent. This synergy encourages the sharing of knowledge, resources, and expertise, which accelerates the development of novel protein expression technologies and applications.

Key Market Challenges

High Costs

One of the primary challenges in the protein expression market is the high cost associated with protein production. The expenses incurred in terms of equipment, reagents, and skilled labor can be prohibitive for many research and development projects. This issue can limit the accessibility of protein expression technologies for smaller laboratories and research institutions.

T%lI%address this challenge, efforts are being made t%lI%develop more cost-effective expression systems, improve process efficiency, and provide affordable alternatives for protein expression. Also, collaborative research initiatives and shared resources can help reduce costs for the broader scientific community.

Variability in Protein Expression

Protein expression can be highly variable, even under controlled conditions. Factors such as the choice of expression system, host organism, and growth conditions can significantly impact the yield and quality of expressed proteins. This variability poses a significant challenge for researchers, as they strive for consistent and reproducible results.

Researchers are actively working t%lI%address this challenge by optimizing expression systems and improving the predictability of protein expression outcomes. Innovations in synthetic biology, protein engineering, and bioprocess optimization are helping t%lI%reduce variability and enhance the reliability of protein expression.

Complex Protein Targets

Another major challenge in the protein expression market is the production of complex proteins, including membrane proteins, multi-subunit complexes, and post-translationally modified proteins. These proteins are critical in drug discovery and structural biology but are often challenging t%lI%produce in sufficient quantities and with the desired functional properties.

T%lI%tackle this challenge, researchers are developing innovative strategies, such as cell-free expression systems, cell line engineering, and advanced purification techniques, t%lI%improve the expression and purification of complex proteins. These developments are essential for advancing our understanding of disease mechanisms and developing new therapies.

Regulatory and Ethical Considerations

The protein expression market faces regulatory and ethical challenges, particularly in the context of using expression systems involving genetically modified organisms (GMOs). Safety, biosecurity, and ethical concerns regarding GMOs are significant obstacles for researchers and companies working in this field.

Efforts t%lI%overcome these challenges include stringent adherence t%lI%regulatory guidelines, transparency in research practices, and the development of alternative expression systems that d%lI%not rely on GMOs. Ethical considerations als%lI%encourage the development of alternative methods t%lI%minimize the use of animals in protein expression, aligning with the principles of the 3Rs (Replacement, Reduction, Refinement).

Data Management and Analysis

The vast amount of data generated in protein expression experiments presents a significant challenge in terms of data management and analysis. Effective data management tools and analytical methods are essential t%lI%make sense of the complex datasets generated during protein expression experiments.

Researchers are turning t%lI%bioinformatics and data science t%lI%develop tools and algorithms that streamline data analysis and provide meaningful insights. Additionally, data sharing and collaboration within the scientific community are essential for overcoming this challenge.

Key Market Trends

Technological Advancements

In recent years, the global biotechnology and pharmaceutical industries have been witnessing a remarkable surge in technological advancements, leading t%lI%significant progress in various areas of research and development. One of the notable areas benefiting from these advancements is the field of protein expression. The global protein expression market is experiencing unprecedented growth as a result of these technological breakthroughs, offering new possibilities and revolutionizing the way scientists and researchers study and produce proteins.

The advent of NGS has transformed the way researchers study protein expression at the molecular level. NGS enables precise identification and quantification of proteins in complex biological samples, allowing for a deeper understanding of their functions and interactions. This technology has provided researchers with a more comprehensive view of protein expression and has accelerated drug discovery and biomarker identification. The revolutionary CRISPR-Cas9 gene-editing technology has played a pivotal role in enhancing protein expression studies. It enables precise modification of the host cells used for protein production, resulting in improved protein yields and quality. CRISPR technology has streamlined the process of generating cell lines for protein expression, making it more efficient and cost-effective.

High-Throughput Screening (HTS) methods have become indispensable in drug discovery and protein expression. Automated systems and robotics have made it possible t%lI%screen thousands of protein variants and cell lines simultaneously, leading t%lI%the identification of optimal conditions for protein expression and purification. This high-throughput approach has significantly reduced the time and resources required for protein production. Advances in synthetic biology and metabolic engineering have led t%lI%the development of novel host organisms, such as microalgae and synthetic yeast, with enhanced capabilities for protein expression. These genetically modified organisms can produce proteins efficiently and cost-effectively, opening new avenues for biomanufacturing and industrial-scale production.

Innovations in mass spectrometry and proteomics have revolutionized the analysis of protein expression patterns. Researchers can now perform in-depth proteome profiling, identifying and quantifying thousands of proteins simultaneously. This technology has applications in disease biomarker discovery, drug development, and personalized medicine.

Segmental Insights

Expression System Insights

Based on Expression System, Prokaryotic have emerged as the fastest growing segment in the Global Protein Expression Market in 2023. Prokaryotic expression systems, exemplified by bacterial systems like E. coli, often offer greater cost-effectiveness in contrast t%lI%eukaryotic systems. This cost advantage renders prokaryotic expression systems appealing t%lI%researchers and biopharmaceutical firms, particularly for large-scale manufacturing endeavors. Additionally, prokaryotic expression systems typically exhibit accelerated protein expression rates compared t%lI%their eukaryotic counterparts. This swift expression facilitates expedited protein production, rendering prokaryotic systems advantageous for time-critical projects. Furthermore, prokaryotic expression systems boast relative simplicity in manipulation and optimization relative t%lI%eukaryotic systems. This ease of operation enables straightforward genetic engineering and modification of expression vectors, empowering researchers t%lI%customize the system t%lI%suit their precise requirements efficiently.

End user Insights

Based on End User, Pharmaceutical and Biotechnological Companies have emerged as the fastest growing segment in Global Protein Expression Market during the forecast period. Pharmaceutical companies are investing heavily in protein expression technologies t%lI%develop novel drugs and therapies. Recombinant proteins, antibodies, and vaccines are vital components of modern medicine, and protein expression systems are essential for their production. These companies use a variety of expression systems, such as E. coli, yeast, and mammalian cells, t%lI%create proteins that are potential drug candidates. They rely on high-throughput protein expression technologies t%lI%screen and identify promising candidates faster and more efficiently. Biotechnological companies are instrumental in the production of therapeutic proteins and biopharmaceuticals. Their expertise in protein expression systems helps scale up the production of these complex molecules. Companies like Amgen, Genentech, and Nov%lI%Nordisk have established large-scale biomanufacturing facilities that utilize state-of-the-art protein expression technologies, ensuring a reliable supply of critical drugs for patients worldwide.

Regional Insights

Based on Region, North America have emerged as the dominating region in the Global Protein Expression market in 2023. One of the primary reasons for North America's leadership in the protein expression market is its thriving biotechnology sector. The region is home t%lI%some of the world's most prominent biotechnology companies, academic institutions, and research centers. These organizations are at the forefront of cutting-edge research in protein expression, continuously driving innovation in the field. The presence of these key players attracts top talent, fosters collaboration, and accelerates the development of novel protein expression technologies. North America boasts a robust R&D infrastructure that encompasses both the public and private sectors. Public research institutions, such as the National Institutes of Health (NIH) and the National Science Foundation (NSF), provide substantial funding for scientific research, including protein expression studies. Concurrently, private enterprises invest heavily in R&D, enabling them t%lI%develop and commercialize state-of-the-art protein expression technologies.

Key Market Players

%lI%Agilent Technologies, Inc.

%lI%Bio-Rad Laboratories, Inc.

%lI%Therm%lI%Fisher Scientific, Inc.

%lI%Merck KGaA

%lI%New England BioLabs, Inc.

%lI%Promega Corporation

%lI%QIAGEN GmbH

%lI%Takara Bio, Inc.

%lI%Oxford Expression Technologies Ltd

%lI%LGC Genomics Limited

Report Scope:

In this report, the Global Protein Expression Market has been segmented int%lI%the following categories, in addition t%lI%the industry trends which have als%lI%been detailed below:

%lI%Protein Expression Market, By Expression System:

%lI%Prokaryotic

%lI%Mammalian Cell

%lI%Insect Cell

%lI%Yeast

%lI%Others

%lI%Protein Expression Market, By Product:

%lI%Reagents

%lI%Competent Cells

%lI%Expression Vectors

%lI%Services

%lI%Instruments

%lI%Protein Expression Market, By End user:

%lI%Pharmaceutical and Biotechnological Companies

%lI%Academic Research

%lI%Contract research organizations

%lI%Others

%lI%Protein Expression Market, By Region:

%lI%North America

%lI%United States

%lI%Canada

%lI%Mexico

%lI%Europe

%lI%France

%lI%United Kingdom

%lI%Italy

%lI%Germany

%lI%Spain

%lI%Asia Pacific

%lI%China

%lI%India

%lI%Japan

%lI%Australia

%lI%South Korea

%lI%South America

%lI%Brazil

%lI%Argentina

%lI%Colombia

%lI%Middle East & Africa

%lI%South Africa

%lI%Saudi Arabia

%lI%UAE

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in the Global Protein Expression Market.

Available Customizations:

Global Protein Expression Market report with the given market data, Tech Sci Research offers customizations according t%lI%a company's specific needs. The following customization options are available for the report:

Company Information

%lI%Detailed analysis and profiling of additional market players (up t%lI%five).
1. PRODUCT OVERVIEW

1.1. Market Definition
1.2. Scope of the Market
  1.2.1. Markets Covered
  1.2.2. Years Considered for Study
  1.2.3. Key Market Segmentations

2. RESEARCH METHODOLOGY

2.1. Objective of the Study
2.2. Baseline Methodology
2.3. Key Industry Partners
2.4. Major Association and Secondary Sources
2.5. Forecasting Methodology
2.6. Data Triangulation & Validation
2.7. Assumptions and Limitations

3. EXECUTIVE SUMMARY

3.1. Overview of the Market
3.2. Overview of Key Market Segmentations
3.3. Overview of Key Market Players
3.4. Overview of Key Regions/Countries
3.5. Overview of Market Drivers, Challenges, Trends

4. GLOBAL PROTEIN EXPRESSION MARKET OUTLOOK

4.1. Market Size & Forecast
  4.1.1. By Value
4.2. Market Share & Forecast
  4.2.1. By Expression System (Prokaryotic, Mammalian Cell, Insect Cell, Yeast, Others)
  4.2.2. By Product (Reagents, Competent Cells, Expression Vectors, Services, Instruments)
  4.2.3. By End user (Pharmaceutical and Biotechnological Companies, Academic Research, Contract research organizations, Others)
  4.2.4. By Region
  4.2.5. By Company (2023)
4.3. Market Map
  4.3.1. By Expression System
  4.3.2. By Product
  4.3.3. By End user
  4.3.4. By Region

5. ASIA PACIFIC PROTEIN EXPRESSION MARKET OUTLOOK

5.1. Market Size & Forecast
  5.1.1. By Value
5.2. Market Share & Forecast
  5.2.1. By Expression System
  5.2.2. By Product
  5.2.3. By End user
  5.2.4. By Country
5.3. Asia Pacific: Country Analysis
  5.3.1. China Protein Expression Market Outlook
    5.3.1.1. Market Size & Forecast
      5.3.1.1.1. By Value
    5.3.1.2. Market Share & Forecast
      5.3.1.2.1. By Expression System
      5.3.1.2.2. By Product
      5.3.1.2.3. By End user
  5.3.2. India Protein Expression Market Outlook
    5.3.2.1. Market Size & Forecast
      5.3.2.1.1. By Value
    5.3.2.2. Market Share & Forecast
      5.3.2.2.1. By Expression System
      5.3.2.2.2. By Product
      5.3.2.2.3. By End user
  5.3.3. Australia Protein Expression Market Outlook
    5.3.3.1. Market Size & Forecast
      5.3.3.1.1. By Value
    5.3.3.2. Market Share & Forecast
      5.3.3.2.1. By Expression System
      5.3.3.2.2. By Product
      5.3.3.2.3. By End user
  5.3.4. Japan Protein Expression Market Outlook
    5.3.4.1. Market Size & Forecast
      5.3.4.1.1. By Value
    5.3.4.2. Market Share & Forecast
      5.3.4.2.1. By Expression System
      5.3.4.2.2. By Product
      5.3.4.2.3. By End user
  5.3.5. South Korea Protein Expression Market Outlook
    5.3.5.1. Market Size & Forecast
      5.3.5.1.1. By Value
    5.3.5.2. Market Share & Forecast
      5.3.5.2.1. By Expression System
      5.3.5.2.2. By Product
      5.3.5.2.3. By End user

6. EUROPE PROTEIN EXPRESSION MARKET OUTLOOK

6.1. Market Size & Forecast
  6.1.1. By Value
6.2. Market Share & Forecast
  6.2.1. By Expression System
  6.2.2. By Product
  6.2.3. By End user
  6.2.4. By Country
6.3. Europe: Country Analysis
  6.3.1. France Protein Expression Market Outlook
    6.3.1.1. Market Size & Forecast
      6.3.1.1.1. By Value
    6.3.1.2. Market Share & Forecast
      6.3.1.2.1. By Expression System
      6.3.1.2.2. By Product
      6.3.1.2.3. By End user
  6.3.2. Germany Protein Expression Market Outlook
    6.3.2.1. Market Size & Forecast
      6.3.2.1.1. By Value
    6.3.2.2. Market Share & Forecast
      6.3.2.2.1. By Expression System
      6.3.2.2.2. By Product
      6.3.2.2.3. By End user
  6.3.3. Spain Protein Expression Market Outlook
    6.3.3.1. Market Size & Forecast
      6.3.3.1.1. By Value
    6.3.3.2. Market Share & Forecast
      6.3.3.2.1. By Expression System
      6.3.3.2.2. By Product
      6.3.3.2.3. By End user
  6.3.4. Italy Protein Expression Market Outlook
    6.3.4.1. Market Size & Forecast
      6.3.4.1.1. By Value
    6.3.4.2. Market Share & Forecast
      6.3.4.2.1. By Expression System
      6.3.4.2.2. By Product
      6.3.4.2.3. By End user
  6.3.5. United Kingdom Protein Expression Market Outlook
    6.3.5.1. Market Size & Forecast
      6.3.5.1.1. By Value
    6.3.5.2. Market Share & Forecast
      6.3.5.2.1. By Expression System
      6.3.5.2.2. By Product
      6.3.5.2.3. By End user

7. NORTH AMERICA PROTEIN EXPRESSION MARKET OUTLOOK

7.1. Market Size & Forecast
  7.1.1. By Value
7.2. Market Share & Forecast
  7.2.1. By Expression System
  7.2.2. By Product
  7.2.3. By End user
  7.2.4. By Country
7.3. North America: Country Analysis
  7.3.1. United States Protein Expression Market Outlook
    7.3.1.1. Market Size & Forecast
      7.3.1.1.1. By Value
    7.3.1.2. Market Share & Forecast
      7.3.1.2.1. By Expression System
      7.3.1.2.2. By Product
      7.3.1.2.3. By End user
  7.3.2. Mexico Protein Expression Market Outlook
    7.3.2.1. Market Size & Forecast
      7.3.2.1.1. By Value
    7.3.2.2. Market Share & Forecast
      7.3.2.2.1. By Expression System
      7.3.2.2.2. By Product
      7.3.2.2.3. By End user
  7.3.3. Canada Protein Expression Market Outlook
    7.3.3.1. Market Size & Forecast
      7.3.3.1.1. By Value
    7.3.3.2. Market Share & Forecast
      7.3.3.2.1. By Expression System
      7.3.3.2.2. By Product
      7.3.3.2.3. By End user

8. SOUTH AMERICA PROTEIN EXPRESSION MARKET OUTLOOK

8.1. Market Size & Forecast
  8.1.1. By Value
8.2. Market Share & Forecast
  8.2.1. By Expression System
  8.2.2. By Product
  8.2.3. By End user
  8.2.4. By Country
8.3. South America: Country Analysis
  8.3.1. Brazil Protein Expression Market Outlook
    8.3.1.1. Market Size & Forecast
      8.3.1.1.1. By Value
    8.3.1.2. Market Share & Forecast
      8.3.1.2.1. By Expression System
      8.3.1.2.2. By Product
      8.3.1.2.3. By End user
  8.3.2. Argentina Protein Expression Market Outlook
    8.3.2.1. Market Size & Forecast
      8.3.2.1.1. By Value
    8.3.2.2. Market Share & Forecast
      8.3.2.2.1. By Expression System
      8.3.2.2.2. By Product
      8.3.2.2.3. By End user
  8.3.3. Colombia Protein Expression Market Outlook
    8.3.3.1. Market Size & Forecast
      8.3.3.1.1. By Value
    8.3.3.2. Market Share & Forecast
      8.3.3.2.1. By Expression System
      8.3.3.2.2. By Product
      8.3.3.2.3. By End user

9. MIDDLE EAST AND AFRICA PROTEIN EXPRESSION MARKET OUTLOOK

9.1. Market Size & Forecast
  9.1.1. By Value
9.2. Market Share & Forecast
  9.2.1. By Expression System
  9.2.2. By Product
  9.2.3. By End user
  9.2.4. By Country
9.3. MEA: Country Analysis
  9.3.1. South Africa Protein Expression Market Outlook
    9.3.1.1. Market Size & Forecast
      9.3.1.1.1. By Value
    9.3.1.2. Market Share & Forecast
      9.3.1.2.1. By Expression System
      9.3.1.2.2. By Product
      9.3.1.2.3. By End user
  9.3.2. Saudi Arabia Protein Expression Market Outlook
    9.3.2.1. Market Size & Forecast
      9.3.2.1.1. By Value
    9.3.2.2. Market Share & Forecast
      9.3.2.2.1. By Expression System
      9.3.2.2.2. By Product
      9.3.2.2.3. By End user
  9.3.3. UAE Protein Expression Market Outlook
    9.3.3.1. Market Size & Forecast
      9.3.3.1.1. By Value
    9.3.3.2. Market Share & Forecast
      9.3.3.2.1. By Expression System
      9.3.3.2.2. By Product
      9.3.3.2.3. By End user

10. MARKET DYNAMICS

10.1. Drivers
10.2. Challenges

11. MARKET TRENDS & DEVELOPMENTS

11.1. Recent Developments
11.2. Product Launches
11.3. Mergers & Acquisitions

12. GLOBAL PROTEIN EXPRESSION MARKET: SWOT ANALYSIS

13. PORTER’S FIVE FORCES ANALYSIS

13.1. Competition in the Industry
13.2. Potential of New Entrants
13.3. Power of Suppliers
13.4. Power of Customers
13.5. Threat of Substitute Product

14. COMPETITIVE LANDSCAPE

14.1. Agilent Technologies, Inc.
  14.1.1. Business Overview
  14.1.2. Company Snapshot
  14.1.3. Products & Services
  14.1.4. Financials (In case of listed)
  14.1.5. Recent Developments
  14.1.6. SWOT Analysis
14.2. Bio-Rad Laboratories, Inc.
14.3. Thermo Fisher Scientific, Inc.
14.4. Merck KGaA
14.5. New England BioLabs, Inc.
14.6. Promega Corporation
14.7. QIAGEN GmbH
14.8. Takara Bio, Inc.
14.9. Oxford Expression Technologies Ltd
14.10. LGC Genomics Limited

15. STRATEGIC RECOMMENDATIONS

16. ABOUT US & DISCLAIMER


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