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Hepatic Encephalopathy- Market Insights, Epidemiology, and Market Forecast-2028

September 2019 | 160 pages | ID: H33FB1F9A14EN
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DelveInsight’s ‘Hepatic Encephalopathy- Market Insights, Epidemiology, and Market Forecast-2028’ report deliver an in-depth understanding of the disease, historical & forecasted epidemiology as well as the market trends of Hepatic Encephalopathy in the United States, EU5 (Germany, Spain, Italy, France and the United Kingdom), and Japan.

The Report provides the current treatment practices, emerging drugs, market share of the individual therapies, the current and forecasted market size of Hepatic Encephalopathy from 2017 to 2028 segmented by seven major markets. The Report also covers current treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assess the underlying potential of the market.

Geography Covered
  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan
Study Period: 2017–2028

Hepatic Encephalopathy - Disease Understanding and Treatment Algorithm

The DelveInsight Hepatic Encephalopathy market report gives a thorough understanding of the Hepatic Encephalopathy by including details such as disease definition, classification, symptoms, etiology, pathophysiology, diagnostic trends. It also provides treatment algorithms and treatment guidelines for Hepatic Encephalopathy in the US, Europe, and Japan.

Hepatic Encephalopathy

The Hepatic Encephalopathy epidemiology division provide insights about historical and current patient pool and forecasted trend for every 7 major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the DelveInsight report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology (Total Prevalence of Hepatic Encephalopathy in 7MM, Total Diagnosed Prevalence of Hepatic Encephalopathy in 7MM, Gender-specific Diagnosed Prevalence of Hepatic Encephalopathy, Age-specific Diagnosed Prevalence of Hepatic Encephalopathy, and Type Specific Diagnosed Prevalence of Hepatic Encephalopathy) scenario of Hepatic Encephalopathy in the 7MM covering United States, EU5 countries (Germany, Spain, Italy, France and United Kingdom) and Japan from 2017–2028.

According to DelveInsight, the total number of diagnosed prevalent population of Hepatic Encephalopathy in 7MM was found to be approximately 358,910 in the year 2017.

Hepatic Encephalopathy Drug Chapters

This segment of the Hepatic Encephalopathy report encloses the detailed analysis of marketed drugs and late stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug and the latest news and press releases.

Management of overt HE includes treating patients with acute HE episodes, preventing HE recurrence, and identifying and managing precipitating factors associated with the development of HE. The two main forms of medical therapy for HE are non-absorbable disaccharides (i.e., lactitol and lactulose) and non-absorbable antibiotics (i.e. rifaximin). The hyperammonemia and inflammation that occurs due to urea breakdown in cirrhotics have led to the development of HE treatments that target gut bacteria. Treatments for OHE approved by the US Food and Drug Administration (FDA), as well as some unapproved treatments, are available for use. It is important to remember that in patients with cirrhosis and portosystemic shunting, skeletal muscle mass and renal clearance are vital to neurotoxin clearance. Nutrition may also play a key role in managing HE and preventing a recurrence. The second line, less accepted therapies, include probiotics, branched-chain amino acids (BCAAs), flumazenil, zinc, and ammonia scavengers.

The first-line agent used to prevent acute or persistent HE is the nonabsorbable disaccharides (lactulose or lactitol). Clinical trials have established the efficacy of the nonabsorbable disaccharides in enema form to treat acute episodes of HE. Nonabsorbable disaccharides, lactulose, and lactitol (not used in the United States) have long been the mainstay of treatment for HE.

The second-line agents include oral antibiotics (neomycin, metronidazole, and rifaximin) that can reduce urease-producing bacteria in the intestines, resulting in a decrease of ammonia production and absorption through the gastrointestinal tract. The current guidelines recommend the addition of rifaximin to lactulose for the prevention of HE recurrence after the second episode of HE.

The third-line agents available for patients who cannot tolerate the above agents or still have persistent or episodic HE on the above agents are sodium benzoate, zinc, or bromocriptine. In addition, patients with unique situations may also benefit from an agent in this class.

There is only one drug that is going to be launched in 2023 which will contribute to an increase in the market size of Hepatic Encephalopathy. Mallinckrodt Therapeutics is developing MNK-6105/MNK-6106 for treatment and prevention of Hepatic encephalopathy.

Hepatic Encephalopathy Market Outlook

The Hepatic Encephalopathy market outlook of the report helps to build the detailed comprehension of the historic, current and forecasted trend of the market by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers and demand of better technology.

This segment gives a through detail of market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on annual cost of therapy, inclusion and exclusion criteria’s, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

According to DelveInsight, the market of Hepatic Encephalopathy in 7MM was found to be approximately USD 910.0 million in 2017 and is expected to increase from 2017-2028.

Hepatic Encephalopathy Drugs Uptake

This section focusses on the rate of uptake of the potential drugs recently launched in the market or will get launched in the market during the study period from 2017-2028. The analysis covers market uptake by drugs; patient uptake by therapies and sales of each drug.

This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allow the comparison of the drugs on the basis of market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Hepatic Encephalopathy Report Insights
  • Patient Population
  • Therapeutic Approaches
  • Pipeline Analysis
  • Market Size and Trends
  • Market Opportunities
  • Impact of upcoming Therapies
Hepatic Encephalopathy Report Key Strengths
  • 10 Year Forecast
  • 7MM Coverage
  • Epidemiology Segmentation
  • Drugs Uptake
  • Highly Analyzed Market
  • Key Cross Competition
Hepatic Encephalopathy Report Assessment
  • Current Treatment Practices
  • Unmet Needs
  • Detailed Pipeline Product Profiles
  • Market Attractiveness
  • Market Drivers and Barriers
Key Benefits
  • This DelveInsight report will help to develop Business Strategies by understanding the trends shaping and driving Hepatic Encephalopathy Infections market
  • Organize sales and marketing efforts by identifying the best opportunities for Hepatic Encephalopathy market
      • To understand the future market competition in the Hepatic Encephalopathy market.
1. KEY INSIGHTS

2. HEPATIC ENCEPHALOPATHY MARKET OVERVIEW AT A GLANCE

2.1. Market Share (%) Distribution of Hepatic Encephalopathy (HE) in 2017
2.2. Market Share (%) Distribution of Hepatic Encephalopathy (HE) in 2028

3. HEPATIC ENCEPHALOPATHY (HE): DISEASE BACKGROUND AND OVERVIEW

3.1. Introduction
3.2. Classification of Hepatic Encephalopathy
3.3. Symptoms of Hepatic Encephalopathy
3.4. Cause and risk factors of Hepatic Encephalopathy
3.5. Pathophysiology
3.6. Pathogenesis of Hepatic Encephalopathy
3.7. Diagnosis
3.8. The differential diagnosis for Hepatic Encephalopathy
3.9. Hepatic encephalopathy 2018: A clinical practice guideline by the Italian Association for the Study of the Liver (AISF)

4. EPIDEMIOLOGY AND PATIENT POPULATION

4.1. Key Findings
4.2. Methodology
4.3. 7MM Total Prevalent Patient Population of Hepatic Encephalopathy
4.4. 7MM Total Diagnosed Prevalent Patient Population of Hepatic Encephalopathy

5. COUNTRY WISE-EPIDEMIOLOGY OF HEPATIC ENCEPHALOPATHY

5.1. United States Epidemiology
  5.1.1. Assumptions and Rationale
  5.1.2. Total Prevalent Cases of Hepatic Encephalopathy in the United States
  5.1.3. Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in the United States
  5.1.4. Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United States
  5.1.5. Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United States
  5.1.6. Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United States
5.2. EU5 Epidemiology
  5.2.1. Germany
    5.2.1.1. Assumptions and Rationale
    5.2.1.2. Total Prevalent Cases of Hepatic Encephalopathy in Germany
    5.2.1.3. Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in Germany
    5.2.1.4. Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Germany
    5.2.1.5. Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Germany
    5.2.1.6. Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Germany
  5.2.2. France
    5.2.2.1. Assumptions and Rationale
    5.2.2.2. Total Prevalent Cases of Hepatic Encephalopathy in France
    5.2.2.3. Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in France
    5.2.2.4. Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in France
    5.2.2.5. Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in France
    5.2.2.6. Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in France
  5.2.3. Italy
    5.2.3.1. Assumptions and Rationale
    5.2.3.2. Total Prevalent Cases of Hepatic Encephalopathy in Italy
    5.2.3.3. Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in Italy
    5.2.3.4. Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Italy
    5.2.3.5. Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Italy
    5.2.3.6. Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Italy
  5.2.4. Spain
    5.2.4.1. Assumptions and Rationale
    5.2.4.2. Total Prevalent Cases of Hepatic Encephalopathy in Spain
    5.2.4.3. Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in Spain
    5.2.4.4. Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Spain
    5.2.4.5. Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Spain
    5.2.4.6. Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Spain
  5.2.5. United Kingdom
    5.2.5.1. Assumptions and Rationale
    5.2.5.2. Total Prevalent Cases of Hepatic Encephalopathy in the United Kingdom
    5.2.5.3. Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in the United Kingdom
    5.2.5.4. Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the UK
    5.2.5.5. Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the UK
    5.2.5.6. Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the UK

6. JAPAN EPIDEMIOLOGY

6.1. Assumptions and Rationale
6.2. Total Prevalent Cases of Hepatic Encephalopathy in Japan
6.3. Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan
6.4. Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Japan
6.5. Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Japan
6.6. Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Japan

7. TREATMENT AND MANAGEMENT OF HEPATIC ENCEPHALOPATHY

7.1. Line of therapies for the treatment of Hepatic Encephalopathy
7.2. Treatment algorithm
7.3. Treatment Guideline
  7.3.1. Practice Guideline on Hepatic Encephalopathy from the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver
  7.3.2. Hepatic encephalopathy 2018: A clinical practice guideline by the Italian Association for the Study of the Liver (AISF)

8. UNMET NEEDS

9. MARKETED DRUGS

9.1. Xifaxan: Salix Pharmaceuticals
  9.1.1. Product Description
  9.1.2. Regulatory Milestones
  9.1.3. Research and Development
  9.1.4. Clinical Trials Information
  9.1.5. Product Profile

10. EMERGING DRUGS

10.1. Key Cross Competition
10.2. SYNB1020: Synlogic
  10.2.1. Product Description
  10.2.2. Other Developmental Activities
  10.2.3. Clinical Development
  10.2.4. Clinical Trials Information
  10.2.5. Product Profile
10.3. GR3027: Umecrine Cognition
  10.3.1. Product Description
  10.3.2. Other Developmental Activities
  10.3.3. Clinical Development
  10.3.4. Safety and Efficacy
  10.3.5. Product Profile
10.4. MNK-6105/ MNK-6106: Mallinckrodt Therapeutics
  10.4.1. Product Description
  10.4.2. Other Developmental Activities
  10.4.3. Clinical Development
  10.4.4. Clinical Trials Information
  10.4.5. Product Profile

11. HEPATIC ENCEPHALOPATHY: 7 MAJOR MARKET ANALYSIS

11.1. Key Findings
11.2. Market Size of Hepatic Encephalopathy in the 7MM
11.3. Market Size of Hepatic Encephalopathy by Therapies in the 7MM

12. MARKET OUTLOOK: THE UNITED STATES

12.1. United States Market Size
  12.1.1. The total Market size of Hepatic Encephalopathy
  12.1.2. Hepatic Encephalopathy Market by Current Treatment & Emerging Therapy

13. MARKET OUTLOOK: EUROPE

13.1. Germany
  13.1.1. Total Market size of Hepatic Encephalopathy
  13.1.2. Hepatic Encephalopathy Market by Current Treatment & Emerging Therapy
13.2. France
  13.2.1. Total Market size of Hepatic Encephalopathy
  13.2.2. Hepatic Encephalopathy Market by Current Treatment & Emerging Therapy
13.3. Italy
  13.3.1. Total Market size of Hepatic Encephalopathy
  13.3.2. Hepatic Encephalopathy Market by Current Treatment & Emerging Therapy
13.4. Spain
  13.4.1. Total Market size of Hepatic Encephalopathy
  13.4.2. Hepatic Encephalopathy Market by Current Treatment & Emerging Therapy
13.5. United Kingdom
  13.5.1. Total Market size of Hepatic Encephalopathy
  13.5.2. Hepatic Encephalopathy Market by Current Treatment & Emerging Therapy

14. MARKET OUTLOOK: JAPAN

14.1. Total Market size of Hepatic Encephalopathy
14.2. Hepatic Encephalopathy Market by Current Treatment & Emerging Therapy

15. MARKET DRIVERS

16. MARKET BARRIERS

17. APPENDIX

17.1. Report Methodology

18. DELVEINSIGHT CAPABILITIES

19. DISCLAIMER

20. ABOUT DELVEINSIGHT

LIST OF TABLES

Table 1 Clinical Description of Hepatic Encephalopathy (Adapted from AASLD-EASL Guideline 2014
Table 2 West Haven Criteria for hepatic encephalopathy and symptoms
Table 3 Stages of Hepatic Encephalopathy (HE)
Table 4 Total Prevalent Patient Population of Hepatic Encephalopathy in 7MM (2017-2028)
Table 5 Total Diagnosed Prevalent Patient Population of Hepatic Encephalopathy in 7MM (2017-2028)
Table 6 Total Prevalent Population of Hepatic Encephalopathy in the United States (2017-2028)
Table 7 Total Diagnosed Prevalent Population of Hepatic Encephalopathy in the United States (2017-2028)
Table 8 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United States (2017-2028)
Table 9 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United States (2017-2028)
Table 10 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United States (2017-2028)
Table 11 Total Prevalent Population of Hepatic Encephalopathy in Germany (2017-2028)
Table 12 Total Diagnosed Prevalent Population of Hepatic Encephalopathy in Germany (2017-2028)
Table 13 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Germany (2017-2028)
Table 14 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Germany (2017-2028)
Table 15 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Germany (2017-2028)
Table 16 Total Prevalent Population of Hepatic Encephalopathy in France (2017-2028)
Table 17 Total Diagnosed Prevalent Population of Hepatic Encephalopathy in France (2017-2028)
Table 18 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in France (2017-2028)
Table 19 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in France (2017-2028)
Table 20 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in France (2017-2028)
Table 21 Total Prevalent Population of Hepatic Encephalopathy in Italy (2017-2028)
Table 22 Total Diagnosed Prevalent Population of Hepatic Encephalopathy in Italy (2017-2028)
Table 23 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Italy (2017-2028)
Table 24 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Italy (2017-2028)
Table 25 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Italy (2017-2028)
Table 26 Total Prevalent Population of Hepatic Encephalopathy in Spain (2017-2028)
Table 27 Total Diagnosed Prevalent Population of Hepatic Encephalopathy in Spain (2017-2028)
Table 28 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Spain (2017-2028)
Table 29 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Spain (2017-2028)
Table 30 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Spain (2017-2028)
Table 31 Total Prevalent Population of Hepatic Encephalopathy in the United Kingdom (2017-2028)
Table 32 Total Diagnosed Prevalent Population of Hepatic Encephalopathy in the United Kingdom (2017-2028)
Table 33 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United Kingdom (2017-2028)
Table 34 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United Kingdom (2017-2028)
Table 35 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United Kingdom (2017-2028)
Table 36 Total Prevalent Population of Hepatic Encephalopathy in Japan (2017-2028)
Table 37 Total Diagnosed Prevalent Population of Hepatic Encephalopathy in Japan (2017-2028)
Table 38 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Japan (2017-2028)
Table 39 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Japan (2017-2028)
Table 40 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Japan (2017-2028)
Table 41 Common Treatment Options for Hepatic Encephalopathy
Table 42 Treatment Summary
Table 43 Rifaximin, Clinical Trial Description, 2019
Table 44 List of Few Emerging Drugs Analysis
Table 45 SYNB1020, Clinical Trial Description, 2019
Table 46 MNK6106, Clinical Trial Description, 2019
Table 47 Market size of Hepatic Encephalopathy by Region in USD Million (2017–2028)
Table 48 Market Size of Hepatic Encephalopathy by Current Treatment and Emerging Therapy in 7MM, in USD Million (2017-2028)
Table 49 United States Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Table 50 The US Market Size of Hepatic Encephalopathy by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Table 51 Germany Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Table 52 Germany Market Size of HE by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Table 53 France Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Table 54 France Market Size of HE by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Table 55 Italy Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Table 56 Italy Market Size of HE by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Table 57 Spain Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Table 58 Spain Market Size of HE by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Table 59 United Kingdom Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Table 60 The UK Market Size of HE by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Table 61 Japan Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Table 62 Japan Market Size of HE by Current Treatment and Emerging Therapy in USD Million (2017-2028)

LIST OF FIGURES

Figure 1 Symptoms of Hepatic Encephalopathy
Figure 2 Grading of the symptoms of Hepatic Encephalopathy
Figure 3 Symptoms of Hepatic Encephalopathy
Figure 4 Pathophysiology of hepatic encephalopathy
Figure 5 Pathophysiology of hepatic encephalopathy
Figure 6 Ammonia trafficking in hepatic encephalopathy (HE) from an organism (left panel) and an organ (right panel) perspective
Figure 7 The classification of HE, adapted from Amodio et al.
Figure 8 Total Prevalent Cases of Hepatic Encephalopathy in the 7MM (2017-2028)
Figure 9 Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in the 7MM (2017-2028)
Figure 10 Total Prevalent Cases of Hepatic Encephalopathy in the United States (2017-2028)
Figure 11 Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in the United States (2017-2028)
Figure 12 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United States (2017-2028)
Figure 13 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United States (2017-2028)
Figure 14 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United States (2017-2028)
Figure 15 Total Prevalent Cases of Hepatic Encephalopathy in Germany (2017-2028)
Figure 16 Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in Germany (2017-2028)
Figure 17 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Germany (2017-2028)
Figure 18 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Germany (2017-2028)
Figure 19 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Germany (2017-2028)
Figure 20 Total Prevalent Cases of Hepatic Encephalopathy in France (2017-2028)
Figure 21 Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in France (2017-2028)
Figure 22 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in France (2017-2028)
Figure 23 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in France (2017-2028)
Figure 24 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in France (2017-2028)
Figure 25 Total Prevalent Cases of Hepatic Encephalopathy in Italy (2017-2028)
Figure 26 Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in Italy (2017-2028)
Figure 27 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Italy (2017-2028)
Figure 28 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Italy (2017-2028)
Figure 29 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Italy (2017-2028)
Figure 30 Total Prevalent Cases of Hepatic Encephalopathy in Spain (2017-2028)
Figure 31 Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in Spain (2017-2028)
Figure 32 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Spain (2017-2028)
Figure 33 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Spain (2017-2028)
Figure 34 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Spain (2017-2028)
Figure 35 Total Prevalent Cases of Hepatic Encephalopathy in the United Kingdom (2017-2028)
Figure 36 Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in the United Kingdom (2017-2028)
Figure 37 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United Kingdom (2017-2028)
Figure 38 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United Kingdom (2017-2028)
Figure 39 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in the United Kingdom (2017-2028)
Figure 40 Total Prevalent Cases of Hepatic Encephalopathy in Japan (2017-2028)
Figure 41 Total Diagnosed Prevalent Cases of Hepatic Encephalopathy in Japan (2017-2028)
Figure 42 Gender-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Japan (2017-2028)
Figure 43 Age-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Japan (2017-2028)
Figure 44 Type-Specific Diagnosed Prevalence of Hepatic Encephalopathy in Japan (2017-2028)
Figure 45 Management of patients with hepatic encephalopathy (HE)
Figure 46 Treatment algorithm for patients with minimal HE
Figure 47 Treatment algorithm for patients with minimal HE
Figure 48 Practice Guideline on Hepatic Encephalopathy from the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver
Figure 49 Unmet Needs
Figure 50 Market size of Hepatic Encephalopathy by Region in USD Million (2017–2028)
Figure 51 Market Size of Hepatic Encephalopathy by Therapies in the Seven Major Market (7MM), in USD Million (2017–2028)
Figure 52 United States Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Figure 53 The US Market Size of Hepatic Encephalopathy by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Figure 54 Germany Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Figure 55 Germany Market Size of Hepatic Encephalopathy by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Figure 56 France Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Figure 57 France Market Size of Hepatic Encephalopathy by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Figure 58 Italy Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Figure 59 Italy Market Size of Hepatic Encephalopathy by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Figure 60 Spain Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Figure 61 Spain Market Size of Hepatic Encephalopathy by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Figure 62 United Kingdom Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Figure 63 The UK Market Size of Hepatic Encephalopathy by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Figure 64 Japan Market Size of Hepatic Encephalopathy in USD Million (2017-2028)
Figure 65 Japan Market Size of Hepatic Encephalopathy by Current Treatment and Emerging Therapy in USD Million (2017-2028)
Figure 66 Market Drivers
Figure 67 Market Barriers


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