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Advanced Melanoma Market: Epidemiology, Industry Trends, Share, Size, Growth, Opportunity, and Forecast 2024-2034

May 2024 | 130 pages | ID: AA2199019C75EN
IMARC Group

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The 7 major advanced melanoma markets reached a value of US$ 3.9 Billion in 2023. Looking forward, IMARC Group expects the 7MM to reach US$ 10.0 Billion by 2034, exhibiting a growth rate (CAGR) of 8.91% during 2024-2034.

The advanced melanoma market has been comprehensively analyzed in IMARC's new report titled "Advanced Melanoma Market: Epidemiology, Industry Trends, Share, Size, Growth, Opportunity, and Forecast 2024-2034". Advanced melanoma, also known as stage III or stage IV melanoma, is a type of skin cancer that has spread beyond the original tumor and nearby lymph nodes to distant organs or lymph nodes. Some of the common symptoms include the presence of a large or growing mole or skin lesion, changes in the size, shape, or color of existing moles, ulceration or bleeding of the skin, itching, pain, or tenderness in the affected area, swollen lymph nodes, development of new lumps or nodules, etc. As advanced melanoma can spread to distant organs, indications may also include respiratory difficulties, bone pain, neurological symptoms, abdominal discomfort, etc. The diagnosis of the ailment typically involves a comprehensive evaluation that combines clinical examination, imaging tests, and biopsy confirmation. A dermatologist or oncologist may conduct a thorough physical exam, assessing the characteristics of skin lesions and checking for enlarged lymph nodes. Various imaging studies, such as computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), etc., help determine the extent of the disease and identify possible metastases. Additionally, numerous molecular diagnostic techniques, including genetic testing and biomarker analysis, may be performed to guide treatment decisions.

The increasing cases of prolonged sun exposure and severe sunburns, especially during childhood or adolescence, are primarily driving the advanced melanoma market. In addition to this, the rising prevalence of numerous associated risk factors, including genetic mutations, weakened immune systems, presence of atypical moles, etc., is also creating a positive outlook for the market. Moreover, the widespread adoption of novel targeted inhibitors, such as vemurafenib and dabrafenib, that specifically target genetic mutations or molecular abnormalities present in melanoma cells is further bolstering the market growth. Apart from this, the inflating application of adoptive cell transfer (ACT) therapy, which involves harvesting a patient's immune cells, modifying them to enhance their cancer-fighting abilities, and then reintroducing them into the body, where they can attack melanoma cells more effectively, is also acting as another significant growth-inducing factor. Additionally, the emerging popularity of reflectance confocal microscopy, since it aids in the non-invasive evaluation of suspicious skin lesions, thereby allowing dermatologists to visualize architectural features and cellular structures within the skin layers, is expected to drive the advanced melanoma market during the forecast period.

IMARC Group's new report provides an exhaustive analysis of the advanced melanoma market in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. This includes treatment practices, in-market, and pipeline drugs, share of individual therapies, market performance across the seven major markets, market performance of key companies and their drugs, etc. The report also provides the current and future patient pool across the seven major markets. According to the report the United States has the largest patient pool for advanced melanoma and also represents the largest market for its treatment. Furthermore, the current treatment practice/algorithm, market drivers, challenges, opportunities, reimbursement scenario and unmet medical needs, etc. have also been provided in the report. This report is a must-read for manufacturers, investors, business strategists, researchers, consultants, and all those who have any kind of stake or are planning to foray into the advanced melanoma market in any manner.

Time Period of the Study

Base Year: 2023
Historical Period: 2018-2023
Market Forecast: 2024-2034

Countries Covered

United States
Germany
France
United Kingdom
Italy
Spain
Japan

Analysis Covered Across Each Country

Historical, current, and future epidemiology scenario
Historical, current, and future performance of the advanced melanoma market
Historical, current, and future performance of various therapeutic categories in the market
Sales of various drugs across the advanced melanoma market
Reimbursement scenario in the market
In-market and pipeline drugs
Competitive Landscape:
This report also provides a detailed analysis of the current advanced melanoma marketed drugs and late-stage pipeline drugs.

In-Market Drugs

Drug Overview
Mechanism of Action
Regulatory Status
Clinical Trial Results
Drug Uptake and Market Performance

Late-Stage Pipeline Drugs

Drug Overview
Mechanism of Action
Regulatory Status
Clinical Trial Results
Drug Uptake and Market Performance

*Kindly note that the drugs in the above table only represent a partial list of marketed/pipeline drugs, and the complete list has been provided in the report.

Key Questions Answered in this Report:
Market Insights

How has the advanced melanoma market performed so far and how will it perform in the coming years?
What are the markets shares of various therapeutic segments in 2023 and how are they expected to perform till 2034?
What was the country-wise size of the advanced melanoma market across the seven major markets in 2023 and what will it look like in 2034?
What is the growth rate of the advanced melanoma market across the seven major markets and what will be the expected growth over the next ten years?
What are the key unmet needs in the market?

Epidemiology Insights

What is the number of prevalent cases (2018-2034) of advanced melanoma across the seven major markets?
What is the number of prevalent cases (2018-2034) of advanced melanoma by age across the seven major markets?
What is the number of prevalent cases (2018-2034) of advanced melanoma by gender across the seven major markets?
How many patients are diagnosed (2018-2034) with advanced melanoma across the seven major markets?
What is the size of the advanced melanoma patient pool (2018-2023) across the seven major markets?
What would be the forecasted patient pool (2024-2034) across the seven major markets?
What are the key factors driving the epidemiological trend of advanced melanoma?
What will be the growth rate of patients across the seven major markets?

Advanced Melanoma: Current Treatment Scenario, Marketed Drugs and Emerging Therapies

What are the current marketed drugs and what are their market performance?
What are the key pipeline drugs and how are they expected to perform in the coming years?
How safe are the current marketed drugs and what are their efficacies?
How safe are the late-stage pipeline drugs and what are their efficacies?
What are the current treatment guidelines for advanced melanoma drugs across the seven major markets?
Who are the key companies in the market and what are their market shares?
What are the key mergers and acquisitions, licensing activities, collaborations, etc. related to the advanced melanoma market?
What are the key regulatory events related to the advanced melanoma market?
What is the structure of clinical trial landscape by status related to the advanced melanoma market?
What is the structure of clinical trial landscape by phase related to the advanced melanoma market?
What is the structure of clinical trial landscape by route of administration related to the advanced melanoma market?
1 PREFACE

2 SCOPE AND METHODOLOGY

2.1 Objectives of the Study
2.2 Stakeholders
2.3 Data Sources
  2.3.1 Primary Sources
  2.3.2 Secondary Sources
2.4 Market Estimation
  2.4.1 Bottom-Up Approach
  2.4.2 Top-Down Approach
2.5 Forecasting Methodology

3 EXECUTIVE SUMMARY

4 ADVANCED MELANOMA - INTRODUCTION

4.1 Overview
4.2 Regulatory Process
4.3 Epidemiology (2018-2023) and Forecast (2024-2034)
4.4 Market Overview (2018-2023) and Forecast (2024-2034)
4.5 Competitive Intelligence

5 ADVANCED MELANOMA - DISEASE OVERVIEW

5.1 Introduction
5.2 Symptoms and Diagnosis
5.3 Pathophysiology
5.4 Causes and Risk Factors
5.5 Treatment

6 PATIENT JOURNEY

7 ADVANCED MELANOMA - EPIDEMIOLOGY AND PATIENT POPULATION

7.1 Epidemiology - Key Insights
7.2 Epidemiology Scenario - Top 7 Markets
  7.2.1 Epidemiology Scenario (2018-2023)
  7.2.2 Epidemiology Forecast (2024-2034)
  7.2.3 Epidemiology by Age (2018-2034)
  7.2.4 Epidemiology by Gender (2018-2034)
  7.2.5 Diagnosed Cases (2018-2034)
  7.2.6 Patient Pool/Treated Cases (2018-2034)
7.3 Epidemiology Scenario - United States
  7.3.1 Epidemiology Scenario (2018-2023)
  7.3.2 Epidemiology Forecast (2024-2034)
  7.3.3 Epidemiology by Age (2018-2034)
  7.3.4 Epidemiology by Gender (2018-2034)
  7.3.5 Diagnosed Cases (2018-2034)
  7.3.6 Patient Pool/Treated Cases (2018-2034)
7.4 Epidemiology Scenario - Germany
  7.4.1 Epidemiology Scenario (2018-2023)
  7.4.2 Epidemiology Forecast (2024-2034)
  7.4.3 Epidemiology by Age (2018-2034)
  7.4.4 Epidemiology by Gender (2018-2034)
  7.4.5 Diagnosed Cases (2018-2034)
  7.4.6 Patient Pool/Treated Cases (2018-2034)
7.5 Epidemiology Scenario - France
  7.5.1 Epidemiology Scenario (2018-2023)
  7.5.2 Epidemiology Forecast (2024-2034)
  7.5.3 Epidemiology by Age (2018-2034)
  7.5.4 Epidemiology by Gender (2018-2034)
  7.5.5 Diagnosed Cases (2018-2034)
  7.5.6 Patient Pool/Treated Cases (2018-2034)
7.6 Epidemiology Scenario - United Kingdom
  7.6.1 Epidemiology Scenario (2018-2023)
  7.6.2 Epidemiology Forecast (2024-2034)
  7.6.3 Epidemiology by Age (2018-2034)
  7.6.4 Epidemiology by Gender (2018-2034)
  7.6.5 Diagnosed Cases (2018-2034)
  7.6.6 Patient Pool/Treated Cases (2018-2034)
7.7 Epidemiology Scenario - Italy
  7.7.1 Epidemiology Scenario (2018-2023)
  7.7.2 Epidemiology Forecast (2024-2034)
  7.7.3 Epidemiology by Age (2018-2034)
  7.7.4 Epidemiology by Gender (2018-2034)
  7.7.5 Diagnosed Cases (2018-2034)
  7.7.6 Patient Pool/Treated Cases (2018-2034)
7.8 Epidemiology Scenario - Spain
  7.8.1 Epidemiology Scenario (2018-2023)
  7.8.2 Epidemiology Forecast (2024-2034)
  7.8.3 Epidemiology by Age (2018-2034)
  7.8.4 Epidemiology by Gender (2018-2034)
  7.8.5 Diagnosed Cases (2018-2034)
  7.8.6 Patient Pool/Treated Cases (2018-2034)
7.9 Epidemiology Scenario - Japan
  7.9.1 Epidemiology Scenario (2018-2023)
  7.9.2 Epidemiology Forecast (2024-2034)
  7.9.3 Epidemiology by Age (2018-2034)
  7.9.4 Epidemiology by Gender (2018-2034)
  7.9.5 Diagnosed Cases (2018-2034)
  7.9.6 Patient Pool/Treated Cases (2018-2034)

8 ADVANCED MELANOMA - TREATMENT ALGORITHM, GUIDELINES, AND MEDICAL PRACTICES

8.1 Guidelines, Management and Treatment
8.2 Treatment Algorithm

9 ADVANCED MELANOMA - UNMET NEEDS

10 ADVANCED MELANOMA - KEY ENDPOINTS OF TREATMENT

11 ADVANCED MELANOMA - MARKETED PRODUCTS

11.1 List of Advanced Melanoma Marketed Drugs Across the Top 7 Markets
  11.1.1 Opdualag (Nivolumab/relatlimab) - Bristol-Myers Squibb
    11.1.1.1 Drug Overview
    11.1.1.2 Mechanism of Action
    11.1.1.3 Regulatory Status
    11.1.1.4 Clinical Trial Results
    11.1.1.5 Sales Across Major Markets
  11.1.2 Tecentriq (Atezolizumab) - Genentech
    11.1.2.1 Drug Overview
    11.1.2.2 Mechanism of Action
    11.1.2.3 Regulatory Status
    11.1.2.4 Clinical Trial Results
    11.1.2.5 Sales Across Major Markets
  11.1.3 Imlygic (Talimogene laherparepvec) - Amgen
    11.1.3.1 Drug Overview
    11.1.3.2 Mechanism of Action
    11.1.3.3 Regulatory Status
    11.1.3.4 Clinical Trial Results
    11.1.3.5 Sales Across Major Markets
  11.1.4 Sylatron (Peginterferon alfa-2b) - Enzon/Merck & Co.
    11.1.4.1 Drug Overview
    11.1.4.2 Mechanism of Action
    11.1.4.3 Regulatory Status
    11.1.4.4 Clinical Trial Results
    11.1.4.5 Sales Across Major Markets
  11.1.5 Yervoy (Ipilimumab) - Bristol Myers Squibb
    11.1.5.1 Drug Overview
    11.1.5.2 Mechanism of Action
    11.1.5.3 Regulatory Status
    11.1.5.4 Clinical Trial Results
    11.1.5.5 Sales Across Major Markets
Kindly note that the above only represents a partial list of marketed drugs, and the complete list has been provided in the report.

12 ADVANCED MELANOMA - PIPELINE DRUGS

12.1 List of Advanced Melanoma Pipeline Drugs Across the Top 7 Markets
  12.1.1 LTX315 - Lytix Biopharma
    12.1.1.1 Drug Overview
    12.1.1.2 Mechanism of Action
    12.1.1.3 Clinical Trial Results
    12.1.1.4 Safety and Efficacy
    12.1.1.5 Regulatory Status
  12.1.2 Botensilimab - Agenus
    12.1.2.1 Drug Overview
    12.1.2.2 Mechanism of Action
    12.1.2.3 Clinical Trial Results
    12.1.2.4 Safety and Efficacy
    12.1.2.5 Regulatory Status
  12.1.3 Tebentafusp - Immunocore
    12.1.3.1 Drug Overview
    12.1.3.2 Mechanism of Action
    12.1.3.3 Clinical Trial Results
    12.1.3.4 Safety and Efficacy
    12.1.3.5 Regulatory Status
  12.1.4 APX005M - Apexigen
    12.1.4.1 Drug Overview
    12.1.4.2 Mechanism of Action
    12.1.4.3 Clinical Trial Results
    12.1.4.4 Safety and Efficacy
    12.1.4.5 Regulatory Status
  12.1.5 BNT 111 - BioNTech
    12.1.5.1 Drug Overview
    12.1.5.2 Mechanism of Action
    12.1.5.3 Clinical Trial Results
    12.1.5.4 Safety and Efficacy
    12.1.5.5 Regulatory Status
Kindly note that the above only represents a partial list of pipeline drugs, and the complete list has been provided in the report.

13. ADVANCED MELANOMA - ATTRIBUTE ANALYSIS OF KEY MARKETED AND PIPELINE DRUGS

14. ADVANCED MELANOMA – CLINICAL TRIAL LANDSCAPE

14.1 Drugs by Status
14.2 Drugs by Phase
14.3 Drugs by Route of Administration
14.4 Key Regulatory Events

15 ADVANCED MELANOMA - MARKET SCENARIO

15.1 Market Scenario - Key Insights
15.2 Market Scenario - Top 7 Markets
  15.2.1 Advanced Melanoma - Market Size
    15.2.1.1 Market Size (2018-2023)
    15.2.1.2 Market Forecast (2024-2034)
  15.2.2 Advanced Melanoma - Market Size by Therapies
    15.2.2.1 Market Size by Therapies (2018-2023)
    15.2.2.2 Market Forecast by Therapies (2024-2034)
15.3 Market Scenario - United States
  15.3.1 Advanced Melanoma - Market Size
    15.3.1.1 Market Size (2018-2023)
    15.3.1.2 Market Forecast (2024-2034)
  15.3.2 Advanced Melanoma - Market Size by Therapies
    15.3.2.1 Market Size by Therapies (2018-2023)
    15.3.2.2 Market Forecast by Therapies (2024-2034)
  15.3.3 Advanced Melanoma - Access and Reimbursement Overview
15.4 Market Scenario - Germany
  15.4.1 Advanced Melanoma - Market Size
    15.4.1.1 Market Size (2018-2023)
    15.4.1.2 Market Forecast (2024-2034)
  15.4.2 Advanced Melanoma - Market Size by Therapies
    15.4.2.1 Market Size by Therapies (2018-2023)
    15.4.2.2 Market Forecast by Therapies (2024-2034)
  15.4.3 Advanced Melanoma - Access and Reimbursement Overview
15.5 Market Scenario - France
  15.5.1 Advanced Melanoma - Market Size
    15.5.1.1 Market Size (2018-2023)
    15.5.1.2 Market Forecast (2024-2034)
  15.5.2 Advanced Melanoma - Market Size by Therapies
    15.5.2.1 Market Size by Therapies (2018-2023)
    15.5.2.2 Market Forecast by Therapies (2024-2034)
  15.5.3 Advanced Melanoma - Access and Reimbursement Overview
15.6 Market Scenario - United Kingdom
  15.6.1 Advanced Melanoma - Market Size
    15.6.1.1 Market Size (2018-2023)
    15.6.1.2 Market Forecast (2024-2034)
  15.6.2 Advanced Melanoma - Market Size by Therapies
    15.6.2.1 Market Size by Therapies (2018-2023)
    15.6.2.2 Market Forecast by Therapies (2024-2034)
  15.6.3 Advanced Melanoma - Access and Reimbursement Overview
15.7 Market Scenario - Italy
  15.7.1 Advanced Melanoma - Market Size
    15.7.1.1 Market Size (2018-2023)
    15.7.1.2 Market Forecast (2024-2034)
  15.7.2 Advanced Melanoma - Market Size by Therapies
    15.7.2.1 Market Size by Therapies (2018-2023)
    15.7.2.2 Market Forecast by Therapies (2024-2034)
  15.7.3 Advanced Melanoma - Access and Reimbursement Overview
15.8 Market Scenario - Spain
  15.8.1 Advanced Melanoma - Market Size
    15.8.1.1 Market Size (2018-2023)
    15.8.1.2 Market Forecast (2024-2034)
  15.8.2 Advanced Melanoma - Market Size by Therapies
    15.8.2.1 Market Size by Therapies (2018-2023)
    15.8.2.2 Market Forecast by Therapies (2024-2034)
  15.8.3 Advanced Melanoma - Access and Reimbursement Overview
15.9 Market Scenario - Japan
  15.9.1 Advanced Melanoma - Market Size
    15.9.1.1 Market Size (2018-2023)
    15.9.1.2 Market Forecast (2024-2034)
  15.9.2 Advanced Melanoma - Market Size by Therapies
    15.9.2.1 Market Size by Therapies (2018-2023)
    15.9.2.2 Market Forecast by Therapies (2024-2034)
  15.9.3 Advanced Melanoma - Access and Reimbursement Overview

16 ADVANCED MELANOMA - RECENT EVENTS AND INPUTS FROM KEY OPINION LEADERS

17 ADVANCED MELANOMA MARKET - SWOT ANALYSIS

17.1 Strengths
17.2 Weaknesses
17.3 Opportunities
17.4 Threats

18 ADVANCED MELANOMA MARKET – STRATEGIC RECOMMENDATIONS

19 APPENDIX


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