Epiomic Epidemiology Series: Mucopolysaccharidosis-III (MPS-III) Sanfilippo Syndrome Forecast in 23 Major Markets 2017-2027

January 2017 | 74 pages | ID: E107408A7B7EN
Black Swan Analysis limited

Abstracts

Mucopolysaccharidosis-III, also known as MPS-III or Sanfilippo syndrome, is part of the Mucopolysaccharidoses (MPS) disorders - a group of rare genetic disorders caused by deficiencies of lysosomal enzymes. These are in-born errors of metabolism, and are autosomal recessive genetic disorders.

There are 4 distinct sub-types of MPS-III (A, B, C & D), with patients ranging from mild to severe in terms of symptoms. Prevalence of the different subtypes varies markedly country to country.

This report provides the current prevalent population for MPS-III across 23 Major Markets (USA, Canada, France, Germany, Italy, Spain, UK, Brazil, Japan, India, China, Australia, Netherlands, Denmark, Sweden, Norway, Turkey, Greece, Portugal, Poland, Estonia, Russia, Czech Republic) split by gender and 5-year age cohort. Along with the current prevalence, the report also contains a disease overview of the risk factors, disease diagnosis and prognosis along with specific variations by geography and ethnicity.

Providing a value-added level of insight from the analysis team at Black Swan, several of the main symptoms and co-morbidities of MPS-III have been quantified and presented alongside the overall prevalence figures. These sub-populations within the main disease are also included at a country level across the 10-year forecast snapshot.

Main symptoms and co-morbidities for MPS-III disease include:

• Hernia
• Hearing loss and otitis
• Sleep disorders
• Neurological and behavioural disorders

This report is built using data and information sourced from the proprietary Epiomic patient segmentation database. To generate accurate patient population estimates, the Epiomic database utilises a combination of several world class sources that deliver the most up to date information form patient registries, clinical trials and epidemiology studies. All of the sources used to generate the data and analysis have been identified in the report.

Reason to buy

• Able to quantify patient populations in global MPS-III market to target the development of future products, pricing strategies and launch plans.
• Gain further insight into the prevalence of the subdivided types of MPS-III and identify patient segments with high potential.
• Delivery of more accurate information for clinical trials in study sizing and realistic patient recruitment for various countries.
• Provide a level of understanding on the impact from specific co-morbid conditions on MPS-III prevalent population.
• Identify sub-populations within MPS-III which require treatment.
• Gain an understanding of the specific markets that have the largest number of MPS-III patients.

Contents

Introduction
Cause of the Disease
Risk Factors & Prevention
Diagnosis of the Disease
Variation by Geography/Ethnicity
Disease Prognosis & Clinical Course
Key comorbid conditions/Features associated with the disease
Methodology for quantification of patient numbers
Top-line prevalence for MPS-III
  Main Subtype
Features of MPS-III patients
Abbreviations used in the report
Other Black Swan Analysis Publications
Black Swan Analysis Online Patient-Based Databases
Patient-Based Offering
Online Pricing Data and Platforms
References
Appendix

List Of Tables

LIST OF TABLES

Prevalence of MPS-III, total (000s)
Prevalence of MPS-III, males (000s)
Prevalence of MPS-III, females (000s)
MPS-III patients by Sub-type, total (000s)
MPS-III patients with coarse features, total (000s)
MPS-III patients with Hepatomegaly, total (000s)
MPS-III patients with language delay, total (000s)
MPS-III patients with Abnormal behaviour, total (000s)
MPS-III patients with ASD, total (000s)
MPS-III patients with epilepsy, total (000s)
Abbreviations and Acronyms used in the report
USA Prevalence of MPS-III by 5-yr age cohort, males (000s)
USA Prevalence of MPS-III by 5-yr age cohort, females (000s)
Canada Prevalence of MPS-III by 5-yr age cohort, males (000s)
Canada Prevalence of MPS-III by 5-yr age cohort, females (000s)
France Prevalence of MPS-III by 5-yr age cohort, males (000s)
France Prevalence of MPS-III by 5-yr age cohort, females (000s)
Germany Prevalence of MPS-III by 5-yr age cohort, males (000s)
Germany Prevalence of MPS-III by 5-yr age cohort, females (000s)
Italy Prevalence of MPS-III by 5-yr age cohort, males (000s)
Italy Prevalence of MPS-III by 5-yr age cohort, females (000s)
Spain Prevalence of MPS-III by 5-yr age cohort, males (000s)
Spain Prevalence of MPS-III by 5-yr age cohort, females (000s)
UK Prevalence of MPS-III by 5-yr age cohort, males (000s)
UK Prevalence of MPS-III by 5-yr age cohort, females (000s)
Brazil Prevalence of MPS-III by 5-yr age cohort, males (000s)
Brazil Prevalence of MPS-III by 5-yr age cohort, females (000s)
Japan Prevalence of MPS-III by 5-yr age cohort, males (000s)
Japan Prevalence of MPS-III by 5-yr age cohort, females (000s)
India Prevalence of MPS-III by 5-yr age cohort, males (000s)
India Prevalence of MPS-III by 5-yr age cohort, females (000s)
China Prevalence of MPS-III by 5-yr age cohort, males (000s)
China Prevalence of MPS-III by 5-yr age cohort, females (000s)
Russia Prevalence of MPS-III by 5-yr age cohort, males (000s)
Russia Prevalence of MPS-III by 5-yr age cohort, females (000s)
Australia Prevalence of MPS-III by 5-yr age cohort, males (000s)
Australia Prevalence of MPS-III by 5-yr age cohort, females (000s)
Netherlands Prevalence of MPS-III by 5-yr age cohort, males (000s)
Netherlands Prevalence of MPS-III by 5-yr age cohort, females (000s)
Denmark Prevalence of MPS-III by 5-yr age cohort, males (000s)
Denmark Prevalence of MPS-III by 5-yr age cohort, females (000s)
Sweden Prevalence of MPS-III by 5-yr age cohort, males (000s)
Sweden Prevalence of MPS-III by 5-yr age cohort, females (000s)
Norway Prevalence of MPS-III by 5-yr age cohort, males (000s)
Norway Prevalence of MPS-III by 5-yr age cohort, females (000s)
Turkey Prevalence of MPS-III by 5-yr age cohort, males (000s)
Turkey Prevalence of MPS-III by 5-yr age cohort, females (000s)
Greece Prevalence of MPS-III by 5-yr age cohort, males (000s)
Greece Prevalence of MPS-III by 5-yr age cohort, females (000s)
Portugal Prevalence of MPS-III by 5-yr age cohort, males (000s)
Portugal Prevalence of MPS-III by 5-yr age cohort, females (000s)
Poland Prevalence of MPS-III by 5-yr age cohort, males (000s)
Poland Prevalence of MPS-III by 5-yr age cohort, females (000s)
Estonia Prevalence of MPS-III by 5-yr age cohort, males (000s)
Estonia Prevalence of MPS-III by 5-yr age cohort, females (000s)
Czech Republic Prevalence of MPS-III by 5-yr age cohort, males (000s)
Czech Republic Prevalence of MPS-III by 5-yr age cohort, females (000s)