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E-Selectin inhibitor– Pipeline Insight, 2022

January 2022 | 60 pages | ID: P809DF06422EN
DelveInsight

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DelveInsight’s, “E-Selectin inhibitor - Pipeline Insight, 2022” report provides comprehensive insights about 4+ companies and 7+ pipeline drugs in E-selectin inhibitor pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
E-Selectin inhibitor Understanding

E-SELECTIN inhibitor: Overview

E-Selectin (CD62E or previously referred to as ELAM-1) is a 115 kDa, inducible endothelial cell surface molecule. Its expression on endothelial cells is transcriptionally upregulated by various proinflammatory substances such as IL-1, TNF? and lipopolysaccharide (LPS). Expression of E-selectin on the endothelium is a hallmark of inflammation. E-selectin has been chosen as a target for several therapeutic and medical imaging applications, based on its expression in the vicinity of inflammation, infection or cancer.

Structure- E-selectin is a transmembrane receptor of the selectin family that also contains L- and P-selectins. Two glycosylated forms of E-selectin are detected at 100 and 115 kDa. The primary structure of E-selectin contains several domains: an amino terminal lectin-like domain, followed by an epidermal growth factor (EGF)-like domain and six repeated motifs similar to those found in some complement-binding proteins.

Function – E-Selectin is involved in the accumulation process of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.

E-SELECTIN Inhibitors- In research studies, Inhibiting E-selectin attenuated inflammation in atherosclerotic plaques, likely by reducing leukocyte recruitment into plaques and by mitigating hematopoietic stem and progenitor cell activation in the spleen of mice with myocardial Infarction. Various strategies are studied to exploit and modulate E-selectin-mediated binding include blocking its interaction with its ligands, blocking its ligands and inhibiting the glycosyl transferases associated with biosynthesis of selectin carbohydrate binding determinants. These strategies could inhibit immune and cancer cell adhesion in inflammation and metastasis, respectively.

E-SELECTIN inhibitor Emerging Drugs Chapters

This segment of the E-SELECTIN inhibitor report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

E-SELECTIN inhibitor Emerging Drugs
  • Uproleselan: GlycoMimetics
A specific E-selectin antagonist, Uproleselan is an investigational small molecule with potential anti-thrombotic, antineoplastic and chemopotentiating activities. Uproleselan binds to E-selectin expressed on endothelial cells and prevents their interaction with selectin-E ligand-expressing cancer cells. This may prevent tumor cell activation, migration and metastasis. In combination with chemotherapy, uproleselan is used to treat patients with acute myeloid leukemia (AML) and potentially other hematologic cancers. The drug is currently in Phase III clinical studies for acute myeloid leukaemia.
  • PF-07209326: Pfizer
PF-07209326 is an investigational biological therapy as E-Selectin antagonist. The therapy is currently in Phase I clinical development for the treatment of Sickle Cell disease.

Further product details are provided in the report……..

E-SELECTIN inhibitor: Therapeutic Assessment

This segment of the report provides insights about the different E-SELECTIN inhibitor drugs segregated based on following parameters that define the scope of the report, such as:
  • Major Players working on E-SELECTIN inhibitor
There are approx. 4+ key companies which are developing the E-SELECTIN inhibitor. The companies which have their E-SELECTIN inhibitor drug candidates in the most advanced stage, i.e. Phase III include, GlycoMimetics.
  • Phases
DelveInsight’s report covers around 7+ products under different phases of clinical development like
  • Late-stage products (Phase III and
  • Mid-stage products (Phase II and
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
E-SELECTIN inhibitor pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Intravaginal
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical.
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

E-SELECTIN inhibitor: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses E-SELECTIN inhibitor therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging E-SELECTIN inhibitor drugs.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence E-SELECTIN inhibitor R&D. The therapies under development are focused on novel approaches for E-SELECTIN inhibitor.
  • In January 2020, GlycoMimetics and Apollomics announce exclusive collaboration and license agreement to develop and commercialize uproleselan and GMI-1687 in Greater China. Under the terms of the agreement, Apollomics will be responsible for clinical development and commercialization in Greater China. GlycoMimetics to receive an upfront cash payment with eligibility to receive development, regulatory, and sales-based milestones, and tiered royalties.
E-SELECTIN inhibitor Report Insights
  • E-SELECTIN inhibitor Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
E-SELECTIN inhibitor Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions

Current Scenario and Emerging Therapies:
  • How many companies are developing E-SELECTIN inhibitor drugs?
  • How many E-SELECTIN inhibitor drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for E-SELECTIN inhibitor?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the E-SELECTIN inhibitor therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for E-SELECTIN inhibitor and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • GlycoMimetics
  • Modus Therapeutics
  • Pfizer
Key Products
  • Uproleselan
  • Rivipansel
  • Sevuparin
  • GMI-1687
  • GMI-1359
  • PF-07209326
Introduction
Executive Summary
E-SELECTIN inhibitor: Overview
  Structure
  Mechanism of Action
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
E-SELECTIN inhibitor – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
  E-SELECTIN inhibitor companies’ collaborations, Licensing, Acquisition -Deal Value Trends
E-SELECTIN inhibitor Collaboration Deals
  Company-Company Collaborations (Licensing / Partnering) Analysis
  Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
  Comparative Analysis
Uproleselan: GlycoMimetics
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
  Comparative Analysis
PF-07209326: Pfizer
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
  Comparative Analysis
GMI-1687: GlycoMimetics
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
  Comparative Analysis
E-SELECTIN inhibitor Key Companies
E-SELECTIN inhibitor Key Products
E-SELECTIN inhibitor- Unmet Needs
E-SELECTIN inhibitor- Market Drivers and Barriers
E-SELECTIN inhibitor- Future Perspectives and Conclusion
E-SELECTIN inhibitor Analyst Views
E-SELECTIN inhibitor Key Companies
Appendix


LIST OF TABLES

Table 1 Total Products for E-SELECTIN inhibitor
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products


LIST OF FIGURES

Figure 1 Total Products for E-SELECTIN inhibitor
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products


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