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Global TROP2 Antibody Market & Clinical Trials Insight 2026

November 2021 | 90 pages | ID: GFF98B09EAD6EN
Kuick Research

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Global TROP2 Antibody Market & Clinical Trials Insight 2026 Report Analysis and Data Highlights:
  • Research Methodology
  • Global & Regional Market Analysis
  • Global TROP2 Antibody Market Opportunity Assessment: > USD 4 Billion
  • Market and Drug Sales Insight 2020 Till 2026
  • Approved Drug In Market: 1 Drugs
  • Approved TROP2 Antibody Patent, Price and Sales insight 2020 Till 2026
  • Future Market Assessment By Indication Till 2026
  • Ongoing Clinical Trials Assessment by Status, Phase & Region
  • Key Market Dynamics
  • Competitor Landscape
Trophoblast surface antigen 2 (Trop2) is a cell surface protein which spans the epithelial membrane surface and plays role in cell self-renewal, proliferation, and transformation. Under normal physiological conditions, Trop2 has demonstrated its role in embryonic development, placental tissue formation, embryo implantation, stem cell proliferation, and organ development. Further, studies have also demonstrated that Trop2 is highly expressed on several cancer cells and is generally associated with its aggressive nature. Apart from this, it is also involved in several signaling pathways which ultimately lead to cancer cell growth and proliferation. Therefore, targeting Trop2 can be an alternative to target cancer.

Recently, scientists developed novel antibody drug conjugate in which the therapeutic antibody is targeted towards Trop2, thereby delivering the cytotoxin to the surface of tumor cell. Sacituzumab govitecan-hziy (Trodelvy) developed by Immunomedics is the first trop2 targeted antibody drug conjugate which has been approved for patients with unresectable locally advanced or metastatic triple-negative breast cancer (mTNBC) who have received two or more prior systemic therapies, at least one of them for metastatic disease. The introduction of Trodelvy in 2020 is expected to witness high growth rates in market due to lack of effective targeted therapies in mTNBC. It is believed that Trodelvy will revolutionize the overall treatment of TNBC and will significantly improve the survival outcomes.

Beyond the approval of Trodelvy in US, it has also gained approval in Australia, Canada, UK, and Switzerland for adults with metastatic TNBC. Apart from this, the drug is present in regulatory view in other regions including Europe, China and Singapore. Recently, European Medicines Agency has recommended the marketing of Trodelvy, indicating that the drug will enter the market in coming months. The rapid approval of drug in different regions will fuel the growth of market in coming years.

The quick approval of Trodelvy has further empowered innovation and development in this sector. To date, a cocktail of Trop2 targeted drugs including DS-1062a, RN927C, BAT8003, SKB264, JS108 are present in clinical development. These drugs have been designed to target a wide range of cancer including non-small cell lung cancer, epithelial cancer, skin cancer, colon cancer, and others. Apart from this, several investigational studies are also ongoing to evaluate the efficacy of Trodelvy for the treatment of hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer and metastatic non-small cell lung cancer. Additional evaluation across multiple solid tumors is also underway. The forthcoming years will see rapid influx of Trop-2 targeted therapies in wide range of cancers.

The key players in the TROP2 Antibody market include Daiichi Sankyo, Immunomedics, Gilead Sciences, AstraZeneca, Pfizer, BioThera Solution, and others. The major players in the market have adopted strategic alliances such as collaboration, partnerships, or joint ventures to cope up with the high cost of research and development and to maintain their share in market. For instance, Daiichi Sankyo and AstraZeneca have recently announced second trial collaboration with Merck to evaluate the combination of datopotamab deruxtecan (Dato-DXd), a TROP2 directed DXd antibody drug conjugate (ADC) and Keytruda in non-small cell lung cancer patients.

The global Trop2 targeting drug market is expected to surpass US$ 4 Billion by 2026. Surge in prevalence of cancer across geographies, high demand for targeted therapeutics for cancer treatment, favorable reimbursement policies offered by manufacturers and insurance providers, and rise in awareness of Trop-2 targeting drug owing o high efficiency will propel the growth of market. In addition, surge in geriatric population and increase in technological advancements in screening & diagnosis of cancer supplement the market growth.
1. INTRODUCTION TO TROP2 TARGETING THERAPY MARKET

1.1 Overview
1.2 History of TROP2 Targeting Therapeutics

2. TROP2 IDEAL CLINICAL BIOMARKER FOR CANCER

3. TROP2 TARGETING THERAPEUTICS MECHANISM

4. GLOBAL TROP2 TARGETING THERAPY MARKET ANALYSIS

4.1 Current Market Scenario
4.2 Future Market Opportunity

5. GLOBAL TROP2 TARGETING THERAPY MARKET OPPORTUNITY BY REGION

5.1 US
5.2 Europe
5.3 Japan
5.4 Rest of World

6. GLOBAL TROP2 TARGETING THERAPY MARKET BY CANCER

6.1 Breast Cancer
6.2 Urothelial Carcinoma
6.3 Lung Cancer
6.4 Pancreatic Cancer
6.5 Prostate Cancer

7. FIRST APPROVED TRO2 TARGETING ANTIBODY - TRODELVY (SACITUZUMAB GOVITECAN)

7.1 Overview
7.2 Approval, Patent & Exclusivity

8. TRODELVY - COMMERCIAL INFORMATION

8.1 Dosage & Price Analysis
8.2 Sales Analysis

9. TRODELVY SALES FORECAST 2026

10. TROP2 TARGETED THERAPY CLINICAL TRIALS INSIGHT

10.1 By Phase
10.2 By Development Status
10.3 By Region

11. GLOBAL TROP2 TARGETING THERAPY MARKET - ONGOING RESEARCH & DEVELOPMENT

11.1 Datopotamab Deruxtecan (DS-1062)
11.2 SKB264
11.3 JS108
11.4 BAT 8003
11.5 Trodelvy (Sacituzumab Govitecan)

12. GLOBAL TROP2 TARGETED THERAPY MARKET DYNAMICS

12.1 Market Drivers
12.2 Market Challenges

13. GLOBAL TROP2 TARGETING THERAPY MARKET FUTURE OUTLOOK

14. COMPETITIVE LANDSCAPE

14.1 Amunix
14.2 ARIUS Research
14.3 AstraZeneca
14.4 Biothera
14.5 Daiichi Sankyo Company
14.6 Gilead
14.7 Immunomedics
14.8 Janux Therapy
14.9 Klus Pharma
14.10 Myeloid therapeutics
14.11 Pfizer Inc
14.12 Shanghai Junshi Bioscience

LIST OF FIGURES

Figure 1-1: Evolution of TROP2 Targeting Therapeutics
Figure 2-1: Frequency of TROP2 Expression by Cancer Type (%)
Figure 2-2: Role of TROP2 in Cancer
Figure 3-1: TROP2 Stimulated Effectors, Biomarker & Pathways
Figure 3-2: TROP2 Regulated Oncogenic Cell Signaling Pathways
Figure 3-3: General Mechanism of TROP2 Targeting Therapy
Figure 3-4: Trodelvy - Mechanism of Action
Figure 4-1: Global – Number of Newly Diagnosed Cancer Cases (Million), 2020, 2025 & 2030
Figure 4-2: Global – Number of Cancer Deaths (Million), 2020, 2025 & 2030
Figure 4-3: Global – TROP2 Targeting Therapy Market Opportunity (US$ Million), 2020-2026
Figure 4-4: Global – Cancer Drug Market Opportunity (US$ Billion), 2020-2026
Figure 4-5: Global – TROP2 Targeting Therapy Market by Product (%) 2026
Figure 5-1: US – Number of Newly Diagnosed Cancer Cases (Million), 2020-2026
Figure 5-2: US – TROP2 Targeting Therapy Market Opportunity (US$ Million), 2020-2026
Figure 5-3: US – TROP2 Targeting Therapy Market by Product (%), 2026
Figure 5-4: Europe – Number of Newly Diagnosed Cancer Cases (Million), 2020-2026
Figure 5-5: Europe – TROP2 Targeting Therapy Market Opportunity (US$ Million), 2022-2026
Figure 5-6: Europe – TROP2 Targeting Therapy Market by Product (%), 2026
Figure 5-7: UK – TROP2 Targeting Therapy Market Opportunity (US$ Million), 2022 - 2026
Figure 5-8: Switzerland - TROP2 Targeting Therapy Market Opportunity (US$ Million), 2022 - 2026
Figure 5-9: Japan – Number of Newly Diagnosed Cancer Cases (Million), 2020-2026
Figure 5-10: Japan – TROP2 Targeting Therapy Market Opportunity (US$ Million), 2022-2026
Figure 5-11: Japan – TROP2 Targeting Therapy Market by Product (%), 2026
Figure 5-12: ROW – TROP2 Targeting Therapy Market Opportunity (US$ Million), 2022-2026
Figure 5-13: ROW – TROP2 Targeting Therapy Market by Product (%), 2026
Figure 5-14: Canada - TROP2 Targeting Therapy Market Opportunity (US$ Million), 2022 - 2026
Figure 5-15: Australia - TROP2 Targeting Therapy Market Opportunity (US$ Million), 2022 - 2026
Figure 6-1: Global – Number of Newly Diagnosed Breast Cancer Cases (Million), 2021-2026
Figure 6-2: Global – Number of Newly Diagnosed Triple Negative Breast Cancer Cases, 2021-2026
Figure 6-3: Global – Breast Cancer TROP2 Targeting Therapy Market Opportunity (US$ Million), 2021 - 2026
Figure 6-4: Global – Number of Urotheluial Cancer Cases, 2021-2026
Figure 6-5: Global – Urothelial Cancer TROP2 Targeting Therapy Market Opportunity (US$ Million), 2021-2026
Figure 6-6: Global – Number of Newly Diagnosed Lung Cancer Cases (Million), 2020-2026
Figure 6-7: Global –TROP2 Targeting Therapy Market Opportunity in Lung Cancer (US$ Million), 2023 - 2026
Figure 6-8: Global – Number of Newly Diagnosed Pancreatic Cancer Cases, 2020-2026
Figure 6-9: Global – Number of Newly Diagnosed Prostate Cancer Cases (Million), 2020-2026
Figure 6-10: Global – Number of Newly Diagnosed Castration Positive Prostate Cancer Cases, 2020-2026
Figure 6-11: Global - Estimated Adoption Rates for TROP2 Targeting Therapy for Castration Positive Prostate Cancer, 2021-2026
Figure 7-1: Trodelvy – Response Rate in Clinical Study (%)
Figure 7-2: Trodelvy – FDA Approval Year Indication
Figure 7-3: Trodelvy – Patent Expiration Year by Region
Figure 7-4: Trodelvy – FDA Orphan Designation Year by Indication
Figure 8-1: Trodelvy – Average Cost of Single Dose Cycle & Single Treatment Cycle (US$), September’2021
Figure 8-2: Global - Trodelvy Quarterly Sales Value (US$ Million), Q2 – Q4’ 2020
Figure 8-3: Global - Trodelvy Quarterly Sales Value (US$ Million), Q1 – Q3’ 2021
Figure 8-4: Trodelvy - US & Europe Sales Value (US$ Million), Q3’2021
Figure 9-1: Global - Trodelvy Sales Forecast (US$ Million), 2021 - 2026
Figure 9-2: US - Trodelvy Sales Forecast (US$ Million), 2021 - 2026
Figure 9-3: Europe - Trodelvy Sales Forecast (US$ Million), 2022 - 2026
Figure 9-4: Japan - Trodelvy Sales Forecast (US$ Million), 2022 - 2026
Figure 9-5: ROW - Trodelvy Sales Forecast (US$ Million), 2022 - 2026
Figure 9-6: UK - Trodelvy Sales Forecast (US$ Million), 2022 - 2026
Figure 9-7: Switzerland - Trodelvy Sales Forecast (US$ Million), 2022 - 2026
Figure 9-8: Canada - Trodelvy Sales Forecast (US$ Million), 2022 - 2026
Figure 9-9: Australia - Trodelvy Sales Forecast (US$ Million), 2022 - 2026
Figure 10-1: Global – Number of TROP2 Related Clinical Trials by Phase, September’2021
Figure 10-2: Global – TROP2 Related Clinical Trials by Phase (%), November’2021
Figure 10-3: Global – Number of TROP2 Related Clinical Trials by Development Status, November’2021
Figure 10-4: Global – Number of TROP2 Related Clinical Trials by Development Status (%), November’2021
Figure 10-5: Global – Number of TROP2 Related Clinical Trials by Region, November’2021
Figure 11-1: Investigational TROP2 Targeting Therapeutics
Figure 11-2: DS1062a Phase II Trial – NSCLC Study Initiation & Completion Year
Figure 11-3: DS1062a Phase II Trial – Metastatic NSCLC Study Initiation & Completion Year
Figure 11-4: DS1062a Phase III Trial – Comparitive Study Initiation & Completion Year
Figure 11-5: DS1062a Phase I Trial – Study Initiation & Completion Year
Figure 11-6: DS1062a Phase I Combinational Trial – Metastatic NSCLC Study Initiation & Completion Year
Figure 11-7: SKB264 Phase I-II Trial – Study Initiation & Completion Year
Figure 11-8: JS108 Phase I Trial – Study Initiation & Completion Year
Figure 11-9: BAT8003 Phase I Trial – Study Initiation & Completion Year
Figure 11-10: IMMU132 Phase II Trial – Prostate Cancer Study Initiation & Completion Year
Figure 11-11: IMMU132 Phase II Trial – Endometrial Carcinoma Study Initiation & Completion Year
Figure 11-12: IMMU132 Phase II Trial – Metastatic Solid Tumors Study Initiation & Completion Year
Figure 11-13: IMMU132 Phase I-II Trial – Epithelial Cancer Study Initiation & Completion Year
Figure 11-14: IMMU132 Phase II Trial – Glioblastoma Study Initiation & Completion Year
Figure 12-1: Global TROP2 Targeting Therapy Market Drivers
Figure 12-2: Challenges for Global TROP2 Targeting Therapy Market
Figure 12-3: US – Annual Cost Comparison of TROP2 Targeting Therapy with other Treatments (US$), November ’2021


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