2018 POC/Point-of-Care Infectious Disease Testing Market: Physician Offices/Group Practices, Emergency Rooms, Ambulatory Care Centers, Surgery Centers, Birth Centers--Volume and Sales Segment Forecasts, Technology Trends, Instrumentation Review
This new 835-page report from VPGMarketResearch contains 80 tables, and provides a comprehensive analysis of the POC infectious disease testing market, including trends, dynamics, size, growth, regulatory requirements, technological trends, competitive landscape, and emerging opportunities for instrument and consumable suppliers. This report will help diagnostic product suppliers develop effective business, R&D and marketing strategies for the global POC infectious disease testing market
RationaleThe growing economic pressures on hospitals, coupled with advances in diagnostic technologies, intensifying competition among suppliers and physicians, and changing consumer demands are shifting diagnostic testing from hospitals and commercial laboratories closer to the patient
Market Segmentation Analysis- Review of five POC market segments, including their dynamics, trends, structure, size, growth and major suppliers.- Five-year test volume and reagent sales forecasts for major infectious disease tests by market segment:- Physician Offices/Group Practices - Emergency Rooms - Ambulatory Care Centers- Surgery Centers - Birth Centers
Sales and Market Share Analysis
Market shares of major infectious disease diagnostic reagent and instrument suppliers
Current and Emerging Products- Analysis of infectious disease diagnostic tests performed in POC testing locations.- Review of leading infectious disease testing analyzers, both currently marketed and those in development, including their operating characteristics, features and selling prices
Technology Review- Emerging technologies and their applications for POC testing.- Comprehensive listings of companies developing or marketing coagulation testing technologies and products, by assay.
Competitive Assessments
Assessments of major suppliers and emerging market entrants including their sales, product portfolios, marketing tactics, joint ventures, and new products in R&D.
Strategic Recommendations
Specific opportunities for new infectious disease testing instruments and reagent systems with potentially significant market appeal during the next five years.- Design criteria for POC testing products.- Alternative business expansion strategies.- Potential market entry barriers and risks
MethodologyThis report is based on a combination of primary and secondary sources of information, including review of the latest technical and business publications, manufacturer product literature, industry analyst reports, and VPGMarketResearch's proprietary data files.
Contains 835 pages and 80 tables
RationaleThe growing economic pressures on hospitals, coupled with advances in diagnostic technologies, intensifying competition among suppliers and physicians, and changing consumer demands are shifting diagnostic testing from hospitals and commercial laboratories closer to the patient
Market Segmentation Analysis- Review of five POC market segments, including their dynamics, trends, structure, size, growth and major suppliers.- Five-year test volume and reagent sales forecasts for major infectious disease tests by market segment:- Physician Offices/Group Practices - Emergency Rooms - Ambulatory Care Centers- Surgery Centers - Birth Centers
Sales and Market Share Analysis
Market shares of major infectious disease diagnostic reagent and instrument suppliers
Current and Emerging Products- Analysis of infectious disease diagnostic tests performed in POC testing locations.- Review of leading infectious disease testing analyzers, both currently marketed and those in development, including their operating characteristics, features and selling prices
Technology Review- Emerging technologies and their applications for POC testing.- Comprehensive listings of companies developing or marketing coagulation testing technologies and products, by assay.
Competitive Assessments
Assessments of major suppliers and emerging market entrants including their sales, product portfolios, marketing tactics, joint ventures, and new products in R&D.
Strategic Recommendations
Specific opportunities for new infectious disease testing instruments and reagent systems with potentially significant market appeal during the next five years.- Design criteria for POC testing products.- Alternative business expansion strategies.- Potential market entry barriers and risks
MethodologyThis report is based on a combination of primary and secondary sources of information, including review of the latest technical and business publications, manufacturer product literature, industry analyst reports, and VPGMarketResearch's proprietary data files.
Contains 835 pages and 80 tables
INTRODUCTION
EXECUTIVE SUMMARY
RATIONALE FOR TESTING DECENTRALIZATION
1. OVERVIEW
2. REGULATORY TRENDS
3. ECONOMIC TRENDS
4. DEMOGRAPHIC TRENDS
5. TECHNOLOGICAL TRENDS
6. SOCIAL TRENDS
7. QUALITY OF CARE
8. DEFENSIVE MEDICINE
9. QUALITY CONTROL ISSUES
WORLDWIDE MARKET AND TECHNOLOGY OVERVIEW
1. INTRODUCTION
2. ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT)
3. ALPHA-2 ANTIPLASMIN
4. ANTITHROMBIN III
5. BLEEDING TIME
6. D-DIMER
7. FACTOR VIII
8. FIBRIN DEGRADATION PRODUCTS
9. FIBRINOGEN
10. HEPARIN
11. PROTEINS C AND S
12. PROTHROMBIN TIME (PT)
13. THROMBIN TIME
INSTRUMENTATION: Coagulation Analyzers Manufactured by:
Behnk Elektronik
Bio/Data
Cardiovascular Diagnostics
Diagnostica Stago
Helena Laboratories
INSTRUMENTATION Laboratory
ITC Hemochron
Roche
Siemens
Sysmex
Teco Medical Instruments
Trinity Biotech
CURRENT AND EMERGING TECHNOLOGIES
1. MONOCLONAL ANTIBODIES
2. IMMUNOASSAYS
a. Technological Principle
b. Enzyme Immunoassays (EIA)
Overview
ELISA
Dot Immunobinding Assays
Capillary Immunoassays
Particle-Membrane Capture Immunoassay
Enzyme Amplification
c. Fluorescent Immunoassays
Fluorescent Polarization
Time-Resolved Pulse Fluorescence
d. Luminescence
Chemiluminescence
Bioluminescence
e. Latex Agglutination
f. Immunoprecipitation
3. DRY CHEMISTRY
4. BIOSENSORS
5. IT AND AUTOMATION
6. MOLECULAR DIAGNOSTICS
a. Technology Overview
b. Amplification Methods
Polymerase Chain Reaction
Ligase Chain Reaction
Branched DNA
Q-Beta Replicase
Strand Displacement Activation
Self-Sustained Sequence Replicase
U.S.A.
A. Market Overview
1. BUSINESS ENVIRONMENT
a. Health Care Expenditures
b. Cost Consciousness
c. Reimbursement
d. Industry Consolidation
e. Managed Care
PPO
HMO
f. Hospitals
g. Admissions
h. Length of Stay
i. Industry Diversification
j. Physician Demographics
k. Aging Population
More Chronic Illness
Disease Incidence
Susceptibility to latrogenesis
Multiple Illnesses Cases
l. Laboratory Regulations
2. MARKET STRUCTURE
a. Hospitals
b. Commercial/Private Laboratories
B. Physician Offices/Group Practices
1. MARKET SUMMARY
2. MARKET STRUCTURE
3. TEST VOLUME AND SALES FORECASTS
C. Ancillary Hospital Locations
1. INTRODUCTION
a. Emergency Departments
b. Operating Suites
c. Intensive Care Units
2. EMERGENCY DEPARTMENTS
a. Market Summary
b. Test volume and Sales Forecasts
3. OPERATING AND RECOVERY SUITES
a. Market Summary
b. Test Volume and Sales Forecasts
4. ICUS/CCUS
a. Market Summary
b. Test Volume and Sales Forecasts
D. Cancer Clinics
1. INTRODUCTION
2. MARKET SUMMARY
3. TEST VOLUME AND SALES FORECASTS
E. Ambulatory Care Centers
1. INTRODUCTION
2. MARKET SUMMARY
3. MARKET STRUCTURE
4. TEST VOLUME AND SALES FORECASTS
F. Surgery Centers
1. INTRODUCTION
2. MARKET SUMMARY
3. MARKET STRUCTURE
4. TEST VOLUME AND SALES FORECASTS
G. Nursing Homes
1. INTRODUCTION
2. MARKET SUMMARY
3. MARKET STRUCTURE
4. TEST VOLUME AND SALES FORECASTS
H. Birth Centers
1. INTRODUCTION
2. MARKET SUMMARY
3. MARKET STRUCTURE
4. TEST VOLUME AND SALES FORECASTS
1. MAJOR SUPPLIERS’ INSTRUMENT PLACEMENTS, INSTALLED BASE, CONSUMABLES SALES AND MARKET SHARES
Germany
A. Market Overview
B. Market Structure
C. Market Summary
D. Test Volume and Sales Forecasts
E. Major Suppliers’ Instrument Placements, Installed Base, Consumables Sales and Market Shares
Spain A. Business Environment
B. Market Structure
C. Market Summary
D. Test Volume and Sales Forecasts
E. Major Suppliers’ Instrument Placements, Installed Base, Consumables Sales and Market Shares
MAJOR PRODUCT DEVELOPMENT OPPORTUNITIES
A. Routine and Special Chemistry
B. Microbiology/Infectious Diseases
C. Hematology and Flow Cytometry
D. Coagulation
DESIGN CRITERIA FOR DECENTRALIZED TESTING PRODUCTS
ALTERNATIVE MARKET PENETRATION STRATEGIES
A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies for Decentralized Testing Markets
1. MARKETING APPROACHES
2. PRODUCT COMPLEXITY
3. CUSTOMER PREFERENCE
4. ESTABLISHED SUPPLIERS
5. EMERGING SUPPLIERS
6. MAJOR TYPES OF DISTRIBUTORS
7. MARKET SEGMENTATION
POTENTIAL MARKET ENTRY BARRIERS AND RISKS
A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge and Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges
COMPANY PROFILE
Abbott
ADI/American Diagnostica
Agilent Technologies
Alere/Biosite/Inverness
Axis-Shield
Beckman Coulter/Danaher
Becton Dickinson
Bio/Data
Biomerieux
Bio-Rad
Cephid
Chrono-Log
Corgenix
Decode Genetics
Diadexus
Diagnocure
Diagnostica Stago/Trinity Biotech
Diamedix
Diasorin
Eiken Chemical
EKF Diagnostics
Fujirebio
Grifols
Helena Laboratories
Hologic/Gen-Probe
Horiba
INSTRUMENTATION Laboratory
International Technidyne/Nexus DX
Kreatech/Leica
Kyowa Medex
Lonza
Mackay Life Sciences
Matritech
Nihon Kohden
Ortho-Clinical Diagnostics
Polartechnics
Polymedco
Qiagen
Roche
SDIX
Sequenom
Siemens
Sienco
Sysmex
Takara Bio
ThermoFisher
Tosoh
Wako
Zycare/Alere
EXECUTIVE SUMMARY
RATIONALE FOR TESTING DECENTRALIZATION
1. OVERVIEW
2. REGULATORY TRENDS
3. ECONOMIC TRENDS
4. DEMOGRAPHIC TRENDS
5. TECHNOLOGICAL TRENDS
6. SOCIAL TRENDS
7. QUALITY OF CARE
8. DEFENSIVE MEDICINE
9. QUALITY CONTROL ISSUES
WORLDWIDE MARKET AND TECHNOLOGY OVERVIEW
1. INTRODUCTION
2. ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT)
3. ALPHA-2 ANTIPLASMIN
4. ANTITHROMBIN III
5. BLEEDING TIME
6. D-DIMER
7. FACTOR VIII
8. FIBRIN DEGRADATION PRODUCTS
9. FIBRINOGEN
10. HEPARIN
11. PROTEINS C AND S
12. PROTHROMBIN TIME (PT)
13. THROMBIN TIME
INSTRUMENTATION: Coagulation Analyzers Manufactured by:
Behnk Elektronik
Bio/Data
Cardiovascular Diagnostics
Diagnostica Stago
Helena Laboratories
INSTRUMENTATION Laboratory
ITC Hemochron
Roche
Siemens
Sysmex
Teco Medical Instruments
Trinity Biotech
CURRENT AND EMERGING TECHNOLOGIES
1. MONOCLONAL ANTIBODIES
2. IMMUNOASSAYS
a. Technological Principle
b. Enzyme Immunoassays (EIA)
Overview
ELISA
Dot Immunobinding Assays
Capillary Immunoassays
Particle-Membrane Capture Immunoassay
Enzyme Amplification
c. Fluorescent Immunoassays
Fluorescent Polarization
Time-Resolved Pulse Fluorescence
d. Luminescence
Chemiluminescence
Bioluminescence
e. Latex Agglutination
f. Immunoprecipitation
3. DRY CHEMISTRY
4. BIOSENSORS
5. IT AND AUTOMATION
6. MOLECULAR DIAGNOSTICS
a. Technology Overview
b. Amplification Methods
Polymerase Chain Reaction
Ligase Chain Reaction
Branched DNA
Q-Beta Replicase
Strand Displacement Activation
Self-Sustained Sequence Replicase
U.S.A.
A. Market Overview
1. BUSINESS ENVIRONMENT
a. Health Care Expenditures
b. Cost Consciousness
c. Reimbursement
d. Industry Consolidation
e. Managed Care
PPO
HMO
f. Hospitals
g. Admissions
h. Length of Stay
i. Industry Diversification
j. Physician Demographics
k. Aging Population
More Chronic Illness
Disease Incidence
Susceptibility to latrogenesis
Multiple Illnesses Cases
l. Laboratory Regulations
2. MARKET STRUCTURE
a. Hospitals
b. Commercial/Private Laboratories
B. Physician Offices/Group Practices
1. MARKET SUMMARY
2. MARKET STRUCTURE
3. TEST VOLUME AND SALES FORECASTS
C. Ancillary Hospital Locations
1. INTRODUCTION
a. Emergency Departments
b. Operating Suites
c. Intensive Care Units
2. EMERGENCY DEPARTMENTS
a. Market Summary
b. Test volume and Sales Forecasts
3. OPERATING AND RECOVERY SUITES
a. Market Summary
b. Test Volume and Sales Forecasts
4. ICUS/CCUS
a. Market Summary
b. Test Volume and Sales Forecasts
D. Cancer Clinics
1. INTRODUCTION
2. MARKET SUMMARY
3. TEST VOLUME AND SALES FORECASTS
E. Ambulatory Care Centers
1. INTRODUCTION
2. MARKET SUMMARY
3. MARKET STRUCTURE
4. TEST VOLUME AND SALES FORECASTS
F. Surgery Centers
1. INTRODUCTION
2. MARKET SUMMARY
3. MARKET STRUCTURE
4. TEST VOLUME AND SALES FORECASTS
G. Nursing Homes
1. INTRODUCTION
2. MARKET SUMMARY
3. MARKET STRUCTURE
4. TEST VOLUME AND SALES FORECASTS
H. Birth Centers
1. INTRODUCTION
2. MARKET SUMMARY
3. MARKET STRUCTURE
4. TEST VOLUME AND SALES FORECASTS
1. MAJOR SUPPLIERS’ INSTRUMENT PLACEMENTS, INSTALLED BASE, CONSUMABLES SALES AND MARKET SHARES
Germany
A. Market Overview
B. Market Structure
C. Market Summary
D. Test Volume and Sales Forecasts
E. Major Suppliers’ Instrument Placements, Installed Base, Consumables Sales and Market Shares
Spain A. Business Environment
B. Market Structure
C. Market Summary
D. Test Volume and Sales Forecasts
E. Major Suppliers’ Instrument Placements, Installed Base, Consumables Sales and Market Shares
MAJOR PRODUCT DEVELOPMENT OPPORTUNITIES
A. Routine and Special Chemistry
B. Microbiology/Infectious Diseases
C. Hematology and Flow Cytometry
D. Coagulation
DESIGN CRITERIA FOR DECENTRALIZED TESTING PRODUCTS
ALTERNATIVE MARKET PENETRATION STRATEGIES
A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies for Decentralized Testing Markets
1. MARKETING APPROACHES
2. PRODUCT COMPLEXITY
3. CUSTOMER PREFERENCE
4. ESTABLISHED SUPPLIERS
5. EMERGING SUPPLIERS
6. MAJOR TYPES OF DISTRIBUTORS
7. MARKET SEGMENTATION
POTENTIAL MARKET ENTRY BARRIERS AND RISKS
A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge and Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges
COMPANY PROFILE
Abbott
ADI/American Diagnostica
Agilent Technologies
Alere/Biosite/Inverness
Axis-Shield
Beckman Coulter/Danaher
Becton Dickinson
Bio/Data
Biomerieux
Bio-Rad
Cephid
Chrono-Log
Corgenix
Decode Genetics
Diadexus
Diagnocure
Diagnostica Stago/Trinity Biotech
Diamedix
Diasorin
Eiken Chemical
EKF Diagnostics
Fujirebio
Grifols
Helena Laboratories
Hologic/Gen-Probe
Horiba
INSTRUMENTATION Laboratory
International Technidyne/Nexus DX
Kreatech/Leica
Kyowa Medex
Lonza
Mackay Life Sciences
Matritech
Nihon Kohden
Ortho-Clinical Diagnostics
Polartechnics
Polymedco
Qiagen
Roche
SDIX
Sequenom
Siemens
Sienco
Sysmex
Takara Bio
ThermoFisher
Tosoh
Wako
Zycare/Alere
LIST OF TABLES
Major Companies Developing or Marketing APTT Tests
Major Companies Developing or Marketing Alpha-2 Antiplasmin Tests
Major Companies Developing or Marketing Antithrombin III Tests
Major Companies Developing or Marketing Bleeding Time Tests
Major Companies Developing or Marketing D-Dimer Tests
Major Companies Developing or Marketing Factor Assays Tests
Major Companies Developing or Marketing Fibrin Degradation Product Tests
Major Companies Developing or Marketing Fibrinogen Tests
Major Companies Developing or Marketing Heparin Tests
Major Companies Developing or Marketing Protein C Tests
Major Companies Developing or Marketing Protein S Tests
Major Companies Developing or Marketing PT Tests
Major Companies Developing or Marketing Thrombin Time Tests
U.S.A., Physician Office/Group Practice Laboratories Forecast by Practice Size
U.S.A., Physician Offices/Group Practices Forecast by Type
U.S.A., Office-Based Physicians Forecast by Practice Type
U.S.A., Physician Offices/Group Practices Coagulation Test Volume Forecast
U.S.A., Physician Offices/Group Practices Coagulation Reagent and Instrument Sales Forecast
U.S.A., Ancillary Hospital Locations Estimated Number
U.S.A., Ancillary Hospital Locations Annual Utilization
U.S.A., Hospital Emergency Departments Coagulation Test Volume Forecast
U.S.A., Hospital Emergency Departments Coagulation Reagent and Instrument Sales Forecast
U.S.A., Hospital Operating and Recovery Suites Coagulation Test Volume Forecast
U.S.A., Hospital Operating and Recovery Suites Coagulation Reagent and Instrument Sales Forecast
U.S.A., Hospital ICUs/CCUs Coagulation Test Volume Forecast
U.S.A., Hospital ICUs/CCUs Coagulation Reagent and Instrument Sales Forecast
U.S.A., Cancer Clinics Major Coagulation Test Volume Forecast
U.S.A., Cancer Clinics Coagulation Reagent and Instrument Sales Forecast
U.S.A., Ambulatory Care Centers Estimated Number of Facilities and Patient Visits
U.S.A., Ambulatory Care Centers Most Frequent Diagnoses
U.S.A., Ambulatory Care Centers Coagulation Test Volume Forecast
U.S.A., Ambulatory Care Centers Coagulation Reagent and Instrument Sales Forecast
U.S.A., Surgery Centers Most Frequently Performed Procedures
U.S.A., Surgery Centers Coagulation Test Volume Forecast
U.S.A., Surgery Centers Coagulation Reagent and Instrument Sales Forecast
U.S.A., Nursing Homes Estimated Number of Facilities, Beds and Occupancy Rate
U.S.A., Nursing Homes Coagulation Test Volume Forecast
U.S.A., Nursing Homes Coagulation Reagent and Instrument Sales Forecast
U.S.A., Birth Centers Facilities, Patient Visits, and Births
U.S.A., Birth Centers Coagulation Test Volume Forecast
U.S.A., Birth Centers Coagulation Reagent and Instrument Sales Forecast
U.S.A., Major Suppliers of Coagulation Diagnostic Products Estimated Market Shares
Germany, Laboratory Performing Diagnostic Tests by Market Segment
Germany, Physician Offices/Group Practices Coagulation Test Volume Forecast
Germany, Physician Offices/Group Practices Coagulation Reagent and Instrument Sales Forecast
Germany, Major Suppliers of Coagulation Diagnostic Products Estimated Market Shares
Spain, Laboratory Performing Coagulation Tests by Market Segment
Spain, Ambulatory Care Centers Coagulation Test Volume Forecast
Spain, Ambulatory Care Centers Coagulation Reagent and Instrument Sales Forecast
Spain, Major Suppliers of Coagulation Diagnostic Products Estimated Market Shares
Major Companies Developing or Marketing APTT Tests
Major Companies Developing or Marketing Alpha-2 Antiplasmin Tests
Major Companies Developing or Marketing Antithrombin III Tests
Major Companies Developing or Marketing Bleeding Time Tests
Major Companies Developing or Marketing D-Dimer Tests
Major Companies Developing or Marketing Factor Assays Tests
Major Companies Developing or Marketing Fibrin Degradation Product Tests
Major Companies Developing or Marketing Fibrinogen Tests
Major Companies Developing or Marketing Heparin Tests
Major Companies Developing or Marketing Protein C Tests
Major Companies Developing or Marketing Protein S Tests
Major Companies Developing or Marketing PT Tests
Major Companies Developing or Marketing Thrombin Time Tests
U.S.A., Physician Office/Group Practice Laboratories Forecast by Practice Size
U.S.A., Physician Offices/Group Practices Forecast by Type
U.S.A., Office-Based Physicians Forecast by Practice Type
U.S.A., Physician Offices/Group Practices Coagulation Test Volume Forecast
U.S.A., Physician Offices/Group Practices Coagulation Reagent and Instrument Sales Forecast
U.S.A., Ancillary Hospital Locations Estimated Number
U.S.A., Ancillary Hospital Locations Annual Utilization
U.S.A., Hospital Emergency Departments Coagulation Test Volume Forecast
U.S.A., Hospital Emergency Departments Coagulation Reagent and Instrument Sales Forecast
U.S.A., Hospital Operating and Recovery Suites Coagulation Test Volume Forecast
U.S.A., Hospital Operating and Recovery Suites Coagulation Reagent and Instrument Sales Forecast
U.S.A., Hospital ICUs/CCUs Coagulation Test Volume Forecast
U.S.A., Hospital ICUs/CCUs Coagulation Reagent and Instrument Sales Forecast
U.S.A., Cancer Clinics Major Coagulation Test Volume Forecast
U.S.A., Cancer Clinics Coagulation Reagent and Instrument Sales Forecast
U.S.A., Ambulatory Care Centers Estimated Number of Facilities and Patient Visits
U.S.A., Ambulatory Care Centers Most Frequent Diagnoses
U.S.A., Ambulatory Care Centers Coagulation Test Volume Forecast
U.S.A., Ambulatory Care Centers Coagulation Reagent and Instrument Sales Forecast
U.S.A., Surgery Centers Most Frequently Performed Procedures
U.S.A., Surgery Centers Coagulation Test Volume Forecast
U.S.A., Surgery Centers Coagulation Reagent and Instrument Sales Forecast
U.S.A., Nursing Homes Estimated Number of Facilities, Beds and Occupancy Rate
U.S.A., Nursing Homes Coagulation Test Volume Forecast
U.S.A., Nursing Homes Coagulation Reagent and Instrument Sales Forecast
U.S.A., Birth Centers Facilities, Patient Visits, and Births
U.S.A., Birth Centers Coagulation Test Volume Forecast
U.S.A., Birth Centers Coagulation Reagent and Instrument Sales Forecast
U.S.A., Major Suppliers of Coagulation Diagnostic Products Estimated Market Shares
Germany, Laboratory Performing Diagnostic Tests by Market Segment
Germany, Physician Offices/Group Practices Coagulation Test Volume Forecast
Germany, Physician Offices/Group Practices Coagulation Reagent and Instrument Sales Forecast
Germany, Major Suppliers of Coagulation Diagnostic Products Estimated Market Shares
Spain, Laboratory Performing Coagulation Tests by Market Segment
Spain, Ambulatory Care Centers Coagulation Test Volume Forecast
Spain, Ambulatory Care Centers Coagulation Reagent and Instrument Sales Forecast
Spain, Major Suppliers of Coagulation Diagnostic Products Estimated Market Shares
