Global Galectin Inhibitors Market Trends & Clinical Trials Insight 2023
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Global Galectin Inhibitors Market Trends & Clinical Trials Insight 2023 Report Highlights:
Many medications that target the galectins have been created to far, including OTX008 and LLS30, however only a select few have been successful in reaching clinical trials. Even then, numerous applicants had their trials halted or withdrew for a variety of reasons. These kinds of factors significantly hurt the pharmaceutical sector. Nevertheless, a few new businesses have emerged with a primary focus on the creation of medications and treatments that target the various galectins; some of these have already started clinical trials. Biotechnology companies with the support of specialists with years of experience and knowledge about the functioning and pathology of galectins in various disorders predominate the market for these medications.
Around 15 therapeutic candidates have been created for various indications and are in various stages of development and clinical review, demonstrating that the functions of galectins are not only limited to a small number of disorders. The most well-known and likely to succeed of the candidates created to date is GR-MD-O2, the lead candidate of Galectin Therapeutics. The fact that GR-MD-O2 was granted fast track status by the US FDA in 2013 for the treatment of non-alcoholic steatohepatitis (NASH) with hepatic fibrosis, also known as fatty liver disease with advanced fibrosis, supports this conclusion.
Galectin-3 inhibitor GR-MD-O2, also known as belapectin, is being tested for both cancer and non-cancer indications, while non-cancer indications studies were initiated sooner. In order to determine the effectiveness and safety of GR-MD-O2 in treating cirrhosis brought on by non-alcoholic steatohepatitis (NASH), patients with esophageal varices are participating in a phase 2/3 randomized multinational trial. Further, the investigational new drug medication application for the evaluation of GR-MD-O2 in patients with advanced or metastatic head and neck cancer in combination with a checkpoint inhibitor received FDA clearance in the third quarter of 2022. In response, Galectin began a phase 1 dose escalation research to examine the outcomes of GR-MD-O2 and pembrolizumab in patients with advanced melanoma, non-small cell lung cancer, and head and neck squamous cell cancer.
However, ProLectin M, a galectin-3 inhibitor, is the candidate that has advanced the furthest in clinical studies for the treatment of COVID-19 patients at various stages of infection. For treating COVID-19 patients with an early and severe infection, the medication has been developed in different formulations that are a chewable tablet and an intravenous infusion. Its developer Bioxytran is conducting preclinical research or has submitted the IND application for the medicine to be assessed in viral infections such COVID-19, influenza, monkeypox, and Ebola, as well as in pulmonary fibrosis and other fibrotic disorders.
Other companies are also striving to create viable candidates for blocking galectins to treat various ailments. Some companies, like MandalMed, developed candidates with unique modes of action. MandalMed's candidate MM-003 was a human protein inhibitor of galectin-3 developed to stop and treat harmful remodeling during myocardial infarction. Preclinical investigations on the candidate were being conducted until the project was abandoned by the company. Yet, this raises hope for the introduction of additional innovative modalities with greater efficacies in the upcoming years.
Galectin inhibitors are still in their infancy on the market, but some companies are working to develop them by accelerating research and development efforts to take advantage of the untapped potential of galectins as a medical treatment. The involvement of galectins in a variety of pathways gives hope for the possibility of one inhibitor to be used for more than one disease, which might help the company grow its patient base. As companies performing preclinical and clinical investigations release their findings, the market is predicted to grow in the coming years.
Global Galectin Inhibitors Market Trends & Clinical Trials Insight 2023 Report Highlights:
- Global Galectin Inhibitors Clinical Pipeline By Company, Indication & Phase
- Insight On All 16 Galectin Inhibitors In Clinical Pipeline
- Clinical Study Initiation & Completion Timeline By Key Drugs
- Global Galectin Inhibitors Market Dynamics
- Insight On Top 10 Companies Involved In Development Of Galectin Inhibitors Drugs
- Galectin Inhibitors Market Future Opportunity Outlook
Many medications that target the galectins have been created to far, including OTX008 and LLS30, however only a select few have been successful in reaching clinical trials. Even then, numerous applicants had their trials halted or withdrew for a variety of reasons. These kinds of factors significantly hurt the pharmaceutical sector. Nevertheless, a few new businesses have emerged with a primary focus on the creation of medications and treatments that target the various galectins; some of these have already started clinical trials. Biotechnology companies with the support of specialists with years of experience and knowledge about the functioning and pathology of galectins in various disorders predominate the market for these medications.
Around 15 therapeutic candidates have been created for various indications and are in various stages of development and clinical review, demonstrating that the functions of galectins are not only limited to a small number of disorders. The most well-known and likely to succeed of the candidates created to date is GR-MD-O2, the lead candidate of Galectin Therapeutics. The fact that GR-MD-O2 was granted fast track status by the US FDA in 2013 for the treatment of non-alcoholic steatohepatitis (NASH) with hepatic fibrosis, also known as fatty liver disease with advanced fibrosis, supports this conclusion.
Galectin-3 inhibitor GR-MD-O2, also known as belapectin, is being tested for both cancer and non-cancer indications, while non-cancer indications studies were initiated sooner. In order to determine the effectiveness and safety of GR-MD-O2 in treating cirrhosis brought on by non-alcoholic steatohepatitis (NASH), patients with esophageal varices are participating in a phase 2/3 randomized multinational trial. Further, the investigational new drug medication application for the evaluation of GR-MD-O2 in patients with advanced or metastatic head and neck cancer in combination with a checkpoint inhibitor received FDA clearance in the third quarter of 2022. In response, Galectin began a phase 1 dose escalation research to examine the outcomes of GR-MD-O2 and pembrolizumab in patients with advanced melanoma, non-small cell lung cancer, and head and neck squamous cell cancer.
However, ProLectin M, a galectin-3 inhibitor, is the candidate that has advanced the furthest in clinical studies for the treatment of COVID-19 patients at various stages of infection. For treating COVID-19 patients with an early and severe infection, the medication has been developed in different formulations that are a chewable tablet and an intravenous infusion. Its developer Bioxytran is conducting preclinical research or has submitted the IND application for the medicine to be assessed in viral infections such COVID-19, influenza, monkeypox, and Ebola, as well as in pulmonary fibrosis and other fibrotic disorders.
Other companies are also striving to create viable candidates for blocking galectins to treat various ailments. Some companies, like MandalMed, developed candidates with unique modes of action. MandalMed's candidate MM-003 was a human protein inhibitor of galectin-3 developed to stop and treat harmful remodeling during myocardial infarction. Preclinical investigations on the candidate were being conducted until the project was abandoned by the company. Yet, this raises hope for the introduction of additional innovative modalities with greater efficacies in the upcoming years.
Galectin inhibitors are still in their infancy on the market, but some companies are working to develop them by accelerating research and development efforts to take advantage of the untapped potential of galectins as a medical treatment. The involvement of galectins in a variety of pathways gives hope for the possibility of one inhibitor to be used for more than one disease, which might help the company grow its patient base. As companies performing preclinical and clinical investigations release their findings, the market is predicted to grow in the coming years.
1. INTRODUCTION TO GALECTIN INHIBITORS
1.1 Overview
1.2 Discovery of Galectins & Their Inhibitors
2. ROLE OF GALECTIN INHIBITORS & MECHANISM OF ACTION BY INDICATION
2.1 Cancer
2.2 Viral Infection
2.3 Liver Diseases
2.4 Neurodegenerative Disease
2.5 Cardiovascular Diseases
3. GLOBAL GALECTIN INHIBITORS CLINICAL TRIALS LANDSCAPE
3.1 By Company
3.2 By Country
3.3 By Indication
3.4 By Phase
3.5 By Patient Segment
4. GLOBAL GALECTIN INHIBITORS CLINICAL PIPELINE BY COMPANY, INDICATION & PHASE
4.1 Research
4.2 Preclinical
4.3 Phase-I/II
4.4 Phase-II
4.5 Phase-II/III
5. GLOBAL GALECTIN INHIBITORS MARKET DYNAMICS
5.1 Favorable Factors & Opportunities
5.2 Challenges & Restraints
6. GLOBAL GALECTIN INHIBITORS MARKET OPPORTUNITY OUTLOOK
7. COMPETITIVE LANDSCAPE
7.1 BioXyTran
7.2 G3 Pharmaceuticals
7.3 Galectin Therapeutics
7.4 Galecto
7.5 GlycoMimetics
7.6 HiFiBiO
7.7 PureTech Health
7.8 TrueBinding
7.9 University Medical Center Groningen
7.10 University Of Michigan Medical School
1.1 Overview
1.2 Discovery of Galectins & Their Inhibitors
2. ROLE OF GALECTIN INHIBITORS & MECHANISM OF ACTION BY INDICATION
2.1 Cancer
2.2 Viral Infection
2.3 Liver Diseases
2.4 Neurodegenerative Disease
2.5 Cardiovascular Diseases
3. GLOBAL GALECTIN INHIBITORS CLINICAL TRIALS LANDSCAPE
3.1 By Company
3.2 By Country
3.3 By Indication
3.4 By Phase
3.5 By Patient Segment
4. GLOBAL GALECTIN INHIBITORS CLINICAL PIPELINE BY COMPANY, INDICATION & PHASE
4.1 Research
4.2 Preclinical
4.3 Phase-I/II
4.4 Phase-II
4.5 Phase-II/III
5. GLOBAL GALECTIN INHIBITORS MARKET DYNAMICS
5.1 Favorable Factors & Opportunities
5.2 Challenges & Restraints
6. GLOBAL GALECTIN INHIBITORS MARKET OPPORTUNITY OUTLOOK
7. COMPETITIVE LANDSCAPE
7.1 BioXyTran
7.2 G3 Pharmaceuticals
7.3 Galectin Therapeutics
7.4 Galecto
7.5 GlycoMimetics
7.6 HiFiBiO
7.7 PureTech Health
7.8 TrueBinding
7.9 University Medical Center Groningen
7.10 University Of Michigan Medical School
LIST OF FIGURES
Figure 1-1: Timeline of Discovery of Galectin Inhibitors
Figure 2-1: Roles of Galectins in Cancer
Figure 2-2: LYT-200 Phase I/II Study – Initiation & Completion Years
Figure 2-3: GR-MD-02 Phase I Study – Initiation & Completion Years
Figure 2-4: GB1211 Phase I/II Study – Initiation & Completion Years
Figure 2-5: Roles of Galectins in Viral Infections
Figure 2-6: ProLectin M Phase III PROTECT Study – Initiation & Completion Years
Figure 2-7: ProLectin-M Phase II Study – Initiation & Completion Years
Figure 2-8: Roles of Galectins in Liver Diseases
Figure 2-9: Belapectin Phase II/III NAVIGATE Study – Initiation & Completion Years
Figure 2-10: GB1211 Phase I/II GULLIVER-2 Study – Initiation & Completion Years
Figure 2-11: Roles of Galectins in Neurodegenerative Disease
Figure 2-12: Roles of Galectins in Cardiovascular Diseases
Figure 3-1: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Company (Numbers), 2023
Figure 3-2: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Country (Numbers), 2023
Figure 3-3: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Indication (Numbers), 2023
Figure 3-4: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Phase (Numbers), 2023
Figure 3-5: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Patient Segment (Numbers), 2023
Figure 5-1: Factors Driving Galectin Inhibitors Market
Figure 5-2: Factors Limiting Galectin Inhibitors Market
Figure 1-1: Timeline of Discovery of Galectin Inhibitors
Figure 2-1: Roles of Galectins in Cancer
Figure 2-2: LYT-200 Phase I/II Study – Initiation & Completion Years
Figure 2-3: GR-MD-02 Phase I Study – Initiation & Completion Years
Figure 2-4: GB1211 Phase I/II Study – Initiation & Completion Years
Figure 2-5: Roles of Galectins in Viral Infections
Figure 2-6: ProLectin M Phase III PROTECT Study – Initiation & Completion Years
Figure 2-7: ProLectin-M Phase II Study – Initiation & Completion Years
Figure 2-8: Roles of Galectins in Liver Diseases
Figure 2-9: Belapectin Phase II/III NAVIGATE Study – Initiation & Completion Years
Figure 2-10: GB1211 Phase I/II GULLIVER-2 Study – Initiation & Completion Years
Figure 2-11: Roles of Galectins in Neurodegenerative Disease
Figure 2-12: Roles of Galectins in Cardiovascular Diseases
Figure 3-1: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Company (Numbers), 2023
Figure 3-2: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Country (Numbers), 2023
Figure 3-3: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Indication (Numbers), 2023
Figure 3-4: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Phase (Numbers), 2023
Figure 3-5: Global - Galectin Inhibitors Drugs In Clinical Pipeline By Patient Segment (Numbers), 2023
Figure 5-1: Factors Driving Galectin Inhibitors Market
Figure 5-2: Factors Limiting Galectin Inhibitors Market
LIST OF TABLES
Table 2-1: Galectins & Their Disease Implications
Table 2-1: Galectins & Their Disease Implications
