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2013 Analysis of the European Molecular Diagnostics Market: France, Germany, Italy, Spain, UK Emerging Opportunities, Supplier Shares, Country Forecasts, Innovative Technologies, and Competitive Landscape

April 2013 | 970 pages | ID: 25A6B9B1123EN
Venture Planning Group

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This comprehensive five-country report is designed to help current suppliers and potential market entrants identify and evaluate major business opportunities emerging in the molecular diagnostics market during the next five years. The report explores business and technological trends in major European countries (France, Germany, Italy, Spain, UK); provides 5-year test volume/sales forecasts; estimates shares of leading competitors; compares features of major analyzers; profiles leading market players; and identifies specific product and business opportunities facing instrument and consumable suppliers during the next five years.

The $4.5 billion molecular diagnostics market is unquestionably the most rapidly growing segment of the in vitro diagnostics industry. The next five years will witness significant developments in reagent systems and automation, as well as introduction of a wide range of new products that will require innovative marketing approaches. The rate of market penetration into routine clinical laboratories, however, will depend on the introduction of cost-effective and automated systems with amplification methods.

In order to successfully capitalize on the opportunities presented by the molecular diagnostics market, many companies are already exploiting new technologies as corporate strategic assets, managed in support of business and marketing strategies. Integrating new technology planning with business and corporate strategies will be one of the most challenging tasks for diagnostics companies during the next five years.

Contains 970 pages and 75 tables
INTRODUCTION

WORLDWIDE MARKET AND TECHNOLOGY OVERVIEW

A. DNA Sequencing
  1. Introduction
  2. Sequencing Methods
  3. Autoradiography
  4. The Human Genome Project
  5. Sequencing Automation
  6. Image Scanners
  7. Fluorescent Detection
  8. Gene Profiling
  9. Gene Expression
  10. Polymorphism Screening
  11. Protein Interaction Networks
B. DNA And RNA Probe Technology
  1. Basic Principles
  2. Probe Preparation
  3. The DNA Probe Test
    a. Sample Preparation
    b. Hybridization
    c. Separation
    d. Detection/Measurement
  4. Test Formats
    a. Filter Hybridization
    b. Southern Blot
    c. Northern Blot
    d. In Situ Hybridization
    e. Others
  5. Labeling Techniques
  6. Amplification Methods
    Polymerase Chain Reaction
      Temperature Cyclers
      PCR Variations
        Immuno-PCR
        QC-PCR
        DAP-PCR
      Strand Displacement Activation
      TMA
      Ligase Chain Reaction
      Branched DNA
    Hybridization Protection Assay
      Nucleic-Acid Sequence-Based Amplification
      Self-Sustained Sequence Replicase
      Others
    Ampliprobe
    CAR
    CAS
    CPT
    Dendritic Polymer Technology
    ISO-CR
    LAT
    Probe Networks
    RAMP
    Repair Chain Reaction
    Rolling Circles
    Sequence Independent Gene Amplification
    Sequence Initiation Reaction
    SISPA
    Solid Phase Amplification
C. Detection Technologies
  1. Radioactive Methods
    a. Overview
    b. Major Isotopes
      P-32
      S-35
      H-3
      I-125
  2. Non-Isotopic Methods
    a. Enzymatic Labels
    b. Chemical Labeling
      Indirect Chemical Labeling
      Direct Chemical Labeling
    c. Fluorescence
    d. Chemiluminescence
    e. Electrical Conductivity
D. Instrumentation Review
  1. Abbott LCx
  2. Beckman Coulter/Biomek FK
  3. Becton Dickinson SDA
  4. Bio-Rad GeneScope
  5. Gen-Probe Tigris
  6. Roche Cobas Amplicor
  7. Tecan LS Series
E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip
  Liquid Transportation and Mixing
  Separation
  Reaction
  Detection
F. Pharmacogenomics
G. Major Applications
  1. Microbiology/Infectious Diseases
    a. Overview
    b. Major Infectious Diseases
      AIDS
        Structure and Composition
        Classification
        AIDS Origins
        Animal Lentivirus Systems
        Virus Receptors
        HIV Infections in Humans
          Pathogenesis and Pathology
        CD4T Lymphocytes and Memory Cells
        Monocytes and Macrophages
        Lymphoid Organs
        Neural Cells
        Viral Coinfections
          Clinical Findings
        Plasma Viral Load
        Pediatric AIDS
          Neurologic Disease
          Opportunistic Infections
          Cancer
        Immunity
          Virus Isolation
          Serology
          Viral Nucleic Acid/Antigen Detection
        Epidemiology
          Worldwide Spread of AIDS
          United States
          Routes of Transmission
        DNA Probes
          Overview
          Quantitative PCR
          In Situ PCR
          Needed Improvements
        Viral Load/Drug Resistance Testing
        Genotype and Phenotype Testing
        Blood Banking Considerations
      Adenovirus
          Background
          Diagnostic Tests
          Vaccines and Drugs
          Adeno-Associated Viruses (AAV)
        Anthrax/Bacillus Anthracis
          Background
          Diagnostic Tests
          Vaccines and Drugs
        Babesiosis
          Background
        BEA and Other Bartonella Diseases
          Background
          Diagnostic Tests
          Vaccines and Drugs
        Chagas Disease
          Background
        Campylobacter
          Background
          Diagnostic Tests
            Culture Identification
          Vaccines and Drugs
        Chlamydia
          Background
            Chlamydia psittaci
            Chlmaydia pneumoniae
            Chlamydia trachomatis
          Diagnostic Tests
          Vaccines and Drugs
        Creutzfeldt-Jakob’s Disease
          Background
          Blood Transmission
          Diagnostic Tests
          Major Commercial and Academic Players
            Bayer
            Disease Sciences/Bio Tec Global
            Imperial College School of Medicine
            Ortho-Clinical Diagnostics
            Pall
            ProMetic Life Sciences
            Proteome Sciences/Idexx
            Q-One Biotech
            Serono
            U.S. Agricultural Research Service
          Drugs
          Vaccines
        Cytomegalovirus
          Background
            Chorioretinitis
            Gastrointestinal
            Central Nervous System Disease
          Diagnostic Tests
          Vaccines and Drugs
        Ebola Virus
          Background
            Epidemiology
            Clinical Syndromes
          Diagnostic Tests
          Vaccines and Drugs
        EchoVirus
          Background
            Acute Aseptic Meningitisis
            Encephalitis
            Exanthems
            Respiratory Disease
            Myopericarditis
            Neonatal Infections
        Diagnostic Tests
        Vaccines and Drugs
      Encephalitis
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Enteroviruses
        Background
        Diagnostic Tests
          Viral Isolation and Identification
          Antibody Tests
        Vaccines and Drugs
      Epstein-Barr Virus
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Gonorrhea
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Hepatitis
        Hepatitis A
        Hepatitis B
          Structure and Composition
          Replication
        Hepatitis C
        Hepatitis D (Delta)
        Hepatitis E
        Hepatitis G
        Hepatitis Infections Pathology
        Clinical Findings
        Laboratory Tests
          Hepatitis A
          Hepatitis B
          Hepatitis C
          Hepatitis D
          Hepatitis E
        Virus-Host Immune Reactions
        Epidemiology
          Hepatitis A
          Hepatitis B
          Hepatitis C
          Hepatitis D (Delta)
        Vaccines and Drugs
      Herpes Simplex Virus
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Legionella
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Lyme Disease
        Background
          Clinical Description
          Clinical Case Definition
          Laboratory Criteria for Diagnosis
          Case Classification
        Diagnostic Tests
        Vaccines and Drugs
      Malaria
      Mycoplasma
        Background
          Ureaplasma Urealyticum & Mycoplasma Hominis
        Diagnostic Tests
        Vaccines and Drugs
      Papillomaviruses/HPV
        Background
          HPV in Cancer
          Cervical Neoplasm
        Diagnostic Tests
        Vaccines and Drugs
          Prevention
      Parvovirus B19
        Background
          Microbiology
          Epidemiology
          Clinical Syndromes
          Erythema Infectiosum (Slapped Cheek)
          Adult Polyarthropathy
          Transient Aplastic Crisis
          Transient Pancytopenia
          Red Cell Aplasia in Immunocompromised
          Perinatal Infections
        Diagnostic Test
        Vaccines and Drugs
      Pneumonia
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Polyomaviruses
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Salmonellosis
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Shigellosis
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Streptococci
        Background
        Diagnostic Tests
        Vaccines and Drugs
          Group A Streptococci
          Group B Streptococci
      Toxoplasmosis
        Background
        Diagnostic Tests
        Vaccines and Drugs
      Tuberculosis
        Background
        Diagnostic Tests
          Microscopic Characteristics
          Cultural Characteristics
          Skin Tests
          MDRTB
        Vaccines and Drugs
      West Nile Virus
        Background
          Clinical Syndromes
        Diagnostic Tests
        Vaccines and Drugs
      Yersinia
        Background
        Diagnostic Tests
        Vaccines and Drugs
    c. Antibiotic Susceptibility
  2. Cancer Testing
    a. Overview
    b. Major Cancer Types
      Prostate
      Lung
      Colon and Rectum
      Breast
      Skin
      Uterine
      Leukemia
      Oral
    c. Oncogenes
      Abl/abl-bcr
      AIB1
      BCL-2
      BRCA1
      CD44
      C-fos
      C-myb
      C-myc
      CYP17
      Erb-B
      HPC1
      N-myc
      P40
      P51
      P53
      PIK3CA
      PTI-1
      Ras
      Reg
      Sis
      Src
  3. Genetic Diseases
    a. Overview
    b. Nucleic Acid Amplification
    c. Chromosome Imaging
    d. Genomics Technologies
    e. Proteomics Technologies
    f. Current Pharmacogenomic Tests
    g. Future Pharmacogenomic Testing
    h. Major Diseases
      Achondroplasia
      Autosomal Dominant Polycystic Kidney Disease
      Cancer
      Cosmetogenomics
      Cystic Fibrosis
      Down's Syndrome
      Duchenne and Becker Muscular Dystrophy
      Factor V (Leiden)
      Factor IX Deficiency
      Fragile X Syndrome
      Heart Disease
      Hemochomatosis
      Hemophilia
      Huntington's Disease
      Maternal-Fetal Incompatibility
      Multiple Endocrine Neoplasia
      Phenylketonuria (PKU)
      Polycystic Kidney Disease (PKD)
      Prenatal Screening
      Retinitis Pigmentosa
      Retinoblastoma
      Sickle Cell Anemia
      Spinal Muscular Atrophy
      Vitamin B12 Metabolism
    i. Social Issues and Concerns
  4. Forensic Testing
    a. Overview
    b. Multilocus and Single Locus Probes
      Multilocus Probes
      Single Locus Probes
      PCR and RFLP
    c. The FBI
    d. DNA Profile Data Banks
      U.S.A.
      U.K.
    e. Judicial Implementation
    f. Major Crime Categories
    g. Factors Contributing to the DNA Probe Market Expansion
      Technology Availability
      Use of Hair as Evidence
    h. Wildlife Forensics
  5. Paternity Testing/HLA Typing
  6. Other Applications
    a. Disease Susceptibility Testing
    b. Cardiovascular Diseases
    c. Diabetes
    d. Alzheimer's Disease
    e. Periodontal Disease
    f. Plasma Purification
    g. Organ Transplantation
    h. Water Contamination
    i. Other
H. Competing/complementing Technologies
  1. Monoclonal Antibodies/Immunoassays
  2. RNA Probes
  3. Two-Dimensional Electrophoresis
  4. Flow Cytometry

FRANCE

A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares

GERMANY

A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares

ITALY

A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares

SPAIN

A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares

U.K.

A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares

MAJOR PRODUCT DEVELOPMENT OPPORTUNITIES

A. Instrumentation
B. Reagent Kits and Test Systems/panels
C. Computers, Software and Automation
D. Auxiliary Products

DESIGN CRITERIA FOR DECENTRALIZED TESTING PRODUCTS

ALTERNATIVE MARKET PENETRATION STRATEGIES

A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies For Decentralized Testing Markets
  1. Marketing Approaches
  2. Product Complexity
  3. Customer Preference
  4. Established Suppliers
  5. Emerging Suppliers
  6. Major Types Of Distributors
  7. Market Segmentation

POTENTIAL MARKET ENTRY BARRIERS AND RISKS

A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge And Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges

COMPETITIVE PROFILES

Abbott
Affymetrix
Agilent
Applied Gene Technologies
Arca
Beckman Coulter/Danaher
Becton Dickinson
Biokit
BioMerieux
Bio-Rad
Biotest
Caliper
Cepheid
Decode
Diadexus
Eiken
Enzo
Exact Sciences
Fujirebio
Gen-Probe
Hologic
Illumina
Innogenetics/Solvay
Kreatech
Li-Cor Biosciences
Life Technologies
Monogram Biosciences
Myriad Genetics
Nanogen/Elitech
Novartis
Orchid CellMark
Ortho-Clinical Diagnostics
Proteome Sciences
Qiagen
Roche
Scienion
Sequenom
Shimadzu
Siemens
Sierra Molecular
Takara Bio
Tecan Group

APPENDIXES

Appendix I: Major Universities and Research Centers Developing Molecular Diagnostic Technology
Appendix II: Glossary of Terms
Appendix III: Currency Exchange Rates

LIST OF TABLES

Major Companies Developing or Marketing AIDS Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Adenovirus Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Campylobacter Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Chlamydia Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing CMV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing EBV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Gonorrhea Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Hepatitis Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Herpes Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Legionella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Lyme Disease Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Mycoplasma Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Papilloma Virus Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Pneumonia Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Salmonella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Shigella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Streptococci Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Toxoplasmosis Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Tuberculosis Molecular Diagnostic And Other Direct Identification Tests
Oncogenes Potential Application in Cancer Diagnosis Major Companies Developing or Marketing Cancer Molecular Diagnostic Tests
Major Companies Developing or Marketing Molecular Diagnostic Test For Genetic Diseases
Summary Table France, Molecular Diagnostic Test Volume And Sales Forecast by Major Application
France, Laboratories Performing DNA Sequencing By Market Segment
France, Molecular Diagnostics Market Potential Laboratory Universe by Market Segment
France, Molecular Diagnostic Test Volume Forecast By Major Application
France, Major Infectious Disease Molecular Diagnostics Test Volume Forecast
France, Infectious Disease Screening NAT Volume Forecast
France, Molecular Diagnostics Market Forecast By Major Application
France, Infectious Disease Screening NAT Reagent Market Forecast by Test
France, Molecular Diagnostics Market By Major Supplier
France, HIV/Hepatitis NAT Market Reagent Sales By Major Supplier
Summary Table Germany, Molecular Diagnostics Test Volume And Sales Forecast by Major Application
Germany, Laboratories Performing DNA Sequencing by Market Segment
Germany, Molecular Diagnostics Market Potential Laboratory Universe by Market Segment
Germany, Molecular Diagnostics Test Volume Forecast By Major Application
Germany, Major Infectious Disease Molecular Diagnostics Test Volume Forecast
Germany, Infectious Disease Screening NAT Volume Forecast
Germany, Molecular Diagnostics Market Forecast By Major Application
Germany, Infectious Disease Screening NAT Reagent Market Forecast by Test
Germany, Molecular Diagnostics Market by Major Supplier
Germany, HIV/Hepatitis NAT Market Reagent Sales by Major Supplier
Summary Table Italy, Molecular Diagnostics Test Volume And Sales Forecast by Major Application
Italy, Laboratories Performing DNA Sequencing by Market Segment
Italy, Molecular Diagnostics Market Potential Laboratory Universe by Market Segment
Italy, Molecular Diagnostics Test Volume Forecast By Major Application
Italy, Major Infectious Disease Molecular Diagnostics Test Volume Forecast
Italy, Infectious Disease Screening NAT Volume Forecast
Italy, Molecular Diagnostics Market Forecast By Major Application
Italy, Infectious Disease Screening Nat Reagent Market Forecast by Test
Italy, Molecular Diagnostics Market By Major Supplier
Italy, HIV/Hepatitis NAT Market By Major Supplier
Summary Table Spain, Molecular Diagnostics Test Volume And Sales Forecast by Major Application
Spain, Laboratories Performing DNA Sequencing by Market Segment
Spain, Molecular Diagnostics Market, Potential Laboratory Universe by Market Segment
Spain, Molecular Diagnostics Test Volume Forecast by Major Application
Spain, Major Infectious Disease Molecular Diagnostics Test Volume Forecast
Spain, Infectious Disease Screening NAT Volume Forecast
Spain, Molecular Diagnostics Market Forecast By Major Application
Spain, Infectious Disease Screening Nat Reagent Market Forecast by Test
Spain, Molecular Diagnostics Market By Major Supplier
Spain, HIV/Hepatitis NAT Market Reagent Sales by Major Supplier
Summary Table U.K., Molecular Diagnostics Test Volume And Sales Forecast by Major Application
U.K., Laboratories Performing Dna Sequencing by Market Segment
U.K., Molecular Diagnostics Market Potential Laboratory Universe by Market Segment
U.K., Molecular Diagnostics Test Volume Forecast By Major Application
U.K., Major Infectious Disease Molecular Diagnostics Test Volume Forecast
U.K., Infectious Disease Screening NAT Volume Forecast
U.K., Molecular Diagnostics Market Forecast By Major Application
U.K., Infectious Disease Screening NAT Reagent Market Forecast by Test
U.K., Molecular Diagnostics Market by Major Supplier


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