Buffer Manufacturing Market: Focus on Buffer Manufacturing Systems and Service Providers - Distribution by Scale of Operation (Preclinical / Clinical and Commercial), Type of System Component (Single-use Buffer Mixing / Preparation Equipment and Reusable Buffer Mixing / Preparation Equipment) and Key Geographical Regions (North America, Europe, Asia-Pacific and Rest of the World): Industry Trends and Global Forecasts, 2023-2035
The global buffer manufacturing market is anticipated to grow at a CAGR of 5.9% during the forecast period 2023-2035
Buffers, aqueous solutions essential for pH regulation in drug manufacturing, hold a crucial role in maintaining stability for both biologics and small molecules throughout production. They are extensively used across bioprocessing stages, ensuring stable pH in cultures, optimizing yield, maintaining purification conditions, and preserving product functionality. However, conventional buffer manufacturing methods are complex, requiring significant space and skilled labor. These processes are time-consuming, multi-step, leading to high production costs and batch inconsistencies. Crafting a 2,000 L buffer traditionally takes over 35 hours, as reported by BioPharma.
To address these challenges, pharmaceutical companies are either adopting innovative in-house buffer preparation systems or outsourcing to third-party providers. Recent trends show a rapid uptake of these systems due to their space efficiency and integration of advanced technologies, ensuring stable buffer conditions during downstream processes. These novel systems can produce a 2,000 L buffer in 40-50 minutes, according to Pall Corporation. Implementing buffer management systems could reduce labor costs by 50% and buffer manufacturing expenses by 12%. Outsourcing buffer manufacturing is expected to save around USD 90,000 annually and cut buffer preparation time by 75%. With growing demand for buffers and the complexities in their manufacturing, the buffer preparation systems market is set for steady growth in the coming decade.
Report Coverage
Buffers, aqueous solutions essential for pH regulation in drug manufacturing, hold a crucial role in maintaining stability for both biologics and small molecules throughout production. They are extensively used across bioprocessing stages, ensuring stable pH in cultures, optimizing yield, maintaining purification conditions, and preserving product functionality. However, conventional buffer manufacturing methods are complex, requiring significant space and skilled labor. These processes are time-consuming, multi-step, leading to high production costs and batch inconsistencies. Crafting a 2,000 L buffer traditionally takes over 35 hours, as reported by BioPharma.
To address these challenges, pharmaceutical companies are either adopting innovative in-house buffer preparation systems or outsourcing to third-party providers. Recent trends show a rapid uptake of these systems due to their space efficiency and integration of advanced technologies, ensuring stable buffer conditions during downstream processes. These novel systems can produce a 2,000 L buffer in 40-50 minutes, according to Pall Corporation. Implementing buffer management systems could reduce labor costs by 50% and buffer manufacturing expenses by 12%. Outsourcing buffer manufacturing is expected to save around USD 90,000 annually and cut buffer preparation time by 75%. With growing demand for buffers and the complexities in their manufacturing, the buffer preparation systems market is set for steady growth in the coming decade.
Report Coverage
- The report examines the buffer preparation market, focusing on operational scale, system component types, and major geographical regions.
- An analysis is conducted on the factors influencing market growth, including drivers, restraints, opportunities, and challenges.
- It evaluates the potential advantages and barriers within the market, providing insights into the competitive landscape for leading market players.
- Revenue forecasts are provided for market segments across four major regions.
- A comprehensive exploration of buffer manufacturing encompasses both conventional and innovative methods, addressing associated challenges and the benefits of outsourcing. It also discusses critical considerations for selecting outsourcing partners and explores future market prospects.
- The evaluation of buffer preparation and manufacturing systems involves a multifaceted analysis, considering system types, operation modes, scales, vessel materials, mobility options, features, integrated techniques, manufacturing processes, buffer forms, and their applications in bioprocessing methods.
- This analysis includes an in-depth assessment of buffer manufacturing system providers based on establishment year, company size, headquarters location, and involvement in offering buffer manufacturing systems.
- A thorough product competitiveness analysis of buffer manufacturing systems considers developer experience and factors like system types, operation modes, vessel materials, mobility options, features, integrated techniques, manufacturing processes, buffer forms, bioprocessing methods, GMP manufacturing availability, and single-use components.
- Detailed profiles of key players involved in developing buffer preparation systems cover company overviews, product portfolios, recent developments, and future outlooks based on specific criteria.
- An extensive evaluation of buffer manufacturing service providers considers parameters such as establishment year, company size, headquarters location, facility locations, operation scales, manufactured buffers, formulations, packaging formats, compatible biologics, application areas, service types, and active players in the domain.
- A comprehensive company competitiveness analysis of buffer manufacturing service providers in North America, Europe, and Asia considers supplier experience and factors like facility numbers, locations, operation scales, provided buffers, formulations, packaging formats, compatible biologics, application areas, service types, and GMP manufacturing availability.
- Detailed profiles of key companies offering buffer manufacturing services include company summaries, key executives, portfolios, recent developments, and future outlooks based on proprietary criteria.
- Lastly, a detailed analysis of industry stakeholder partnerships since 2017 covers partnership years, types (acquisitions, agreements, alliances, etc.), partner types, company sizes, most active players, and regional distribution of partnership activities within the industry.
- Asahi Kasei
- Avantor
- Canvax
- Cytiva
- Lonza
- Merck
- Pall Corporation
- Thermo Fisher Scientific
- Uniogen
1. PREFACE
1.1. Introduction
1.2. Key Market Insights
1.3. Scope of the Report
1.4. Research Methodology
1.5. Key Questions Answered
1.6. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. Chapter Overview
3.2. Overview of Buffer Manufacturing
3.2.1. Conventional Methods of Buffer Manufacturing
3.2.2. Novel Methods of Buffer Manufacturing
3.3. Challenges Associated with Buffer Manufacturing
3.4. Advantages of Outsourcing Buffer Manufacturing
3.5. Key Considerations While Selecting an Outsourcing Partner
3.6. Future Perspectives
4 .MARKET LANDSCAPE: BUFFER MANUFACTURING SYSTEMS
4.1. Chapter Overview
4.2 Buffer Manufacturing System: Overall Market Landscape
4.2.1. Analysis by Type of System
4.2.2. Analysis by Mode of Operation
4.2.3. Analysis by Scale of Operation
4.2.4. Analysis by Vessel Fabrication Material(s)
4.2.5. Analysis by System Mobility Option
4.2.6. Analysis by Feature(s) of Buffer Manufacturing System
4.2.7. Analysis by Integrated Technique(s)
4.2.8. Analysis by Buffer Manufacturing Process
4.2.9. Analysis by Type of Buffer Form(s)
4.2.10. Analysis by Bioprocessing Method
4.3. Buffer Manufacturing System Providers Landscape
4.3.1. Analysis by Year of Establishment
4.3.2. Analysis by Location of Headquarters
4.3.3. Analysis by Company Size
4.3.4. Most Active Players: Analysis by Number of Products Offered
5. PRODUCT COMPETITIVENESS ANALYSIS
5.1. Chapter Overview
5.2. Assumptions and Key Parameters
5.3. Methodology
5.4. Product Competitiveness Analysis
5.4.1. Buffer Manufacturing Systems Offered by Companies based in North America
5.4.2. Buffer Manufacturing Systems Offered by Companies based in Europe
5.4.3. Buffer Manufacturing Systems Offered by Companies based in Asia
6. COMPANY PROFILES: BUFFER MANUFACTURING SYSTEM PROVIDERS
6.1. Chapter Overview
6.2. Asahi Kasei
6.2.1. Company Overview
6.2.2. Product Portfolio
6.2.3. Recent Developments and Future Outlook
6.3 Cytiva
6.3.1. Company Overview
6.3.2. Product Portfolio
6.3.3. Recent Developments and Future Outlook
6.4. Pall Corporation
6.4.1. Company Overview
6.4.2. Product Portfolio
6.4.3. Recent Developments and Future Outlook
6.5 Thermo Fisher Scientific
6.5.1. Company Overview
6.5.2. Product Portfolio
6.5.3. Recent Developments and Future Outlook
7. MARKET LANDSCAPE: BUFFER MANUFACTURING SERVICE PROVIDERS
7.1. Chapter Overview
7.2. Buffer Manufacturing Service Providers: Overall Market Landscape
7.2.1. Analysis by Year of Establishment
7.2.2. Analysis by Company Size
7.2.3. Analysis by Location of Headquarters
7.2.4. Analysis by Location of Facilities
7.2.5. Analysis by Scale of Operation
7.2.6. Analysis by Type of Buffer(s) Provided
7.2.7. Analysis by Buffer(s) Manufactured
7.2.8. Analysis by Buffer Formulation
7.2.9. Analysis by Buffer Packaging Format
7.2.10. Analysis by Compatible Biologic(s)
7.2.11. Analysis by Application Area(s)
7.2.12. Analysis by Type of Service
7.2.13. Most Active Players: Analysis by Number of Facilities
7.2.14. Most Active Players: Analysis by Number of Services
8. COMPANY COMPETITIVENESS ANALYSIS
8.1. Chapter Overview
8.2. Assumptions and Key Parameters
8.3. Methodology
8.4. Company Competitiveness Analysis
8.4.1. Buffer Manufacturing Service Providers based in North America
8.4.2. Buffer Manufacturing Service Providers based in Europe
8.4.3. Buffer Manufacturing Service Providers based in Asia
9. COMPANY PROFILES: BUFFER MANUFACTURING SERVICE PROVIDERS
9.1. Chapter Overview
9.2. Avantor
9.2.1. Company Overview
9.2.2. Buffer Manufacturing Service Portfolio
9.2.3. Recent Developments and Future Outlook
9.3 Canvax
9.3.1. Company Overview
9.3.2. Buffer Manufacturing Service Portfolio
9.3.3. Recent Developments and Future Outlook
9.4. Lonza
9.4.1. Company Overview
9.4.2. Buffer Manufacturing Service Portfolio
9.4.3. Recent Developments and Future Outlook
9.5 Merck
9.5.1. Company Overview
9.5.2. Buffer Manufacturing Service Portfolio
9.5.3. Recent Developments and Future Outlook
9.6. Uniogen
9.6.1 Company Overview
9.6.2. Buffer Manufacturing Service Portfolio
9.6.3 Recent Developments and Future Outlook
10. PARTNERSHIPS AND COLLABORATIONS
10.1. Chapter Overview
10.2. Partnership Models
10.2.1. Buffer Manufacturing System Providers: List of Partnerships and Collaborations
10.2.2. Analysis by Year of Partnership
10.2.3. Analysis by Type of Partnership
10.2.4. Analysis by Type of Partner
10.2.5. Analysis by Company Size
10.2.6. Analysis by Geography
10.2.6.1. Local and International Agreements
10.2.6.2. Intracontinental and Intercontinental Agreements
10.2.7. Most Active Players: Analysis by Number of Partnerships
11. MARKET FORECAST
11.1. Chapter Overview
11.2. Key Assumptions and Methodology
11.3. Global Buffer Preparation Systems Market: Historical, Base and Forecasted Scenario, 2018-2035
11.3.1. Buffer Preparation Systems Market: Distribution by Scale of Operation, 2023 -2035
11.3.1.1. Buffer Preparation Systems Market for Preclinical / Clinical Scale, 2023-2035
11.3.1.2. Buffer Preparation Systems Market for Commercial Scale, 2023-2035
11.3.2. Buffer Preparation Systems Market: Distribution by Type of System Component, 2023-2035
11.3.2.1. Buffer Preparation Systems Market for Single-use Buffer Mixing / Preparation Equipment, 2023-2035
11.3.2.2. Buffer Preparation Systems Market for Reusable Buffer Mixing / Preparation Equipment, 2023-2035
11.3.3. Buffer Preparation Systems Market: Distribution by Key Geographical Regions, 2023-2035
11.3.3.1. Buffer Preparation Systems Market in North America, 2023-2035 (USD Billion)
11.3.3.2. Buffer Preparation Systems Market in Europe, 2023-2035 (USD Billion)
11.3.3.3. Buffer Preparation Systems Market in Asia-Pacific, 2023-2035 (USD Billion)
11.3.3.4. Buffer Preparation Systems Market in Rest of the World, 2023-2035 (USD Billion)
12. CONCLUSION
13. APPENDIX I: TABULATED DATA
14. APPENDIX II: LIST OF COMPANIES AND ORGANIZATIONS
1.1. Introduction
1.2. Key Market Insights
1.3. Scope of the Report
1.4. Research Methodology
1.5. Key Questions Answered
1.6. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. Chapter Overview
3.2. Overview of Buffer Manufacturing
3.2.1. Conventional Methods of Buffer Manufacturing
3.2.2. Novel Methods of Buffer Manufacturing
3.3. Challenges Associated with Buffer Manufacturing
3.4. Advantages of Outsourcing Buffer Manufacturing
3.5. Key Considerations While Selecting an Outsourcing Partner
3.6. Future Perspectives
4 .MARKET LANDSCAPE: BUFFER MANUFACTURING SYSTEMS
4.1. Chapter Overview
4.2 Buffer Manufacturing System: Overall Market Landscape
4.2.1. Analysis by Type of System
4.2.2. Analysis by Mode of Operation
4.2.3. Analysis by Scale of Operation
4.2.4. Analysis by Vessel Fabrication Material(s)
4.2.5. Analysis by System Mobility Option
4.2.6. Analysis by Feature(s) of Buffer Manufacturing System
4.2.7. Analysis by Integrated Technique(s)
4.2.8. Analysis by Buffer Manufacturing Process
4.2.9. Analysis by Type of Buffer Form(s)
4.2.10. Analysis by Bioprocessing Method
4.3. Buffer Manufacturing System Providers Landscape
4.3.1. Analysis by Year of Establishment
4.3.2. Analysis by Location of Headquarters
4.3.3. Analysis by Company Size
4.3.4. Most Active Players: Analysis by Number of Products Offered
5. PRODUCT COMPETITIVENESS ANALYSIS
5.1. Chapter Overview
5.2. Assumptions and Key Parameters
5.3. Methodology
5.4. Product Competitiveness Analysis
5.4.1. Buffer Manufacturing Systems Offered by Companies based in North America
5.4.2. Buffer Manufacturing Systems Offered by Companies based in Europe
5.4.3. Buffer Manufacturing Systems Offered by Companies based in Asia
6. COMPANY PROFILES: BUFFER MANUFACTURING SYSTEM PROVIDERS
6.1. Chapter Overview
6.2. Asahi Kasei
6.2.1. Company Overview
6.2.2. Product Portfolio
6.2.3. Recent Developments and Future Outlook
6.3 Cytiva
6.3.1. Company Overview
6.3.2. Product Portfolio
6.3.3. Recent Developments and Future Outlook
6.4. Pall Corporation
6.4.1. Company Overview
6.4.2. Product Portfolio
6.4.3. Recent Developments and Future Outlook
6.5 Thermo Fisher Scientific
6.5.1. Company Overview
6.5.2. Product Portfolio
6.5.3. Recent Developments and Future Outlook
7. MARKET LANDSCAPE: BUFFER MANUFACTURING SERVICE PROVIDERS
7.1. Chapter Overview
7.2. Buffer Manufacturing Service Providers: Overall Market Landscape
7.2.1. Analysis by Year of Establishment
7.2.2. Analysis by Company Size
7.2.3. Analysis by Location of Headquarters
7.2.4. Analysis by Location of Facilities
7.2.5. Analysis by Scale of Operation
7.2.6. Analysis by Type of Buffer(s) Provided
7.2.7. Analysis by Buffer(s) Manufactured
7.2.8. Analysis by Buffer Formulation
7.2.9. Analysis by Buffer Packaging Format
7.2.10. Analysis by Compatible Biologic(s)
7.2.11. Analysis by Application Area(s)
7.2.12. Analysis by Type of Service
7.2.13. Most Active Players: Analysis by Number of Facilities
7.2.14. Most Active Players: Analysis by Number of Services
8. COMPANY COMPETITIVENESS ANALYSIS
8.1. Chapter Overview
8.2. Assumptions and Key Parameters
8.3. Methodology
8.4. Company Competitiveness Analysis
8.4.1. Buffer Manufacturing Service Providers based in North America
8.4.2. Buffer Manufacturing Service Providers based in Europe
8.4.3. Buffer Manufacturing Service Providers based in Asia
9. COMPANY PROFILES: BUFFER MANUFACTURING SERVICE PROVIDERS
9.1. Chapter Overview
9.2. Avantor
9.2.1. Company Overview
9.2.2. Buffer Manufacturing Service Portfolio
9.2.3. Recent Developments and Future Outlook
9.3 Canvax
9.3.1. Company Overview
9.3.2. Buffer Manufacturing Service Portfolio
9.3.3. Recent Developments and Future Outlook
9.4. Lonza
9.4.1. Company Overview
9.4.2. Buffer Manufacturing Service Portfolio
9.4.3. Recent Developments and Future Outlook
9.5 Merck
9.5.1. Company Overview
9.5.2. Buffer Manufacturing Service Portfolio
9.5.3. Recent Developments and Future Outlook
9.6. Uniogen
9.6.1 Company Overview
9.6.2. Buffer Manufacturing Service Portfolio
9.6.3 Recent Developments and Future Outlook
10. PARTNERSHIPS AND COLLABORATIONS
10.1. Chapter Overview
10.2. Partnership Models
10.2.1. Buffer Manufacturing System Providers: List of Partnerships and Collaborations
10.2.2. Analysis by Year of Partnership
10.2.3. Analysis by Type of Partnership
10.2.4. Analysis by Type of Partner
10.2.5. Analysis by Company Size
10.2.6. Analysis by Geography
10.2.6.1. Local and International Agreements
10.2.6.2. Intracontinental and Intercontinental Agreements
10.2.7. Most Active Players: Analysis by Number of Partnerships
11. MARKET FORECAST
11.1. Chapter Overview
11.2. Key Assumptions and Methodology
11.3. Global Buffer Preparation Systems Market: Historical, Base and Forecasted Scenario, 2018-2035
11.3.1. Buffer Preparation Systems Market: Distribution by Scale of Operation, 2023 -2035
11.3.1.1. Buffer Preparation Systems Market for Preclinical / Clinical Scale, 2023-2035
11.3.1.2. Buffer Preparation Systems Market for Commercial Scale, 2023-2035
11.3.2. Buffer Preparation Systems Market: Distribution by Type of System Component, 2023-2035
11.3.2.1. Buffer Preparation Systems Market for Single-use Buffer Mixing / Preparation Equipment, 2023-2035
11.3.2.2. Buffer Preparation Systems Market for Reusable Buffer Mixing / Preparation Equipment, 2023-2035
11.3.3. Buffer Preparation Systems Market: Distribution by Key Geographical Regions, 2023-2035
11.3.3.1. Buffer Preparation Systems Market in North America, 2023-2035 (USD Billion)
11.3.3.2. Buffer Preparation Systems Market in Europe, 2023-2035 (USD Billion)
11.3.3.3. Buffer Preparation Systems Market in Asia-Pacific, 2023-2035 (USD Billion)
11.3.3.4. Buffer Preparation Systems Market in Rest of the World, 2023-2035 (USD Billion)
12. CONCLUSION
13. APPENDIX I: TABULATED DATA
14. APPENDIX II: LIST OF COMPANIES AND ORGANIZATIONS
