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Single Use Bioreactors Market (3rd Edition) – Distribution by Type of Bioreactor (Stirred Tank, Pneumatically Mixed, Rocker / Rotating, Wave-Induced, Paddle Sleeve, Fixed-Bed, Hollow Fibre, Diffusion, and Orbitally Shaken), Scale of Operation (Lab, Clinical and Commercial), Type of Cell Culture (Mammalian, Insect, Microbial, Viral, Plant and Bacterial), Type of Biologics Synthesized (Vaccine, Monoclonal Antibody, Recombinant Protein, Stem Cell, Cell Therapy, and Gene Therapy), Application Area (Cancer Research, Stem Cell Research, Tissue Engineering / Regenerative Medicine, Drug Discovery / Toxicity Testing and Others), End-users (Biopharmaceutical / Pharmaceutical Industries, Academic / Research Institutes), and Key Geographical Regions (North America, Europe, Asia-Pacific, Latin America, and Middle East and North Africa): Industry Trends and Global Forecasts, 2023-2035

July 2023 | 356 pages | ID: SD3C14B7E2DBEN
Roots Analysis

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The global single use bioreactors market is expected to reach USD 6.60 billion by 2035 anticipated to grow at a CAGR of 17% during the forecast period 2023-2035.

In recent years, biopharmaceuticals have gained immense attention for their outstanding therapeutic effectiveness. The USFDA has approved over 170 biologics in the past 20 years, and more than 10,000 are currently in various stages of development. To manufacture these complex biomolecules, specialized bioprocessing equipment is crucial. While stainless steel bioreactors were once dominant, there's been a gradual shift toward single-use bioreactors. These use disposable bioreactor bags instead of steel vessels and are essential for producing high-quality antibodies, cell therapies, gene therapies, and other bio-therapeutics. This transition brings several advantages over traditional bioreactors. Single-use bioreactors are cost-efficient, saving about 40%, and can shorten production timelines by roughly 35%. They also reduce energy and water consumption by 45%-50%, improve product yield, and lower contamination risks. Consequently, stakeholders across the industry have embraced disposable bioreactors for biologics manufacturing. Moreover, manufacturers are incorporating advanced features like alert systems, electronic process logs, control sensors, touchscreens, remote monitoring, and enhanced safety measures into their offerings. These efforts aim to meet the rising demand for biologics by creating more efficient single-use bioreactors for global markets, encouraging their widespread adoption. The global market for single-use bioreactors is expected to grow significantly to meet the escalating demand for biologics in the forecast period.

Report Coverage
  • The report examines the single-use bioreactors market across various dimensions such as type of bioreactor, scale of operation, type of cell culture, type of biologics synthesized, application area, end-users, and key geographical regions
  • It assesses the market's growth drivers, limitations, opportunities, and challenges while evaluating potential advantages and hurdles faced by stakeholders. Additionally, it offers insights into the competitive landscape among major market players.
  • Forecasting revenue for market segments across five major regions is a key component, alongside an in-depth analysis of the current state and anticipated future trends within the single-use bioreactors market. This encompasses technological specifications, industry comparisons with conventional stainless steel bioreactors, regulatory standards, challenges, advantages, market landscapes, and insights into companies involved in developing these bioreactors.
  • The report provides an overview of single-use bioreactors, emphasizing technology specifications, current/future industry trends, and a comparative analysis with traditional stainless steel bioreactors. This section highlights regulatory standards, existing challenges, and various advantages linked with single-use bioreactors.
  • Detailed analysis of both commercialized and in-development single-use bioreactors is presented, focusing on parameters such as bioreactor type, operational scale, technology specifications, operational modes, cell culture types, biologics synthesized, end-users, and an overview of market players.
  • Market trends are thoroughly examined using various graphical representations, including hybrid charts, stacked bar charts, heat maps, and world maps displaying companies engaged in single-use bioreactors based on factors such as company size, bioreactor types, operational modes, biologics synthesized, operational scales, and geographical distribution.
  • A four-dimensional bubble chart is employed to evaluate the competitiveness of single-use bioreactor manufacturers, considering supplier strength, product portfolio diversity, and strength.
  • Tabulated profiles of key companies in North America, Europe, Asia-Pacific, and the Rest of the World involved in developing single-use bioreactors are included. Each profile covers an overview, financial information (if available), product portfolio, recent developments, and future outlook.
  • Analysis of partnerships and collaborations established from 2007 to January 2023 is presented, encompassing types, focus areas, involved biologics, bioreactor types, locations, capacities, and active players.
  • It evaluates the competitiveness of single-use bioreactors based on supplier strength and product competitiveness, categorized by bioreactor types for comparison.
  • It offers an opinion on the popularity and perception of key industry stakeholders' brands across various market segments, considering portfolio strength, diversity, experience, patents, partnerships, and identifying areas for competitive advantage.
  • A detailed examination of patents filed/granted for single-use bioreactors is included, highlighting trends, leading players, patent valuation, and relative importance.
  • Exploration of technological advancements in single-use bioreactors, including automation, control sensors, alarm systems, electronic-logs, touch screens, real-time tracking, and their impact on bioprocess development, is discussed.
  • The report also delves into industry trends, drivers, challenges, and impacts using a SWOT framework, indicating the relative effect of each parameter on the single-use bioreactors industry.
  • Lastly, an overview of bioprocess controllers and automation systems, including operational scale, key features, compatibility, and details of companies involved in their development, is provided.
Key Market Companies
  • Applikon Biotechnology
  • Biolinx Labsystems
  • Celartia
  • Cell Culture Company
  • Cellexus
  • Cercell
  • CESCO Bioengineering
  • Cytiva
  • Eppendorf
  • Merck Millipore
  • Pall Corporation
  • PBS Biotech
  • PerfuseCell
  • ProlifeCell
  • Sartorius Stedim Biotech
  • Solaris Biotech
  • Synthecon
  • Thermo Fisher Scientific
1. PREFACE

1.1. Introduction
1.2. Key Market Insights
1.3. Scope of the Report
1.4. Research Methodology
1.5. Frequently Asked Questions
1.6. Chapter Outlines

2. EXECUTIVE SUMMARY

3. INTRODUCTION

3.1. Chapter Overview
3.2. Overview of Single-use Bioreactors
  3.2.1. Historical Evolution
  3.2.2. Single-use versus Traditional Bioreactors
3.3. Types of Single-use Bioreactors
  3.3.1. Based on Cell Culture
  3.3.2. Based on Agitation Mechanism
3.4. Advantages of Single-use Bioreactors
3.5. Key Applications Areas
3.6. Prevalent Regulatory Standards
3.7. Challenges Associated with Single-use Bioreactors
3.8. Concluding Remarks

4. MARKET LANDSCAPE

4.1. Chapter Overview
4.2. Single-use Bioreactors: Overall Market Landscape
  4.2.1. Analysis by Type of Bioreactor
  4.2.2. Analysis by Scale of Operation
  4.2.3. Analysis by Working Volume (Liters)
  4.2.4. Analysis by Stirrer Speed (RPM)
  4.2.5. Analysis by Weight of Bioreactor (Kg)
  4.2.6. Analysis by Advanced Display / Control Features
  4.2.7. Analysis by Mode of Operation
  4.2.8. Analysis by Type of Culture
  4.2.9. Analysis by Type of Cell Culture
  4.2.10. Analysis by Type of Biologics Synthesized
  4.2.11. Analysis by End-users
4.3. Single-use Bioreactor Manufacturers: Overall Market Landscape
  4.3.1. Analysis by Year of Establishment
  4.3.2. Analysis by Company Size
  4.3.3. Analysis by Location of Headquarters (Region)
  4.3.4. Analysis by Location of Headquarters (Country)
4.4. Leading Manufacturers: Analysis by Number of Products

5. KEY INSIGHTS

5.1. Chapter Overview
5.2. Analysis by Company Size of Manufacturer and Type of Single-use Bioreactor
5.3. Analysis by Type of Single-use Bioreactor and Mode of Operation
5.4. Analysis by Type of Single-use Bioreactor and Type of Biologics Synthesized
5.5. Analysis by Scale of Operation, Type of Cell Culture and Type of Biologics Synthesized
5.6. Analysis by Company Size and Location of Headquarters
5.7. Analysis by Location of Headquarters

6. COMPANY COMPETITIVENESS ANALYSIS

6.1. Chapter Overview
6.2. Methodology
6.3. Assumptions / Key Parameters
6.4. Single-use Bioreactor Manufacturers: Company Competitiveness Analysis
  6.4.1. Small Companies
  6.4.2. Mid-sized Companies
  6.4.3. Large Companies

7. SINGLE-USE BIOREACTOR MANUFACTURERS IN NORTH AMERICA: COMPANY PROFILES

7.1. Chapter Overview
  7.2.1. Celartia
    7.2.1.1. Company Overview
    7.2.1.2. Product Portfolio
    7.2.1.3. Recent Developments and Future Outlook
  7.2.2. Cell Culture Company
    7.2.2.1. Company Overview
    7.2.2.2. Product Portfolio
    7.2.2.3. Recent Developments and Future Outlook
  7.2.3. Cytiva
    7.2.3.1. Company Overview
    7.2.3.2. Financial Information
    7.2.3.3. Product Portfolio
    7.2.3.4. Recent Developments and Future Outlook
  7.2.4. Merck Millipore
    7.2.4.1. Company Overview
    7.2.4.2. Financial Information
    7.2.4.3. Product Portfolio
    7.2.4.4. Recent Developments and Future Outlook
  7.2.5. Pall Corporation
    7.2.5.1. Company Overview
    7.2.5.2. Financial Information
    7.2.5.3. Product Portfolio
    7.2.5.4. Recent Developments and Future Outlook
  7.2.6. PBS Biotech
    7.2.6.1. Company Overview
    7.2.6.2. Product Portfolio
    7.2.6.3. Recent Developments and Future Outlook
  7.2.7. Synthecon
    7.2.7.1. Company Overview
    7.2.7.2. Product Portfolio
    7.2.7.3. Recent Developments and Future Outlook
  7.2.8. Thermo Fisher Scientific
    7.2.8.1. Company Overview
    7.2.8.2. Financial Information
    7.2.8.3. Product Portfolio
    7.2.8.4. Recent Developments and Future Outlook

8. SINGLE-USE BIORECTOR MANUFACTURERS IN EUROPE, ASIA-PACIFIC AND REST OF THE WORLD: COMPANY PROFILES

8.1. Chapter Overview
8.2. Leading Players based in Europe
  8.2.1. Applikon Biotechnology
    8.2.1.1. Company Overview
    8.2.1.2. Product Portfolio
    8.2.1.3. Recent Developments and Future Outlook
  8.2.2. Cellexus
    8.2.2.1. Company Overview
    8.2.2.2. Product Portfolio
    8.2.2.3. Recent Developments and Future Outlook
  8.2.3. CerCell
    8.2.3.1. Company Overview
    8.2.3.2. Product Portfolio
    8.2.3.3. Recent Developments and Future Outlook
  8.2.4. Eppendorf
    8.2.4.1. Company Overview
    8.2.4.2. Financial Information
    8.2.4.3. Product Portfolio
    8.2.4.4. Recent Developments and Future Outlook
  8.2.5. PerfuseCell
    8.2.5.1. Company Overview
    8.2.5.2. Product Portfolio
    8.2.5.3. Recent Developments and Future Outlook
  8.2.6. ProlifeCell
    8.2.6.1. Company Overview
    8.2.6.2. Product Portfolio
    8.2.6.3. Recent Developments and Future Outlook
  8.2.7. Sartorius Stedim Biotech
    8.2.7.1. Company Overview
    8.2.7.2. Financial Information
    8.2.7.3. Product Portfolio
    8.2.7.4. Recent Developments and Future Outlook
  8.2.8. Solaris Biotech
    8.2.8.1. Company Overview
    8.2.8.2. Product Portfolio
    8.2.8.3. Recent Developments and Future Outlook
8.3. Leading Players based in Asia-Pacific and Rest of the World
  8.3.1. Biolinx Labsystems
    8.3.1.1. Company Overview
    8.3.1.2. Product Portfolio
    8.3.1.3. Recent Developments and Future Outlook
  8.3.2. CESCO Bioengineering
    8.3.2.1. Company Overview
    8.3.2.2. Product Portfolio
    8.3.2.3. Recent Developments and Future Outlook

9. PARTNERSHIPS AND COLLABORATIONS

9.1. Chapter Overview
9.2. Partnership Models
9.3. Single-use Bioreactors: List of Partnerships and Collaborations
  9.3.1. Analysis by Year of Partnership
  9.3.2. Analysis by Type of Partnership
  9.3.3. Analysis by Year and Type of Partnership
  9.3.4. Analysis by Focus Area
  9.3.5. Analysis by Year of Partnership and Focus Area
  9.3.6. Analysis by Type of Partner
  9.3.7. Analysis by Type of Biologics Synthesized
  9.3.8. Analysis by Type of Bioreactor Involved
  9.3.9. Analysis by Location of Facility (Country) and Expanded Bioreactor Capacity
  9.3.10. Most Active Players: Analysis by Number of Partnerships
  9.3.11. Analysis by Geography
    9.3.11.1. Local and International Agreements
    9.3.11.2. Intracontinental and Intercontinental Agreements

10. PRODUCT COMPETITIVENESS ANALYSIS

10.1. Chapter Overview
10.2. Methodology
10.3. Assumptions / Key Parameters
10.4. Single-use Bioreactors: Product Competitiveness Analysis
  10.4.1. Stirred Tank Single-use Bioreactors
    10.4.1.1 Products Offered by Players based In North America
    10.4.1.2 Products Offered by Players based In Europe
    10.4.1.3 Products Offered by Players based In Asia-Pacific and Rest of the World
  10.4.2 Fixed-Bed Single-use Bioreactors
  10.4.3 Wave-Induced / Rocking Single-use Bioreactors
  10.4.4. Other Types of Single-use Bioreactors
    10.4.4.1 Products Offered by Players based In North America
    10.4.4.2 Products Offered by Players based In Europe
    10.4.4.3 Products Offered by Players based In Asia-Pacific and Rest of the World

11. BRAND POSITIONING ANALYSIS

11.1. Chapter Overview
11.2. Methodology
11.3. Key Parameters
11.4. Brand Positioning Matrix
11.5. Brand Positioning Matrix: Pall Corporation
11.6. Brand Positioning Matrix: Biolinx Labsystems
11.7. Brand Positioning Matrix: Eppendorf
11.8. Brand Positioning Matrix: Solaris Biotech
11.9. Brand Positioning Matrix: Sartorius Stedim Biotech
11.10. Brand Positioning Matrix: Applikon Biotechnology
11.11. Brand Positioning Matrix: Cercell

12. PATENT ANALYSIS

12.1. Chapter Overview
12.2. Scope and Methodology
12.3. Single-use Bioreactors: Patent Analysis
  12.3.1. Analysis by Application Year
  12.3.2. Analysis by Publication Year
  12.3.3. Analysis by Type of Patents and Publication Year
  12.3.4. Analysis by Patent Jurisdiction
  12.3.5. Analysis by CPC Symbols
  12.3.6. Analysis by Type of Applicant
  12.3.7. Leading Industry Players: Analysis by Number of Patents
  12.3.8. Leading Patent Assignees: Analysis by Number of Patents
12.4. Single-use Bioreactors: Patent Benchmarking Analysis
  12.4.1. Analysis by Patent Characteristics
12.5. Single-use Bioreactors: Patent Valuation
12.6. Leading Patents by Number of Citations

13. MARKET FORECAST AND OPPORTUNITY ANALYSIS

13.1. Chapter Overview
13.2. Key Assumptions and Methodology
13.3. Global Single-use Upstream Bioprocessing Technology Market, 2023-2035
  13.3.1. Global Single-use Upstream Bioprocessing Technology Market: Distribution by Scale of Operation, 2023-2035
  13.3.2. Global Single-use Upstream Bioprocessing Technology Market: Distribution by Type of Equipment, 2023-2035
  13.3.3. Global Single-use Upstream Bioprocessing Technology Market: Distribution by Geographical Region, 2023-2035
13.4. Global Single-use Bioreactors Market, 2023-2035
  13.4.1. Global Single-use Bioreactors Market: Distribution by Type of Bioreactor, 2023-2035
  13.4.2. Global Single-use Bioreactors Market: Distribution by Scale of Operation, 2023-2035
  13.4.3. Global Single-use Bioreactors Market: Distribution by Type of Cell Culture, 2023-2035
  13.4.4. Global Single-use Bioreactors Market: Distribution by Type of Biologics Synthesized, 2023-2035
  13.4.5. Global Single-use Bioreactors Market: Distribution by Application Area, 2023-2035
  13.4.6. Global Single-use Bioreactors Market: Distribution by End-users, 2023-2035
  13.4.7. Global Single-use Bioreactors Market: Distribution by Geographical Region, 2023-2035

14. CASE STUDY: KEY TECHNOLOGICAL INNOVATIONS IN THE SINGLE-USE BIOREACTORS INDUSTRY

14.1. Chapter Overview
14.2. Innovations in Bioreactor Display / Control Features
  14.2.1. Built-in System Control Sensors
  14.2.2. Advanced Alarm Systems
  14.2.3. Electronic-Log Records and Touch Screens
  14.2.4. Real-Time Tracking and Remote Monitoring
14.3. Innovation in Mixing Technologies
14.4. Automation in Single-use bioreactors
14.5. Concluding Remarks

15. SWOT ANALYSIS

15.1. Chapter Overview
15.2. Single-use Bioreactors: SWOT Analysis
15.3. Strengths
15.4. Weaknesses
15.5. Opportunities
15.6. Threats
15.7. Comparison of SWOT Factors

16. CASE STUDY: BIOPROCESS CONTROLLERS AND AUTOMATION SYSTEMS

16.1. Chapter Overview
16.2. Bioprocess Control Software: Overall Market Landscape
  16.2.1. Analysis by Scale of Operation
  16.2.2. Analysis by Key Features
  16.2.3. Analysis by Compatibility with System
  16.2.4. Analysis by Type of Process Controlled
16.3. Bioprocess Control Software Manufacturers: Overall Market Landscape
  16.3.1. Analysis by Year of Establishment
  16.3.2. Analysis by Company Size
  16.3.3. Analysis by Location of Headquarters
16.4. Upstream Controllers: Overall Market Landscape
  16.4.1. Analysis by Scale of Operation
  16.4.2. Analysis by Key Features
  16.4.3. Analysis by Compatibility with Bioreactor System
  16.4.4. Analysis by Type of Bioprocess
  16.4.5. Analysis by Type of Process Controlled
16.5. Upstream Controller Manufacturers: Overall Market Landscape
  16.5.1. Analysis by Year of Establishment
  16.5.2. Analysis by Company Size
  16.5.3. Analysis by Location of Headquarters
16.6. Downstream Controller Systems: Overall Market Landscape
  16.6.1. Analysis by Scale of Operation
  16.6.2. Analysis by Key Features
  16.6.3. Analysis by Type of System
  16.6.4. Analysis by Type of Bioprocess
  16.6.5. Analysis by Application Area
16.7. Downstream Controller System Manufacturers: Overall Market Landscape
  16.7.1. Analysis by Year of Establishment
  16.7.2. Analysis by Company Size
  16.7.3. Analysis by Location of Headquarters

17. CONCLUSION

18. EXECUTIVE INSIGHTS

18.1. Chapter Overview
18.2. Membio
  18.2.1. Company Snapshot
  18.2.2. Interview Transcript: Shane Kilpatrick, Founder and Chief Executive Officer
18.3. Distek
  18.3.1. Company Snapshot
  18.3.2. Interview Transcript: Justin Cesmat, Manager, Bioprocessing
18.4. Refine Technology
  18.4.1. Company Snapshot
  18.4.2. Interview Transcript: Bradley Maykow, Quality and Products Manager
18.5. CerCell
  18.5.1. Company Snapshot
  18.5.2. Interview Transcript: Per Stobbe, Chief Executive Officer
18.6. CelVivo
  18.6.1. Company Snapshot
  18.6.2. Interview Transcript: Torsten Due Bryld, Global Director of Sales Support

19. APPENDIX I: TABULATED DATA

20. APPENDIX II: LIST OF COMPANIES AND ORGANIZATIONS

21. APPENDIX III: LIST OF BUSINESSES OFFERING BIOPROCESS RELATED ACCESSORIES, EQUIPMENT, AND AUTOMATION SOLUTIONS


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