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Global DNA Sequencing: Research, Applied and Clinical Markets

July 2021 | 296 pages | ID: GFA72702B4AEN
BCC Research

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Report Scope

The report’s scope covers sequencing technologies, industries, applications, patents, initiatives and companies. The markets for sequencing services and products are given for the years 2020, 2021 and 2026.

This report reviews the leading sequencing technologies and describes why genetic variation is essential in clinical testing. It then discusses some of the important research initiatives that impact sequencing applications. The main market driving forces for sequencing services and products are listed and discussed.?

The report segments the sequencing markets by delivered format, including sequencing workflow products (sample preparation kits and reagents, informatics, and sequencing instruments and consumables) and sequencing services. The sample preparation reagents and kits market is fragmented by type, that is, DNA isolation and extraction; library preparation; and target enrichment. The sequencing instruments and consumables market are given by platform (NGS, Sanger and 3GS) and by product type (consumables, instruments).

The sequencing services market is segmented by end user applications (clinical, applied, research and development). Within sequencing services, the applied market is further analyzed by end user applications (biopharma, consumer, agriculture, microbiology, synthetic biology, population-scale genomics and others).

Also, within sequencing services, the clinical market is studied by disease category (clinical microbiology and infectious diseases, cardiovascular, mendelian disorders, metabolic/immune disorders, oncology, neurology, reproductive health and transplant medicine).

Industry sectors analyzed include long-read sequencing; sequencing instruments; target enrichment; informatics; blockchain; gene editing; liquid biopsy; reproductive health diagnostics; agriculture; consumer genomics; and DNA data storage.

By geography, the market has been fragmented into Europe, North America, Asia-Pacific (APAC) and the Rest of the World (RoW). For market estimates, data is provided for 2020 as the base year and for 2021, and it is forecast through year-end 2026. Estimated values used are based on product manufacturers’ and service providers’ total revenues. Projected and forecasted revenue values are in constant U.S. dollars that have not been adjusted for inflation.

Report Includes:
  • 85 tables
  • An updated review of the global market for DNA sequencing technologies and their applications in research, applied and clinical segments
  • Analyses of the global market trends, with data from 2020, estimates for 2021, and projections of compound annual growth rates (CAGRs) through 2026
  • Estimation of the market size and market forecast for DNA sequencing industry, and corresponding market share analysis by delivered format, product type, end use segment, application, disease category, and geography
  • Highlights of key market dynamics (DROs) for DNA sequencing, regulatory scenario, and impact of COVID-19 on the progress of this market
  • Discussion of market opportunities for DNA sequencing, industry structure, applications and business considerations of sequencing technologies, along with ongoing dramatic changes in the structure of MedTech industry
  • Review of the leading next-generation sequencing (NGS) technologies, emerging applications, and penetration of DNA sequencing-based diagnostics and research initiatives affecting the marketplace
  • Patent analysis for novel sequencing technologies, latest developments, clinical trials, and potential markets for future developments
  • Insight into the sequencing industry activities including major acquisitions and strategic alliances, competitive benchmarking of key sequencing industry participants and their growth strategies
  • Market share analysis of the key companies of the industry and their detailed company profiles including Agilent Technologies, Becton, Dickinson and Co., Bio-Rad, Danaher Corp., Illumina Inc., Merck KGaA, Roche, and Thermo Fisher
CHAPTER 1 INTRODUCTION

Study Goals and Objectives
Reasons for Doing This Study
What's New in This Report
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports

CHAPTER 2 SUMMARY AND HIGHLIGHTS

CHAPTER 3 OVERVIEW

Introduction
DNA Sequencing Markets
Sequencing Growth Driving Forces
Sequencing Applications
Sequencing Industry

CHAPTER 4 TECHNOLOGY BACKGROUND

Importance of DNA
Genetic Variation and Analysis
History of Sequencing
Sequencing Technologies
Sanger Sequencing
Next-Generation Sequencing (NGS)
Short-Read Platforms
Long-Read Platforms
Informatics Technologies
Base Calling
Mapping to a Reference Sequence
Variant Analysis
Clinical Sequencing Technology Challenges

CHAPTER 5 SEQUENCING INITIATIVES

Sequencing Initiatives
R&D Initiatives and Programs
1+ Million Genomes
Access to Comprehensive Genomic Profiling Coalition (ACGP)
Access to Treatment and Testing (ACTT)
Africa Pathogen Genomics Initiative
Blood Profiling Atlas
Cancer-ID
Cancer Moon Shots Program
China Precision Medicine Initiative
ClinGen
Early Cancer Detection Consortium
EpiFemCare
France Genomic Medicine Plan
Friends of Cancer Research Project
Genomic Medicine Sweden
HCA-Organoid
Human Cell Atlas
Human Immunomics Initiative
Immunomonitor Consortium
Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy Program
Intervene
Liquid Biopsies and Imaging for Improved Cancer Care
Liquid Biopsy-Based Malignant Tumor Early Screening Technology Research and Development Project
Lung-Map
Matchmaker Exchange
Metagenomics and Metadesign of Subways and Urban Biomes (MetaSub)
Medical Genome Initiative
Million Veteran Program (MVP)
MIND (Molecular Integration in Neurological Diagnosis)
MedSeq
National Microbiome Initiative (NMI)
Next Generation Single Cell Analysis Program
Precision Medicine Initiative
Prospective Registry of Multiplex Testing (PROMPT)
Quality Assurance Initiative Pathology (QuIP) Initiative
TopMed (Trans Omics for Precision Medicine)
Treehouse Childhood Cancer Initiative
Very Rare Cancer Consortium (VRCC)
Worldwide Innovative Networking (WIN) Consortium
Single-Cell Research
Cambridge Single-Cell Analysis Core Facility
Harvard Medical School Single-Cell Core
Mayo Medical Genome Facility
National Center for Single-Cell Biology
Next-Generation Single-Cell Analysis Program
Single-Cell Analysis Core
UC San Francisco Single-Cell Analysis Center
Population Sequencing Projects

CHAPTER 6 IMPACT OF COVID-19 PANDEMIC

Introduction
Impact on MedTech
Elective and Noncritical Procedures
Shift in Manufacturing
Regulatory Delays, Clinical Trials and Product Launches
Supply Chain Disruptions
Impact of COVID-19 on DNA Sequencing

CHAPTER 7 RESEARCH AND APPLIED APPLICATIONS

Introduction
Research and Development Applications
Applied Applications
Direct to Consumer
Biopharma
Agriculture
Forensics
Microbiome
Synthetic Biology

CHAPTER 8 CLINICAL APPLICATIONS

Introduction
Cancer Applications
Mendelian Disorders Applications
Reproductive Health Applications
Microbiology and Infectious Disease Applications
Complex Disorders Applications
Transplant Diagnostics Applications

CHAPTER 9 SEQUENCING INDUSTRY

Introduction
Sequencing Instruments Industry
Companies
Long-Read Sequencing Industry
Target Enrichment and Amplification Industry
Gene Editing Industry
Sequencing Informatics Industry
Liquid Biopsy Assay Industry
Reproductive Health Diagnostics Industry
Noninvasive Prenatal Testing (NIPT) Industry
Agriculture Industry
Consumer Genomics Industry
DNA Data Storage Industry

CHAPTER 10 DNA SEQUENCING MARKETS

Market Dynamics
Market Drivers
Market for DNA Sequencing
Sequencing Services Market
Sample Prep Kits and Reagents Market
Informatics Market
Sequencing Instruments and Consumables Market
Agriculture Market
Biopharma Market
Consumer Genomics Market
Microbiology Market
Population Genomics Market
Synthetic Biology Market
Clinical Diagnostic Sequencing
Cardiology Market
Clinical Microbiology and Infectious Disease Market
Mendelian Disorders Market
Metabolic/Immune Disorders Market
Neurology Market
Oncology Market
Reproductive Health Market
Transplant Market
Cancer Clinical Diagnostics Sequencing
Lung Cancer
Breast Cancer
Colorectal Cancer
Pan-Cancer
Other Cancers
Oncology Screening/Early Detection
Oncology Diagnosis
Oncology Therapy Guidance
Oncology Monitoring
Reproductive Health
IVF
Newborn Screening
Carrier Screening
NIPT
Transplant
Geographical Markets

CHAPTER 11 PATENT REVIEW/ NEW DEVELOPMENTS

Patents on Circulating Tumor Cells
Patents on Exosomes
Patents on Cell-Free DNA
Patents Related to Biomarkers
Sequencing-Related Patent Disputes

CHAPTER 12 COMPETITIVE LANDSCAPE

Acquisitions
Strategic Alliances

CHAPTER 13 COMPANY PROFILES

ADMERA HEALTH
ADAPTIVE BIOTECHNOLOGIES INC.
AGILENT TECHNOLOGIES INC.
AMBRY GENETICS
ASURAGEN INC.
ATHENA DIAGNOSTICS INC.
BAYLOR GENETICS
BECTON, DICKINSON AND CO.
BERRY GENOMICS CO. LTD.
BGI SHENZHEN
BIODESIX INC.
BIO-RAD LABORATORIES INC.
CAREDX INC.
CARIS LIFE SCIENCES
CEGAT GMBH
CELLMAX LIFE
CENTOGENE AG
COOPERSURGICAL INC.
CYGNUS BIOSCIENCES CO. LTD.
DANAHER CORP.
DARUI BIOTECHNOLOGY CO. LTD.
DEVYSER AB
DIACARTA INC.
DNA ELECTRONICS
ELECTRONIC BIOSCIENCES
EPIC SCIENCES INC.
EUROFINS SCIENTIFIC
FRY LABORATORIES LLC
GENAPSYS INC.
GENDX BV
GENE BY GENE LTD.
GENOMATIX SOFTWARE GMBH
GENOME PROFILING LLC
GOLDEN HELIX
GRANDOMICS BIOSCIENCES CO. LTD.
GUARDANT HEALTH INC.
HELIX OPCO LLC
HISTOGENETICS LLC
HTG MOLECULAR DIAGNOSTICS INC.
ILLUMINA INC.
INEX INNOVATIONS EXCHANGE PTE. LTD.
INIVATA LTD.
INTERPACE DIAGNOSTICS LLC
INVIVOSCRIBE INC.
IREPERTOIRE INC.
KEW INC.
LABORATORY CORP. OF AMERICA INC.
MACROGEN INC.
MDXHEALTH INC.
MERCK KGAA
MYRIAD GENETICS INC.
NATERA INC.
NEOGENOMICS LABORATORIES
NEW ENGLAND BIOLABS
NGENEBIO CO., LTD.
NOVOGENE CO. LTD.
NUGEN TECHNOLOGIES INC.
OMNISEQ CORP.
OXFORD NANOPORE TECHNOLOGIES LTD.
PACIFIC BIOSCIENCES OF CALIFORNIA INC.
PARADIGM DIAGNOSTICS INC.
PARSEQ LAB CO. LTD.
PERKINELMER INC.
PERSONAL GENOME DIAGNOSTICS INC.
PERSONALIS INC.
PREDICINE INC.
PREVENTIONGENETICS INC.
QIAGEN N.V.
QUANTUM BIOSYSTEMS INC.
QUEST DIAGNOSTICS INC.
REAL TIME GENOMICS INC.
ROCHE HOLDING AG
SEEKIN
SEQUENCING.COM
SEVEN BRIDGES GENOMICS INC.
SISTEMAS GENOMICOS SL
SOPHIA GENETICS
TAKARA BIO INC.
THERMO FISHER SCIENTIFIC INC.
UBIQUITY GENOMICS INC.
VORTEX BIOSCIENCES
YOURGENE HEALTH PLC

CHAPTER 14 APPENDIX: ACRONYMS

LIST OF TABLES

Summary Table: Global Market for DNA Sequencing, by Major Segment, Through 2026
Table 1: Global Market for DNA Sequencing, by Product Type, Through 2026
Table 2: Market for DNA Sequencing Growth Driving Forces
Table 3: Sequencing End Users and Applications
Table 4: Key Sequencing Industry Participants, by Sector
Table 5: DNA Chemical Building Blocks
Table 6: DNA Translation and Transcription
Table 7: Long-Range DNA Structure
Table 8: Genetic Variant Types
Table 9: Molecular Diagnostic Technology Platforms
Table 10: Genome Coverage of PCR, Microarray and NGS Technology Platforms
Table 11: DNA Sequencing Historical Timeline
Table 12: Sequencing Technology Development, 1990-2020
Table 13: Cost to Sequence a Single Human Genome, 2001-2021
Table 14: Sequencing Technology Summary
Table 15: Summary of Sanger Sequencing
Table 16: Improvements in Sanger Sequencing
Table 17: NGS Technologies
Table 18: Illumina NGS Workflow
Table 19: Thermo Fisher Scientific NGS Workflow
Table 20: NGS Bioinformatics Workflow
Table 21: Sequence Annotation Steps
Table 22: Future Challenges in Implementing Clinical NGS
Table 23: Key Sequencing Research and Development Programs
Table 24: Single-Cell Core Research Facilities
Table 25: Population Sequencing Projects
Table 26: Number of Sequencing Projects in GOLD Database, 2018-2020
Table 27: Main Sequencing Applications
Table 28: Genetic Analysis Platform Comparison
Table 29: Sequencing Impact on Agricultural Product Classes
Table 30: Key Applications in Forensics/Human Identity Sequencing
Table 31: Key Applications in Microbial Sequencing
Table 32: Genetic Testing Scope
Table 33: Key Applications for Sequencing-Based Diagnostics
Table 34: Cancer Applications
Table 35: Mendelian Disorders Applications
Table 36: Reproductive Health Screening Applications
Table 37: Ethical Issues Associated with NIPT
Table 38: Microbiology/Infectious Disease Applications
Table 39: Complex Disorder Applications
Table 40: Transplant Diagnostics Applications
Table 41: Subsectors within the Sequencing Industries
Table 42: NGS and 3GS Industry Company Positioning
Table 43: Long-Read Sequencing Industry
Table 44: NGS Target Enrichment Industry
Table 45: Gene Editing Tools Industry
Table 46: Agricultural Gene Editing Industry
Table 47: Sequencing Informatics Industry
Table 48: Liquid Biopsy Assay Industry: Company Focus
Table 49: Example of NGS-Based Liquid Biopsy Market Differentiation
Table 50: NIPT Industry
Table 51: Key Players in Synthetic Biology Agriculture Industry
Table 52: Players in Consumer Genomics Industry
Table 53: Key Forces Driving Growth in Market for DNA Sequencing and Their Implications
Table 54: Global Market for DNA Sequencing, by Format, Through 2026
Table 55: Global Market for Sequencing Instruments and Consumables, by Product Type, Through 2026
Table 56: Global Market for Sequencing Instruments and Consumables, by Product Generation, Through 2026
Table 57: Global Market for Sample Preparation, by Product Type, Through 2026
Table 58: Global Market for Sequencing Services, by End User, Through 2026
Table 59: Global Market for Applied Sequencing Services, by Application, Through 2026
Table 60: Global Market for Clinical Diagnostic Sequencing, by Disease Category, Through 2026
Table 61: NGS-Based Dilated Cardiomyopathy Test Providers
Table 62: NGS-Based Infectious Disease Landscape
Table 63: Multiple Sclerosis Diagnostic Technologies
Table 64: Limitations of Tissue Biopsy in Cancer Applications
Table 65: National Institutes of Health Liquid Biopsy Early Detection Initiative
Table 66: Clinical Trials on Lung Cancer Liquid Biopsies
Table 67: Five-Year Survival Rate for Ovarian Cancer
Table 68: MRI and Liquid Biopsy Methods
Table 69: Early Detection Tissue of Origin Approaches
Table 70: Global Market for DNA Sequencing, by Region, Through 2026
Table 71: North American Market for DNA Sequencing, by Country, Through 2026
Table 72: North American Market for DNA Sequencing, by Major Segment, Through 2026
Table 73: European Market for DNA Sequencing, by Country, Through 2026
Table 74: European Market for DNA Sequencing, by Major Segment, Through 2026
Table 75: Asia-Pacific Market for DNA Sequencing, by Country, Through 2026
Table 76: Asia-Pacific Market for DNA Sequencing, by Major Segment, Through 2026
Table 77: Rest of the World Market for DNA Sequencing, by Major Segment, Through 2026
Table 78: Patent Activity on Circulating Tumor Cells (CTCs), by Country/Region, January 2010–June 2020
Table 79: Patent Activity on Exosomes, by Country/Region, January 2010–December 2020
Table 80: Patent Activity on Cell-Free DNA, by Country/Region, January 2010–December 2020
Table 81: Patent Activity on Cancer Biomarkers, by Country/Region, January 2010–December 2020
Table 82: Status of NGS-Based Liquid Biopsy Patent Disputes
Table 83: Sequencing Industry Acquisitions
Table 84: Sequencing Industry Strategic Alliances
Table 85: Acronyms Used in the DNA Sequencing Industry

LIST OF FIGURES

Summary Figure: Global Market for DNA Sequencing, by Major Segment, 2020-2026
Figure 1: Agilent: Annual Revenue, 2018–2020
Figure 2: Agilent: Revenue Share, by Region, 2020
Figure 3: Agilent: Revenue Share, by Segment, 2020
Figure 4: BD: Annual Revenue, 2018-2020
Figure 5: BD: Revenue Share, by Geography, 2020
Figure 6: BD: Revenue Share, by Segment, 2020
Figure 7: Bio-Rad: Annual Revenue, 2018–2020
Figure 8: Bio-Rad: Revenue Share, by Segment, 2020
Figure 9: Danaher Corp.: Annual Revenue, 2018-2020
Figure 10: Danaher Corp.: Revenue Share, by Region, 2020
Figure 11: Danaher Corp.: Revenue Share, by Segment, 2020
Figure 12: Illumina Inc.: Annual Revenue, 2018–2020
Figure 13: Illumina Inc.: Revenue Share, by Region/ Country, 2020
Figure 14: Illumina Inc.: Revenue Share, by Segment, 2020
Figure 15: Merck KGaA: Annual Revenue, 2019 and 2020
Figure 16: Merck KGaA: Revenue Share, by Region, 2020
Figure 17: Merck KGaA: Revenue Share, by Segment, 2020
Figure 18: Thermo Fisher Scientific: Annual Revenue, 2019 and 2020
Figure 19: Thermo Fisher Scientific: Revenue Share, by Segment, 2020


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