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Arteriovenous fistula (AV) – Pipeline Insight, 2020

November 2020 | 40 pages | ID: A763E7660341EN
DelveInsight

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DelveInsight’s, “Arteriovenous fistula (AV) – Pipeline Insight, 2020,” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Arteriovenous fistula (AV) pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
Arteriovenous fistula (AV) Understanding

Arteriovenous fistula (AV): Overview

Arteriovenous fistula (AV) is an abnormal connection between an artery and a vein, in which blood flows directly from an artery into a vein, bypassing some capillaries. Small arteriovenous fistulas in your legs, arms, lungs, kidneys or brain are not much complicated while a large untreated arteriovenous fistula can lead to serious complications. An AV can develop anywhere in the body, though typically occur in the head, neck, spine, and liver. They can be caused from congenital defects or acquired as a results of cardiac catheterization complication, injuries that pierce the skin, and genetic conditions. Arteriovenous fistulas are often surgically created by vascular surgeon for use in dialysis in people with severe kidney disease.

Symptoms

Small arteriovenous fistulas often won't have any signs or symptoms and are usually don't need specialized treatment. Large arteriovenous fistulas may cause signs and symptoms. The symptoms of large Arteriovenous fistula (AV) include:
  • Heartburn or gastroesophageal reflux (backup of stomach contents into the esophagus)
  • Purplish, bulging veins that you can see through your skin, similar to varicose veins
  • Swelling in the arms or legs
  • Decreased blood pressure
  • Fatigue
  • Heart failure
  • bluish tinge on the skin
  • Clubbing of fingers
  • Coughing up blood
  • An arteriovenous fistula in your gastrointestinal tract can cause bleeding in digestive tract
Diagnosis

A diagnosis of Arteriovenous fistula (AV) is made based upon a thorough clinical evaluation, a detailed patient history, and a variety of specialized tests. Tests to diagnose an Arteriovenous fistula can include: Duplex ultrasound, Computerized tomography (CT) angiogram, and Magnetic resonance angiography (MRA).

Treatment

For small arteriovenous fistula a close monitoring by a doctor is sufficient, these fistula may close by themselves without treatment. Treatment options for large fistula includes endovascular embolization, ultrasound-guided compression, microsurgery, or stereotactic radiosurgery.

Arteriovenous fistula (AV) Emerging Drugs Chapters

This segment of the Arteriovenous fistula (AV) report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Arteriovenous fistula (AV) Emerging Drugs
  • REM-001: Kintara Therapeutics
REM-001 is a photosensitizer agent. REM-001, a photodynamic therapy (PDT) that consists of a drug, a laser light source and a light delivery device. Kintara Therapeutics has received Small Business Technology Transfer grant to study REM-001 for the prevention of arteriovenous fistula maturation failure (AFMF).

Further product details are provided in the report

Arteriovenous fistula (AV): Therapeutic Assessment

This segment of the report provides insights about the different Arteriovenous fistula (AV) drugs segregated based on following parameters that define the scope of the report, such as:
  • Major Players in Arteriovenous fistula (AV)
There are approx. 5+ key companies which are developing the therapies for Arteriovenous fistula (AV). The companies which have their Arteriovenous fistula (AV) drug candidates in the most advanced stage, i.e. phase II include, Enceladus Pharmaceuticals.
  • Phases
DelveInsight’s report covers around 5+ products under different phases of clinical development like
  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
Arteriovenous fistula (AV) pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Oral
  • Parenteral
  • intravitreal
  • Subretinal
  • Topical.
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Arteriovenous fistula (AV): Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Arteriovenous fistula (AV) therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Arteriovenous fistula (AV) drugs.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence Arteriovenous fistula (AV) R&D. The therapies under development are focused on novel approaches to treat/improve Arteriovenous fistula (AV).
Arteriovenous fistula (AV) Report Insights
  • Arteriovenous fistula (AV) Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
Arteriovenous fistula (AV) Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions

Current Treatment Scenario and Emerging Therapies:
  • How many companies are developing Arteriovenous fistula (AV) drugs?
  • How many Arteriovenous fistula (AV) drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Arteriovenous fistula (AV)?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Arteriovenous fistula (AV) therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Arteriovenous fistula (AV) and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • Kintara Therapeutics
  • Enceladus Pharmaceuticals
  • Symic Bio
  • Vascular Therapies
  • C. R. Bard
Key Products
  • Rostaporfin
  • Liposome encapsulated prednisolone
  • Proteoglycan-like compounds
  • Sirolimus-eluting implant
  • Lutonix DCB
Introduction
Executive Summary
Arteriovenous fistula (AV): Overview
  Causes
  Mechanism of Action
  Signs and Symptoms
  Diagnosis
  Disease Management
Pipeline Therapeutics
  Comparative Analysis
Therapeutic Assessment
  Assessment by Product Type
  Assessment by Stage and Product Type
  Assessment by Route of Administration
  Assessment by Stage and Route of Administration
  Assessment by Molecule Type
  Assessment by Stage and Molecule Type
Arteriovenous fistula (AV) – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
  Arteriovenous fistula (AV) companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Arteriovenous fistula (AV) Collaboration Deals
  Company-Company Collaborations (Licensing / Partnering) Analysis
  Company-University Collaborations (Licensing / Partnering) Analysis
Mid Stage Products (Phase II)
  Comparative Analysis
Liposome encapsulated prednisolone: Enceladus Pharmaceuticals
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report
Pre-clinical and Discovery Stage Products
  Comparative Analysis
Rostaporfin - Kintara Therapeutics
  Product Description
  Research and Development
  Product Development Activities
Drug profiles in the detailed report
Inactive Products
  Comparative Analysis
Arteriovenous fistula (AV) Key Companies
Arteriovenous fistula (AV) Key Products
Arteriovenous fistula (AV)- Unmet Needs
Arteriovenous fistula (AV)- Market Drivers and Barriers
Arteriovenous fistula (AV)- Future Perspectives and Conclusion
Arteriovenous fistula (AV) Analyst Views
Arteriovenous fistula (AV) Key Companies
Appendix

LIST OF TABLES

Table 1 Total Products for Arteriovenous fistula (AV)
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products

LIST OF FIGURES

Figure 1 Total Products for Arteriovenous fistula (AV)
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products


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